Risteys · H7_HERPESKERATITIS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H19.1, H19.1B00.5 Cause of death: ICD-10 — H19.1, H19.1B00.5 2 out of 7 registries used, show all original rules.	1622
4. Check minimum number of events None	1622
5. Include endpoints None	1622
6. Filter based on genotype QC (FinnGen only)	1622

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	12217	6572	5592
Only index persons	11504	6258	5246
Unadjusted period prevalence (%)
Whole population	0.17	0.19	0.16
Only index persons	0.22	0.23	0.20
Median age at first event (years)
Whole population	53.84	55.22	52.20
Only index persons	53.05	54.42	51.40

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	1622	917	705
Unadjusted period prevalence (%)	0.31	0.31	0.31
Median age at first event (years)	55.80	53.67	58.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1456: Matched controls
14558

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

S01AD03

ATC

aciclovir; ophthalmic

302.8

323.0

1136

168

H19.1

ICD-10 Finland

Herpesviral keratitis and keratoconjunctivitis

+∞

323.0

445

H19.1*B00.5

ICD-10 Finland

Herpesviral keratoconjunctivitis

4503599627370496.0

323.0

1179

J05AB01

ATC

aciclovir; systemic

10.5

323.0

876

1826

H16.0

ICD-10 Finland

Corneal ulcer

43.3

241.2

301

H16.9

ICD-10 Finland

Keratitis, unspecified

544.1

238.6

231

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

698.2

190.4

184

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

5.1

183.2

948

3888

B00.5

ICD-10 Finland

Herpesviral ocular disease

204.0

143.5

147

J05AB11

ATC

valaciclovir; oral

5.8

136.2

453

1054

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

3.3

94.9

698

3176

H04.10

ICD-10 Finland

Dry eye syndrome

5.4

87.0

290

639

H19.2*B02.3

ICD-10 Finland

Keratitis and keratoconjunctivitis (interstitial) in zoster

364.0

70.2

H16.2

ICD-10 Finland

Keratoconjunctivitis

197.4

55.4

H20.1

ICD-10 Finland

Chronic iridocyclitis

+∞

52.4

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.0

50.7

338

1317

H03.1*B00.5

ICD-10 Finland

Herpesviral dermatitis of eyelid

48.8

50.5

H10.3

ICD-10 Finland

Acute conjunctivitis, unspecified

5.5

49.5

156

312

XCW99

NOMESCO Finland

Other investigative procedure of eye

3.6

48.9

243

759

H18.8

ICD-10 Finland

Other specified disorders of cornea

105.6

47.1

H20.9

ICD-10 Finland

Iridocyclitis, unspecified

450.7

44.5

B00.10

ICD-10 Finland

Herpes simplex facialis

16.3

41.2

Z96.1

ICD-10 Finland

Presence of intraocular lens

3.2

39.9

237

839

S01BA01

ATC

dexamethasone; ophthalmic (corticosteroids, plain)

7.1

39.4

147

H22.0*B00.5

ICD-10 Finland

Herpesviral iridocyclitis

+∞

38.7

S01FA04

ATC

cyclopentolate; ophthalmic

22.9

35.4

S01ED51

ATC

timolol, combinations; ophthalmic

3.8

35.2

158

448

H16.1

ICD-10 Finland

Other superficial keratitis without conjunctivitis

126.4

34.8

05405

ICD-8 Finland

Herpes simplex, Kerato-conjunctivitis herpetica

344.7

34.0

S01AX11

ATC

[U] ofloxacin; ophthalmic

5.6

33.9

102

192

F01

ICPC

Eye pain

7.0

32.7

125

H17.1

ICD-10 Finland

Other central corneal opacity

323.7

32.0

H13.1*B00.5

ICD-10 Finland

Herpesviral conjunctivitis

89.6

31.8

317

Kela drug reimbursment

Topical pimecrolimus and tacrolimus

10.1

31.8

H57.1

ICD-10 Finland

Ocular pain

5.9

30.1

152

S01ED01

ATC

timolol; ophthalmic

5.3

30.0

190

D11AX14

ATC

[U] tacrolimus; topical

29.3

29.9

H15.1

ICD-10 Finland

Episcleritis

32.4

29.1

Z94.7

ICD-10 Finland

Corneal transplant status

152.9

28.7

H10.9

ICD-10 Finland

Conjunctivitis, unspecified

4.0

27.6

116

309

H16.8

ICD-10 Finland

Other keratitis

+∞

27.2

S01GX01

ATC

cromoglicic acid; ophthalmic

2.2

26.8

325

1689

H17.8

ICD-10 Finland

Other corneal scars and opacities

275.8

26.8

S01BA04

ATC

prednisolone; ophthalmic (corticosteroids, plain)

9.5

26.6

XCK10

NOMESCO Finland

Photography of fundus of eye

2.8

26.3

181

697

L20.0

ICD-10 Finland

Besnier prurigo

3.5

26.2

128

388

H17.9

ICD-10 Finland

Corneal scar and opacity, unspecified

265.0

25.8

CG2S4

NOMESCO Finland

Photography of cornea

137.4

25.7

H02AB06

ATC

prednisolone; systemic

1.8

24.8

692

4887

B02.3

ICD-10 Finland

Zoster ocular disease

28.1

24.5

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

1.9

24.5

425

2547

D07AA02

ATC

hydrocortisone; topical

2.4

24.1

225

1027

S01EC01

ATC

acetazolamide; systemic

6.7

24.1

CGG45

NOMESCO Finland

Full thickness transplantation of cornea using homograft

+∞

24.0

H16.3

ICD-10 Finland

Interstitial and deep keratitis

+∞

24.0

F29

ICPC

Eye symptom/complaint other

3.0

23.5

144

513

H40.5

ICD-10 Finland

Glaucoma secondary to other eye disorders

15.6

23.3

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

2.9

23.0

147

540

S01EA05

ATC

brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)

5.7

22.7

120

CG2X4

NOMESCO Finland

Optical coherence tomography (OCT) of cornea

45.7

22.4

CG2T4

NOMESCO Finland

Topography assessment of cornea

24.3

22.2

H18.1

ICD-10 Finland

Bullous keratopathy

+∞

21.9

H18.5

ICD-10 Finland

Hereditary corneal dystrophies

223.1

21.6

S01AA01

ATC

chloramphenicol; ophthalmic (antibiotics)

3.5

21.6

106

322

J01DB01

ATC

cefalexin; oral

1.9

20.9

1164

9928

H22.0*B02.3

ICD-10 Finland

Zoster iridocyclitis

+∞

20.9

D06BB03

ATC

aciclovir; topical

3.4

20.7

104

322

H10.0

ICD-10 Finland

Mucopurulent conjunctivitis

3.4

20.5

102

314

D07BA04

ATC

hydrocortisone and antiseptics; topical

2.5

20.3

167

709

D11AX15

ATC

[U] pimecrolimus; topical

58.3

19.9

H19.2

ICD-10 Finland

Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere

202.5

19.6

H03.1

ICD-10 Finland

Involvement of eyelid in other infectious diseases classified elsewhere

34.8

18.9

D11AH01

ATC

tacrolimus; topical

10.0

18.7

E000002

ATC

2.3

18.4

182

850

TCG10

NOMESCO Finland

Removal of sutures from cornea

27.1

17.8

S01FA02

ATC

scopolamine; ophthalmic

13.9

17.8

H18.6

ICD-10 Finland

Keratoconus

182.0

17.5

XCH00

NOMESCO Finland

Eye pressure measurement

3.6

17.1

224

E0000UV

ATC

1.6

16.1

545

3912

H03.1*B02.3

ICD-10 Finland

Zoster blepharitis

16.9

16.1

TCG00

NOMESCO Finland

Protection of cornea and sclera with soft lens

48.0

16.0

E000001

ATC

1.8

15.6

295

1780

H01.0

ICD-10 Finland

Blepharitis

2.9

14.9

347

H10

ICD-10 Finland

Conjunctivitis

2.8

14.8

349

CJB10

NOMESCO Finland

Laser discission of secondary cataract

2.5

14.8

123

527

TCW99

NOMESCO Finland

Other minor procedure in eye surgery

6.2

14.7

H25.1

ICD-10 Finland

Senile nuclear cataract

1.7

14.2

326

2084

S01CA02

ATC

prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

9.8

14.2

S01EA03

ATC

apraclonidine; ophthalmic

8.9

14.0

H26.4

ICD-10 Finland

After-cataract

2.3

13.9

135

624

H20.8

ICD-10 Finland

Other iridocyclitis

141.2

13.5

TCF00

NOMESCO Finland

Subconjunctival therapeutic injection

141.2

13.5

114

Kela drug reimbursment

Glaucoma

2.3

13.4

127

578

L04AD01

ATC

ciclosporin; systemic

5.5

13.3

R50.9

ICD-10 Finland

Fever, unspecified

1.9

13.3

196

1080

S01EE01

ATC

latanoprost; ophthalmic

2.6

13.3

375

69100

ICD-8 Finland

Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum

5.4

13.2

R03AC02

ATC

salbutamol; inhalant

1.5

13.2

710

5615

H191, B023

ICD-10 Finland

+∞

12.5

F02

ICPC

Red eye

3.0

12.5

248

D07AC01

ATC

betamethasone; topical

1.6

12.5

464

3360

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

1.8

12.4

239

1441

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.5

12.4

574

4370

D07AC13

ATC

mometasone; topical

1.6

12.0

390

2725

F03

ICPC

Eye discharge

2.5

12.0

402

D07AB02

ATC

hydrocortisone butyrate; topical

1.6

11.7

372

2581

S01BA07

ATC

fluorometholone; ophthalmic (corticosteroids, plain)

5.1

11.7

R06AE07

ATC

cetirizine; oral

1.5

11.7

578

4445

S01BC03

ATC

diclofenac; ophthalmic

4.3

11.7

S01BC05

ATC

ketorolac; ophthalmic

3.0

11.7

230

D07CC01

ATC

betamethasone and antibiotics; topical

1.9

11.6

184

1039

H26.2

ICD-10 Finland

Complicated cataract

6.5

11.6

H11.1

ICD-10 Finland

Conjunctival degenerations and deposits

11.2

11.5

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.5

11.5

548

4173

J01CA04

ATC

amoxicillin; systemic

1.5

11.3

1100

9724

A02BC02

ATC

pantoprazole; systemic

1.5

11.3

860

7213

WX140

NOMESCO Finland

Parabulbar anesthesy

3.0

11.3

230

L04AA01

ATC

[U] ciclosporin; systemic

5.0

11.3

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

2.5

11.3

383

J01MA14

ATC

moxifloxacin; systemic

2.1

11.2

131

659

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

2.0

11.2

153

817

S01XA18

ATC

ciclosporin; ophthalmic

17.2

11.2

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

2.1

11.1

132

666

Z3229

NOMESCO Finland

Other healthcare associate professional

2.1

10.9

120

587

H20

ICD-10 Finland

Iridocyclitis

43.6

10.9

S01EC04

ATC

brinzolamide; ophthalmic

3.1

10.9

202

H02AB07

ATC

prednisone; oral

1.8

10.8

197

1166

B02.9

ICD-10 Finland

Zoster without complication

2.4

10.7

396

H18.9

ICD-10 Finland

Disorder of cornea, unspecified

60.4

10.6

H18.4

ICD-10 Finland

Corneal degeneration

60.4

10.6

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.4

10.5

666

5356

H15.0

ICD-10 Finland

Scleritis

110.7

10.4

H19.2*B30.0

ICD-10 Finland

Epidemic keratoconjunctivitis

+∞

10.4

H17.0

ICD-10 Finland

Adherent leukoma

+∞

10.4

CGG99

NOMESCO Finland

Other reconstructive operations on cornea and sclera

+∞

10.4

H16.4

ICD-10 Finland

Corneal neovascularization

+∞

10.4

J01DA01

ATC

[U] cefalexin; systemic

1.4

10.4

846

7132

E000007

ATC

2.5

10.4

337

F73

ICPC

Eye infection/inflammation other

4.1

10.3

CHD50

NOMESCO Finland

Shunt operation on anterior chamber

32.7

10.3

N02AX02

ATC

tramadol; systemic, rectal

1.5

10.3

551

4275

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.6

10.0

257

1682

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.5

10.0

368

2634

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

2.0

10.0

128

668

S01EX03

ATC

4.1

10.0

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

4.0

9.8

D07AB08

ATC

desonide; topical

1.9

9.8

153

859

H19.3*M35.0

ICD-10 Finland

Keratoconjunctivitis sicca

55.3

9.7

L04AX01

ATC

azathioprine; systemic

2.6

9.6

266

S01FA01

ATC

atropine; ophthalmic

11.4

9.6

H40.0

ICD-10 Finland

Glaucoma suspect

2.1

9.5

103

502

S05.0

ICD-10 Finland

Injury of conjunctiva and corneal abrasion without mention of foreign body

4.0

9.4

B00.11

ICD-10 Finland

Herpes simplex labialis

5.0

9.4

N02BE01

ATC

paracetamol; systemic, rectal

1.5

9.4

1175

10673

E85.80

ICD-10 Finland

Meretoja sick

+∞

9.4

H22.0

ICD-10 Finland

Iridocyclitis in infectious and parasitic diseases classified elsewhere

+∞

9.4

CGF35

NOMESCO Finland

Repair of cornea using graft

+∞

9.4

Z3231

NOMESCO Finland

Registered nurse

1.5

9.2

347

2492

H3603, E103

ICD-10 Finland

5.9

9.1

D11AH02

ATC

pimecrolimus; topical

9.1

9.0

C03CA01

ATC

furosemide; systemic

1.5

9.0

353

2549

H10.1

ICD-10 Finland

Acute atopic conjunctivitis

3.5

9.0

116

L04AA06

ATC

mycophenolic acid; systemic

4.4

8.9

6918B

ICD-9 Finland

Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]

6.1

8.9

B00.19

ICD-10 Finland

Other vesicular dermatitis caused by the herper simplex virus

8.7

8.8

J01FF01

ATC

clindamycin; systemic

1.5

8.7

342

2469

R03BA02

ATC

budesonide; inhalant

1.6

8.7

222

1446

H16

ICD-10 Finland

Keratitis

50.3

8.7

H13.1

ICD-10 Finland

Conjunctivitis in infectious and parasitic diseases classified elsewhere

50.3

8.7

TQW80

NOMESCO Finland

Local dermatologic skincare

3.1

8.7

147

R03AC13

ATC

formoterol; inhalant

2.4

8.7

318

ZXA10

NOMESCO Finland

Bilateral

1.6

8.6

240

1597

L20

ICD-10 Finland

Atopic dermatitis

3.3

8.5

127

H10.4

ICD-10 Finland

Chronic conjunctivitis

6.4

8.5

D02AE01

ATC

carbamide; topical

2.1

8.5

454

127

Kela drug reimbursment

Transplant complication

4.4

8.4

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

1.7

8.4

171

1046

H18.2

ICD-10 Finland

Other corneal oedema

90.5

8.4

WX100

NOMESCO Finland

Conjunctival surface anesthesia

1.8

8.4

135

766

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.4

8.3

450

3463

H190, B005

ICD-10 Finland

+∞

8.3

TCA20

NOMESCO Finland

Peribulbar therapeutic injection into orbit

+∞

8.3

H10.5

ICD-10 Finland

Blepharoconjunctivitis

4.2

8.3

N03AX16

ATC

pregabalin; oral

1.5

8.3

296

2095

CD2S4

NOMESCO Finland

Photography of eye

6.9

8.1

UJF32

NOMESCO Finland

Coloscopy

1.5

8.0

310

2229

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

1.4

7.9

394

2977

E000006

ATC

2.0

7.9

100

519

J01FA06

ATC

roxithromycin; oral

1.4

7.9

523

4170

R06.0

ICD-10 Finland

Dyspnoea

1.5

7.8

306

2206

H10.2

ICD-10 Finland

Other acute conjunctivitis

5.1

7.7

H25.8

ICD-10 Finland

Other senile cataract

1.8

7.7

127

727

J01DA09

ATC

[U] cefadroxil; inhalant, oral

1.5

7.6

346

2570

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

2.0

7.6

100

530

B00.0

ICD-10 Finland

Eczema herpeticum

8.9

7.5

S01AA12

ATC

tobramycin; ophthalmic

10.1

7.5

J18.9

ICD-10 Finland

Pneumonia, unspecified

1.5

7.5

278

1978

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

1.8

7.4

123

705

H02AB04

ATC

methylprednisolone; systemic

1.6

7.4

179

1149

J45.0

ICD-10 Finland

Predominantly allergic asthma

1.9

7.4

106

576

CFD10

NOMESCO Finland

Repair of conjunctiva

80.4

7.4

B02.8

ICD-10 Finland

Zoster with other complications

7.7

7.4

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.4

7.4

400

3067

0544B

ICD-9 Finland

Herpes simplex, With ophthalmic complications[KERATITIS DENDRITICA, HERPETICA]

+∞

7.3

H19.8*E85.80

ICD-10 Finland

Reticular keratitis in Meretoja's patients

+∞

7.3

R42

ICD-10 Finland

Dizziness and giddiness

1.5

7.2

257

1808

S01EC54

ATC

brinzolamide, combinations; ophthalmic

5.2

7.2

N03AX12

ATC

gabapentin; oral

1.6

7.1

194

1283

CKD65

NOMESCO Finland

Pars plana or pars plicata vitrectomy

3.3

7.1

106

B00.1

ICD-10 Finland

Herpesviral vesicular dermatitis

6.1

7.1

R03BA05

ATC

fluticasone; inhalant

1.5

7.0

230

1591

L30.9

ICD-10 Finland

Dermatitis, unspecified

1.5

7.0

220

1506

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

1.7

7.0

150

932

H01

ICPC

Ear pain/earache

1.8

7.0

121

701

T89

ICPC

Diabetes insulin dependent

2.5

7.0

220

UDC00

NOMESCO Finland

Ear microscopy

1.9

7.0

495

J45.9

ICD-10 Finland

Asthma, unspecified

1.6

7.0

212

1440

A10AA01

ATC

2.8

6.9

148

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

3.9

6.9

N05BB01

ATC

hydroxyzine; systemic

2.0

6.9

419

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

1.8

6.8

107

601

H43.1

ICD-10 Finland

Vitreous haemorrhage

3.2

6.8

104

R06AX13

ATC

loratadine; oral

1.6

6.8

186

1231

SPAT1249

SPAT

Treatment-related counselling outside office

1.4

6.8

503

4064

H02AB09

ATC

hydrocortisone; systemic

3.1

6.8

110

CGD10

NOMESCO Finland

Laser keratoplasty for error of refraction

9.4

6.8

H26.02

ICD-10 Finland

Presenil cataract

2.9

6.8

137

N02AJ06

ATC

codeine and paracetamol; systemic

1.4

6.8

460

3662

A46

ICD-10 Finland

Erysipelas

1.6

6.7

170

1104

R51.80

ICD-10 Finland

Headache

1.6

6.6

178

1173

H33.0

ICD-10 Finland

Retinal detachment with retinal break

2.7

6.6

153

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

1.6

6.6

158

1010

H40.9

ICD-10 Finland

Glaucoma, unspecified

3.6

6.6

J30.10

ICD-10 Finland

Allergic rhinitis due to pollen

2.3

6.6

267

R06AX27

ATC

desloratadine; oral

1.4

6.6

324

2439

E000003

ATC

2.2

6.5

292

J15.8

ICD-10 Finland

Other bacterial pneumonia

6.9

6.5

D09AB01

ATC

zinc bandage without supplements; topical

3.2

6.5

L20.9

ICD-10 Finland

Atopic dermatitis, unspecified

2.6

6.5

166

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

2.4

6.4

204

R06AX22

ATC

ebastine; oral

1.5

6.4

202

1383

R06AE09

ATC

levocetirizine; oral

1.6

6.4

174

1150

R10.1

ICD-10 Finland

Pain localized to upper abdomen

1.5

6.3

191

1293

R03AC03

ATC

terbutaline; inhalant

1.6

6.3

172

1135

N02AA05

ATC

oxycodone; systemic

1.6

6.3

172

1135

F70

ICPC

Conjunctivitis infectious

3.0

6.3

111

A10AE04

ATC

insulin glargine; parenteral

1.7

6.3

120

723

D06BX01

ATC

metronidazole; topical

1.7

6.3

133

826

H19.3

ICD-10 Finland

Keratitis and keratoconjunctivitis in other diseases classified elsewhere

+∞

6.3

ZZL00

NOMESCO Finland

Free graft of amniotic membrane

+∞

6.3

3604

FHL

Penetration of the cornea

+∞

6.3

XCK00

NOMESCO Finland

Perimetry

1.9

6.2

470

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.4

6.2

350

2691

A10AE05

ATC

insulin detemir; parenteral

2.0

6.2

364

XQ800

NOMESCO Finland

Prick test

1.9

6.1

481

H00.03

ICD-10 Finland

Preseptal cellulite in the eyelid

7.7

6.1

B00.9

ICD-10 Finland

Herpesviral infection, unspecified

7.7

6.1

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

2.7

6.1

143

H40.13

ICD-10 Finland

Chronic glaucoma with open ventricular angle

2.2

6.1

271

H01.1

ICD-10 Finland

Noninfectious dermatoses of eyelid

8.6

6.1

E10.3

ICD-10 Finland

Type 1 diabetes mellitus, With ophthalmic complications

2.7

6.0

147

H25.0

ICD-10 Finland

Senile incipient cataract

2.0

6.0

347

Mortality – FinRegistry

↥

Association

Association between endpoint H7_HERPESKERATITIS and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_HERPESKERATITIS	1.265 [1.13, 1.41]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.337

During the follow-up period (1.1.1998 — 31.12.2019), 1095 out of 6103 females with H7_HERPESKERATITIS died.

Males

Parameter	HR [95% CI]	p-value
H7_HERPESKERATITIS	1.22 [1.09, 1.37]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.006

During the follow-up period (1.1.1998 — 31.12.2019), 1073 out of 5181 males with H7_HERPESKERATITIS died.

Mortality risk

Mortality risk for people of age

years, who have H7_HERPESKERATITIS.

N-year risk	Females	Males
1	0.162%	0.24%
5	0.728%	1.368%
10	1.919%	3.58%
15	3.975%	6.901%
20	6.792%	11.807%

Relationships between endpoints

↥

Index endpoint: H7_HERPESKERATITIS – Herpesviral keratitis and keratoconjunctivitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	H7_HERPESKERATITIS
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H191
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H191
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Herpesviral keratitis and keratoconjunctivitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints