Risteys · M13_INFARCMUSC

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M62.2 Cause of death: ICD-10 — M62.2 2 out of 7 registries used, show all original rules.	27
4. Check minimum number of events None	27
5. Include endpoints None	27
6. Filter based on genotype QC (FinnGen only)	27

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	262	93	166
Only index persons	216	78	138
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.01
Median age at first event (years)
Whole population	49.89	46.84	51.32
Only index persons	46.39	41.91	48.91

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	27	7	20
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	54.20	40.43	59.02

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3044640) Blood type and Crossmatch panel - Blood

2.81

1.67

2.3

3.3

—

(3033658) Prothrombin time (PT) actual/Normal

3.04

1.66

6.2

3.2

92.1

93.1

—

(42870588) Differential panel, method unspecified - Blood

2.75

1.60

4.4

6.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

2.51

1.45

3.5

4.3

—

(3026008) Bacteria identified in Urine by Culture

2.04

0.93

3.1

2.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.04

0.93

2.3

3.6

—

(3023368) Bacteria identified in Blood by Culture

2.04

0.88

5.8

4.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.84

0.0

1.4

—

(36304419) Bacteria [Presence] in Urine

1.50

0.47

3.1

2.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.56

0.43

1.6

3.4

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.42

0.0

1.6

—

0.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.42

0.0

1.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

133

1.50

0.37

2.9

pmol/l

13.8

15.0

1.30

121

(3010813) Leukocytes [#/volume] in Blood

232

0.72

0.25

28.8

20.0

e9/l

7.9

6.5

1.57

225

(3026361) Erythrocytes [#/volume] in Blood

231

0.74

0.24

28.6

20.1

e12/l

4.5

4.6

0.25

224

(3007461) Platelets [#/volume] in Blood

231

0.74

0.24

28.6

20.1

e9/l

222.2

235.5

0.63

224

(3003694) ABO and Rh group [Type] in Blood

1.35

0.22

1.2

1.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.35

0.22

1.5

1.6

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.22

0.0

1.4

—

1.7

—

(4010399)

0.00

0.21

0.0

1.4

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

2.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

174

1.31

0.17

28.4

11.9

40.1

41.4

0.43

130

(3002385) Erythrocyte distribution width [Ratio]

165

1.27

0.17

26.2

15.6

14.2

13.9

0.27

160

(3044889) 12 lead EKG panel

125

1.25

0.14

4.1

3.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

124

0.81

0.12

2.5

3.0

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

209

1.28

0.09

25.8

14.7

mmol/l

140.0

139.5

0.59

203

(3023103) Potassium [Moles/volume] in Serum or Plasma

208

1.31

0.09

25.8

14.8

mmol/l

3.9

4.0

0.02

202

(3013512) EKG study

0.81

0.09

4.0

4.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

132

1.13

0.03

4.6

3.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.97

0.00

3.3

2.8

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

221

0.98

0.00

10.6

u/l

134.0

29.3

0.49

214

(40758558) Short blood count panel - Blood

1.00

0.00

6.2

6.7

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.5

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.7

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.6

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.1

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.6

—

(40768804) Tissue Pathology biopsy report

0.93

0.00

1.3

2.1

—

(40761511) CBC panel - Blood by Automated count

208

1.04

0.00

18.1

13.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.0

1.0

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

0.00

0.0

8.8

—

4.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

681.6

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

222

0.95

0.00

19.9

16.0

umol/l

77.2

80.8

0.29

222

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

1.7

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

10.6

—

9.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.02

0.00

1.2

4.0

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

3.8

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

3.0

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

26.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.0

3.6

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.0

1.2

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.0

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.1

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(4146454)

0.00

0.0

1.7

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

0.0

5.4

—

1195.6

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

1.0

—

1.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

2.6

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.4

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_INFARCMUSC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_INFARCMUSC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_INFARCMUSC – Ischaemic infarction of muscle

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	M13_INFARCMUSC
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M622
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M622
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Ischaemic infarction of muscle

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints