Rhabdomyosarcoma

C3_RHABDOMYOSARCOMA

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Cause of death: ICD-10 — C48.4\|C49.4 Cancer registry: Topography ICD-O-3 — ANY Cancer registry: Morphology ICD-O-3 — 8900\|8901\|8910\|8920\|8963 Cancer registry: Behaviour codes — 3 2 out of 7 registries used, show all original rules.	30
4. Check minimum number of events None	30
5. Include endpoints None	30
6. Filter based on genotype QC (FinnGen only)	30

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze: DF8

NAME	C3_RHABDOMYOSARCOMA
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	C48.4\|C49.4
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	ANY
CANC_TOPO_EXCL
CANC_MORPH	8900\|8901\|8910\|8920\|8963
CANC_MORPH_EXCL
CANC_BEHAV	3

Similar endpoints

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List of similar endpoints to Rhabdomyosarcoma based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Not enough data for upset table.

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	30	12	18
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	17.47	15.45	18.83

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(4035726)

25.23

17.48

2.1

1.1

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

16.79

10.80

6.0

8.4

260.73

162.10

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

11.56

10.37

7.6

5.6

31.50

32.80

0.28

(3036489) Thrombin time

15.21

10.17

5.5

7.9

23.82

23.36

0.07

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

11.63

9.86

11.5

3.4

364.21

266.71

u/l

0.54

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

12.78

9.07

6.8

9.1

90.64

87.85

0.10

(3021879) Hepatitis B virus core Ab [Presence] in Serum

10.44

8.29

1.3

1.7

—

(36304419) Bacteria [Presence] in Urine

8.91

8.16

6.1

4.2

—

(3023368) Bacteria identified in Blood by Culture

8.53

7.82

7.5

3.2

—

(3044640) Blood type and Crossmatch panel - Blood

7.52

6.88

6.5

2.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

8.20

6.76

6.3

4.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

7.15

6.74

6.1

2.2

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

17.87

6.65

6.0

11.5

3.60

2.52

g/l

—

(40768804) Tissue Pathology biopsy report

6.70

6.07

3.9

1.7

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

6.94

5.51

25.3

12.6

1.20

1.22

mmol/l

0.98

(3007853) Bacteria identified in Skin by Aerobe culture

6.48

5.40

1.4

2.2

—

(40758558) Short blood count panel - Blood

5.89

5.38

41.8

6.2

—

(3012320) Pathologist interpretation of Cerebral spinal fluid tests

+∞

5.35

1.0

0.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

5.32

4.65

7.6

3.6

—

(3042936) Bacteria identified in Isolate by Culture

5.85

4.62

2.3

1.7

—

(3016244) Insulin [Units/volume] in Serum or Plasma

12.52

4.25

2.3

2.9

6.46

14.44

mu/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

4.97

4.21

1.5

1.7

—

(21494815) CD4 cells/100 lymphocytes in Specimen

12.05

3.67

2.2

3.2

—

(3044290) Cell count panel - Cerebral spinal fluid

10.31

3.43

1.2

3.4

—

(3000991) Gas panel - Venous blood

4.67

3.38

34.2

15.6

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

9.00

3.21

1.2

3.1

211.67

465.75

mg/l

—

(42870588) Differential panel, method unspecified - Blood

3.79

3.11

29.5

9.0

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

11.61

3.09

2.0

1.8

15.00

16.20

u/ml

—

(3003694) ABO and Rh group [Type] in Blood

3.69

2.99

2.2

1.5

—

(3023410) Appearance of Cerebral spinal fluid

9.66

2.85

1.2

4.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

3.65

2.82

1.6

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.83

2.39

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.83

2.39

1.4

1.5

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

5.74

2.16

29.0

7.8

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

5.21

2.02

1.0

1.5

—

(3012544) pH of Venous blood

3.23

2.01

29.6

13.9

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.13

1.94

1.8

1.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

133

2.92

1.94

7.7

4.7

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

135

2.84

1.93

65.0

9.8

4.03

4.09

e9/l

0.02

115

(3044889) 12 lead EKG panel

115

2.78

1.86

3.4

3.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.38

1.79

1.4

1.6

—

(3002256) Pathology report gross observation

3.68

1.76

1.0

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

4.06

1.68

3.8

4.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.94

1.63

15.0

15.9

24.93

24.20

mmol/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.56

1.60

1.3

2.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.63

1.48

3.7

4.2

—

(3019309) Folate [Moles/volume] in Red Blood Cells

0.00

1.04

0.0

1.9

—

1126.43

—

(3003338) MCHC [Mass/volume]

201

2.46

1.01

64.7

16.4

333.56

335.65

g/l

0.44

201

(3000494) Fungus identified in Specimen by Culture

2.52

1.00

1.5

1.2

—

(3015736) pH of Urine

2.04

0.97

3.6

4.2

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

0.00

0.83

0.0

1.3

—

0.94

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.83

0.0

1.2

—

(36660697) Celiac disease serology panel - Serum

0.00

0.82

0.0

1.1

—

(3013707) Erythrocyte sedimentation rate by Westergren method

144

1.87

0.80

4.4

4.0

5.74

10.01

mm/h

2.36

134

(3011288) Drugs identified in Urine by Screen method

0.00

0.63

0.0

2.0

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.63

0.0

1.8

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.63

0.0

1.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.63

0.0

1.5

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

0.63

0.0

3.3

—

31.50

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

206

0.60

0.59

3.5

3.2

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

1.60

0.51

3.9

2.7

1738.46

73.95

ug/l

0.54

(3026008) Bacteria identified in Urine by Culture

1.56

0.50

1.9

3.8

—

(3022313) Gas panel - Capillary blood

1.56

0.43

6.0

10.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.42

0.0

1.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.41

0.0

1.6

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.33

0.29

7.6

4.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

143

0.73

0.27

5.3

3.4

40.50

34.70

u/l

0.25

138

(1002224) Polysomnography panel

0.00

0.22

0.0

1.0

—

(3008898) HLA-B27 [Presence]

0.00

0.21

0.0

1.2

—

(3019225) pH of Specimen

0.00

0.21

0.0

3.4

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.20

0.0

1.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

177

0.79

0.16

2.9

3.5

1.42

1.35

mmol/l

0.25

166

(3019150) Specific gravity of Urine by Refractometry

1.23

0.11

1.6

3.8

—

1.01

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.19

0.11

13.2

4.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

173

0.84

0.10

3.2

3.1

1.03

1.30

mmol/l

1.47

163

(3019832) Treponema pallidum Ab [Presence] in Serum

1.10

0.10

1.0

1.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.16

0.10

1.2

2.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.07

0.09

10.5

3.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

190

0.87

0.06

5.9

3.9

2.60

1.88

mu/l

1.02

176

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

179

0.88

0.05

3.4

3.5

4.25

4.44

mmol/l

0.38

167

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

171

1.13

0.04

2.9

3.2

5.28

5.73

mmol/l

1.82

157

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.0

—

108.80

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.8

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.21

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

0.0

1.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.0

—

4.06

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

2.1

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

3.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.9

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.0

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

0.00

0.0

1.0

—

169.80

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.3

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

2.7

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.90

0.00

1.7

1.5

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.1

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

2.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

1.0

—

0.98

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: C3_RHABDOMYOSARCOMA – Rhabdomyosarcoma

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Rhabdomyosarcoma

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints