Rhabdomyosarcoma

C3_RHABDOMYOSARCOMA

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Cause of death: ICD-10 — C48.4\|C49.4 Cancer registry: Topography ICD-O-3 — ANY Cancer registry: Morphology ICD-O-3 — 8900\|8901\|8910\|8920\|8963 Cancer registry: Behaviour codes — 3 2 out of 7 registries used, show all original rules.	33
4. Check minimum number of events None	33
5. Include endpoints None	33
6. Filter based on genotype QC (FinnGen only)	31

Control definitions (FinnGen only)

Control exclude: C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze: DF8

NAME	C3_RHABDOMYOSARCOMA
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	C48.4\|C49.4
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	ANY
CANC_TOPO_EXCL
CANC_MORPH	8900\|8901\|8910\|8920\|8963
CANC_MORPH_EXCL
CANC_BEHAV	3

Similar endpoints

↥

List of similar endpoints to Rhabdomyosarcoma based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Not enough data for upset table.

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	31	12	19
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	17.25	15.45	18.39

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(4035726) Immunohistochemistry procedure

46.88

15.75

2.0

1.1

—

(3023368) Bacteria identified in Blood by Culture

11.76

11.35

7.3

2.7

—

(36304419) Bacteria [Presence] in Urine

10.56

10.30

7.1

3.8

—

(40768804) Tissue Pathology biopsy report

10.14

9.91

3.5

1.5

—

(3030467) Casts [#/volume] in Urine by Automated count

10.14

9.91

7.1

3.7

0.06

0.50

e6/l

1.51

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

16.04

9.46

10.2

2.3

371.88

260.83

u/l

0.76

(3002582) Erythrocytes [#/volume] in Urine

9.38

9.19

7.2

3.7

175.53

1143.72

e6/l

0.44

(3044640) Blood type and Crossmatch panel - Blood

8.82

8.88

7.1

2.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

8.42

8.72

6.8

2.2

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

18.49

8.50

5.5

3.3

240.77

157.09

1.30

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

9.48

8.21

7.3

3.8

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

19.96

8.16

5.4

4.7

3.35

2.52

g/l

—

(3036489) Thrombin time

14.43

7.67

5.1

2.9

23.77

22.86

0.18

(3018677) aPTT in Platelet poor plasma by Coagulation assay

9.78

7.57

7.5

3.6

31.59

32.49

0.19

(40758558) Short blood count panel - Blood

7.43

7.45

35.7

4.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

13.44

7.42

6.2

4.7

93.77

84.27

0.46

(3018095) Leukocytes [#/volume] in Urine

8.27

7.37

10.2

4.3

20.98

85.69

e6/l

0.64

(3021879) Hepatitis B virus core Ab [Presence] in Serum

12.70

6.77

1.3

1.6

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

107

7.69

6.41

28.4

13.7

1.20

1.23

mmol/l

1.47

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

7.86

6.32

6.9

4.3

1.00

1.96

e6/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

6.05

5.94

7.6

2.6

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

7.19

5.71

7.3

4.2

0.75

5.25

e6/l

—

(3012320) Pathologist interpretation of Cerebral spinal fluid tests

+∞

5.33

1.0

0.0

—

(40768795) Lymph node Pathology biopsy report

+∞

5.33

1.2

0.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

6.57

5.12

1.5

1.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

6.95

5.07

1.4

2.2

—

(3042936) Bacteria identified in Isolate by Culture

6.44

4.80

2.1

1.7

—

(3031040) Bacteria [#/volume] in Urine by Automated count

120

5.44

4.71

4.6

3.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

6.36

4.50

1.7

2.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

6.11

4.37

1.6

1.9

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

8.37

4.33

5.9

19.6

103.67

121.64

g/l

—

(3000991) Gas panel - Venous blood

5.62

4.32

28.8

16.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

4.67

4.25

1.6

1.9

—

(3016244) Insulin [Units/volume] in Serum or Plasma

12.23

4.23

2.3

3.4

6.46

15.83

mu/l

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

10.68

3.98

26.0

34.4

24.71

23.75

mmol/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

10.68

3.98

21.0

37.6

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

138

4.33

3.70

21.1

9.7

6.58

6.29

mmol/l

0.15

132

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

4.94

3.69

1.8

2.0

—

(3014007) Fractional oxyhemoglobin in Arterial blood

7.06

3.21

26.4

22.9

95.74

94.17

—

(3044290) Cell count panel - Cerebral spinal fluid

8.83

3.20

1.2

1.0

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

7.84

3.00

1.2

1.0

211.67

528.00

mg/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

7.84

3.00

1.3

1.8

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

9.52

2.84

2.0

1.8

15.00

19.67

u/ml

—

(3003694) ABO and Rh group [Type] in Blood

3.31

2.78

1.9

1.5

—

(3002256) Pathology report gross observation

5.61

2.76

1.3

1.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

145

3.39

2.76

8.8

4.4

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

4.36

2.73

41.3

18.7

1.24

1.08

mmol/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

123

3.37

2.71

40.2

5.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

8.14

2.64

1.0

1.4

—

(3023410) Appearance of Cerebral spinal fluid

8.14

2.64

1.2

1.1

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

3.77

2.56

32.8

7.0

24.20

23.26

mmol/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

150

3.19

2.49

68.6

5.1

3.89

4.03

e9/l

0.06

124

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.20

2.35

23.9

17.0

25.87

23.89

mmol/l

1.62

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.99

2.19

6.3

3.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.92

2.12

1.3

2.2

—

(3044889) 12 lead EKG panel

117

2.80

2.10

3.3

3.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

4.01

1.68

4.4

4.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.49

1.49

30.4

17.9

111.20

133.06

g/l

—

(3015736) pH of Urine

2.26

1.38

5.9

3.9

—

6.05

—

(3000494) Fungus identified in Specimen by Culture

2.59

1.25

1.5

1.3

—

(21494755) Public health laboratory ask at order entry panel

0.00

1.02

0.0

1.3

—

(3026008) Bacteria identified in Urine by Culture

2.00

0.86

1.7

3.4

—

(36660697) Celiac disease serology panel - Serum

0.00

0.82

0.0

1.1

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

104

1.81

0.82

3.6

2.7

1527.33

82.15

ug/l

0.54

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.85

0.66

1.4

2.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.62

0.0

1.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.62

0.0

1.7

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.62

0.0

1.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.60

0.0

1.5

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

1.63

0.57

2.1

2.7

69.23

70.83

nmol/l

0.10

(40761511) CBC panel - Blood by Automated count

250

1.79

0.54

25.6

9.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

222

0.66

0.45

3.7

3.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.3

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

0.42

0.0

3.3

—

33.20

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.42

0.0

1.1

—

1.99

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.41

0.0

2.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

(3022313) Gas panel - Capillary blood

1.44

0.37

8.5

10.6

—

(3019150) Specific gravity of Urine by Refractometry

1.37

0.35

1.5

3.9

—

1.02

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.36

0.24

6.9

3.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.26

0.23

1.0

1.8

—

(3019225) pH of Specimen

0.00

0.22

0.0

3.3

—

(3008898) HLA-B27 [Presence]

0.00

0.22

0.0

1.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.27

0.21

1.2

2.6

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.20

0.0

1.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.20

0.0

1.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

180

1.28

0.20

3.1

3.3

5.29

5.68

mmol/l

1.68

165

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.82

0.09

2.6

1.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

185

0.94

0.00

3.0

3.5

1.39

mmol/l

0.01

175

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

186

1.05

0.00

3.5

3.6

4.28

4.48

mmol/l

0.47

177

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

205

0.94

0.00

5.7

4.0

2.33

2.03

mu/l

0.53

190

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

147

1.04

0.00

4.6

3.2

37.47

35.97

u/l

0.07

142

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

183

0.96

0.00

3.3

3.1

1.08

1.27

mmol/l

0.93

173

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.7

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

1.5

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.3

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.3

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.0

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.1

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

9.58

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

-0.00

0.0

1.0

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

2.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.02

-0.00

10.5

2.7

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

-0.00

0.0

1.0

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

-0.00

0.0

1.0

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

0.95

-0.00

1.4

1.8

0.72

1.56

mmol/l

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

1.02

-0.00

4.3

2.2

1.75

2.77

mg/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.00

-0.00

1.5

1.7

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3003633) Ovomucoid IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.8

—

0.35

—

(3045414) Leukocytes [Presence] in Urine

0.00

-0.00

0.0

2.6

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: C3_RHABDOMYOSARCOMA – Rhabdomyosarcoma

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

R13

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Rhabdomyosarcoma

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Relationships between endpoints