Risteys · DRUGADVERS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E23.1# 1 out of 7 registries used, show all original rules.	34
4. Check minimum number of events None	34
5. Include endpoints None	34
6. Filter based on genotype QC (FinnGen only)	34

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	261	129	132
Only index persons	239	119	120
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	25.93	18.19
Only index persons	21.87	25.57	18.19

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	34	14	20
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	34.89	28.38	39.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3032080) INR in Blood by Coagulation assay

6.58

6.67

8.2

8.8

1.0

1.1

inr

—

(3012544) pH of Venous blood

6.59

5.78

5.3

9.4

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

5.91

5.65

4.6

2.4

16.7

14.2

nmol/l

0.52

(3035637) Corticotropin [Mass/volume] in Plasma

16.82

5.38

2.4

1.8

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

10.02

4.33

14.3

14.5

1.5

1.6

mg/l

—

(3023368) Bacteria identified in Blood by Culture

4.41

4.24

10.1

4.4

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

4.77

3.85

3.4

5.0

29.5

29.7

0.04

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

113

4.20

3.82

13.4

8.7

9.1

10.5

umol/l

0.68

104

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

179

5.20

3.68

19.3

7.1

92.2

72.9

u/l

1.24

171

(3021901) Oxygen saturation in Capillary blood

11.76

3.64

6.0

4.8

—

(42870588) Differential panel, method unspecified - Blood

3.85

3.60

16.0

7.9

—

(3000991) Gas panel - Venous blood

5.43

3.27

12.3

16.3

—

(3000850) Epithelial cells [#/volume] in Urine

3.86

3.26

11.5

2.6

4.0

4.7

e6/l

0.18

(3030905) Polymorphonuclear cells [#/volume] in Blood

11.39

3.07

7.6

4.0

2.7

3.6

e9/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

11.39

3.07

10.2

4.2

50.6

53.6

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

11.39

3.07

5.4

4.8

132.4

138.8

g/l

—

(3006504) Eosinophils/100 leukocytes in Blood

135

3.64

3.00

17.1

6.8

2.1

3.0

1.63

127

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

7.80

3.00

2.0

9.4

1.6

0.8

—

(3019069) Monocytes/100 leukocytes in Blood

136

3.60

2.95

17.5

7.0

8.2

0.02

131

(3022096) Basophils/100 leukocytes in Blood

130

3.38

2.78

17.5

6.9

0.4

0.6

0.91

125

(3009214) Lutropin [Units/volume] in Serum or Plasma

4.89

2.77

3.3

1.9

8.5

5.2

u/l

—

(3018010) Neutrophils/100 leukocytes in Blood

142

3.35

2.63

14.8

6.3

58.9

55.2

0.81

136

(3002030) Lymphocytes/100 leukocytes in Blood

144

3.27

2.53

17.2

6.6

28.1

29.9

0.35

138

(40758558) Short blood count panel - Blood

3.05

2.44

19.3

6.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

4.61

2.40

5.1

3.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

2.99

2.37

5.0

3.3

19.9

21.7

ng/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.41

2.34

3.9

2.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

6.28

2.29

2.2

9.4

0.8

0.6

—

(3013290) Carbon dioxide [Partial pressure] in Blood

6.28

2.29

13.0

2.7

5.2

5.1

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

6.28

2.29

13.0

2.7

10.1

8.3

kpa

—

(3026782) Osmolality of Urine

3.22

2.28

10.5

2.4

584.7

587.2

mosm/kgh2o

0.01

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.89

2.11

4.4

3.3

—

(3002582) Erythrocytes [#/volume] in Urine

2.79

2.11

12.2

2.5

192.2

49.1

e6/l

0.37

(3026008) Bacteria identified in Urine by Culture

2.95

2.10

7.5

3.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.80

2.07

15.8

5.6

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.73

2.00

20.9

8.7

23.8

25.2

mmol/l

—

(36304419) Bacteria [Presence] in Urine

2.70

1.94

10.2

2.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

173

2.67

1.92

11.0

4.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.55

1.92

3.7

1.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.58

1.87

12.4

2.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.40

1.84

4.0

1.9

—

(40768797) Stomach Pathology biopsy report

2.95

1.73

1.1

1.4

—

(40761536) Microorganisms panel - Urine sediment

3.12

1.68

16.7

3.4

—

(3013512) EKG study

2.59

1.60

2.1

3.7

—

(3022313) Gas panel - Capillary blood

3.24

1.58

16.3

4.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

138

2.36

1.56

10.9

4.3

0.0

estimate

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.53

1.53

2.3

1.8

—

(3033658) Prothrombin time (PT) actual/Normal

2.45

1.51

6.9

4.5

93.9

88.5

0.36

(3009261) Glucose [Presence] in Urine by Test strip

140

2.31

1.48

10.0

3.1

0.0

estimate

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

1.45

0.0

1.7

—

(3002256) Pathology report gross observation

2.81

1.37

1.0

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

2.24

1.35

1.7

89.3

98.2

pmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

109

2.12

1.26

11.7

2.8

—

(3020961) Endomysium IgA Ab [Titer] in Serum

2.90

1.26

1.4

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

137

2.12

1.25

10.5

3.0

0.0

estimate

—

(3000494) Fungus identified in Specimen by Culture

2.58

1.24

1.7

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

2.18

1.20

15.9

3.3

0.0

estimate

—

(3021960) Folate [Moles/volume] in Serum or Plasma

2.29

1.15

1.9

1.4

13.8

19.9

nmol/l

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.02

0.0

1.5

—

(3042936) Bacteria identified in Isolate by Culture

2.12

1.01

2.3

1.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.38

0.97

2.5

1.9

—

(3048689) Calprotectin [Mass/mass] in Stool

2.00

0.78

4.3

2.1

140.1

79.3

ug/g

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.99

0.71

4.2

3.9

30.2

27.7

—

(3015736) pH of Urine

110

1.65

0.64

9.4

2.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.69

0.63

12.8

2.4

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.62

0.0

2.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.86

0.62

2.0

1.2

—

(3003694) ABO and Rh group [Type] in Blood

0.54

2.4

1.7

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

203

1.62

0.54

6.1

3.1

62.2

42.4

u/l

0.88

195

(3044889) 12 lead EKG panel

155

1.51

0.48

4.8

3.0

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.54

0.46

5.2

4.2

1.7

1.8

ug/l

0.07

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.42

0.0

1.5

—

(3007461) Platelets [#/volume] in Blood

324

+∞

0.42

51.5

16.6

237.8

247.5

e9/l

0.44

319

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.31

0.32

4.7

2.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.36

0.29

2.0

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

1.27

0.28

5.3

2.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

258

1.48

0.28

36.1

9.2

84.1

93.6

ml/min/173m2

0.89

203

(40768804) Tissue Pathology biopsy report

1.37

0.28

1.8

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.7

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.22

0.0

1.5

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.22

0.0

1.7

—

3.2

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.22

0.0

1.6

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.3

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3026361) Erythrocytes [#/volume] in Blood

326

+∞

0.20

51.5

16.5

4.6

4.7

e12/l

0.27

321

(3010813) Leukocytes [#/volume] in Blood

326

+∞

0.20

51.4

16.5

6.5

6.6

e9/l

0.08

320

(3019150) Specific gravity of Urine by Refractometry

1.17

0.18

10.8

2.7

—

1.0

—

(1761868) Lipid panel - Serum or Plasma

113

1.24

0.16

3.9

2.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

244

0.82

0.12

4.6

3.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.84

0.08

1.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.83

0.08

2.0

1.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

112

0.97

0.00

6.8

4.5

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3023183) Ammonium ion [Moles/volume] in Plasma

0.00

0.0

19.8

—

52.0

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(4094501)

0.00

0.0

1.0

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.0

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

7.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.1

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.8

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

281

0.98

0.00

31.6

12.2

39.1

41.5

0.45

240

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

9.5

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.4

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.1

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_HYPOPI and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_HYPOPI.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_HYPOPI – Drug-induced hypopituitarism

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	DRUGADVERS_HYPOPI
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E231
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Drug-induced hypopituitarism

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints