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Hypothalamic dysfunction, including iatrogenic, not elsewhere classified

DOID Endpoint Browser PheWeb

E4_HYPOTHALDYSF

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E23.1#, E23.3
  • Hospital discharge: ICD-9 — 2537
  • Cause of death: ICD-10 — E23.1#, E23.3
  • Cause of death: ICD-9 — 2537

2 out of 7 registries used, show all original rules.

69

4. Check minimum number of events

None

69

5. Include endpoints

None

69

6. Filter based on genotype QC (FinnGen only)

69

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 500 262 235
Only index persons 443 232 211
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 36.55 37.24 35.34
Only index persons 34.34 35.41 33.16

-FinnGen-

Key figures

All Female Male
Number of individuals 69 40 29
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 39.36 38.41 40.68

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
63
Matched controls
631
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB09
ATC
hydrocortisone; systemic
253.7
37.4
35
*
E23.3
ICD-10 Finland
Hypothalamic dysfunction, not elsewhere classified
+∞
34.6
30
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
33.3
29
*
E23.1
ICD-10 Finland
Drug-induced hypopituitarism
+∞
33.3
29
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
23.4
21
*
H01AC01
ATC
somatropin; parenteral
+∞
18.6
17
*
H03AA01
ATC
levothyroxine sodium; systemic
11.0
15.8
36
68
E23.03
ICD-10 Finland
Lack of ACTH
+∞
14.1
13
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
14.1
13
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
9.0
11.9
28
51
102
Kela drug reimbursment
Diabetes insipidus
+∞
10.7
10
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
12.8
10.1
18
19
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
20.7
8.5
12
7
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
20.7
8.5
12
7
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
16.0
8.3
13
10
E23.2
ICD-10 Finland
Diabetes insipidus
+∞
7.4
7
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
34.4
7.4
9
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
77.4
6.6
7
*
H02AA02
ATC
fludrocortisone; oral
77.4
6.6
7
*
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
+∞
6.3
6
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
6.3
6
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
6.7
6.0
15
28

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
193
5.50
10.69
29.6
6.9
1.2
1.2
mmol/l
0.11
41
162
32
103
4.93
9.66
10.9
4.1
—
—
—
0
0
20
44
5.99
9.29
4.6
2.0
15.5
14.2
nmol/l
0.26
20
44
19
42
5.86
8.75
7.8
6.4
—
—
—
0
0
30
109
4.10
7.43
12.1
4.1
7.4
7.4
ph
—
10
21
38
165
3.90
7.26
14.1
7.1
1.0
1.1
inr
1.37
13
56
37
164
3.71
6.74
14.6
6.6
—
—
—
0
0
9
7
14.52
5.76
5.0
4.3
—
—
—
0
0
8
5
17.81
5.55
3.6
1.2
302.0
279.6
mosm/kgh2o
—
8
5
8
5
17.81
5.55
13.1
7.0
—
—
—
0
0
18
55
4.07
5.48
6.3
1.6
—
—
—
0
0
13
31
4.93
5.36
15.4
11.6
—
—
—
0
0
17
51
4.10
5.29
2.7
1.6
—
—
—
0
0
9
9
11.27
5.19
7.3
3.2
53.4
58.3
%
—
9
9
9
9
11.27
5.19
5.9
3.1
3.2
4.0
e9/l
—
9
9
34
165
3.09
5.01
5.4
3.4
26.0
18.6
ng/l
0.38
27
95
11
27
4.66
4.34
21.0
7.4
23.7
24.8
mmol/l
0.48
11
27
13
37
4.10
4.29
8.1
6.1
0.1
0.0
%
—
8
8
27
125
2.91
4.20
3.4
3.4
—
—
—
0
0
13
38
3.98
4.14
45.6
9.8
2.5
1.9
mmol/l
—
7
29
42
247
2.79
4.12
15.7
6.7
0.6
0.7
%
0.20
42
231
7
7
10.94
4.11
11.0
10.0
—
—
—
0
0
43
257
2.79
4.08
15.6
6.5
2.1
2.8
%
1.72
43
240
43
258
2.77
4.03
16.0
7.0
7.9
8.1
%
0.16
43
244
20
81
3.07
3.90
8.6
2.1
564.7
622.3
mosm/kgh2o
0.43
20
68
26
123
2.79
3.84
6.7
2.5
—
—
—
0
0
43
268
2.60
3.59
13.8
6.1
59.7
55.6
%
1.64
43
254
17
67
3.04
3.44
3.5
1.3
—
—
—
0
0
43
272
2.54
3.42
15.7
6.4
26.3
30.0
%
1.47
43
257
10
28
4.01
3.33
11.2
4.0
—
—
—
0
0
6
7
9.24
3.33
3.2
10.0
78.0
70.7
%
—
6
7
63
508
3.76
3.18
8.7
4.1
1.5
1.8
mu/l
1.24
58
479
12
40
3.42
3.15
8.3
5.0
0.5
0.4
%
—
6
7
16
64
2.95
3.14
1.9
1.7
1206.1
1233.1
nmol/l
—
10
48
13
46
3.25
3.12
8.2
5.3
0.7
0.7
%
—
8
14
7
12
6.35
3.10
11.9
2.4
5.0
5.1
kpa
—
7
12
7
12
6.35
3.10
11.9
2.4
9.8
8.6
kpa
—
7
12
13
47
3.18
3.01
12.6
3.2
—
—
—
0
0
22
107
2.55
2.99
5.3
2.8
1910.1
57.5
mg/l
0.47
15
72
20
94
2.59
2.91
9.6
2.2
3.6
5.4
e6/l
0.64
20
81
10
31
3.60
2.90
1.3
1.1
—
—
—
0
0
9
23
4.34
2.89
52.6
4.5
—
—
—
0
0
9
23
4.34
2.89
13.2
12.4
0.7
0.8
%
—
9
23
9
23
4.34
2.89
13.6
12.4
1.9
1.3
%
—
9
23
37
235
2.24
2.71
26.2
9.1
0.0
0.0
e9/l
0.45
31
194
49
351
2.37
2.67
9.4
3.7
—
—
—
0
0
10
33
3.37
2.65
3.8
5.4
—
—
—
0
0
8
21
4.17
2.55
1.0
4.1
—
—
—
0
0
7
16
4.74
2.54
83.0
19.5
—
—
—
0
0
7
16
4.74
2.54
1.7
2.6
1.3
1.3
mmol/l
—
7
16
5
8
6.63
2.41
1.6
1.0
797.4
248.9
pmol/l
—
5
8
21
112
2.26
2.28
8.0
3.6
5.1
8.4
mg/mmol
0.30
14
76
24
137
2.15
2.21
5.9
2.2
—
—
—
0
0
10
38
2.91
2.11
1.3
1.2
133.3
135.7
u/ml
—
10
31
27
168
2.00
1.95
2.0
1.7
91.5
94.6
pmol/l
0.12
17
85
63
544
2.82
1.95
51.4
12.0
139.7
139.8
mmol/l
0.19
63
526
64
557
3.05
1.88
43.0
11.1
18.7
20.8
mg/l
0.23
56
408
63
547
2.74
1.79
52.7
12.0
3.9
3.9
mmol/l
0.57
63
529
23
140
1.96
1.74
10.5
3.5
0.0
0.0
estimate
0.00
11
54
23
141
1.95
1.70
12.7
5.7
—
—
—
0
0
13
65
2.23
1.61
1.2
1.3
—
—
—
0
0
7
27
2.77
1.56
2.4
2.0
—
—
—
0
0
5
15
3.51
1.55
1.6
2.3
—
—
—
0
0
5
15
3.51
1.55
2.8
1.7
—
—
—
0
0
7
28
2.66
1.49
1.0
1.5
—
211.6
miu/ml
—
0
12
6
22
2.89
1.47
19.2
12.8
94.5
95.8
%
—
6
22
22
141
1.82
1.40
10.8
2.5
136.3
48.4
e6/l
0.33
22
96
23
151
1.78
1.35
1.6
1.3
0.4
1.9
u/ml
—
7
39
9
44
2.20
1.33
23.9
19.7
—
1.4
—
0
7
6
25
2.53
1.27
16.0
4.2
24.8
25.3
mmol/l
—
6
25
11
57
2.11
1.25
1.3
1.2
—
—
—
0
0
20
130
1.76
1.20
9.7
2.3
—
—
—
0
0
8
39
2.19
1.20
2.3
1.3
—
—
—
0
0
20
134
1.69
1.07
17.7
6.5
—
—
—
0
0
19
126
1.70
1.06
3.7
3.4
—
—
—
0
0
28
209
1.57
0.98
2.4
1.8
—
—
—
0
0
9
52
1.84
0.97
1.4
1.3
—
—
—
0
0
35
276
1.54
0.96
8.9
4.1
0.0
0.0
estimate
0.00
12
54
35
278
1.53
0.92
8.0
3.1
0.0
0.0
estimate
0.00
12
49
8
45
1.88
0.88
2.1
1.8
—
—
—
0
0
22
159
1.56
0.87
9.4
2.4
—
—
—
0
0
34
275
1.47
0.78
8.1
3.0
0.0
0.0
estimate
0.00
12
54
5
93
0.50
0.73
1.0
1.6
—
—
—
0
0
10
62
1.72
0.69
1.2
1.1
—
—
—
0
0
13
88
1.59
0.66
2.7
1.7
—
—
—
0
0
28
226
1.40
0.62
6.4
2.8
—
—
—
0
0
6
37
1.68
0.57
2.0
1.4
—
—
—
0
0
63
590
1.78
0.57
40.5
9.8
—
—
—
0
0
6
38
1.63
0.56
3.5
2.9
—
—
—
0
0
13
162
0.76
0.33
1.8
1.5
—
—
—
0
0
52
550
0.78
0.31
36.6
11.4
38.5
41.2
%
0.88
33
456
37
340
1.19
0.24
4.5
3.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
25
226
1.17
0.19
3.8
2.4
—
—
—
0
0
5
43
1.18
0.10
1.0
1.2
—
—
—
0
0
12
117
1.03
0.00
2.4
1.7
—
—
—
0
0
13
133
0.97
0.00
8.8
3.0
—
1.0
—
0
15
15
147
1.03
0.00
2.2
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.3
—
14.0
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
7.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_HYPOTHALDYSF and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_HYPOTHALDYSF.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: E4_HYPOTHALDYSF – Hypothalamic dysfunction, including iatrogenic, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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