≡ Risteys
R13

Documentation Changelog GitHub Contact & Feedback

Isolated growth hormone deficiency

Endpoint Browser PheWeb

E4_ISOLATED_GROWTH_HORMONE_DEFICIENCY

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E23.01
  • Cause of death: ICD-10 — E23.01

2 out of 7 registries used, show all original rules.

254

4. Check minimum number of events

None

254

5. Include endpoints

None

254

6. Filter based on genotype QC (FinnGen only)

224

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 224 93 131
Unadjusted period prevalence (%) 0.05 0.03 0.06
Median age at first event (years) 10.69 11.71 9.98

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
254
Matched controls
2540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H01AC01
ATC
somatropin; parenteral
779.8
307.7
236
42
101
Kela drug reimbursment
Anterior pituitary hypofunction
1241.5
307.7
211
10
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
307.7
253
*
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
139.3
225.1
115
15
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
19.7
132.4
143
156
E34.35
ICD-10 Finland
Abnormal growth retardation
19.7
94.1
83
61
301
Kela drug reimbursment
Growth hormone
27.0
84.8
62
30
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
23.0
84.7
67
39
E23.00
ICD-10 Finland
Panhypopituitarism
677.8
56.9
54
*
H03AA01
ATC
levothyroxine sodium; systemic
7.9
45.8
77
133
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
15.7
42.6
39
29
H02AB09
ATC
hydrocortisone; systemic
8.0
41.3
66
107
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
5.5
36.9
101
274
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
61.5
32.3
37
7
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.4
30.1
74
180
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
7.1
24.9
41
67
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
227.9
20.9
21
*
602
Kela drug reimbursment
Children's severe malnutrition
5.7
19.8
40
80
E34.30
ICD-10 Finland
Short stature NOS
20.3
19.6
29
16
E34.31
ICD-10 Finland
Short stature, prenatal disorder
23.1
19.1
27
13
Z31.5
ICD-10 Finland
Genetic counselling
4.3
18.2
54
149
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.1
17.5
113
516
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.2
15.9
86
352
E23.0
ICD-10 Finland
Hypopituitarism
+∞
15.8
15
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
170.0
15.7
16
*
Z3231
NOMESCO Finland
Registered nurse
2.9
15.6
145
797
E23.05
ICD-10 Finland
Lack of TSH
158.8
14.6
15
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.9
14.3
48
144
ZXD10
NOMESCO Finland
Scheduled procedure
2.7
13.8
131
714
E23.1
ICD-10 Finland
Drug-induced hypopituitarism
+∞
13.7
13
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.6
13.2
49
157
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
6.4
12.8
22
37
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
34.0
12.7
16
5
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.8
12.7
43
129
XCK00
NOMESCO Finland
Perimetry
10.1
12.3
24
26
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
14.4
12.2
20
15
121
Kela drug reimbursment
Severe hypofunction of sexual glands
18.1
11.4
17
10
ZXE00
NOMESCO Finland
One hour or less
2.5
11.3
139
835
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.6
10.9
27
64
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
4.2
10.9
31
82
Z3226
NOMESCO Finland
Physiotherapist
2.5
10.8
98
510
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.7
10.8
76
350
102
Kela drug reimbursment
Diabetes insipidus
62.7
10.7
12
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
10.6
70
311
G03DB01
ATC
dydrogesterone; oral
4.5
10.2
26
63
F83
ICD-10 Finland
Mixed specific developmental disorders
3.7
10.1
35
106
BF20A, ,
NOMESCO Finland
27.3
9.9
13
5
XA800
NOMESCO Finland
Neuropsychological investigation
3.0
9.6
49
189
E22.80
ICD-10 Finland
Central precocious puberty
18.4
9.5
14
8
L02AE02
ATC
leuprorelin; implant, parenteral
11.3
9.4
17
16
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
+∞
9.4
9
*
G03FB08
ATC
dydrogesterone and estrogen; systemic
16.4
9.1
14
9
RD210, ,
NOMESCO Finland
3.2
9.0
38
131
E23.03
ICD-10 Finland
Lack of ACTH
93.0
8.5
9
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
93.0
8.5
9
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
8.5
57
254
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
7.5
8.4
19
27
H47.2
ICD-10 Finland
Optic atrophy
17.9
8.2
12
7
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
8.1
103
606
T99
ICPC
Endocr/metab/nutrit disease other
13.6
8.0
13
10
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
7.9
60
283
Z2446
NOMESCO Finland
Social worker
2.3
7.8
70
356
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
19.1
7.7
11
6
H53.4
ICD-10 Finland
Visual field defects
12.4
7.7
13
11
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
7.6
74
389
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
7.3
100
599
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
+∞
7.3
7
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.7
7.3
17
38
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.8
7.2
40
161
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
20.7
7.2
10
5
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.1
7.1
20
52
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
6.7
7.1
17
27
Z2445
NOMESCO Finland
Psychologist
2.4
7.0
56
269
A06AD11
ATC
lactulose; oral
3.4
6.9
26
83
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.5
6.9
24
73
Y28
ICPC
Limited function/disability (Y)
41.2
6.8
8
*
WX1PA
NOMESCO Finland
Total body mineral density measurement with Dual energy X-ray absorptiometry (DXA)
10.4
6.6
12
12
R4110
NOMESCO Finland
Physiotherapy
2.1
6.6
89
528
ZXC86
NOMESCO Finland
Use of endoscopic device
71.6
6.5
7
*
E23.2
ICD-10 Finland
Diabetes insipidus
71.6
6.5
7
*
E30.09
ICD-10 Finland
Delayed puberty NOS
14.8
6.4
10
7
TAB00
NOMESCO Finland
Lumbar puncture
3.2
6.4
26
87
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.2
6.4
26
87
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
6.3
94
575
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
+∞
6.3
6
*
E23.08
ICD-10 Finland
Hypopituitarism
+∞
6.3
6
*
Q96.0
ICD-10 Finland
Karyotype 45,X
+∞
6.3
6
*
UKC02
NOMESCO Finland
Cystoscopy
3.5
6.1
21
63
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
5.8
6.1
16
29
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.1
6.1
17
44
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.7
6.0
19
54

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
129
267
8.79
67.49
4.4
3.1
312.17
321.95
nmol/l
0.22
124
259
79
105
10.47
59.65
1.8
1.8
—
—
—
0
0
91
197
6.64
43.32
3.2
2.2
4.35
5.13
u/l
0.58
60
121
85
177
6.71
41.99
3.0
2.3
6.69
8.99
iu/l
0.63
58
116
53
121
5.27
22.77
2.9
1.5
319.83
340.34
mu/l
0.19
53
112
49
109
5.33
21.63
2.9
3.4
4.89
5.21
pmol/l
0.98
49
100
187
1153
3.36
16.80
7.6
6.3
129.98
129.07
u/l
0.05
176
1090
93
407
3.03
15.18
5.8
4.7
7.38
7.40
ph
1.47
20
64
230
1682
4.89
14.50
6.3
3.8
1.86
1.98
mu/l
0.72
216
1589
102
480
2.88
14.46
12.3
13.3
1.32
1.34
mmol/l
0.54
95
458
23
38
6.56
13.65
2.6
1.5
0.22
0.42
nmol/l
0.67
18
29
94
485
2.49
10.49
3.9
3.5
2.40
2.40
mmol/l
0.23
88
448
154
1014
2.32
9.56
17.6
12.9
1.22
1.22
mmol/l
0.63
139
945
177
1256
2.35
8.94
11.1
11.1
8.58
8.37
%
0.45
172
1214
176
1247
2.34
8.90
10.9
10.9
4.08
3.24
%
2.45
171
1203
177
1270
2.30
8.49
10.4
10.9
0.04
0.04
e9/l
0.03
143
1066
180
1302
2.31
8.45
11.0
10.7
36.43
34.24
%
1.62
175
1263
177
1272
2.29
8.43
10.5
10.9
0.56
0.56
e9/l
0.05
143
1069
171
1215
2.25
8.33
11.1
11.1
0.60
0.66
%
0.73
166
1173
179
1303
2.27
8.11
11.3
12.0
0.25
0.22
e9/l
0.88
151
1114
178
1305
2.22
7.74
10.6
10.8
2.29
2.24
e9/l
0.27
146
1127
56
268
2.40
7.06
4.5
3.6
2.52
2.57
g/l
0.34
56
257
16
25
6.75
6.75
1.0
1.0
—
—
—
0
0
181
1374
2.10
6.66
12.0
13.3
3.49
3.52
e9/l
0.04
150
1150
120
792
1.98
6.55
8.0
11.2
—
—
—
0
0
238
2047
3.58
6.41
14.6
8.9
—
—
—
0
0
29
104
3.02
6.40
1.7
2.0
—
—
—
0
0
166
1244
1.97
6.04
11.6
12.5
0.00
0.00
e9/l
0.46
120
948
127
892
1.85
5.44
1.6
1.9
0.72
4.54
u/ml
2.82
18
136
157
1181
1.86
5.36
13.2
11.5
—
—
—
0
0
13
26
5.21
4.70
5.5
2.6
—
—
—
0
0
27
115
2.51
4.33
8.0
6.8
0.00
0.13
%
1.25
13
47
231
2041
2.46
4.28
24.0
17.6
13.48
13.45
%
0.08
231
2022
13
30
4.51
4.19
2.8
2.7
15.32
15.50
umol/l
0.02
13
30
26
111
2.50
4.15
8.2
7.0
0.00
0.00
%
-0.00
12
40
79
516
1.77
4.06
3.4
3.7
2.76
2.65
mg/l
0.21
73
466
118
864
1.68
4.00
1.9
1.7
1.49
1.63
g/l
0.57
51
422
14
43
3.39
3.97
7.5
4.5
3.03
3.29
e9/l
0.21
14
43
27
120
2.40
3.97
11.0
15.7
-0.42
0.37
mmol/l
0.43
22
98
123
913
1.67
3.94
4.5
3.5
87.65
68.32
ug/l
0.50
118
875
27
121
2.38
3.90
8.1
6.8
0.68
0.82
%
0.24
14
55
14
44
3.31
3.84
9.0
5.0
47.21
50.41
%
0.36
14
44
14
44
3.31
3.84
15.4
8.1
—
—
—
0
0
27
124
2.32
3.70
1.1
1.2
—
—
—
0
0
25
111
2.39
3.69
7.2
6.4
0.45
0.69
%
0.39
11
49
31
152
2.18
3.65
2.2
2.3
2.43
2.42
mmol/l
0.13
23
124
13
36
3.75
3.55
14.9
12.9
1.29
2.51
mmol/l
—
7
21
13
36
3.75
3.55
14.9
11.8
9.52
9.52
kpa
0.00
13
36
13
36
3.75
3.55
14.9
12.9
5.03
4.82
kpa
0.52
13
36
6
6
10.20
3.51
4.5
3.5
—
—
—
0
0
6
6
10.20
3.51
4.5
3.5
8.50
12.33
%
—
6
6
14
47
3.09
3.47
3.6
4.6
24.29
24.53
umol/l
0.03
14
47
13
37
3.65
3.45
6.2
2.2
27.25
37.16
mmol/l
0.87
13
37
15
53
2.95
3.42
6.5
9.2
—
—
—
0
0
217
1913
1.92
3.39
12.2
10.2
31.95
26.23
u/l
2.07
211
1858
36
193
2.01
3.37
9.4
11.3
106.39
104.99
mmol/l
0.82
36
193
18
73
2.58
3.20
3.1
4.9
72.44
66.59
%
0.59
18
73
18
73
2.58
3.20
3.1
4.9
8.50
7.85
%
0.25
18
73
72
486
1.67
3.20
13.9
11.3
—
—
—
0
0
6
8
7.65
3.07
1.3
1.0
—
—
—
0
0
62
407
1.69
3.05
1.4
1.2
—
—
—
0
0
160
1320
1.57
3.00
5.6
4.7
8.34
7.20
mm/h
0.79
151
1248
29
150
2.05
2.99
5.3
3.7
1.14
1.44
ug/l
0.79
29
129
8
17
4.82
2.94
2.7
3.1
1.10
1.11
umol/l
—
8
17
138
1107
1.54
2.89
11.1
7.9
6.15
6.26
mmol/l
0.14
129
1035
6
9
6.79
2.88
2.5
2.0
—
—
—
0
0
30
160
1.99
2.86
1.4
1.3
180.21
187.90
iu/ml
—
9
55
10
28
3.67
2.81
19.4
13.1
—
—
—
0
0
6
10
6.11
2.71
5.2
2.8
0.18
0.19
e9/l
—
6
10
8
19
4.31
2.70
2.9
1.9
34.50
32.11
pg
—
8
19
57
384
1.62
2.51
2.1
1.5
104.41
97.19
pmol/l
0.71
28
193
13
51
2.63
2.48
7.3
20.8
—
—
—
0
0
18
83
2.26
2.47
2.5
2.0
0.53
0.64
ug/l
0.59
13
38
17
77
2.29
2.43
3.2
4.8
36.82
35.98
%
0.09
17
77
47
304
1.67
2.42
8.3
8.1
1.43
1.35
%
0.30
42
295
6
12
5.09
2.41
1.0
1.2
—
—
—
0
0
6
12
5.09
2.41
1.0
1.2
—
—
nmol/l
—
0
0
5
8
6.35
2.38
1.2
1.5
194.16
46.26
mu/l
—
5
8
6
171
0.34
2.38
1.0
1.3
—
—
—
0
0
5
9
5.64
2.22
2.4
1.8
5.60
4.87
mmol/24h
—
5
9
6
14
4.36
2.16
1.2
1.1
—
—
—
0
0
6
14
4.36
2.16
1.0
1.3
—
—
—
0
0
12
50
2.47
2.06
2.5
3.0
49.33
24.32
u/ml
0.62
12
50
6
15
4.07
2.05
2.5
1.5
—
—
—
0
0
76
571
1.47
2.03
17.8
12.9
24.29
24.84
mmol/l
0.90
76
571
7
174
0.39
1.99
1.0
1.7
—
—
—
0
0
10
39
2.63
1.96
3.2
1.2
—
—
—
0
0
34
214
1.68
1.95
5.4
3.9
57.58
8.76
mg/mmol
0.53
23
166
6
16
3.81
1.94
1.5
1.1
—
—
—
0
0
77
585
1.45
1.94
3.9
3.5
—
—
—
0
0
43
289
1.59
1.91
2.5
1.9
—
—
—
0
0
12
52
2.37
1.91
4.7
5.4
—
—
—
0
0
38
553
0.63
1.85
2.0
2.1
—
—
—
0
0
145
1241
1.39
1.83
3.7
2.7
5.39
5.47
mmol/l
0.36
136
1142
7
23
3.10
1.81
2.3
1.5
91.29
47.43
pmol/l
—
7
23
13
60
2.23
1.81
1.2
1.5
412.00
352.13
ug/g
—
8
32
72
547
1.44
1.80
14.7
10.3
0.82
1.27
mmol/l
0.38
53
433
34
220
1.63
1.76
4.7
3.4
185.02
74.08
mg/l
0.41
25
168
67
504
1.45
1.76
11.8
9.9
23.51
23.60
mmol/l
0.11
67
504
6
18
3.39
1.75
2.5
4.4
87.83
242.22
ug/l
—
6
18
7
161
0.42
1.74
1.1
1.9
—
—
—
0
0
14
69
2.09
1.68
2.1
4.9
29.57
26.26
%
0.40
14
69
61
456
1.44
1.65
7.4
3.6
539.60
619.63
mosm/kgh2o
2.13
53
401
10
207
0.46
1.63
1.0
1.6
—
—
—
0
0
11
217
0.48
1.58
1.0
1.6
—
—
—
0
0
13
64
2.09
1.57
18.2
24.7
—
—
—
0
0
11
215
0.49
1.54
1.0
1.6
—
—
—
0
0
11
215
0.49
1.54
1.0
1.6
—
—
—
0
0
202
1858
1.43
1.48
26.4
14.1
3.94
3.96
mmol/l
0.34
197
1804
11
211
0.50
1.46
1.0
1.6
—
—
—
0
0
16
88
1.87
1.45
2.1
5.6
359.31
313.68
mg/l
0.26
16
88
15
81
1.91
1.43
2.5
5.9
—
—
—
0
0
5
17
2.98
1.36
4.2
2.6
—
—
—
0
0
5
17
2.98
1.36
1.0
1.1
—
—
—
0
0
12
217
0.53
1.34
1.1
1.3
7.08
7.02
u/ml
—
7
172
12
214
0.54
1.28
1.1
1.3
1.85
0.92
u/ml
—
6
163
5
118
0.41
1.28
1.0
1.8
—
—
—
0
0
9
45
2.04
1.24
3.4
5.0
2.46
5.85
u/ml
—
9
45
11
56
2.01
1.24
2.2
4.0
746.82
617.93
e6/l
0.43
11
56
8
37
2.20
1.22
3.3
16.3
—
—
—
0
0
10
50
2.04
1.18
7.6
22.9
69.30
74.19
%
—
10
50
15
87
1.77
1.18
16.4
14.8
0.68
0.71
%
0.20
15
87
32
226
1.48
1.17
2.1
2.3
—
—
—
0
0
24
159
1.56
1.17
5.5
11.1
22.83
23.81
s
0.63
24
153
32
228
1.46
1.13
4.3
6.0
65.24
64.18
e9/l
0.06
21
153
17
265
0.62
1.12
2.4
2.0
—
—
—
0
0
46
351
1.38
1.12
8.2
5.0
—
—
—
0
0
7
31
2.29
1.11
3.9
2.5
—
—
—
0
0
15
89
1.73
1.10
16.4
14.5
1.07
1.22
%
0.31
15
89
51
398
1.35
1.08
6.5
3.0
—
—
—
0
0
36
265
1.42
1.07
5.1
4.2
8.66
8.76
g/l
0.07
36
253
7
33
2.15
1.06
10.7
8.7
2.15
1.98
mg/l
—
7
25
13
75
1.77
1.05
2.4
6.3
—
—
—
0
0
38
284
1.40
1.05
1.2
1.4
—
77.21
—
0
14
9
46
1.99
1.05
5.9
4.2
333.22
304.72
ug/l
—
9
40
9
46
1.99
1.05
2.1
2.7
—
—
—
0
0
57
456
1.32
1.03
2.2
3.7
126.63
108.73
ug/g
0.12
46
377
58
466
1.32
1.02
8.0
3.7
5.02
4.67
e6/l
0.09
53
416
23
157
1.51
1.00
1.6
1.5
523.13
509.67
pmol/l
0.07
23
141
9
50
1.83
0.97
2.2
5.3
—
—
—
0
0
9
50
1.83
0.97
1.3
1.4
—
—
—
0
0
0
31
0.00
0.97
0.0
1.1
—
—
—
0
0
0
31
0.00
0.97
0.0
1.0
—
—
—
0
0
8
142
0.55
0.96
1.0
1.1
—
22.20
—
0
5
36
271
1.38
0.96
8.6
8.7
4.34
6.42
umol/l
0.99
30
230
43
334
1.35
0.95
4.0
6.4
3.30
1.92
mg/l
0.57
33
243
49
389
1.32
0.94
6.4
3.9
0.00
0.00
estimate
-0.00
22
140
29
211
1.42
0.93
15.5
13.3
1.94
1.37
mmol/l
0.55
29
200
218
2077
1.35
0.89
23.4
17.2
336.52
335.58
g/l
0.81
218
2064
29
213
1.41
0.89
2.8
2.2
0.90
0.95
g/l
0.22
29
204
60
494
1.28
0.88
4.2
6.4
1.02
1.19
inr
3.71
21
114
8
43
1.89
0.88
1.1
1.4
—
—
—
0
0
57
470
1.27
0.83
15.1
8.8
—
—
—
0
0
58
481
1.27
0.81
3.2
3.6
—
—
—
0
0
0
25
0.00
0.79
0.0
1.3
—
31.50
—
0
8
0
25
0.00
0.79
0.0
1.3
—
15.67
—
0
6
6
34
1.78
0.77
3.7
2.1
1.98
1.70
mmol/l
—
6
34
95
838
1.21
0.75
5.6
3.7
0.00
0.00
estimate
-0.00
22
137
12
76
1.61
0.73
10.8
4.9
27.33
37.18
umol/l
1.68
12
76
49
404
1.26
0.72
5.0
4.2
3.07
1.24
e6/l
0.64
30
253
9
58
1.57
0.70
1.2
1.5
—
—
—
0
0
93
824
1.20
0.70
5.7
3.6
0.00
0.00
estimate
-0.00
21
142
62
529
1.23
0.68
16.8
9.0
7.39
7.40
ph
—
8
13
0
20
0.00
0.60
0.0
11.6
—
775.25
—
0
20
0
22
0.00
0.59
0.0
2.6
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
1.58
—
0
16
13
89
1.49
0.59
18.7
14.6
94.92
95.00
%
0.01
13
89
8
125
0.63
0.56
1.0
1.0
—
—
—
0
0
30
241
1.28
0.55
2.6
2.9
—
—
—
0
0
6
38
1.59
0.54
1.0
1.1
—
—
—
0
0
43
362
1.23
0.54
3.6
3.2
1.01
1.01
kg/l
—
8
70
22
171
1.31
0.52
2.0
2.0
—
—
—
0
0
9
65
1.40
0.51
1.7
4.5
—
—
—
0
0
9
65
1.40
0.51
2.2
1.9
—
—
—
0
0
91
825
1.16
0.51
8.1
5.3
0.00
0.00
estimate
-0.00
22
143
12
85
1.43
0.47
1.4
2.4
0.98
0.36
nmol/l
2.18
12
70
56
634
0.85
0.47
1.7
1.6
—
—
—
0
0
13
175
0.73
0.46
1.4
1.5
—
—
—
0
0
38
445
0.83
0.46
1.7
1.7
—
—
—
0
0
26
314
0.81
0.43
1.7
1.6
—
—
—
0
0
5
33
1.53
0.41
2.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
35
298
1.20
0.41
3.0
2.8
15.51
49.86
ng/l
0.85
20
131
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
274.22
—
0
18
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
12
89
1.37
0.38
1.8
3.3
—
—
—
0
0
9
67
1.36
0.38
1.6
1.4
—
—
—
0
0
5
37
1.36
0.37
1.6
1.4
120.71
0.47
u/ml
—
5
37
6
41
1.47
0.36
11.3
24.3
11.27
12.33
%
—
6
41
5
78
0.63
0.36
2.4
4.3
—
—
—
0
0
6
42
1.44
0.36
1.3
1.1
—
—
—
0
0
78
843
0.89
0.33
2.5
2.3
—
—
—
0
0
6
88
0.67
0.33
1.5
1.2
—
—
—
0
0
6
89
0.67
0.33
1.5
1.2
—
—
—
0
0
74
684
1.12
0.30
9.1
4.8
22.12
40.87
e6/l
0.71
64
541
11
85
1.31
0.28
2.4
1.3
1.25
1.20
g/l
0.18
11
80
8
64
1.26
0.27
1.6
1.4
—
—
—
0
0
30
341
0.86
0.27
1.6
1.8
—
—
—
0
0
8
65
1.24
0.27
1.6
1.4
—
—
—
0
0
69
640
1.11
0.27
8.7
4.8
0.03
0.17
e6/l
2.38
59
499
56
609
0.90
0.27
2.1
2.0
—
—
—
0
0
11
87
1.28
0.24
7.0
14.7
0.46
0.66
%
1.78
11
87
11
136
0.80
0.23
4.1
2.4
—
—
—
0
0
16
135
1.20
0.22
11.6
4.0
—
—
—
0
0
69
647
1.09
0.22
8.7
4.7
—
—
—
0
0
5
42
1.19
0.21
1.2
1.0
—
—
—
0
0
8
101
0.79
0.21
1.1
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
5.8
—
4.35
—
0
10
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
7
60
1.17
0.18
2.1
2.1
—
—
—
0
0
116
1119
1.07
0.17
7.4
4.1
5.50
15.27
e6/l
—
6
11
125
1210
1.07
0.17
7.5
4.4
—
—
—
0
0
210
2069
1.09
0.16
18.3
12.4
17.20
24.38
mg/l
3.73
159
1395
49
460
1.08
0.15
2.6
1.8
—
—
—
0
0
19
169
1.13
0.15
1.5
1.5
—
—
—
0
0
11
128
0.85
0.14
1.9
2.1
—
—
—
0
0
9
108
0.83
0.13
1.2
1.1
—
—
—
0
0
25
272
0.91
0.13
2.9
4.4
944.33
1466.19
ng/l
0.22
12
164
82
792
1.05
0.11
10.3
5.6
14.04
30.77
e6/l
1.05
67
562
10
115
0.86
0.11
2.2
1.5
—
—
—
0
0
11
96
1.15
0.10
1.9
2.0
—
—
—
0
0
5
46
1.09
0.09
1.8
1.8
—
—
—
0
0
5
48
1.04
0.09
1.0
1.2
—
—
—
0
0
6
55
1.09
0.09
1.7
1.5
14.63
3.32
u/ml
—
6
55
8
76
1.05
0.07
1.0
1.3
—
—
—
0
0
9
103
0.87
0.06
1.7
1.2
—
—
—
0
0
16
148
1.09
0.06
1.8
1.3
—
—
—
0
0
73
713
1.03
0.06
4.9
3.4
6.17
6.06
ph
—
6
85
36
368
0.97
0.01
6.4
2.6
—
—
—
0
0
42
412
1.02
0.01
3.1
2.1
—
—
—
0
0
15
157
0.95
0.01
2.8
1.4
—
—
—
0
0
13
133
0.98
0.00
1.1
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
75.48
—
0
5
0
8
0.00
-0.00
0.0
6.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
63
0.95
-0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
10.2
—
99.00
—
0
6
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
149.89
—
0
9
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.8
—
0.50
—
0
6

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: E4_ISOLATED_GROWTH_HORMONE_DEFICIENCY – Isolated growth hormone deficiency

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).