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Kidney diseases associated to Fabry's disease

Endpoint Browser PheWeb

E4_FABRY_KIDNEY

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E75.2
  • Cause of death: ICD-10 — E75.2

2 out of 7 registries used, show all original rules.

64

4. Check minimum number of events

None

64

5. Include endpoints

None

64

6. Filter based on genotype QC (FinnGen only)

64

Control definitions (FinnGen only)

Control exclude
E4_METABOLIA

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 64 50 14
Unadjusted period prevalence (%) 0.01 0.02 0.01
Median age at first event (years) 47.32 47.68 46.00

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

Mortality – FinRegistry

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This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

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Index endpoint: E4_FABRY_KIDNEY – Kidney diseases associated to Fabry's disease

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).