Risteys · N14_BLADDDISINOTH

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — N33* Cause of death: ICD-10 — N33* 2 out of 7 registries used, show all original rules.	35
4. Check minimum number of events None	35
5. Include endpoints None	35
6. Filter based on genotype QC (FinnGen only)	35

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	290	95	189
Only index persons	223	79	144
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.01
Only index persons	0.00	0.00	0.01
Median age at first event (years)
Whole population	70.12	66.39	71.85
Only index persons	67.27	62.78	69.73

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	35	8	27
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	67.90	53.45	72.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3026008) Bacteria identified in Urine by Culture

6.07

6.59

5.7

2.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

9.95

4.32

5.4

2.5

—

(3023368) Bacteria identified in Blood by Culture

4.22

5.5

4.8

—

(3021601) Nitrite [Presence] in Urine by Test strip

107

4.35

4.21

10.4

4.5

0.0

estimate

—

(3013512) EKG study

4.14

4.05

4.9

4.3

—

(3009261) Glucose [Presence] in Urine by Test strip

111

4.13

3.91

6.8

3.6

0.0

estimate

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

3.97

3.88

7.3

3.8

—

(3049717) Cytology report of Urine Cyto stain

9.36

3.75

6.4

2.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

11.69

3.64

4.3

7.0

—

(3026782) Osmolality of Urine

4.00

3.59

7.8

3.2

546.7

580.5

mosm/kgh2o

0.26

(3035350) Ketones [Presence] in Urine by Test strip

109

3.74

3.48

6.2

3.5

0.0

estimate

—

(3041096) Erythrocytes [Presence] in Urine by Automated

3.65

3.39

5.8

3.5

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

6.13

3.27

5.0

3.4

5.0

5.1

kpa

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

3.38

3.07

10.4

3.2

—

(3012544) pH of Venous blood

4.89

3.03

3.1

6.0

—

(3042631) Mycobacterium sp identified in Specimen

9.44

2.84

3.2

2.8

—

(3037467) Urinalysis macro (dipstick) panel - Urine

148

3.41

2.75

8.9

4.2

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

5.78

2.51

2.5

3.5

137.3

120.9

g/l

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

4.58

2.39

5.9

5.1

0.0

0.1

e6/l

—

(3022313) Gas panel - Capillary blood

5.10

2.01

4.8

3.2

—

(3015736) pH of Urine

2.53

1.75

4.5

3.5

—

(40761535) Cells panel - Urine sediment

3.70

1.58

7.8

3.3

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

130

2.26

1.48

6.9

6.8

10.2

13.7

umol/l

0.95

125

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.25

1.41

1.4

1.2

—

(3042936) Bacteria identified in Isolate by Culture

2.74

1.40

1.9

2.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

233

2.42

1.24

37.0

20.4

94.4

90.8

umol/l

0.19

233

(3019550) Sodium [Moles/volume] in Serum or Plasma

234

2.39

1.24

35.8

19.0

138.6

139.6

mmol/l

1.19

227

(3023103) Potassium [Moles/volume] in Serum or Plasma

235

2.36

1.23

36.5

19.0

4.0

mmol/l

0.26

228

(3000991) Gas panel - Venous blood

2.74

1.19

8.6

11.5

—

(3022621) pH of Urine by Test strip

2.60

1.13

9.4

2.3

—

(42870588) Differential panel, method unspecified - Blood

2.06

1.11

11.2

4.7

—

(40761536) Microorganisms panel - Urine sediment

2.48

1.07

9.4

2.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.05

0.86

1.0

1.7

—

(3000963) Hemoglobin [Mass/volume] in Blood

247

2.01

0.78

42.2

23.8

129.7

132.9

g/l

0.55

241

(3010813) Leukocytes [#/volume] in Blood

246

2.04

0.77

41.9

23.7

7.6

6.9

e9/l

0.80

239

(3026361) Erythrocytes [#/volume] in Blood

246

2.04

0.77

41.8

23.7

4.4

e12/l

0.07

238

(3007461) Platelets [#/volume] in Blood

246

2.04

0.77

41.9

23.7

246.0

233.5

e9/l

0.41

238

(3024731) MCV [Entitic volume]

246

2.04

0.77

41.8

23.7

90.0

92.0

1.20

241

(3035941) MCH [Entitic mass]

246

2.04

0.77

41.7

23.6

29.7

30.6

1.70

241

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

239

1.86

0.74

13.9

11.1

20.9

24.9

u/l

1.00

228

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

106

1.73

0.74

4.9

3.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.78

0.72

53.3

19.9

—

1.6

—

(3003694) ABO and Rh group [Type] in Blood

1.73

0.66

1.1

1.5

—

(36304419) Bacteria [Presence] in Urine

1.74

0.66

10.9

2.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

110

1.64

0.63

2.5

2.8

—

(3032080) INR in Blood by Coagulation assay

110

1.64

0.63

21.1

10.9

1.3

1.5

inr

—

(40761511) CBC panel - Blood by Automated count

232

1.71

0.59

32.8

15.6

—

(3044640) Blood type and Crossmatch panel - Blood

1.66

0.54

3.6

2.7

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

193

1.56

0.51

10.3

7.7

72.7

82.6

u/l

0.71

186

(40760892) CBC W Ordered Manual Differential panel - Blood

1.50

0.48

9.3

5.2

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.50

0.48

5.1

3.4

2.4

2.5

mmol/l

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

1.49

0.43

2.1

1.6

2.9

3.1

mg/l

—

(3027945) Reticulocytes/100 erythrocytes in Blood

1.55

0.42

3.8

2.5

1.5

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.40

0.36

3.2

1.6

—

(3003338) MCHC [Mass/volume]

179

0.72

0.35

26.4

21.5

332.0

g/l

0.00

179

(1761868) Lipid panel - Serum or Plasma

1.36

0.29

3.8

3.1

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

1.36

0.27

2.7

2.5

237.0

138.5

ug/l

0.86

(3009542) Hematocrit [Volume Fraction] of Blood

186

1.32

0.26

22.7

17.4

29.0

38.7

0.84

120

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.34

0.24

6.8

3.3

2.4

2.3

mmol/l

0.29

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.37

0.24

9.8

2.8

—

(3044889) 12 lead EKG panel

159

1.27

0.21

5.7

4.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.00

0.21

0.0

1.2

—

(4010399)

0.00

0.21

0.0

1.5

—

(40768804) Tissue Pathology biopsy report

1.30

0.21

2.7

2.3

—

(40758558) Short blood count panel - Blood

1.19

0.09

11.5

6.8

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.8

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

5.1

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(4094501)

0.00

0.0

1.6

—

(3047181) Lactate [Moles/volume] in Blood

0.00

0.0

7.6

—

1.4

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.4

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.6

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.7

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

2.7

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

1.5

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

54.7

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.3

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.0

1.7

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.7

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

1.5

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

14.7

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

4.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint N14_BLADDDISINOTH and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
N14_BLADDDISINOTH	1.669 [1.15, 2.43]	0.007
Birth year	0.981 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 174 males with N14_BLADDDISINOTH died.

Mortality risk

Mortality risk for people of age

years, who have N14_BLADDDISINOTH.

N-year risk	Females	Males
1	No data	0.298%
5	No data	1.701%
10	No data	4.177%
15	No data	7.623%
20	No data	13.011%

Relationships between endpoints

↥

Index endpoint: N14_BLADDDISINOTH – Bladder disorders in in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	N14_BLADDDISINOTH
CONTROL_EXCLUDE	N14_URINOTH
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	N33
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	N33
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Bladder disorders in in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints