hypothyroidism: Abnormally low levels of thyroid hormone.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
51 |
4. Check minimum number of eventsNone |
51 |
5. Include endpointsNone |
51 |
6. Filter based on genotype QC (FinnGen only) |
50 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E03
- Name in latin
- Atrophia glandulae thyreoideae [acquisita]
Similar endpoints
↥List of similar endpoints to
Atrophy of thyroid (acquired)
based on the number of shared cases.
Similar with more cases:
- Hypothyroidism (congenital or acquired)
- Hypothyreosis and Thyroxine purchase for inclusion criteria
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 551 | 413 | 132 |
| Only index persons | 364 | 274 | 90 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 64.16 | 64.40 | 63.12 |
| Only index persons | 55.98 | 56.10 | 55.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 50 | 43 | 7 |
| Unadjusted period prevalence (%) | 0.01 | 0.02 | 0.00 |
| Median age at first event (years) | 54.71 | 53.34 | 63.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 51
- Matched controls
- 510
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
+∞
64.5
51
7
104
Kela drug reimbursment
Thyroid insufficiency
+∞
41.4
34
*
E03.4
ICD-10 Finland
Atrophy of thyroid (acquired)
+∞
38.5
32
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
232.6
32.0
30
*
2448B
ICD-9 Finland
Acquired hypothyroidism, Other specified acquired hypothyroidism[HYPOTHYREOSIS ATROPHICANS PRIMARIA]
+∞
21.3
19
*
E03
ICD-10 Finland
Other hypothyroidism
107.0
8.7
9
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
7.5
7
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
79.4
6.6
7
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
+∞
6.4
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
11
38
3.40
2.62
1.7
1.3
1.35
1.17
%
0.49
11
27
6
21
3.10
1.55
5.5
2.7
1.30
1.46
%
—
6
21
11
55
2.27
1.40
2.5
2.5
0.80
0.81
mmol/l
0.07
11
50
21
136
1.93
1.38
2.4
4.1
65.15
63.78
ng/l
0.01
13
98
22
145
1.91
1.37
6.1
4.5
—
—
—
0
0
23
154
1.90
1.37
2.2
1.9
90.32
92.88
pmol/l
0.10
12
74
7
32
2.37
1.13
5.3
3.2
5.74
5.71
kpa
—
7
32
5
22
2.41
1.06
7.0
3.7
50.08
37.89
%
—
5
22
5
22
2.41
1.06
4.2
3.0
23.16
24.66
mmol/l
—
5
22
16
103
1.81
1.03
7.2
2.5
58.25
54.04
u/l
0.22
16
97
41
366
1.61
0.60
23.2
16.6
140.15
139.47
mmol/l
1.63
41
355
41
367
1.60
0.58
23.2
16.6
3.93
3.95
mmol/l
0.20
41
355
6
37
1.70
0.58
4.0
8.9
—
—
—
0
0
12
87
1.50
0.47
1.9
1.6
0.65
1.02
mg/l
—
7
68
29
327
0.74
0.42
19.3
17.1
16.04
14.82
%
0.52
29
320
9
68
1.39
0.40
1.0
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
7
53
1.37
0.32
1.7
1.6
—
—
—
0
0
41
382
1.37
0.31
23.7
16.8
74.85
71.94
umol/l
0.40
41
382
22
251
0.78
0.30
3.0
3.5
—
—
—
0
0
9
76
1.22
0.26
1.9
1.6
—
—
—
0
0
12
97
1.31
0.26
2.2
2.1
—
—
—
0
0
5
40
1.28
0.23
2.4
2.2
—
—
—
0
0
12
99
1.28
0.22
1.9
2.5
40458.58
10171.98
umol/l
0.33
12
84
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
13
110
1.24
0.19
2.2
2.6
21.46
29.99
u/l
1.52
13
101
20
179
1.19
0.18
2.9
2.4
—
—
—
0
0
6
53
1.15
0.09
2.2
1.7
—
—
—
0
0
6
57
1.06
0.09
4.0
1.4
28.03
30.69
s
—
6
52
40
393
1.08
0.02
14.5
9.9
22.75
23.15
u/l
0.06
40
382
13
133
0.97
0.00
4.8
3.2
—
—
—
0
0
41
412
0.98
0.00
35.1
20.8
127.90
131.43
g/l
0.95
41
405
20
198
1.02
0.00
4.8
5.3
13.20
11.43
umol/l
0.21
20
184
8
82
0.97
-0.00
1.3
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
12.80
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_ATROTHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ATROTHY | 1.365 [0.88, 2.11] | 0.16 |
| Birth year | 1.0 [0.99, 1.01] | 0.991 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 182 females with E4_ATROTHY died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_ATROTHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | No data |
| 5 | 0.83% | No data |
| 10 | 1.972% | No data |
| 15 | 4.112% | No data |
| 20 | 7.823% | No data |
Relationships between endpoints
↥Index endpoint: E4_ATROTHY – Atrophy of thyroid (acquired)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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