Ovarian dysfunction: estrogen excess

E4_ODESTRO

hyperestrogenism: ['Abnormally high level of estrogen. [ NICHD NCI ]']

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E28.0# Hospital discharge: ICD-9 — 2560 Hospital discharge: ICD-8 — 2560 Cause of death: ICD-10 — E28.0# Cause of death: ICD-9 — 2560 Cause of death: ICD-8 — 2560 2 out of 7 registries used, show all original rules.	50
4. Check minimum number of events None	50
5. Include endpoints None	50
6. Filter based on genotype QC (FinnGen only)	50

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E28
Name in latin: Hypersecretio oestrogenorum

NAME	E4_ODESTRO
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E280
HD_ICD_9	2560
HD_ICD_8	2560
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E280
COD_ICD_9	2560
COD_ICD_8	2560
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Ovarian dysfunction: estrogen excess based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	403	403	-
Only index persons	320	320	-
Unadjusted period prevalence (%)
Whole population	0.01	0.01	-
Only index persons	0.01	0.01	-
Median age at first event (years)
Whole population	-	35.28	-
Only index persons	-	31.34	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	50	50	-
Unadjusted period prevalence (%)	0.02	0.02	-
Median age at first event (years)	29.52	29.52	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

+∞

5.29

1.2

0.0

39.4

—

nmol/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

3.19

3.46

2.8

3.5

0.5

8.4

mg/mmol

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

3.21

3.27

1.3

3.5

271.3

989.5

ng/l

—

(3012516) Albumin [Mass/volume] in Urine

2.97

2.99

2.6

2.8

5.7

39.7

mg/l

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

5.51

2.48

2.3

2.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

347

3.23

2.30

6.5

4.2

38.9

38.0

mmol/mol

0.23

332

(3009508) Creatinine [Moles/volume] in Urine

2.43

2.15

2.4

2.5

7.9

6.9

mmol/l

0.31

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

1.61

0.0

1.6

—

(40768804) Tissue Pathology biopsy report

176

1.99

1.55

2.2

1.9

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

1.41

0.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

1.41

0.0

1.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

1.41

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

1.41

0.0

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

1.41

0.0

1.3

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

2.27

1.35

1.3

1.7

25.6

29.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

386

2.65

1.34

9.0

9.1

93.6

90.0

ml/min/173m2

0.57

304

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

1.19

0.0

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

1.19

0.0

1.3

—

(4010399)

2.46

1.16

1.1

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

127

1.80

1.10

1.8

2.7

—

(21494755) Public health laboratory ask at order entry panel

2.06

1.08

1.7

1.2

—

(3026008) Bacteria identified in Urine by Culture

137

1.77

1.07

1.7

2.2

—

(36304419) Bacteria [Presence] in Urine

103

1.81

1.04

1.6

2.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

316

1.84

1.00

3.6

3.7

—

(3019225) pH of Specimen

2.38

0.97

2.5

5.1

—

(3002582) Erythrocytes [#/volume] in Urine

114

1.74

0.96

1.8

2.8

11.0

46.5

e6/l

1.23

(3030467) Casts [#/volume] in Urine by Automated count

1.78

0.95

1.6

2.5

0.0

0.3

e6/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

121

0.51

0.94

2.0

1.7

—

(4035726)

2.13

0.90

2.0

1.3

—

(3018095) Leukocytes [#/volume] in Urine

143

1.66

0.89

1.9

3.4

3.2

110.1

e6/l

1.74

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

127

1.65

0.84

2.4

2.8

22.6

26.2

u/l

0.92

119

(42870588) Differential panel, method unspecified - Blood

120

1.63

0.78

2.1

4.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.92

0.76

2.9

7.0

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

2.11

0.75

1.8

1.9

23.7

61.9

u/ml

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

150

0.58

0.73

2.4

2.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

104

0.52

0.72

2.3

1.8

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

150

1.56

0.71

4.5

3.8

35.8

36.6

g/l

0.32

142

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.94

0.70

1.0

1.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

151

1.54

0.69

2.2

1.8

96.8

98.6

pmol/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.87

0.68

1.0

—

(40768793) Breast Pathology biopsy report

0.00

0.62

0.0

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.70

0.58

1.3

2.0

—

(36660697) Celiac disease serology panel - Serum

1.64

0.52

1.1

1.2

—

(3022096) Basophils/100 leukocytes in Blood

188

1.41

0.51

2.3

4.5

0.5

0.6

0.66

171

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

1.50

0.50

1.8

0.3

0.7

mg/l

—

(40768797) Stomach Pathology biopsy report

1.53

0.49

1.0

1.1

—

(3009542) Hematocrit [Volume Fraction] of Blood

410

1.61

0.48

13.9

11.3

40.2

39.5

0.64

327

(3013512) EKG study

1.48

0.45

2.4

2.5

—

(3042936) Bacteria identified in Isolate by Culture

1.48

0.45

1.1

1.5

—

(3000492) Spirometry study

1.68

0.44

1.0

1.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.45

0.44

2.0

1.8

—

(3044889) 12 lead EKG panel

262

1.36

0.42

3.4

2.6

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.42

0.0

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.41

0.0

3.0

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.40

0.0

1.4

—

103.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.40

0.0

1.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.35

0.39

2.1

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.43

0.39

1.6

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.44

0.38

1.3

15.8

39.9

iu/ml

—

(3007164) IgA [Mass/volume] in Serum or Plasma

101

1.39

0.36

1.2

1.5

3.0

2.6

g/l

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.41

0.36

2.8

3.0

4.3

6.9

umol/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

130

1.34

0.34

3.6

2.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

105

0.72

0.33

2.8

2.0

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.34

0.32

2.6

1.9

0.8

mmol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.34

0.32

2.1

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

143

1.29

0.28

2.0

1.5

—

(3015736) pH of Urine

172

1.27

0.28

2.7

3.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.39

0.24

1.6

1.4

—

(3022145) Colonoscopy Study observation

1.21

0.22

1.2

1.5

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

1.2

—

1.3

—

(4094501)

0.00

0.21

0.0

1.1

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.1

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

3.7

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.7

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.21

0.0

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.4

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

0.21

0.0

2.5

—

4.2

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.20

0.0

2.4

—

203.6

—

(40768443) Skin Pathology biopsy report

0.00

0.20

0.0

1.2

—

(3002256) Pathology report gross observation

1.20

0.20

1.3

1.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.26

0.19

1.9

2.0

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.73

0.18

1.8

1.5

—

(3023368) Bacteria identified in Blood by Culture

1.21

0.17

3.8

4.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

171

1.18

0.15

4.1

3.1

—

(3019150) Specific gravity of Urine by Refractometry

0.82

0.15

4.0

3.5

—

1.0

—

(3018418) pH of Serum or Plasma

114

1.19

0.13

8.7

3.2

—

7.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

115

0.84

0.12

3.2

2.1

—

(3000494) Fungus identified in Specimen by Culture

1.18

0.10

1.6

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

126

1.15

0.10

1.4

1.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.10

0.10

1.6

1.5

—

(3026782) Osmolality of Urine

1.07

0.08

1.3

2.0

567.0

556.9

mosm/kgh2o

—

(3000850) Epithelial cells [#/volume] in Urine

1.08

0.08

1.6

2.5

4.4

6.2

e6/l

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

207

1.11

0.08

5.0

4.9

7.3

9.2

umol/l

1.63

194

(3009261) Glucose [Presence] in Urine by Test strip

217

1.11

0.08

3.7

3.3

0.0

estimate

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.85

0.08

1.3

1.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

0.84

0.07

3.1

3.5

—

(40758558) Short blood count panel - Blood

119

1.12

0.06

2.5

4.8

—

(3003338) MCHC [Mass/volume]

392

1.10

0.03

15.7

13.8

329.3

331.6

g/l

0.63

392

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.08

0.01

2.1

1.7

—

(3029937) Albumin [Presence] in Urine by Test strip

114

1.07

0.01

5.1

3.6

0.0

estimate

—

(3003694) ABO and Rh group [Type] in Blood

136

0.94

0.01

1.8

1.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

204

1.05

0.00

3.8

3.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

375

0.95

0.00

4.1

3.8

—

(1761868) Lipid panel - Serum or Plasma

174

0.97

0.00

1.8

2.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

112

0.98

0.00

2.5

4.6

—

(3044640) Blood type and Crossmatch panel - Blood

132

0.98

0.00

2.2

1.8

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.5

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(4268621)

0.00

0.0

2.0

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

3.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.5

—

91.7

—

(4198724)

0.00

0.0

1.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

2.6

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

6.3

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.1

—

112.1

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

2.3

—

64.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.96

0.00

1.3

1.7

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(1616796) Gas panel - Central venous blood

0.00

0.0

1.0

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.0

2.9

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

2.4

—

4.7

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

164.6

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.4

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.4

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

108.9

—

(4306422)

0.00

0.0

1.3

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

2.4

—

10.7

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.4

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

2.3

—

5.8

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

3.8

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_ODESTRO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_ODESTRO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_ODESTRO – Ovarian dysfunction: estrogen excess

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Ovarian dysfunction: estrogen excess

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints