iritis: Inflammation of the iris.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
729 |
4. Check minimum number of eventsNone |
729 |
5. Include endpointsNone |
729 |
6. Filter based on genotype QC (FinnGen only) |
729 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF9
- Parent code in ICD-10
- L68
- Name in latin
- Hirsutismus
Similar endpoints
↥List of similar endpoints to
Hirsutism in women
based on the number of shared cases.
Similar with more cases:
- Hypertrichosis
- Disorders of skin appendages
- Polycystic ovarian syndrome, consortium definition
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4246 | 4246 | - |
| Only index persons | 4165 | 4165 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.12 | - |
| Only index persons | 0.15 | 0.15 | - |
| Median age at first event (years) | |||
| Whole population | - | 30.89 | - |
| Only index persons | - | 30.87 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 729 | 729 | - |
| Unadjusted period prevalence (%) | 0.25 | 0.25 | - |
| Median age at first event (years) | 33.03 | 33.03 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 649
- Matched controls
- 6490
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L68.0
ICD-10 Finland
Hirsutism
13141.8
323.0
624
9
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
22.0
103.7
156
92
C03DA01
ATC
spironolactone; oral
16.0
96.3
164
134
G03HB01
ATC
cyproterone and estrogen; systemic
5.2
71.7
283
838
A10BA02
ATC
metformin; oral
5.5
60.6
211
524
E66.01
ICD-10 Finland
Obesity due to excess calories
4.4
35.8
144
392
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.8
34.4
126
311
7041A
ICD-9 Finland
Diseases of hair and hair follicles, Hirsutism[HIRSUTISMUS]
+∞
31.5
30
*
T90
ICPC
Diabetes non-insulin dependent
4.2
30.6
127
352
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.8
30.0
142
442
G03DB01
ATC
dydrogesterone; oral
3.0
30.0
210
880
103
Kela drug reimbursment
Diabetes, insulin-treated
3.8
29.9
143
449
E66.8
ICD-10 Finland
Other obesity
5.2
29.1
97
214
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.5
27.7
352
2079
L68.9
ICD-10 Finland
Hypertrichosis, unspecified
282.1
26.9
27
*
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
9.0
26.4
57
69
A10BK03
ATC
empagliflozin; oral
7.3
24.8
61
91
G03HA01
ATC
cyproterone; systemic
124.4
22.7
24
*
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
8.1
21.2
48
63
A10BJ06
ATC
semaglutide; parenteral
10.6
20.1
39
39
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.0
19.7
126
479
I10
ICD-10 Finland
Essential (primary) hypertension
2.4
19.6
212
1098
E66.00
ICD-10 Finland
Metabolic syndrome
5.6
19.4
58
112
N05AH04
ATC
quetiapine; oral
2.6
18.9
164
753
T82
ICPC
Obesity
4.9
18.1
60
131
E66.9
ICD-10 Finland
Obesity, unspecified
4.8
17.3
59
133
A10BH01
ATC
sitagliptin; oral
5.1
16.8
54
114
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.9
16.5
71
200
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
3.0
16.2
103
388
N05BA06
ATC
lorazepam; systemic, sublingual
6.3
15.9
42
70
L68.2
ICD-10 Finland
Localized hypertrichosis
+∞
15.7
15
*
N06AB04
ATC
citalopram; systemic
2.3
14.6
166
859
N05CF01
ATC
zopiclone; oral
2.2
14.5
175
931
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
2.8
14.3
100
398
L73.2
ICD-10 Finland
Hidradenitis suppurativa
22.9
14.3
20
9
N05AX08
ATC
risperidone; systemic
3.9
14.2
60
166
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.8
14.2
47
103
N97.0
ICD-10 Finland
Female infertility associated with anovulation
4.3
14.1
53
132
N06AX16
ATC
venlafaxine; oral
2.4
14.0
135
642
N05AX12
ATC
aripiprazole; systemic
3.9
14.0
58
158
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.4
13.7
134
644
N06AX11
ATC
mirtazapine; oral
2.0
13.5
219
1311
M79.6
ICD-10 Finland
Pain in limb
2.0
13.4
236
1464
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.3
13.3
69
226
LCA06
NOMESCO Finland
Biopsy of endometrium
2.4
13.0
125
594
R06.0
ICD-10 Finland
Dyspnoea
2.2
12.8
145
745
A10BB12
ATC
glimepiride; oral
7.7
12.8
29
39
G47.3
ICD-10 Finland
Sleep apnoea
2.5
12.5
108
487
N05BA04
ATC
oxazepam; oral
2.0
12.2
180
1034
N05AA02
ATC
levomepromazine; systemic
5.5
12.1
35
66
L70.0
ICD-10 Finland
Acne vulgaris
5.3
12.0
36
71
H03AA01
ATC
levothyroxine sodium; systemic
2.0
12.0
183
1062
N91.1
ICD-10 Finland
Secondary amenorrhoea
4.1
11.3
44
114
E66
ICD-10 Finland
Obesity
3.5
11.3
52
156
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.1
11.3
138
730
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.3
11.1
106
499
N06AB06
ATC
sertraline; oral
2.3
11.0
110
530
C07AB07
ATC
bisoprolol; oral
1.9
10.9
183
1096
N05AH03
ATC
olanzapine; systemic
3.1
10.8
59
201
SPAT1262
SPAT
Handing over of treatment supplies
2.5
10.7
89
391
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.4
10.6
95
433
A02BC02
ATC
pantoprazole; systemic
1.7
10.4
368
2793
L68.8
ICD-10 Finland
Other hypertrichosis
+∞
10.4
10
*
N03AX09
ATC
lamotrigine; oral
3.0
10.2
60
216
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.6
9.9
75
312
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.6
9.9
158
2385
P01
ICPC
Feeling anxious/nervous/tense
2.0
9.9
138
768
205
Kela drug reimbursment
Chronic hypertension
2.7
9.9
70
282
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
4.8
9.8
32
70
N03AX16
ATC
pregabalin; oral
2.0
9.7
131
719
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
9.6
272
1917
A06AC01
ATC
ispaghula (psylla seeds); oral
2.0
9.6
134
746
N06AB03
ATC
fluoxetine; oral
2.2
9.6
103
514
P76
ICPC
Depressive disorder
2.5
9.5
78
338
L17
ICPC
Foot/toe symptom/complaint
1.9
9.4
148
859
E66.0
ICD-10 Finland
Obesity due to excess calories
12.6
9.4
16
13
E28.1
ICD-10 Finland
Ovarian dysfunction: Androgen excess
+∞
9.4
9
*
A10AE04
ATC
insulin glargine; parenteral
3.0
9.4
53
184
S10
ICPC
Boil/carbuncle
3.4
9.3
44
136
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.2
9.2
94
456
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
9.2
143
824
M54.4
ICD-10 Finland
Lumbago with sciatica
2.1
9.2
114
604
SPAT1240
SPAT
Therapeutic discussion
2.0
9.1
123
675
N03AG01
ATC
valproic acid; systemic, rectal
2.9
8.9
55
202
C09AA02
ATC
enalapril; systemic
2.7
8.9
61
242
N06AX12
ATC
bupropion; oral
2.4
8.8
74
327
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
8.7
116
632
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
4.6
8.6
29
66
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
9.2
8.6
17
19
A10BJ02
ATC
liraglutide; parenteral
6.5
8.5
21
33
N02AX02
ATC
tramadol; systemic, rectal
1.7
8.5
207
1383
M54.5
ICD-10 Finland
Low back pain
1.7
8.4
225
1545
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.2
8.4
91
456
L15
ICPC
Knee symptom/complaint
2.0
8.2
120
675
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.8
8.2
52
197
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.5
8.2
37
111
QBJ30
NOMESCO Finland
Correction of abdominal apron
8.3
8.1
17
21
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
6.4
8.1
20
32
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
4.9
8.0
25
53
C09CA01
ATC
losartan; oral
2.2
7.9
83
408
XLA10
NOMESCO Finland
NA
2.7
7.9
54
214
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.4
7.9
66
292
A28
ICPC
Limited function/disability NOS
3.1
7.8
42
143
SPAT1310
SPAT
Counselling related to known health issue
1.7
7.8
213
1463
160
Kela drug reimbursment
exenatide
11.0
7.8
14
13
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
9.6
7.8
15
16
P99
ICPC
Psychological disorders other
3.6
7.8
33
94
L05.9
ICD-10 Finland
Pilonidal cyst without abscess
6.5
7.8
19
30
WX110
NOMESCO Finland
Local anesthesy
1.7
7.7
470
3982
N03AX11
ATC
topiramate; oral
3.2
7.7
39
128
N05BA01
ATC
diazepam; systemic, rectal
2.3
7.6
74
351
SPAT1216
SPAT
Assessment of functional ability
2.4
7.6
64
283
N06AA09
ATC
amitriptyline; systemic
2.5
7.6
56
232
J01FF01
ATC
clindamycin; systemic
1.7
7.5
161
1030
177
Kela drug reimbursment
Insulin glargine 300 U / ml
7.2
7.5
17
24
C07AA05
ATC
propranolol; systemic
1.8
7.4
151
951
A10BG03
ATC
pioglitazone; oral
13.6
7.4
12
9
N03AX12
ATC
gabapentin; oral
2.1
7.4
88
457
L60.0
ICD-10 Finland
Ingrowing nail
3.6
7.4
31
88
N06AX21
ATC
duloxetine; oral
2.1
7.4
81
405
S29
ICPC
Skin symptom/complaint other
2.0
7.3
93
496
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
0.6
7.3
155
2222
A02BA02
ATC
ranitidine; systemic
2.1
7.2
85
440
F61.0
ICD-10 Finland
Mixed personality disorders
4.3
7.2
25
60
A10BX04
ATC
[U] exenatide; parenteral
20.3
7.1
10
5
S18
ICPC
Laceration/cut
1.6
7.1
201
1393
A10BD07
ATC
metformin and sitagliptin; systemic
4.8
7.1
22
47
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
6.4
7.0
17
27
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
3.4
6.9
31
93
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
6.9
125
756
J02AC01
ATC
fluconazole; systemic
1.5
6.9
334
2637
SPAT1254
SPAT
Administration of medicine
2.0
6.9
90
486
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.7
6.9
45
175
N05CD07
ATC
temazepam; oral
2.7
6.9
44
168
N91.5
ICD-10 Finland
Oligomenorrhoea, unspecified
6.8
6.8
16
24
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
6.8
210
1485
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.9
6.8
97
542
F43.1
ICD-10 Finland
Post-traumatic stress disorder
2.9
6.8
39
139
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.5
6.8
50
206
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
6.8
109
636
M04AA01
ATC
allopurinol; systemic
3.8
6.7
27
74
H01
ICPC
Ear pain/earache
1.9
6.7
96
533
N04AA02
ATC
biperiden; systemic
6.0
6.6
17
29
H02AB09
ATC
hydrocortisone; systemic
4.7
6.6
21
46
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
2.9
6.6
38
135
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.7
6.6
43
166
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.1
6.6
72
361
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.6
6.6
180
1228
A10BK01
ATC
dapagliflozin; oral
4.2
6.6
23
56
L03
ICPC
Low back symptom/complaint
1.7
6.6
162
1076
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.3
6.5
57
256
L29.9
ICD-10 Finland
Pruritus, unspecified
4.1
6.4
23
57
QDH01
NOMESCO Finland
Excision of nail bed in toe
70.5
6.4
7
*
E28.0
ICD-10 Finland
Ovarian dysfunction: Estrogen excess
70.5
6.4
7
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
6.4
87
477
L28
ICPC
Limited function/disability (L)
2.2
6.4
62
296
F32
ICD-10 Finland
Depressive episode
2.3
6.4
56
253
R05FB02
ATC
cough suppressants and expectorants
1.6
6.3
192
1345
WX002
NOMESCO Finland
Sedation and analgesia
1.9
6.3
91
508
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
3.5
6.3
27
79
C10AA05
ATC
atorvastatin; oral
1.9
6.3
95
542
A10BJ01
ATC
exenatide; parenteral
26.9
6.2
8
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
6.2
56
259
D07AC01
ATC
betamethasone; topical
1.6
6.2
191
1342
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
6.2
171
1168
A10BH05
ATC
linagliptin; oral
5.8
6.2
16
28
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.0
6.2
83
453
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
3.4
6.1
28
86
R53
ICD-10 Finland
Malaise and fatigue
1.7
6.1
130
826
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.3
6.0
55
256
-50
ICPC
Medication/prescr/renewal
3.4
6.0
27
82
Mortality – FinRegistry
↥Association
Association between endpoint L12_HIRSUTISM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_HIRSUTISM | 1.3 [1.05, 1.61] | 0.015 |
| Birth year | 0.998 [0.99, 1.01] | 0.583 |
During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 3551 females with L12_HIRSUTISM died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_HIRSUTISM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.129% | No data |
| 5 | 0.784% | No data |
| 10 | 2.05% | No data |
| 15 | 4.113% | No data |
| 20 | 7.223% | No data |
Relationships between endpoints
↥Index endpoint: L12_HIRSUTISM – Hirsutism in women
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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