Hirsutism, drug-induced

L12_HIRSUTISM_ADVERSE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs ANY
  • Hospital discharge: ICD-10 L68.0#

1 out of 7 registries used, show all original rules.

67

4. Check minimum number of events

None

67

5. Include endpoints

None

67

6. Filter based on genotype QC (FinnGen only)

67

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
L68
Name in latin
Hirsutismus

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 67 67 -
Unadjusted period prevalence (%) 0.02 0.02 -
Median age at first event (years) 32.97 32.97 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
62
Matched controls
620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L68.0
ICD-10 Finland
Hirsutism
+∞
82.0
62
5
G03HB01
ATC
cyproterone and estrogen; systemic
12.4
16.9
36
62
C03DA01
ATC
spironolactone; oral
10.5
9.2
18
23
G03DB01
ATC
dydrogesterone; oral
4.7
7.3
30
103
A10BK03
ATC
empagliflozin; oral
19.5
7.0
10
6
T90
ICPC
Diabetes non-insulin dependent
6.2
6.9
19
41
XLA10
NOMESCO Finland
NA
6.1
6.2
17
36

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
110
3.23
4.84
3.7
3.3
1.0
5.8
mg/mmol
0.83
13
62
25
108
3.10
4.45
3.2
2.7
6.7
27.8
mg/l
—
10
65
7
17
4.47
2.43
5.3
6.1
—
—
—
0
0
8
23
3.80
2.35
1.0
1.3
—
—
—
0
0
16
75
2.49
2.31
2.3
3.0
5.4
228.4
ng/l
—
8
40
10
37
3.00
2.21
1.3
1.2
—
—
—
0
0
49
380
2.08
1.87
3.7
2.9
—
—
—
0
0
22
131
2.01
1.78
2.0
1.7
0.6
0.8
mg/l
0.31
17
104
5
14
3.77
1.64
2.2
1.4
60.2
103.6
ng/l
—
5
14
21
129
1.91
1.54
1.3
1.3
8.0
30.5
iu/ml
—
7
47
28
191
1.80
1.48
2.1
1.7
86.7
99.4
pmol/l
0.65
11
106
21
142
1.70
1.10
1.4
1.3
2.9
2.0
u/ml
—
6
44
7
33
2.25
1.09
1.4
1.4
—
—
—
0
0
42
341
1.62
1.06
8.2
8.8
4.2
3.9
e9/l
0.24
37
301
0
31
0.00
0.99
0.0
1.5
—
295.3
—
0
20
26
191
1.59
0.98
4.1
3.1
2.4
2.4
mmol/l
0.53
26
178
17
112
1.69
0.97
1.2
1.4
25.4
21.9
nmol/l
0.42
17
97
19
133
1.60
0.86
1.3
1.3
1.1
10.4
u/ml
1.24
12
61
10
159
0.56
0.86
1.7
1.5
—
—
—
0
0
43
363
1.52
0.82
5.0
4.0
—
677.0
—
0
5
10
59
1.82
0.81
1.4
1.5
—
—
—
0
0
0
24
0.00
0.81
0.0
3.3
—
4.6
—
0
19
24
183
1.49
0.74
2.1
3.1
8.6
18.0
ng/l
2.24
12
95
36
301
1.42
0.68
3.4
4.3
2.1
1.9
e9/l
0.86
31
269
7
111
0.59
0.65
1.1
1.6
—
—
—
0
0
0
20
0.00
0.61
0.0
2.0
—
—
—
0
0
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
8
53
1.58
0.61
2.0
1.4
—
—
—
0
0
12
168
0.65
0.60
2.3
2.1
—
—
—
0
0
0
22
0.00
0.60
0.0
1.1
—
—
—
0
0
60
562
1.65
0.54
16.2
10.9
41.9
40.0
%
3.46
48
465
20
156
1.40
0.53
2.4
2.4
—
—
—
0
0
20
157
1.39
0.51
1.9
3.2
—
—
—
0
0
13
96
1.44
0.46
2.5
2.6
2.5
2.4
mmol/l
0.46
13
86
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
3.1
—
—
—
0
0
5
34
1.51
0.41
2.4
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
10
134
0.70
0.40
1.7
2.3
—
—
—
0
0
6
85
0.68
0.35
1.0
1.2
—
—
—
0
0
10
74
1.41
0.34
1.4
1.1
—
—
—
0
0
16
129
1.32
0.34
6.7
2.3
—
—
—
0
0
15
120
1.32
0.34
3.4
3.7
—
—
—
0
0
17
139
1.30
0.33
8.6
7.0
—
—
—
0
0
10
129
0.74
0.32
1.6
1.7
—
—
—
0
0
10
76
1.37
0.30
1.1
1.2
—
—
—
0
0
19
160
1.26
0.30
1.9
2.7
—
—
—
0
0
5
73
0.66
0.27
1.0
1.4
—
—
—
0
0
5
73
0.66
0.27
1.8
1.7
—
—
—
0
0
13
106
1.28
0.25
4.0
3.8
—
—
—
0
0
22
249
0.83
0.24
2.2
2.0
—
—
—
0
0
5
38
1.34
0.24
11.0
6.6
102.6
104.2
mmol/l
—
5
38
5
40
1.27
0.23
2.6
4.0
—
—
—
0
0
5
42
1.21
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
28
254
1.18
0.21
5.4
7.2
0.0
0.0
e9/l
0.86
20
204
6
51
1.19
0.20
1.5
1.1
—
—
—
0
0
7
60
1.19
0.18
1.7
1.6
—
—
—
0
0
7
61
1.16
0.18
1.4
2.4
—
—
—
0
0
32
296
1.16
0.18
3.4
2.9
93.0
67.3
ug/l
0.57
32
277
9
79
1.16
0.16
1.0
2.1
53.4
85.4
ug/g
—
9
61
23
210
1.15
0.14
3.0
3.2
—
—
—
0
0
19
173
1.14
0.12
3.9
3.9
—
—
—
0
0
13
116
1.15
0.10
4.2
3.7
1.0
1.0
kg/l
—
5
13
28
264
1.10
0.10
2.6
2.3
—
—
—
0
0
5
62
0.79
0.08
1.0
1.3
—
—
—
0
0
7
68
1.03
0.08
1.4
1.3
—
—
—
0
0
37
381
0.94
0.05
4.2
3.9
—
—
—
0
0
17
163
1.06
0.01
3.5
7.3
1.2
1.0
inr
—
5
57
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
59
584
1.09
0.00
12.4
10.8
13.1
18.0
mg/l
1.11
46
439
0
9
0.00
0.00
0.0
2.3
—
9.9
—
0
9
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.3
—
4.8
—
0
9
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
5.7
—
0
5
5
54
0.92
0.00
1.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
221.2
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
0.9
—
0
5
0
7
0.00
0.00
0.0
1.6
—
92.4
—
0
7
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
5.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
7.3
—
0
6
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
28.6
—
2870.2
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
73
0.95
0.00
2.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
6.8
—
0
9
0
5
0.00
0.00
0.0
14.0
—
1335.0
—
0
5
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
49.2
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
63.4
—
0
9
0
7
0.00
0.00
0.0
2.7
—
2.4
—
0
7

Mortality – FinRegistry

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

Index endpoint: L12_HIRSUTISM_ADVERSE – Hirsutism, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).