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Hypertrichosis

L12_HYPERTRICHOSIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L68
  • Cause of death: ICD-10 L68

2 out of 7 registries used, show all original rules.

780

4. Check minimum number of events

None

780

5. Include endpoints

838

6. Filter based on genotype QC (FinnGen only)

838

Control definitions (FinnGen only)

Control exclude
L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L60-L75
Name in latin
Hypertrichosis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 838 828 10
Unadjusted period prevalence (%) 0.28 0.28 0.00
Median age at first event (years) 32.60 32.63 30.32

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
745
Matched controls
7449
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L68.0
ICD-10 Finland
Hirsutism
3600.8
323.0
630
11
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
21.9
110.4
166
96
C03DA01
ATC
spironolactone; oral
15.4
103.9
180
151
G03HB01
ATC
cyproterone and estrogen; systemic
5.4
83.0
312
875
L68.9
ICD-10 Finland
Hypertrichosis, unspecified
684.8
64.9
63
*
A10BA02
ATC
metformin; oral
5.0
63.0
238
636
E66.01
ICD-10 Finland
Obesity due to excess calories
4.7
42.5
160
407
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.4
36.6
145
384
G03DB01
ATC
dydrogesterone; oral
3.1
34.0
229
932
E66.8
ICD-10 Finland
Other obesity
5.3
33.3
108
230
T90
ICPC
Diabetes non-insulin dependent
3.9
31.6
145
436
7041A
ICD-9 Finland
Diseases of hair and hair follicles, Hirsutism[HIRSUTISMUS]
+∞
31.5
30
*
L68.2
ICD-10 Finland
Localized hypertrichosis
314.5
30.0
30
*
L68.8
ICD-10 Finland
Other hypertrichosis
+∞
29.4
28
*
103
Kela drug reimbursment
Diabetes, insulin-treated
3.4
29.4
163
567
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.4
28.6
159
553
70405
ICD-8 Finland
Diseases of hair and hair follicles, Hypertrichosis
+∞
27.2
26
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.3
27.1
384
2321
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
7.6
26.7
64
91
G03HA01
ATC
cyproterone; systemic
72.5
25.0
28
*
A10BK03
ATC
empagliflozin; oral
6.4
24.2
65
109
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
6.9
21.7
55
85
E66.9
ICD-10 Finland
Obesity, unspecified
5.4
21.5
67
135
A10BH01
ATC
sitagliptin; oral
5.6
20.1
60
115
N05AH04
ATC
quetiapine; oral
2.5
19.5
182
861
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.7
18.9
140
579
I10
ICD-10 Finland
Essential (primary) hypertension
2.2
18.7
245
1360
E66.00
ICD-10 Finland
Metabolic syndrome
4.8
18.4
63
141
T82
ICPC
Obesity
4.6
18.0
64
149
A10BB12
ATC
glimepiride; oral
9.2
17.3
36
41
L73.2
ICD-10 Finland
Hidradenitis suppurativa
32.3
17.1
22
7
A10BJ06
ATC
semaglutide; parenteral
7.2
16.9
41
60
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
2.9
16.5
107
406
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
16.0
114
459
N03AX09
ATC
lamotrigine; oral
3.7
15.4
70
205
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.4
15.3
78
250
N06AB04
ATC
citalopram; systemic
2.2
15.3
189
1007
LCA06
NOMESCO Finland
Biopsy of endometrium
2.4
15.1
143
671
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.3
15.1
152
736
G47.3
ICD-10 Finland
Sleep apnoea
2.5
14.9
126
558
N05AX12
ATC
aripiprazole; systemic
3.8
14.6
64
182
N97.0
ICD-10 Finland
Female infertility associated with anovulation
4.1
14.1
56
146
R06.0
ICD-10 Finland
Dyspnoea
2.2
14.1
163
842
H03AA01
ATC
levothyroxine sodium; systemic
2.0
14.1
204
1161
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.1
13.5
77
268
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.5
13.2
109
473
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.8
13.1
88
340
C07AB07
ATC
bisoprolol; oral
2.0
13.1
208
1219
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.2
12.9
153
797
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
12.7
308
2094
E66
ICD-10 Finland
Obesity
3.7
12.7
56
161
M79.6
ICD-10 Finland
Pain in limb
1.8
12.3
267
1745
N06AX16
ATC
venlafaxine; oral
2.1
12.2
146
762
N06AX11
ATC
mirtazapine; oral
1.9
12.1
241
1527
N06AX12
ATC
bupropion; oral
2.8
12.0
81
313
P01
ICPC
Feeling anxious/nervous/tense
2.1
11.7
154
834
A10AE04
ATC
insulin glargine; parenteral
3.2
11.7
61
200
SPAT1262
SPAT
Handing over of treatment supplies
2.4
11.7
105
476
N05AX08
ATC
risperidone; systemic
3.1
11.6
65
223
N05BA04
ATC
oxazepam; oral
1.9
11.5
201
1213
N03AG01
ATC
valproic acid; systemic, rectal
3.2
11.3
61
205
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.2
11.3
117
571
S10
ICPC
Boil/carbuncle
3.6
11.2
50
146
L70.0
ICD-10 Finland
Acne vulgaris
4.5
11.1
39
91
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.6
11.1
49
141
N06AB03
ATC
fluoxetine; oral
2.2
11.1
114
554
N05CF01
ATC
zopiclone; oral
1.9
11.1
195
1178
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
11.4
11.1
20
18
F61.0
ICD-10 Finland
Mixed personality disorders
6.1
10.7
28
47
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
4.6
10.6
36
82
N05AH03
ATC
olanzapine; systemic
2.9
10.5
64
233
205
Kela drug reimbursment
Chronic hypertension
2.4
10.4
88
388
A02BC02
ATC
pantoprazole; systemic
1.7
10.4
416
3216
SPAT1240
SPAT
Therapeutic discussion
2.0
10.2
141
774
N05AA02
ATC
levomepromazine; systemic
4.3
10.2
37
90
P76
ICPC
Depressive disorder
2.4
10.0
84
368
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.6
9.8
173
2575
N05BA06
ATC
lorazepam; systemic, sublingual
3.7
9.8
42
119
N06AB06
ATC
sertraline; oral
2.1
9.8
117
605
N91.1
ICD-10 Finland
Secondary amenorrhoea
3.4
9.8
47
146
N03AX11
ATC
topiramate; oral
3.7
9.6
41
116
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
9.5
165
983
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
5.1
9.5
29
59
L05.9
ICD-10 Finland
Pilonidal cyst without abscess
6.7
9.5
23
35
E28.1
ICD-10 Finland
Ovarian dysfunction: Androgen excess
+∞
9.4
9
*
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.2
9.4
100
493
E66.0
ICD-10 Finland
Obesity due to excess calories
10.8
9.3
17
16
N06AX21
ATC
duloxetine; oral
2.2
9.3
95
460
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
9.3
150
874
A10BJ02
ATC
liraglutide; parenteral
5.8
9.3
25
44
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
6.6
9.0
22
34
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.1
8.9
109
567
SPAT1310
SPAT
Counselling related to known health issue
1.7
8.8
249
1723
Z3231
NOMESCO Finland
Registered nurse
1.8
8.7
171
1062
A10BD07
ATC
metformin and sitagliptin; systemic
5.6
8.7
24
44
J01FF01
ATC
clindamycin; systemic
1.8
8.6
179
1129
N03AX16
ATC
pregabalin; oral
1.8
8.6
148
881
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.7
8.5
57
219
M54.5
ICD-10 Finland
Low back pain
1.6
8.4
253
1779
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.0
8.4
104
548
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
4.3
8.3
29
69
WX110
NOMESCO Finland
Local anesthesy
1.6
8.2
536
4562
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
3.6
8.2
35
100
D07AC01
ATC
betamethasone; topical
1.7
8.1
220
1500
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
8.1
230
1587
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.9
8.0
48
175
R13
ICD-10 Finland
Dysphagia
3.3
8.0
39
124
J01DB01
ATC
cefalexin; oral
1.7
7.9
602
5311
SPAT1254
SPAT
Administration of medicine
2.0
7.9
102
547
C07AA05
ATC
propranolol; systemic
1.7
7.8
172
1103
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
7.7
141
852
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
7.7
133
789
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.4
7.7
35
105
D07AB02
ATC
hydrocortisone butyrate; topical
1.7
7.7
198
1329
P99
ICPC
Psychological disorders other
3.3
7.6
37
117
N02AX02
ATC
tramadol; systemic, rectal
1.6
7.5
229
1605
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.7
7.5
51
199
S18
ICPC
Laceration/cut
1.6
7.4
238
1687
M54.4
ICD-10 Finland
Lumbago with sciatica
1.8
7.4
125
733
E28.0
ICD-10 Finland
Ovarian dysfunction: Estrogen excess
80.9
7.4
8
*
L17
ICPC
Foot/toe symptom/complaint
1.7
7.3
168
1087
XLA10
NOMESCO Finland
NA
2.5
7.3
57
241
E0000UV
ATC
NA
1.6
7.3
290
2166
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
3.7
7.3
30
83
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.3
7.3
68
315
A28
ICPC
Limited function/disability NOS
2.6
7.3
51
204
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.0
7.3
96
517
L68
ICD-10 Finland
Hypertrichosis
+∞
7.3
7
*
QDH01
NOMESCO Finland
Excision of nail bed in toe
+∞
7.3
7
*
L15
ICPC
Knee symptom/complaint
1.8
7.3
134
812
N03AF01
ATC
carbamazepine; oral, rectal
3.5
7.3
32
94
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
7.3
105
586
C09AA02
ATC
enalapril; systemic
2.3
7.2
67
309
P03
ICPC
Feeling depressed
1.9
7.2
110
625
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
2.1
7.2
77
381
N91.5
ICD-10 Finland
Oligomenorrhoea, unspecified
7.4
7.2
16
22
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
7.2
123
727
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.2
7.2
72
347
QBJ30
NOMESCO Finland
Correction of abdominal apron
5.7
7.1
19
34
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.5
7.1
415
3380
J02AC01
ATC
fluconazole; systemic
1.5
7.1
365
2893
C09CA01
ATC
losartan; oral
1.9
7.0
97
531
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
7.0
172
1135
160
Kela drug reimbursment
exenatide
6.4
7.0
17
27
N06AB10
ATC
escitalopram; oral
1.6
6.9
188
1274
N02AA05
ATC
oxycodone; systemic
2.5
6.9
54
228
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
1.9
6.9
109
626
SPAT1234
SPAT
Support of social functional capacity
3.4
6.9
31
93
R03AC02
ATC
salbutamol; inhalant
1.5
6.9
391
3151
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
6.8
6.8
16
24
L28
ICPC
Limited function/disability (L)
2.1
6.8
73
360
N03AE01
ATC
clonazepam; systemic
2.8
6.8
43
162
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.4
6.7
54
234
F32
ICD-10 Finland
Depressive episode
2.2
6.7
64
302
L72.1
ICD-10 Finland
Trichilemmal cyst
3.2
6.6
32
102
N05AN01
ATC
lithium; oral
4.0
6.5
24
61
F29
ICD-10 Finland
Unspecified nonorganic psychosis
2.7
6.5
42
161
L03
ICPC
Low back symptom/complaint
1.6
6.5
181
1232
R42
ICD-10 Finland
Dizziness and giddiness
1.8
6.5
119
720
N02BE01
ATC
paracetamol; systemic, rectal
1.6
6.4
596
5323
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.0
6.4
83
443
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
6.4
118
713
R53
ICD-10 Finland
Malaise and fatigue
1.7
6.4
146
943
M04AA01
ATC
allopurinol; systemic
3.2
6.3
31
100
N06AA09
ATC
amitriptyline; systemic
2.2
6.3
59
275
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
2.6
6.3
44
175
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
11.1
6.3
11
10
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
6.3
234
1709
G03DC02
ATC
norethisterone; oral
2.0
6.3
84
453
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
4.4
6.3
21
49
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.6
6.2
198
1395
F45.8
ICD-10 Finland
Other somatoform disorders
1.9
6.1
85
467
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
6.1
380
3094
F32.1
ICD-10 Finland
Moderate depressive episode
2.1
6.1
64
312
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.1
6.1
64
313
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
5.0
6.1
18
37
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
2.9
6.1
35
125
R51.80
ICD-10 Finland
Headache
1.7
6.1
134
857
P29
ICPC
Psychological sympt/compl other
2.1
6.0
68
343
SPAT1301
SPAT
No procedures
1.5
6.0
211
1519
D10BA01
ATC
isotretinoin; oral
2.1
6.0
70
358

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: L12_HYPERTRICHOSIS – Hypertrichosis

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).