Localized hypertrichosis

L12_LOCHYPERTRICH

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L68.2 Cause of death: ICD-10 — L68.2 2 out of 7 registries used, show all original rules.	29
4. Check minimum number of events None	29
5. Include endpoints None	29
6. Filter based on genotype QC (FinnGen only)	29

Control definitions (FinnGen only)

Control exclude: L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L68
Name in latin: Hypertrichosis localis

NAME	L12_LOCHYPERTRICH
CONTROL_EXCLUDE	L12_DISORDSKINAPPENDIX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L682
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L682
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Localized hypertrichosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	214	169	44
Only index persons	201	162	39
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	32.39	34.41	24.63
Only index persons	32.82	34.51	25.83

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	29	25	-
Unadjusted period prevalence (%)	0.01	0.01	-
Median age at first event (years)	35.16	35.13	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

6.33

5.73

1.8

2.2

11.3

14.7

ng/l

—

(3022411) Androstenedione [Moles/volume] in Serum or Plasma

+∞

5.35

1.2

0.0

9.0

—

nmol/l

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

10.38

3.43

1.3

2.3

42.3

37.7

nmol/l

—

(3019309) Folate [Moles/volume] in Red Blood Cells

3.84

2.21

1.1

1.7

1052.1

994.7

nmol/l

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

3.50

1.68

1.5

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.50

1.68

2.8

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.33

1.42

2.4

1.4

—

(3025941) Bacteria identified in Stool by Culture

3.33

1.42

1.2

1.0

—

(3044889) 12 lead EKG panel

145

2.22

1.27

3.1

2.5

—

(3042936) Bacteria identified in Isolate by Culture

2.64

1.26

4.0

2.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

2.30

1.24

1.2

1.8

82.1

96.4

pmol/l

—

(42870588) Differential panel, method unspecified - Blood

2.22

1.15

5.8

4.7

—

(3013512) EKG study

2.21

1.12

5.4

2.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.18

1.10

2.8

2.9

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

150

2.07

1.08

7.3

7.7

3.7

3.9

e9/l

0.20

135

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

235

0.44

1.08

3.6

4.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

2.10

1.07

2.7

2.6

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

2.10

1.02

3.8

2.8

39.1

37.2

g/l

1.09

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.34

0.96

4.2

3.5

—

(3026008) Bacteria identified in Urine by Culture

2.03

0.91

1.7

2.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.83

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.83

0.0

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.83

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.83

0.0

1.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

1.96

0.83

3.9

2.8

27.9

23.4

u/l

0.69

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.82

0.0

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.10

0.81

2.0

2.1

—

(3013707) Erythrocyte sedimentation rate by Westergren method

174

1.75

0.63

3.4

3.2

7.7

8.0

mm/h

0.07

161

(3001122) Ferritin [Mass/volume] in Serum or Plasma

141

1.73

0.63

2.9

2.5

65.4

54.7

ug/l

0.25

131

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

229

0.59

0.62

12.2

7.4

97.1

96.0

ml/min/173m2

0.08

193

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

112

1.70

0.62

3.1

3.8

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.62

0.0

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.62

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.61

0.0

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.73

0.58

2.2

1.8

—

(3009508) Creatinine [Moles/volume] in Urine

1.78

0.55

3.3

2.4

7.1

9.2

mmol/l

—

(3003694) ABO and Rh group [Type] in Blood

1.62

0.51

1.4

2.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.60

0.47

1.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.42

0.0

2.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.42

0.0

1.8

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.54

0.39

2.5

2.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.42

0.36

2.2

1.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.36

0.30

2.2

1.9

—

(3019198) Lymphocytes [#/volume] in Blood

136

1.39

0.29

5.6

4.3

2.1

1.9

e9/l

0.68

124

(3037467) Urinalysis macro (dipstick) panel - Urine

167

1.40

0.28

3.2

3.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.38

0.25

2.5

2.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.22

0.0

1.8

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.22

0.0

1.5

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.22

0.0

1.9

—

24.8

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.22

0.0

1.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

0.00

0.22

0.0

1.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.22

0.0

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

2.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.22

0.0

1.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.22

0.0

2.1

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.22

0.0

1.5

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.22

0.0

1.4

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.22

0.0

2.4

—

155.7

—

(3015736) pH of Urine

1.34

0.22

2.5

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.21

0.0

1.2

—

100.8

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3000991) Gas panel - Venous blood

0.00

0.21

0.0

8.0

—

(1002224) Polysomnography panel

0.00

0.20

0.0

1.1

—

(3020779) Urea [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

2.9

—

5.2

—

(40758558) Short blood count panel - Blood

1.30

0.20

3.0

6.2

—

(3030467) Casts [#/volume] in Urine by Automated count

1.24

0.19

1.4

2.4

0.2

e6/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.22

0.18

2.2

2.1

—

(3002582) Erythrocytes [#/volume] in Urine

1.11

0.08

1.4

2.4

188.0

16.9

e6/l

—

(36304419) Bacteria [Presence] in Urine

1.11

0.08

1.3

2.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.07

0.08

1.6

2.4

—

(3002030) Lymphocytes/100 leukocytes in Blood

129

1.16

0.07

5.5

4.5

32.0

30.6

0.24

123

(3018010) Neutrophils/100 leukocytes in Blood

129

1.16

0.07

5.4

4.4

54.1

55.6

0.23

123

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.15

0.05

2.4

2.2

—

(1761868) Lipid panel - Serum or Plasma

102

1.13

0.03

1.6

2.0

—

(3019069) Monocytes/100 leukocytes in Blood

123

0.96

0.00

6.3

4.7

7.6

8.0

0.38

117

(3022096) Basophils/100 leukocytes in Blood

116

1.06

0.00

5.9

4.6

0.4

0.6

1.09

109

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.5

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.0

—

17.0

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.6

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

3.0

—

(4306422)

0.00

0.0

1.0

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.97

0.00

1.6

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

2.1

—

4.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.95

0.00

2.0

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.05

0.00

3.0

3.1

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

0.94

0.00

1.3

1.4

2.0

1.3

mmol/l

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

3.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3018095) Leukocytes [#/volume] in Urine

1.02

0.00

1.4

3.0

571.1

46.3

e6/l

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

100.6

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.2

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

0.00

0.0

2.5

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

1.5

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.3

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

9.4

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

0.00

0.0

1.0

—

4.9

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3009343) pH of Capillary blood

0.00

0.0

1.0

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.1

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(4268621)

0.00

0.0

2.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(40768804) Tissue Pathology biopsy report

0.98

0.00

2.1

1.7

—

(3026782) Osmolality of Urine

1.05

0.00

1.2

2.0

834.8

523.1

mosm/kgh2o

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.92

0.00

2.2

1.8

—

(3006504) Eosinophils/100 leukocytes in Blood

120

1.00

0.00

6.1

4.5

2.2

2.7

1.13

112

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

0.0

1.5

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.1

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

130.3

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

3.3

—

0.9

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_LOCHYPERTRICH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_LOCHYPERTRICH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_LOCHYPERTRICH – Localized hypertrichosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Localized hypertrichosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints