Ovarian dysfunction: androgen excess

E4_ODANDRO

ovarian disease: A disease involving the ovary.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E28.1# Hospital discharge: ICD-9 — 2561 Cause of death: ICD-10 — E28.1# Cause of death: ICD-9 — 2561 2 out of 7 registries used, show all original rules.	59
4. Check minimum number of events None	59
5. Include endpoints None	59
6. Filter based on genotype QC (FinnGen only)	59

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E28
Name in latin: Hypersecretio androgenorum

NAME	E4_ODANDRO
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E281
HD_ICD_9	2561
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E281
COD_ICD_9	2561
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Ovarian dysfunction: androgen excess based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Ovarian dysfunction: androgen excess, drug-induced

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	356	356	-
Only index persons	343	343	-
Unadjusted period prevalence (%)
Whole population	0.01	0.01	-
Only index persons	0.01	0.01	-
Median age at first event (years)
Whole population	-	29.95	-
Only index persons	-	29.61	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	59	59	-
Unadjusted period prevalence (%)	0.02	0.02	-
Median age at first event (years)	30.37	30.37	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
53: Matched controls
530

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E28.1

ICD-10 Finland

Ovarian dysfunction: Androgen excess

+∞

58.7

E28.2

ICD-10 Finland

Polycystic ovarian syndrome

+∞

23.7

G03DB01

ATC

dydrogesterone; oral

8.8

11.6

A10BA02

ATC

metformin; oral

8.8

10.7

G03HB01

ATC

cyproterone and estrogen; systemic

7.7

9.9

2561A

ICD-9 Finland

Ovarian dysfunction, Other ovarian hyperfunction

+∞

8.6

N97.0

ICD-10 Finland

Female infertility associated with anovulation

22.6

8.0

L68.0

ICD-10 Finland

Hirsutism

35.4

7.4

ICD-9 Finland

79.0

6.6

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3027923) C peptide [Moles/volume] in Serum or Plasma

+∞

6.35

2.5

0.0

2.3

—

nmol/l

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

+∞

6.35

1.3

0.0

31.7

—

nmol/l

—

(3012516) Albumin [Mass/volume] in Urine

2.67

2.84

5.5

3.2

3049.8

35.7

mg/l

0.49

(3022313) Gas panel - Capillary blood

6.53

2.77

5.8

3.7

—

(4306422)

6.70

2.42

1.4

1.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

140

2.20

2.16

1.8

2.9

15.2

18.6

ng/l

0.27

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

5.34

2.11

1.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

2.32

2.09

7.2

4.1

12.2

6.7

mg/mmol

0.34

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.41

1.45

1.8

1.4

—

(3019225) pH of Specimen

2.60

1.44

6.0

4.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.11

1.39

1.4

3.7

—

(4010399)

2.56

1.35

1.1

1.3

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.66

1.34

1.2

1.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.78

1.24

1.6

1.8

—

(3002256) Pathology report gross observation

2.10

1.21

1.0

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.91

1.10

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

170

1.69

1.10

2.0

1.8

93.0

90.0

pmol/l

0.16

(3002385) Erythrocyte distribution width [Ratio]

455

0.58

1.08

16.2

13.5

13.8

13.5

0.76

449

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

461

2.08

1.04

4.7

3.6

6.4

5.5

mmol/l

2.37

425

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.07

1.01

1.4

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

174

1.64

0.99

3.2

4.3

35.6

37.1

g/l

0.65

168

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

478

2.07

0.95

5.3

3.8

2.8

mmol/l

0.09

445

(3023520) Reticulocytes [#/volume] in Blood

2.11

0.90

1.5

3.7

77.3

67.5

e9/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.90

0.88

1.5

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.77

0.82

1.3

1.2

—

(3019198) Lymphocytes [#/volume] in Blood

257

1.54

0.82

5.8

5.3

2.0

1.9

e9/l

0.34

239

(3042936) Bacteria identified in Isolate by Culture

1.86

0.81

2.1

1.8

—

(42870588) Differential panel, method unspecified - Blood

154

1.56

0.80

6.5

5.2

—

(3001604) Monocytes [#/volume] in Blood

250

1.51

0.76

5.5

5.3

0.6

0.5

e9/l

0.71

232

(3027945) Reticulocytes/100 erythrocytes in Blood

1.85

0.74

2.1

3.7

1.8

1.5

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.77

0.74

2.8

2.5

10.9

14.5

umol/l

—

(40768797) Stomach Pathology biopsy report

1.77

0.74

1.1

1.2

—

(3006315) Basophils [#/volume] in Blood

254

1.46

0.68

5.5

5.3

0.0

e9/l

0.42

233

(3013115) Eosinophils [#/volume] in Blood

265

1.45

0.66

6.2

5.3

0.2

e9/l

1.32

248

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.63

0.66

2.0

1.7

353.2

461.1

pmol/l

0.96

(36660697) Celiac disease serology panel - Serum

1.62

0.63

1.4

1.1

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

0.61

0.0

3.0

—

6.5

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.61

0.0

2.3

—

1.4

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

134

0.61

2.3

1.8

231.4

132.7

u/l

—

126

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

135

1.48

0.61

2.2

2.4

78.7

56.0

u/l

0.32

121

(3021589) Normoblasts [#/volume] in Blood

229

1.42

0.61

4.4

7.6

0.0

e9/l

0.80

192

(40768804) Tissue Pathology biopsy report

220

1.42

0.59

2.3

1.9

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.74

0.59

1.0

1.2

—

(3000492) Spirometry study

1.64

0.56

2.0

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

139

1.42

0.52

1.8

—

(3026782) Osmolality of Urine

1.47

0.49

1.9

2.1

462.8

550.9

mosm/kgh2o

0.79

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

440

0.72

0.48

3.8

4.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.54

0.48

1.5

2.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

124

1.40

0.45

1.6

1.7

—

(3025941) Bacteria identified in Stool by Culture

1.56

0.42

1.2

1.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.42

0.0

1.5

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.42

0.0

1.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.41

0.0

2.3

—

0.7

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

3.9

—

23.8

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.40

0.0

2.0

—

(3013512) EKG study

100

1.38

0.37

2.8

3.0

—

(3022145) Colonoscopy Study observation

1.51

0.37

1.0

1.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.45

0.37

2.1

2.3

0.5

1.0

e6/l

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.37

0.35

3.7

6.1

1.0

mmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

167

1.30

0.35

2.4

2.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

130

0.72

0.34

2.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

140

0.74

0.33

3.0

4.4

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.34

0.32

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

247

1.25

0.31

3.0

4.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

115

0.74

0.31

1.7

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

208

1.26

0.31

3.3

3.4

—

(40758558) Short blood count panel - Blood

126

0.75

0.27

2.3

7.3

—

(1761868) Lipid panel - Serum or Plasma

203

1.22

0.24

2.6

2.5

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

1.1

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.21

0.0

2.4

—

25.1

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

5.4

—

0.0

—

(4094501)

0.00

0.21

0.0

1.0

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

5.4

—

0.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

5.4

—

0.0

—

(3020891) Body temperature

0.00

0.21

0.0

7.5

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.2

—

(3012501) Base excess in Blood by calculation

0.00

0.20

0.0

1.8

—

3.5

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.20

0.0

1.8

—

4.9

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.20

0.0

2.7

—

5.2

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.20

0.0

1.8

—

10.0

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.20

0.0

2.7

—

60.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.17

0.20

2.0

1.8

—

(3026008) Bacteria identified in Urine by Culture

152

0.81

0.20

3.1

2.5

—

(3044889) 12 lead EKG panel

307

1.17

0.18

2.8

2.9

—

(3015736) pH of Urine

198

1.18

0.18

2.9

3.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

368

1.18

0.17

5.4

4.2

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

511

0.86

0.16

13.9

11.2

21.3

18.9

mg/l

0.25

382

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

152

1.17

0.14

1.5

1.6

—

(3044640) Blood type and Crossmatch panel - Blood

162

1.16

0.14

1.7

1.9

—

(3003694) ABO and Rh group [Type] in Blood

168

0.86

0.14

1.7

1.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

133

1.17

0.13

1.3

1.4

2.1

2.6

g/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

186

0.88

0.11

1.4

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.18

0.10

2.0

1.7

—

(3023368) Bacteria identified in Blood by Culture

1.18

0.10

2.8

3.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.09

0.10

2.0

4.5

—

(3030467) Casts [#/volume] in Urine by Automated count

136

1.14

0.10

2.3

2.4

0.2

e6/l

—

101

(3008898) HLA-B27 [Presence]

1.05

0.09

1.0

1.1

—

(3035350) Ketones [Presence] in Urine by Test strip

255

1.11

0.09

3.1

3.4

0.0

estimate

—

(40761536) Microorganisms panel - Urine sediment

0.82

0.08

2.2

3.4

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

526

1.31

0.08

11.1

8.9

23.8

22.5

u/l

0.45

515

(21494755) Public health laboratory ask at order entry panel

1.09

0.08

1.3

1.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.05

0.08

1.1

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

0.84

0.08

2.5

1.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

520

1.19

0.08

15.9

11.1

64.9

66.9

umol/l

0.52

520

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.82

0.07

1.6

1.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.81

0.07

1.3

1.6

—

(3029937) Albumin [Presence] in Urine by Test strip

142

0.89

0.07

2.8

3.9

0.0

estimate

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.84

0.07

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

103

0.85

0.07

3.2

3.8

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

231

0.92

0.05

4.1

5.6

7.3

9.3

umol/l

1.10

214

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

470

0.90

0.05

11.0

9.1

93.9

91.4

ml/min/173m2

0.35

378

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

119

0.91

0.04

1.6

1.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

164

1.05

0.00

3.1

2.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

166

0.95

0.00

1.9

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

306

0.96

0.00

6.3

8.9

4.4

3.9

e9/l

0.80

273

(3021601) Nitrite [Presence] in Urine by Test strip

255

1.04

0.00

5.0

4.6

0.0

estimate

—

(3009542) Hematocrit [Volume Fraction] of Blood

488

1.02

0.00

12.4

12.1

41.1

39.7

1.32

400

(36304419) Bacteria [Presence] in Urine

138

1.02

0.00

2.4

2.3

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.4

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

7.7

—

1.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.1

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.1

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.1

—

(4211845)

0.00

0.0

1.6

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

16.0

—

1486.7

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.0

—

41.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.5

—

106.5

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

108.9

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.4

—

91.6

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.5

—

(44813793)

0.00

0.0

1.0

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.2

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

3.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.00

0.00

2.8

2.0

5.0

5.3

umol/l

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

14.5

—

954.7

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

1.7

—

1.7

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.91

0.00

1.3

1.4

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

2.8

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.6

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.6

—

13.2

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.9

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

2.5

—

68.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.5

—

3.9

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

8.4

—

0.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_ODANDRO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_ODANDRO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_ODANDRO – Ovarian dysfunction: androgen excess

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Ovarian dysfunction: androgen excess

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints