Ovarian dysfunction: androgen excess

E4_ODANDRO

ovarian disease: A disease involving the ovary.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule only females	293218
2. Check conditions None	293218
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E28.1# Hospital discharge: ICD-9 — 2561 Cause of death: ICD-10 — E28.1# Cause of death: ICD-9 — 2561 2 out of 7 registries used, show all original rules.	60
4. Check minimum number of events None	60
5. Include endpoints None	60
6. Filter based on genotype QC (FinnGen only)	56

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E28
Name in latin: Hypersecretio androgenorum

NAME	E4_ODANDRO
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E281
HD_ICD_9	2561
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E281
COD_ICD_9	2561
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Ovarian dysfunction: androgen excess based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Ovarian dysfunction: androgen excess, drug-induced

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	356	356	-
Only index persons	343	343	-
Unadjusted period prevalence (%)
Whole population	0.01	0.01	-
Only index persons	0.01	0.01	-
Median age at first event (years)
Whole population	-	29.95	-
Only index persons	-	29.61	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	56	56	-
Unadjusted period prevalence (%)	0.02	0.02	-
Median age at first event (years)	30.65	30.65	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
60: Matched controls
600

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E28.1

ICD-10 Finland

Ovarian dysfunction: Androgen excess

+∞

68.4

E28.2

ICD-10 Finland

Polycystic ovarian syndrome

476.6

29.5

G03DB01

ATC

dydrogesterone; oral

11.4

20.8

A10BA02

ATC

metformin; oral

10.2

18.9

N97.0

ICD-10 Finland

Female infertility associated with anovulation

30.4

12.4

G03HB01

ATC

cyproterone and estrogen; oral

5.6

10.0

L68.0

ICD-10 Finland

Hirsutism

44.0

9.4

2561A

ICD-9 Finland

Ovarian dysfunction, Other ovarian hyperfunction

+∞

8.5

E, ,

ICD-9 Finland

+∞

7.4

N91.1

ICD-10 Finland

Secondary amenorrhoea

34.6

7.4

E66.01

ICD-10 Finland

Obesity due to excess calories

5.2

7.0

O80.0

ICD-10 Finland

Spontaneous vertex delivery

0.1

6.9

260

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

+∞

7.43

1.6

0.0

31.57

—

nmol/l

—

(3027923) C peptide [Moles/volume] in Serum or Plasma

+∞

6.35

2.5

0.0

2.30

—

nmol/l

—

(3012516) Albumin [Mass/volume] in Urine

2.80

3.18

5.4

3.2

2862.93

35.71

mg/l

0.49

(3022313) Gas panel - Capillary blood

6.52

2.77

5.8

3.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

2.43

2.39

6.6

3.8

14.30

6.69

mg/mmol

0.52

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

144

2.26

2.34

1.8

2.9

15.25

18.19

ng/l

0.23

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

5.34

2.11

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.34

1.41

1.8

1.4

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

3.11

1.38

1.2

2.7

99.40

105.71

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.66

1.34

1.2

1.0

—

(4200892) Spirometry reversibility

2.48

1.33

1.1

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.93

1.31

1.4

3.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.77

1.24

1.6

1.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

468

2.13

1.17

4.6

3.6

6.38

5.51

mmol/l

2.42

432

(3019225) pH of Specimen

2.50

1.17

6.0

4.2

—

(3002256) Pathology report gross observation

2.06

1.16

1.0

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.88

1.05

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

172

1.66

1.04

2.0

1.8

93.00

90.53

pmol/l

0.12

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.07

1.01

1.4

—

(40768797) Stomach Pathology biopsy report

1.91

0.98

1.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

486

2.11

0.95

5.3

3.8

2.77

2.85

mmol/l

0.25

456

(3023520) Reticulocytes [#/volume] in Blood

2.11

0.90

1.5

3.7

77.35

67.51

e9/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.85

0.86

1.5

1.4

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

179

1.57

0.86

3.2

4.2

35.61

37.12

g/l

0.65

172

(3042936) Bacteria identified in Isolate by Culture

1.86

0.81

2.1

1.8

—

(3002385) Erythrocyte distribution width [Ratio]

471

0.64

0.75

15.7

13.4

14.71

14.24

0.29

465

(3027945) Reticulocytes/100 erythrocytes in Blood

1.85

0.74

2.1

3.7

1.84

1.51

—

(40768804) Tissue Pathology biopsy report

222

1.49

0.74

2.2

1.9

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.77

0.74

2.8

2.5

10.91

14.50

umol/l

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

136

0.60

0.71

2.3

1.8

231.44

131.99

u/l

—

128

(3019198) Lymphocytes [#/volume] in Blood

264

1.45

0.68

5.8

5.4

2.00

1.90

e9/l

0.33

249

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.63

0.66

2.0

1.7

353.17

461.08

pmol/l

0.96

(3000494) Fungus identified in Specimen by Culture

1.69

0.64

1.3

1.2

—

(3001604) Monocytes [#/volume] in Blood

256

1.44

0.64

5.5

5.4

0.58

0.52

e9/l

0.74

237

(36660697) Celiac disease serology panel - Serum

1.62

0.62

1.4

1.1

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

0.61

0.0

3.0

—

6.52

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.61

0.0

2.3

—

1.35

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

126

1.49

0.60

1.6

1.7

—

(3006315) Basophils [#/volume] in Blood

259

1.41

0.59

5.5

5.3

0.05

0.04

e9/l

0.42

238

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.74

0.59

1.0

1.2

—

(3013115) Eosinophils [#/volume] in Blood

271

1.39

0.55

6.2

5.4

0.23

0.17

e9/l

1.32

253

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

138

1.43

0.54

2.2

2.4

78.67

55.92

u/l

0.32

122

(3000492) Spirometry study

1.55

0.53

2.0

1.2

—

(3021589) Normoblasts [#/volume] in Blood

233

1.38

0.53

4.4

7.6

0.00

e9/l

0.80

196

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

140

1.41

0.50

1.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

168

1.38

0.49

2.3

2.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.54

0.48

1.5

2.0

—

(3026782) Osmolality of Urine

1.43

0.44

2.0

2.3

462.77

548.22

mosm/kgh2o

0.76

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

210

1.33

0.43

3.2

3.4

—

(3025941) Bacteria identified in Stool by Culture

1.56

0.42

1.2

1.1

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.41

0.0

1.2

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

3.9

—

23.76

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.41

0.0

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

446

0.75

0.41

3.7

4.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.40

0.0

2.3

—

0.71

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.40

0.0

2.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

252

1.29

0.38

2.0

2.5

—

(3022145) Colonoscopy Study observation

1.51

0.37

1.0

1.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.44

0.37

2.1

2.3

0.48

1.00

e6/l

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.37

0.35

3.7

6.1

0.96

1.02

mmol/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

130

0.72

0.34

2.0

—

(3013512) EKG study

102

1.35

0.33

2.8

3.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.33

0.32

1.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

115

0.74

0.31

1.7

—

(40758558) Short blood count panel - Blood

127

0.74

0.29

2.3

7.3

—

(3026008) Bacteria identified in Urine by Culture

158

0.77

0.28

3.3

2.5

—

(3044640) Blood type and Crossmatch panel - Blood

164

1.23

0.24

1.7

1.8

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

5.0

—

0.00

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

5.0

—

0.00

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.21

0.0

2.4

—

25.20

—

(3020891) Body temperature

0.00

0.21

0.0

7.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.21

0.0

3.0

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

5.0

—

0.00

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

1.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

10.48

—

(3037467) Urinalysis macro (dipstick) panel - Urine

375

1.20

0.21

5.1

4.2

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.2

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.20

0.0

1.8

—

9.99

—

(3012501) Base excess in Blood by calculation

0.00

0.20

0.0

1.8

—

3.54

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.20

0.0

2.7

—

5.23

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.20

0.0

2.7

—

60.21

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.20

0.0

1.8

—

4.85

—

(3044889) 12 lead EKG panel

315

1.18

0.20

2.9

—

(1761868) Lipid panel - Serum or Plasma

207

1.18

0.19

2.6

2.5

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

535

1.34

0.18

11.0

8.9

24.05

22.48

u/l

0.59

524

(3003694) ABO and Rh group [Type] in Blood

171

0.84

0.17

1.7

1.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

248

1.16

0.17

6.3

5.9

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

520

0.87

0.16

13.8

11.1

21.81

18.77

mg/l

0.35

387

(3018095) Leukocytes [#/volume] in Urine

180

1.17

0.16

2.6

3.1

14.63

47.51

e6/l

0.70

122

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

190

0.85

0.15

1.4

1.5

—

(3035350) Ketones [Presence] in Urine by Test strip

260

1.14

0.14

3.1

3.4

0.00

estimate

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

152

1.17

0.14

1.5

1.6

—

(3007164) IgA [Mass/volume] in Serum or Plasma

135

1.15

0.11

1.3

1.4

2.10

2.65

g/l

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

236

0.89

0.10

4.1

5.5

7.30

9.45

umol/l

1.19

219

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.18

0.10

2.0

1.7

—

(3023368) Bacteria identified in Blood by Culture

1.18

0.10

2.8

3.6

—

(3030467) Casts [#/volume] in Urine by Automated count

136

1.14

0.10

2.3

2.4

0.24

e6/l

—

101

(3008898) HLA-B27 [Presence]

1.05

0.09

1.0

1.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.05

0.09

2.0

4.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.15

0.09

2.0

1.8

—

(40761536) Microorganisms panel - Urine sediment

0.80

0.08

2.2

3.4

—

(21494755) Public health laboratory ask at order entry panel

1.09

0.08

1.3

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

0.84

0.08

2.5

1.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

530

1.19

0.08

15.9

11.1

65.39

66.88

umol/l

0.35

530

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.82

0.07

1.6

1.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.81

0.07

1.3

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.84

0.07

1.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

481

0.89

0.06

11.0

9.1

92.91

91.25

ml/min/173m2

0.21

387

(3013650) Neutrophils [#/volume] in Blood by Automated count

312

0.92

0.06

6.3

8.8

4.41

3.91

e9/l

0.78

278

(3021601) Nitrite [Presence] in Urine by Test strip

259

1.08

0.05

4.9

4.6

0.00

0.02

estimate

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

119

0.91

0.04

1.6

1.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

167

0.94

0.01

1.9

—

(36304419) Bacteria [Presence] in Urine

139

1.01

0.00

2.4

2.3

—

(3029937) Albumin [Presence] in Urine by Test strip

143

0.97

0.00

2.7

3.9

0.00

0.02

estimate

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

105

0.94

0.00

3.1

3.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

165

1.04

0.00

3.1

2.8

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

14.5

—

954.67

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

-0.00

0.0

2.5

—

68.33

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

8.4

—

0.74

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

2.5

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

0.98

-0.00

2.8

2.0

5.00

5.41

umol/l

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

108.88

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(44813793) Dust mix specific IgE antibody measurement

0.00

-0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

16.0

—

1486.67

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.91

-0.00

1.3

1.4

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

2.5

—

3.93

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

2.6

—

13.24

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.6

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

65.40

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.4

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

-0.00

0.0

1.7

—

1.75

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.2

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

-0.00

0.0

1.1

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

-0.00

0.0

8.0

—

3.98

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.00

-0.00

1.1

1.6

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

-0.00

0.0

1.1

—

(3024928) Oxygen saturation in Venous blood

0.00

-0.00

0.0

3.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

4.0

—

41.00

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

1.4

—

91.56

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

2.5

—

106.50

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

-0.00

0.0

7.7

—

1.49

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_ODANDRO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_ODANDRO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_ODANDRO – Ovarian dysfunction: androgen excess

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Ovarian dysfunction: androgen excess

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints