ovarian disease: A disease involving the ovary.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
59 |
4. Check minimum number of eventsNone |
59 |
5. Include endpointsNone |
59 |
6. Filter based on genotype QC (FinnGen only) |
59 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E28
- Name in latin
- Hypersecretio androgenorum
Similar endpoints
↥List of similar endpoints to
Ovarian dysfunction: androgen excess
based on the number of shared cases.
Similar with more cases:
- Ovarian dysfunction
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 356 | 356 | - |
| Only index persons | 343 | 343 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | - |
| Only index persons | 0.01 | 0.01 | - |
| Median age at first event (years) | |||
| Whole population | - | 29.95 | - |
| Only index persons | - | 29.61 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 59 | 59 | - |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | - |
| Median age at first event (years) | 30.37 | 30.37 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 53
- Matched controls
- 530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E28.1
ICD-10 Finland
Ovarian dysfunction: Androgen excess
+∞
58.7
45
*
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
+∞
23.7
21
*
G03DB01
ATC
dydrogesterone; oral
8.8
11.6
30
68
A10BA02
ATC
metformin; oral
8.8
10.7
26
52
G03HB01
ATC
cyproterone and estrogen; systemic
7.7
9.9
27
63
2561A
ICD-9 Finland
Ovarian dysfunction, Other ovarian hyperfunction
+∞
8.6
8
*
N97.0
ICD-10 Finland
Female infertility associated with anovulation
22.6
8.0
11
6
L68.0
ICD-10 Finland
Hirsutism
35.4
7.4
9
*
E
ICD-9 Finland
NA
79.0
6.6
7
*
Mortality – FinRegistry
↥Association
Association between endpoint E4_ODANDRO and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_ODANDRO.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_ODANDRO – Ovarian dysfunction: androgen excess
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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