No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
61 |
4. Check minimum number of eventsNone |
61 |
5. Include endpointsNone |
61 |
6. Filter based on genotype QC (FinnGen only) |
61 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disease of thymus, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Diseases of thymus
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 334 | 201 | 131 |
| Only index persons | 276 | 163 | 113 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 54.02 | 57.68 | 48.43 |
| Only index persons | 49.25 | 52.02 | 45.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 61 | 40 | 21 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 48.36 | 48.16 | 48.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 52
- Matched controls
- 522
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E32.9
ICD-10 Finland
Disease of thymus, unspecified
+∞
44.2
36
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
10.8
11.4
24
38
25499
ICD-8 Finland
Diseases of thymus gland
+∞
9.7
9
*
E32.8
ICD-10 Finland
Other diseases of thymus
+∞
6.4
6
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
13.4
6.1
10
9
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYMUSDISNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYMUSDISNAS | 2.222 [1.27, 3.88] | 0.005 |
| Birth year | 0.99 [0.98, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 136 females with E4_THYMUSDISNAS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYMUSDISNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.203% | No data |
| 5 | 1.219% | No data |
| 10 | 2.736% | No data |
| 15 | 5.372% | No data |
| 20 | 9.043% | No data |
Relationships between endpoints
↥Index endpoint: E4_THYMUSDISNAS – Disease of thymus, other/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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