Risteys · E4_THYMUSDISNAS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E32.8, E32.9 Hospital discharge: ICD-9 — 254[8-9] Hospital discharge: ICD-8 — 25499 Cause of death: ICD-10 — E32.8, E32.9 Cause of death: ICD-9 — 254[8-9] Cause of death: ICD-8 — 25499 2 out of 7 registries used, show all original rules.	61
4. Check minimum number of events None	61
5. Include endpoints None	61
6. Filter based on genotype QC (FinnGen only)	61

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	334	201	131
Only index persons	276	163	113
Unadjusted period prevalence (%)
Whole population	0.00	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	54.02	57.68	48.43
Only index persons	49.25	52.02	45.26

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	61	40	21
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	48.36	48.16	48.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
52: Matched controls
522

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E32.9

ICD-10 Finland

Disease of thymus, unspecified

+∞

44.2

F32.9

ICD-10 Finland

Depressive episode, unspecified

10.8

11.4

25499

ICD-8 Finland

Diseases of thymus gland

+∞

9.7

E32.8

ICD-10 Finland

Other diseases of thymus

+∞

6.4

T36

ICD-10 Finland

Poisoning by systemic antibiotics

13.4

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

5.73

5.77

1.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

219

3.40

4.97

5.3

4.8

0.0

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

223

3.31

4.75

3.7

3.4

0.0

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

225

3.26

4.64

3.8

3.5

0.0

estimate

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

170

3.05

4.40

5.5

4.1

76.3

39.5

ng/l

0.32

107

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

203

2.89

3.95

6.9

8.6

1.2

mmol/l

0.09

167

(3023368) Bacteria identified in Blood by Culture

117

2.93

3.86

5.1

3.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.25

3.83

1.5

1.4

—

(3015736) pH of Urine

178

2.68

3.49

3.8

3.1

—

(3023520) Reticulocytes [#/volume] in Blood

3.59

3.30

1.4

3.6

75.5

81.6

e9/l

—

(3027945) Reticulocytes/100 erythrocytes in Blood

3.20

3.14

1.9

3.8

1.9

2.0

0.08

(3019060) Gas panel - Arterial blood

3.79

3.05

4.0

4.5

—

(3029937) Albumin [Presence] in Urine by Test strip

118

2.52

2.85

4.3

3.7

0.0

estimate

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

175

2.41

2.81

2.2

2.1

100.1

93.8

pmol/l

0.37

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

170

2.35

2.66

4.1

3.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

114

2.45

2.64

3.5

2.4

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

189

2.30

2.57

6.2

5.0

33.0

36.3

g/l

1.67

179

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

132

2.35

2.52

3.0

3.6

1134.6

1083.1

ng/l

0.05

103

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.64

2.41

1.7

2.6

2.5

2.4

g/l

0.53

(3041096) Erythrocytes [Presence] in Urine by Automated

128

2.28

2.32

3.6

3.0

—

(42870588) Differential panel, method unspecified - Blood

154

2.20

2.25

5.2

5.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

216

2.15

2.21

6.3

4.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

102

2.25

2.06

4.0

3.5

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

204

2.06

2.00

3.4

2.7

124.2

105.2

ug/l

0.21

188

(3022096) Basophils/100 leukocytes in Blood

216

2.01

1.90

6.3

6.2

0.8

0.7

0.52

197

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.37

1.88

2.6

7.2

1.0

1.1

mmol/l

0.75

(3037467) Urinalysis macro (dipstick) panel - Urine

334

2.14

1.87

5.5

4.2

—

(3006504) Eosinophils/100 leukocytes in Blood

217

2.00

1.86

6.6

6.4

2.4

2.7

0.45

199

(1616796) Gas panel - Central venous blood

4.43

1.86

1.4

1.6

—

(3044640) Blood type and Crossmatch panel - Blood

147

2.04

1.85

4.3

2.4

—

(3019069) Monocytes/100 leukocytes in Blood

221

1.94

1.73

7.3

6.7

8.7

8.4

0.17

204

(3026008) Bacteria identified in Urine by Culture

142

1.99

1.71

3.6

3.1

—

(3020891) Body temperature

3.79

1.65

7.6

3.2

—

(3025941) Bacteria identified in Stool by Culture

2.90

1.63

1.6

1.2

—

(3032080) INR in Blood by Coagulation assay

171

1.91

1.60

10.0

6.6

1.0

1.2

inr

—

(3018418) pH of Serum or Plasma

129

1.96

1.57

3.3

4.6

7.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.79

1.56

14.3

8.0

—

(3002030) Lymphocytes/100 leukocytes in Blood

227

1.86

1.55

6.8

6.3

25.0

27.6

0.59

208

(3022313) Gas panel - Capillary blood

2.69

1.50

5.0

4.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

158

1.86

1.45

2.2

3.2

25.2

30.0

u/l

1.37

152

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.59

1.44

18.3

9.3

0.5

0.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.59

1.44

18.3

9.3

1.1

1.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

361

1.94

1.43

5.5

4.0

16.8

11.1

mm/h

1.58

326

(3042936) Bacteria identified in Isolate by Culture

2.13

1.34

1.9

1.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.55

1.27

7.8

5.6

25.7

24.4

mmol/l

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

138

1.80

1.25

3.5

2.5

51.2

56.9

u/l

0.42

129

(3007853) Bacteria identified in Skin by Aerobe culture

2.09

1.21

1.3

1.6

—

(3013512) EKG study

131

1.78

1.20

4.8

4.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.92

1.17

1.6

1.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.50

1.17

2.3

2.9

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.10

1.14

1.2

1.8

373.9

406.8

nmol/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.50

1.11

1.8

1.3

—

(3002385) Erythrocyte distribution width [Ratio]

386

1.78

1.09

28.9

17.0

13.9

0.08

380

(3018095) Leukocytes [#/volume] in Urine

170

1.68

1.08

4.7

3.6

93.2

49.1

e6/l

0.44

113

(3022145) Colonoscopy Study observation

2.06

1.00

1.0

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

155

1.66

1.00

4.0

2.9

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

451

1.80

0.88

19.6

13.2

82.6

83.3

ml/min/173m2

0.08

359

(3021589) Normoblasts [#/volume] in Blood

188

1.56

0.86

11.4

9.3

0.0

e9/l

0.48

151

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.87

0.85

3.1

1.9

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.78

0.81

3.1

2.7

9.8

4.0

e6/l

—

(4010399)

1.91

0.81

1.2

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.78

0.79

1.8

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.78

0.79

1.7

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.67

0.76

2.4

1.8

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

2.09

0.74

5.2

4.9

23.6

24.6

mmol/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.71

0.69

1.1

1.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.67

0.67

2.1

1.5

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.58

0.66

3.4

4.5

1.0

2.0

ug/l

2.08

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.69

0.64

3.4

1.9

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.72

0.63

1.4

2.0

3.1

6.5

ug/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.62

0.62

1.9

1.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

135

1.47

0.60

3.7

3.9

3.3

8.1

mg/mmol

0.73

(3000991) Gas panel - Venous blood

1.79

0.60

17.3

10.3

—

(3012516) Albumin [Mass/volume] in Urine

129

1.44

0.53

2.5

3.3

44.4

512.9

mg/l

0.50

(3019832) Treponema pallidum Ab [Presence] in Serum

1.63

0.51

1.9

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.52

0.49

4.1

3.3

—

(40768804) Tissue Pathology biopsy report

202

0.72

0.47

1.6

1.9

—

(40768797) Stomach Pathology biopsy report

1.51

0.45

1.3

1.2

—

(40761511) CBC panel - Blood by Automated count

507

1.57

0.44

23.3

11.7

—

(3044889) 12 lead EKG panel

318

1.32

0.43

5.2

3.6

—

(4034850)

0.00

0.42

0.0

11.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.40

0.0

1.2

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.42

0.39

1.0

1.2

14.0

166.8

u/ml

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.44

0.37

3.5

2.6

0.4

1.0

e6/l

—

(4035726)

1.47

0.37

1.2

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

343

1.29

0.36

3.2

3.0

—

(3000492) Spirometry study

1.40

0.35

1.2

1.3

—

(3003694) ABO and Rh group [Type] in Blood

120

1.33

0.34

2.2

1.4

—

(3000850) Epithelial cells [#/volume] in Urine

102

1.35

0.33

3.4

2.4

8.3

4.9

e6/l

0.36

(40760892) CBC W Ordered Manual Differential panel - Blood

103

1.33

0.31

9.8

5.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.36

0.30

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

482

1.35

0.30

25.0

13.4

29.6

19.7

mg/l

1.06

370

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

1.31

0.27

1.4

1.2

2.1

0.6

u/ml

—

(3026493) Urate [Moles/volume] in Serum or Plasma

115

1.28

0.26

2.0

3.6

295.8

2691.3

umol/l

—

(40761536) Microorganisms panel - Urine sediment

1.34

0.24

7.2

3.8

—

(3012544) pH of Venous blood

1.27

0.23

2.6

4.7

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.21

0.0

1.7

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

4.2

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.1

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.21

0.0

2.0

—

7.9

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.21

0.0

2.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

453

0.83

0.20

28.8

14.4

39.3

40.1

0.31

349

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.20

0.0

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.17

0.20

6.0

6.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.21

0.19

1.3

1.5

—

(1761868) Lipid panel - Serum or Plasma

172

0.83

0.18

2.7

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

512

1.27

0.15

15.6

10.0

23.2

25.4

u/l

0.77

499

(3020564) Creatinine [Moles/volume] in Serum or Plasma

511

1.28

0.15

25.6

15.1

74.8

75.8

umol/l

0.12

511

(3019225) pH of Specimen

1.15

0.10

3.6

5.8

—

(40758558) Short blood count panel - Blood

117

1.14

0.09

8.5

8.3

—

(3000494) Fungus identified in Specimen by Culture

1.11

0.08

1.6

1.4

—

(36304419) Bacteria [Presence] in Urine

130

1.10

0.05

4.5

2.7

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

469

0.92

0.04

3.6

3.9

1.4

1.3

mmol/l

0.36

432

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

111

0.99

0.00

1.4

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

485

1.05

0.00

4.4

4.8

2.7

2.8

mmol/l

0.21

444

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

1.7

—

(4281824)

0.00

0.0

1.0

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

4.5

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

13.6

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

4.0

—

62.2

—

(4027681)

0.00

0.0

1.2

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.2

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

2.8

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3000963) Hemoglobin [Mass/volume] in Blood

540

1.00

0.00

36.2

19.8

129.1

134.9

g/l

1.63

533

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3026361) Erythrocytes [#/volume] in Blood

540

1.00

0.00

36.0

19.7

4.3

4.5

e12/l

1.23

526

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.4

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.2

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

1.8

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.8

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.1

—

4.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.0

—

33.3

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.6

—

(3024731) MCV [Entitic volume]

540

1.00

0.00

35.9

19.6

91.1

0.03

534

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.2

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(3002256) Pathology report gross observation

0.90

0.00

1.2

1.3

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

0.8

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

2.0

—

(4094501)

0.00

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3035941) MCH [Entitic mass]

539

1.02

0.00

35.9

19.6

30.3

0.02

533

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

231.6

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

87.8

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.1

—

(3011648) Oxygen content in Venous blood

0.00

0.0

3.4

—

11.5

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.6

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.1

—

108.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

10.4

—

1208.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

1235.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.6

—

(4146454)

0.00

0.0

3.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

12.4

—

1861.4

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.9

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.4

—

213.1

—

(3010813) Leukocytes [#/volume] in Blood

540

1.00

0.00

36.0

19.9

6.9

6.5

e9/l

0.94

526

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

1.9

—

(3007461) Platelets [#/volume] in Blood

539

1.02

0.00

35.9

19.8

255.1

254.5

e9/l

0.02

529

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYMUSDISNAS and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_THYMUSDISNAS	2.222 [1.27, 3.88]	0.005
Birth year	0.99 [0.98, 1.0]	0.02

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 136 females with E4_THYMUSDISNAS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYMUSDISNAS.

N-year risk	Females	Males
1	0.203%	No data
5	1.219%	No data
10	2.736%	No data
15	5.372%	No data
20	9.043%	No data

Relationships between endpoints

↥

Index endpoint: E4_THYMUSDISNAS – Disease of thymus, other/unspecified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	E4_THYMUSDISNAS
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E32[8-9]
HD_ICD_9	254[8-9]
HD_ICD_8	25499
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E32[8-9]
COD_ICD_9	254[8-9]
COD_ICD_8	25499
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Disease of thymus, other/unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints