No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
77 |
4. Check minimum number of eventsNone |
77 |
5. Include endpoints |
94 |
6. Filter based on genotype QC (FinnGen only) |
89 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E20-E35
- Name in latin
- Morbi thymi
Similar endpoints
↥List of similar endpoints to
Diseases of thymus
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 615 | 375 | 231 |
| Only index persons | 454 | 281 | 173 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 57.22 | 60.39 | 51.51 |
| Only index persons | 49.79 | 52.25 | 45.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 89 | 52 | 37 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 47.81 | 49.36 | 45.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 94
- Matched controls
- 940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E32.9
ICD-10 Finland
Disease of thymus, unspecified
+∞
48.1
42
*
E32.0
ICD-10 Finland
Persistent hyperplasia of thymus
+∞
24.0
22
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
7.3
18.1
35
71
25499
ICD-8 Finland
Diseases of thymus gland
+∞
10.6
10
*
E32.8
ICD-10 Finland
Other diseases of thymus
+∞
8.5
8
*
2540A
ICD-9 Finland
Diseases of thymus gland, Persistent hyperplasia of thymus
+∞
7.4
7
*
D38.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Mediastinum
+∞
7.4
7
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.1
7.3
24
73
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
43.3
6.9
8
*
N02AX02
ATC
tramadol; systemic, rectal
3.1
6.7
50
254
GEC24
NOMESCO Finland
Thoracoscopic thymectomy
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
57
328
2.87
5.82
8.9
6.7
1.22
1.22
mmol/l
0.04
49
272
14
41
3.84
4.38
1.4
1.2
—
—
—
0
0
34
170
2.57
4.32
3.4
2.2
—
—
—
0
0
55
356
2.31
3.82
4.1
3.6
0.00
0.00
estimate
-0.00
11
74
54
348
2.30
3.77
5.6
5.1
0.00
0.00
estimate
—
10
70
46
283
2.22
3.53
2.1
1.9
102.60
94.96
pmol/l
0.58
25
154
54
357
2.20
3.44
4.2
3.6
0.00
0.00
estimate
—
10
65
22
101
2.54
3.25
3.5
2.1
2.36
2.41
g/l
0.16
22
87
44
281
2.06
2.94
5.2
3.6
65.25
36.46
ng/l
0.34
32
174
47
310
2.03
2.86
4.1
2.6
123.83
114.95
ug/l
0.12
47
284
11
34
3.52
2.84
8.5
4.2
24.45
24.79
mmol/l
0.15
11
34
46
302
2.02
2.82
2.3
2.3
80.03
75.72
nmol/l
0.49
39
263
13
50
2.86
2.66
1.5
1.3
—
—
—
0
0
16
73
2.44
2.37
2.0
1.6
347.12
387.10
nmol/l
0.39
16
67
47
329
1.86
2.25
4.0
2.5
—
—
—
0
0
8
24
3.54
2.23
2.4
1.7
24.57
23.73
mmol/l
—
8
24
11
42
2.83
2.23
13.7
7.9
0.54
0.72
%
1.49
11
42
17
83
2.28
2.17
14.8
6.0
102.76
104.23
mmol/l
0.49
17
83
11
43
2.76
2.17
13.2
7.8
1.04
1.62
%
1.13
11
43
5
10
5.21
2.09
7.2
2.4
2.12
3.09
nmol/l
—
5
10
40
272
1.82
2.06
4.6
3.8
—
—
—
0
0
33
213
1.85
2.00
3.0
3.1
999.55
1198.12
ng/l
0.24
27
170
37
252
1.77
1.86
7.6
3.4
2.35
2.36
mmol/l
0.21
32
213
9
36
2.66
1.79
4.8
2.2
1.83
1.52
%
—
9
36
19
106
1.99
1.75
2.8
2.7
5.90
2.48
e6/l
—
9
56
36
252
1.69
1.61
2.1
3.1
27.22
30.21
u/l
0.74
36
238
8
33
2.55
1.58
8.6
4.2
24.98
24.97
mmol/l
—
8
33
55
436
1.63
1.49
11.7
10.0
3.91
4.00
e9/l
0.11
49
387
41
304
1.62
1.44
17.3
11.3
0.98
1.29
inr
5.58
11
89
28
188
1.70
1.44
5.8
3.9
0.00
0.00
estimate
—
10
70
19
115
1.82
1.38
2.2
1.9
—
—
—
0
0
5
17
3.05
1.37
1.0
1.6
—
—
—
0
0
5
17
3.05
1.37
2.2
3.6
0.00
0.00
g/l
—
5
17
52
414
1.57
1.33
8.2
4.4
7.02
6.71
mmol/l
0.31
52
386
34
245
1.61
1.32
4.1
3.0
—
—
—
0
0
6
24
2.60
1.32
2.2
1.6
—
—
—
0
0
8
35
2.40
1.30
1.7
2.7
55.27
52.30
%
—
8
35
5
18
2.87
1.30
1.0
1.7
—
—
—
0
0
5
18
2.87
1.30
1.2
1.9
122.40
128.69
g/l
—
5
13
5
19
2.72
1.23
1.2
1.1
—
—
—
0
0
5
19
2.72
1.23
5.4
2.6
2.68
3.49
g/l
—
5
19
5
21
2.46
1.10
1.8
1.2
—
—
—
0
0
7
33
2.21
1.08
1.3
1.0
—
—
—
0
0
65
560
1.52
1.05
5.5
4.0
14.26
11.30
mm/h
0.90
57
511
72
636
1.56
1.01
30.9
16.1
14.65
15.11
%
0.33
72
627
9
51
1.84
0.98
3.7
3.7
1.23
1.23
mmol/l
—
9
46
78
706
1.62
0.94
21.1
12.7
82.87
83.55
ml/min/173m2
0.08
70
573
17
112
1.63
0.93
3.1
2.4
0.42
0.83
e6/l
—
9
62
12
73
1.74
0.86
2.3
1.8
—
—
—
0
0
12
73
1.74
0.86
2.4
1.7
—
—
—
0
0
6
33
1.87
0.80
1.0
2.2
—
—
—
0
0
5
24
2.14
0.76
2.4
3.0
—
—
—
0
0
81
753
1.55
0.70
25.3
13.4
28.78
21.11
mg/l
1.12
72
587
58
513
1.34
0.65
3.2
3.1
—
—
—
0
0
26
205
1.37
0.62
3.6
3.6
2.77
8.17
mg/mmol
1.24
18
134
10
64
1.63
0.61
3.7
2.7
25.80
30.56
u/l
—
10
55
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
6
36
1.71
0.58
1.5
3.6
25.43
24.34
mmol/l
—
6
36
6
38
1.62
0.55
1.3
1.6
7.48
8.81
ug/l
—
6
32
9
65
1.42
0.52
4.0
3.4
—
—
—
0
0
7
46
1.56
0.49
1.9
2.1
—
—
—
0
0
15
113
1.39
0.46
1.3
1.3
—
—
—
0
0
23
188
1.30
0.43
1.9
2.9
322.24
1732.14
umol/l
0.50
17
159
5
35
1.45
0.40
1.8
2.5
—
—
—
0
0
83
795
1.38
0.38
26.1
15.1
81.35
75.57
umol/l
0.40
83
795
6
41
1.49
0.37
1.8
1.9
—
—
—
0
0
20
164
1.28
0.36
1.3
1.3
7.69
0.68
u/ml
—
7
43
83
797
1.35
0.35
15.1
10.1
22.77
26.34
u/l
2.38
83
780
6
46
1.32
0.33
1.3
2.6
3.12
5.28
ug/l
—
6
40
12
93
1.33
0.32
3.0
2.1
—
—
—
0
0
23
199
1.21
0.27
4.8
2.8
0.10
0.40
e6/l
1.55
18
148
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
6
48
1.27
0.20
2.5
1.8
248.83
130.78
ng/l
—
6
41
10
81
1.26
0.19
2.9
2.0
—
—
—
0
0
17
153
1.14
0.12
3.4
4.1
17.63
20.03
%
—
6
64
5
46
1.09
0.10
3.6
2.9
6.26
13.21
nmol/l
—
5
46
71
725
0.92
0.08
3.9
3.9
1.31
1.29
mmol/l
0.08
65
675
7
81
0.85
0.07
5.7
6.1
—
—
—
0
0
7
81
0.85
0.07
1.4
1.8
—
—
—
0
0
12
109
1.12
0.06
2.4
2.9
0.41
0.66
ug/l
—
6
70
16
150
1.08
0.04
1.7
1.5
—
—
—
0
0
84
837
1.03
0.00
37.0
19.5
129.64
136.17
g/l
2.93
84
828
13
133
0.97
0.00
1.1
1.3
28.56
37.76
iu/ml
—
5
47
74
745
0.97
0.00
4.2
4.3
4.47
4.70
mmol/l
0.87
69
698
76
756
1.03
0.00
4.6
4.7
2.71
2.81
mmol/l
0.31
70
700
74
739
1.01
0.00
4.0
4.3
1.43
1.46
mmol/l
0.25
69
688
0
5
0.00
-0.00
0.0
1.0
—
1235.00
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
206.80
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
12.12
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
180.62
—
0
6
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYMUSDIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYMUSDIS | 2.212 [1.49, 3.28] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 234 females with E4_THYMUSDIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYMUSDIS | 3.602 [1.75, 7.41] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 149 males with E4_THYMUSDIS died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYMUSDIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.18% | 0.795% |
| 5 | 1.148% | 4.018% |
| 10 | 2.685% | 9.576% |
| 15 | 5.111% | 17.15% |
| 20 | 9.273% | 29.089% |
Relationships between endpoints
↥Index endpoint: E4_THYMUSDIS – Diseases of thymus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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