Diseases of thymus

E4_THYMUSDIS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E32 Cause of death: ICD-10 — E32 2 out of 7 registries used, show all original rules.	77
4. Check minimum number of events None	77
5. Include endpoints E4_HYPERTHY E4_ABSCTHY E4_THYMUSDISNAS	94
6. Filter based on genotype QC (FinnGen only)	94

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E20-E35
Name in latin: Morbi thymi

NAME	E4_THYMUSDIS
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	E4_HYPERTHY\|E4_ABSCTHY\|E4_THYMUSDISNAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E32
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E32
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Diseases of thymus based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	615	375	231
Only index persons	454	281	173
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	57.22	60.39	51.51
Only index persons	49.79	52.25	45.80

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	94	57	37
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	47.72	49.08	45.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
83: Matched controls
830

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E32.9

ICD-10 Finland

Disease of thymus, unspecified

+∞

41.1

E32.0

ICD-10 Finland

Persistent hyperplasia of thymus

+∞

21.8

F32.9

ICD-10 Finland

Depressive episode, unspecified

7.0

10.6

25499

ICD-8 Finland

Diseases of thymus gland

+∞

9.6

M32.9

ICD-10 Finland

Systemic lupus erythematosus, unspecified

87.6

7.5

2540A

ICD-9 Finland

Diseases of thymus gland, Persistent hyperplasia of thymus

+∞

7.4

E32.8

ICD-10 Finland

Other diseases of thymus

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

329

2.86

5.77

8.9

6.9

1.2

mmol/l

0.00

271

(3023368) Bacteria identified in Blood by Culture

180

2.87

5.56

6.0

3.9

—

(3023520) Reticulocytes [#/volume] in Blood

3.55

4.63

1.3

3.0

67.7

78.3

e9/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.84

4.38

1.4

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

170

2.57

4.32

3.4

2.2

—

(42870588) Differential panel, method unspecified - Blood

250

2.33

3.85

4.3

5.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

350

2.28

3.70

5.6

5.1

0.0

estimate

—

(3044640) Blood type and Crossmatch panel - Blood

221

2.31

3.68

3.8

2.3

—

(3035350) Ketones [Presence] in Urine by Test strip

355

2.22

3.51

4.2

3.6

0.0

estimate

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

284

2.21

3.49

2.1

1.9

102.6

95.2

pmol/l

0.56

153

(3009261) Glucose [Presence] in Urine by Test strip

359

2.18

3.37

4.2

3.6

0.0

estimate

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

3.06

3.34

5.8

3.2

5.4

4.9

kpa

2.57

(3004789) Transferrin [Mass/volume] in Serum or Plasma

102

2.51

3.18

3.5

2.2

2.4

g/l

0.13

(3022096) Basophils/100 leukocytes in Blood

347

2.12

3.15

5.8

5.9

0.7

0.20

325

(3002030) Lymphocytes/100 leukocytes in Blood

368

2.10

3.06

6.1

5.9

26.4

27.9

0.42

344

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.43

3.04

8.5

4.5

24.4

24.8

mmol/l

0.14

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

280

2.07

2.98

5.2

3.6

65.3

37.0

ng/l

0.33

171

(3006504) Eosinophils/100 leukocytes in Blood

353

2.06

2.94

6.0

5.9

2.6

2.8

0.32

329

(3001122) Ferritin [Mass/volume] in Serum or Plasma

311

2.02

2.82

4.1

2.6

123.8

115.7

ug/l

0.11

285

(3019198) Lymphocytes [#/volume] in Blood

385

2.03

2.82

6.1

5.6

1.8

e9/l

0.23

349

(3019069) Monocytes/100 leukocytes in Blood

357

2.02

2.81

6.5

6.3

9.2

8.3

1.26

337

(3018418) pH of Serum or Plasma

208

2.09

2.81

7.0

3.8

7.4

—

(3013115) Eosinophils [#/volume] in Blood

386

2.02

2.79

6.2

6.0

0.2

e9/l

1.11

348

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

304

2.00

2.75

2.3

80.0

75.7

nmol/l

0.49

264

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.86

2.66

1.5

1.3

—

(3006315) Basophils [#/volume] in Blood

374

1.96

2.58

6.1

5.6

0.0

e9/l

0.40

333

(3001604) Monocytes [#/volume] in Blood

374

1.96

2.58

6.0

5.5

0.6

e9/l

0.30

329

(3019060) Gas panel - Arterial blood

2.78

2.38

4.0

4.6

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

4.85

2.31

1.2

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.40

2.30

2.0

1.6

347.1

382.2

nmol/l

0.33

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

328

1.87

2.28

5.9

4.1

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

3.54

2.23

2.4

1.7

24.6

23.3

mmol/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

199

1.92

2.19

4.6

3.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

4.50

2.18

1.2

1.3

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.76

2.18

13.7

7.9

0.5

0.7

1.50

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.70

2.10

13.2

7.8

1.0

1.6

1.09

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

5.21

2.09

7.2

2.4

2.1

3.1

nmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

272

1.82

2.06

4.7

3.8

—

(3022313) Gas panel - Capillary blood

2.75

1.99

7.0

3.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

214

1.84

1.97

3.0

3.1

999.6

1193.0

ng/l

0.23

171

(3026008) Bacteria identified in Urine by Culture

215

1.82

1.93

4.6

3.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

254

1.75

1.80

7.6

3.4

2.3

2.4

mmol/l

0.23

215

(3037467) Urinalysis macro (dipstick) panel - Urine

513

1.78

1.79

5.8

4.3

—

(3042936) Bacteria identified in Isolate by Culture

106

1.99

1.75

2.3

1.8

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

107

1.97

1.70

2.8

2.7

5.9

2.4

e6/l

—

(3021589) Normoblasts [#/volume] in Blood

303

1.70

10.6

9.2

0.0

e9/l

0.07

246

(1616796) Gas panel - Central venous blood

3.30

1.69

1.7

1.6

—

(3000991) Gas panel - Venous blood

2.36

1.64

17.6

7.9

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

253

1.69

1.58

2.1

3.1

27.2

30.2

u/l

0.73

239

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

2.55

1.58

8.6

4.2

25.0

mmol/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.01

1.57

1.8

1.5

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.58

1.53

4.8

2.3

1.8

1.5

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

436

1.63

1.49

11.7

10.0

3.9

4.0

e9/l

0.11

387

(3020891) Body temperature

2.62

1.48

5.7

4.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

3.24

1.45

1.6

1.1

—

(3032080) INR in Blood by Coagulation assay

258

1.64

1.45

8.2

7.7

1.0

1.3

inr

5.18

(3025941) Bacteria identified in Stool by Culture

2.38

1.45

1.4

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

188

1.70

1.44

5.8

3.9

0.0

estimate

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

114

1.84

1.42

2.2

1.9

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

3.05

1.37

2.2

3.6

0.0

g/l

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.05

1.37

1.0

1.6

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.21

1.34

2.1

2.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.48

1.33

1.5

1.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.60

1.32

2.2

1.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

158

1.70

1.32

3.5

3.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.40

1.30

1.7

2.7

55.3

52.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

246

1.60

1.30

4.1

3.0

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

2.87

1.30

1.2

1.9

122.4

128.7

g/l

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.87

1.30

1.0

1.7

—

(3021901) Oxygen saturation in Capillary blood

2.87

1.30

1.4

1.6

—

(4035726)

2.04

1.29

1.3

1.2

—

(3018095) Leukocytes [#/volume] in Urine

265

1.58

1.28

4.7

3.7

65.4

47.2

e6/l

0.23

182

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.33

1.28

13.3

7.1

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

2.72

1.23

5.4

2.6

2.7

3.5

g/l

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.72

1.23

1.2

1.1

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.09

1.15

5.4

3.7

133.1

129.1

g/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.28

1.10

1.3

1.0

—

(3002385) Erythrocyte distribution width [Ratio]

611

1.57

1.08

31.7

16.6

13.9

13.8

0.22

601

(1761482) Bacteria [#/volume] in Urine by Culture

2.34

1.04

1.6

5.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.34

1.04

1.8

1.2

—

(4010399)

1.97

1.04

1.1

1.5

—

(3013707) Erythrocyte sedimentation rate by Westergren method

561

1.51

1.03

5.5

4.0

14.3

11.4

mm/h

0.87

512

(3013512) EKG study

195

1.54

1.02

5.4

4.0

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.88

1.00

2.0

2.8

65.0

66.8

g/l

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.88

1.00

3.7

1.2

mmol/l

—

(40768797) Stomach Pathology biopsy report

111

1.65

0.96

1.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

705

1.63

0.96

21.1

12.8

82.9

83.3

ml/min/173m2

0.05

570

(3012516) Albumin [Mass/volume] in Urine

191

1.50

0.90

2.6

3.1

32.4

374.5

mg/l

0.54

126

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

113

1.62

0.90

3.1

2.5

0.4

0.8

e6/l

—

(3012544) pH of Venous blood

1.78

0.86

7.8

3.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.74

0.86

2.4

1.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.74

0.86

2.3

1.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.87

0.80

1.0

2.2

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.14

0.76

2.4

3.0

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.14

0.76

2.4

3.0

3.3

3.4

g/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.61

0.73

1.3

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

753

1.55

0.70

25.3

13.4

28.8

21.0

mg/l

1.14

587

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

512

1.35

0.66

3.2

3.1

—

(40761511) CBC panel - Blood by Automated count

789

1.61

0.66

23.2

11.8

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.63

0.61

3.7

2.7

25.8

30.6

u/l

—

(3002256) Pathology report gross observation

1.55

0.60

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.59

0.0

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

134

1.42

0.58

2.5

1.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

207

1.35

0.58

3.8

3.7

2.8

8.2

mg/mmol

1.28

135

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.71

0.58

1.5

3.6

25.4

24.3

mmol/l

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

1.62

0.55

1.3

1.6

7.5

8.8

ug/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.47

0.54

1.9

1.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.47

0.54

1.1

2.0

—

(3000494) Fungus identified in Specimen by Culture

1.48

0.54

1.3

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.53

0.52

1.8

2.0

—

(3002582) Erythrocytes [#/volume] in Urine

221

1.31

0.50

4.7

3.1

19.5

33.9

e6/l

0.72

167

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.56

0.49

1.9

2.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

112

1.40

0.48

2.3

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.49

0.48

2.1

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

113

1.39

0.46

1.3

—

(40758558) Short blood count panel - Blood

187

1.30

0.44

10.8

7.4

—

(3003338) MCHC [Mass/volume]

657

0.80

0.43

35.0

16.6

332.7

332.4

g/l

0.11

652

(3026493) Urate [Moles/volume] in Serum or Plasma

189

1.29

0.41

1.9

3.0

332.8

1750.0

umol/l

0.50

157

(4094501)

0.00

0.41

0.0

1.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.50

0.41

1.8

2.5

—

(36304419) Bacteria [Presence] in Urine

199

1.28

0.40

4.9

2.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.40

0.40

2.0

1.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.40

0.40

4.0

3.4

—

(3019225) pH of Specimen

1.40

0.40

3.0

4.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

163

1.29

0.38

1.3

7.7

0.7

u/ml

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

795

1.38

0.38

26.1

15.2

81.3

76.2

umol/l

0.35

795

(3000492) Spirometry study

1.30

0.37

1.2

1.4

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

797

1.35

0.35

15.1

10.1

22.8

26.3

u/l

2.37

780

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.32

0.33

1.3

2.6

3.1

5.3

ug/l

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.40

0.32

1.0

1.2

20.5

189.4

u/ml

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.33

0.32

3.0

2.1

—

(3003694) ABO and Rh group [Type] in Blood

189

1.21

0.27

2.0

1.4

—

(3030467) Casts [#/volume] in Urine by Automated count

200

1.20

0.25

4.8

2.9

0.1

0.4

e6/l

1.59

149

(40768804) Tissue Pathology biopsy report

298

1.17

0.24

1.8

1.9

—

(3000764) Benzodiazepines [Presence] in Urine

1.37

0.24

1.6

—

(3028300) Cannabinoids [Presence] in Urine

1.33

0.23

1.6

—

(3027944) Amphetamines [Presence] in Urine

1.33

0.23

1.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.33

0.23

1.4

1.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

154

1.21

0.23

1.6

1.3

1.8

2.7

g/l

1.69

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.21

0.0

2.5

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.2

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

1.2

—

32.6

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.21

0.0

1.4

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

3.6

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.6

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.1

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.27

0.20

2.5

1.8

248.8

130.8

ng/l

—

(1761868) Lipid panel - Serum or Plasma

288

0.87

0.20

2.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.26

0.19

2.9

2.0

—

(3022145) Colonoscopy Study observation

1.26

0.19

1.0

1.3

—

(40761536) Microorganisms panel - Urine sediment

1.18

0.18

14.3

4.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

153

1.14

0.12

3.4

4.1

17.6

20.0

—

(40761535) Cells panel - Urine sediment

1.12

0.09

3.2

3.7

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

725

0.92

0.08

3.9

1.3

mmol/l

0.07

675

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.85

0.07

1.4

1.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.85

0.07

5.7

6.1

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

109

1.12

0.06

2.4

2.9

0.4

0.7

ug/l

—

(3009542) Hematocrit [Volume Fraction] of Blood

701

0.94

0.05

30.7

13.8

38.5

40.4

1.05

540

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

150

1.08

0.04

1.7

1.5

—

(3044889) 12 lead EKG panel

509

1.05

0.04

4.5

3.6

—

(3010813) Leukocytes [#/volume] in Blood

837

1.03

0.00

36.8

19.6

6.8

6.5

e9/l

0.63

819

(3024731) MCV [Entitic volume]

837

1.03

0.00

36.6

19.5

91.7

91.0

0.62

829

(3026361) Erythrocytes [#/volume] in Blood

837

1.03

0.00

36.7

19.5

4.3

4.5

e12/l

2.46

819

(3000963) Hemoglobin [Mass/volume] in Blood

837

1.03

0.00

37.0

19.6

129.6

136.2

g/l

2.92

828

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

133

0.97

0.00

1.1

1.3

28.6

38.4

iu/ml

—

(40760892) CBC W Ordered Manual Differential panel - Blood

177

1.02

0.00

7.6

5.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

745

0.97

0.00

4.2

4.4

4.5

4.7

mmol/l

0.85

697

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

756

1.03

0.00

4.6

4.7

2.7

2.8

mmol/l

0.30

699

(3007461) Platelets [#/volume] in Blood

836

1.04

0.00

36.7

19.6

253.9

252.6

e9/l

0.06

822

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

739

1.01

0.00

4.0

4.3

1.4

1.5

mmol/l

0.25

687

(3035941) MCH [Entitic mass]

836

1.04

0.00

36.6

19.4

30.5

30.3

0.41

828

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(4281824)

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.8

—

180.6

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

1.8

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

1235.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

12.7

—

0.8

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.4

—

26.6

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

2.0

—

12.1

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(36660697) Celiac disease serology panel - Serum

0.95

0.00

1.2

1.1

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

18.5

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

12.9

—

1709.3

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

0.9

—

(3000012) Reticulocyte production index

0.00

0.0

1.4

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.2

—

206.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(4146454)

0.00

0.0

2.6

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.6

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(4211845)

0.00

0.0

1.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

1.6

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

11.4

—

941.1

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

87.8

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.1

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(4062490)

0.00

0.0

1.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYMUSDIS and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_THYMUSDIS	2.212 [1.49, 3.28]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.041

During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 234 females with E4_THYMUSDIS died.

Males

Parameter	HR [95% CI]	p-value
E4_THYMUSDIS	3.602 [1.75, 7.41]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.007

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 149 males with E4_THYMUSDIS died.

Mortality risk

Mortality risk for people of age

years, who have E4_THYMUSDIS.

N-year risk	Females	Males
1	0.18%	0.795%
5	1.148%	4.018%
10	2.685%	9.576%
15	5.111%	17.15%
20	9.273%	29.089%

Relationships between endpoints

↥

Index endpoint: E4_THYMUSDIS – Diseases of thymus

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Diseases of thymus

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints