This is a non-core endpoint: only basic statistics are computed.
Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
F5_ORGAMN
No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleNone |
519870 |
2. Check conditionsNone |
519870 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
45 |
4. Check minimum number of eventsNone |
45 |
5. Include endpointsNone |
45 |
6. Filter based on genotype QC (FinnGen only) |
44 |
Control definitions (FinnGen only)
- Control exclude
- F5_ORGANIC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF3
- Parent code in ICD-10
- F04-F09
- Name in latin
- Syndroma amnesticum organicum non alcoholicum neque ab aliis substantiis psychotropicis inductum
Similar endpoints
↥List of similar endpoints to
Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
based on the number of shared cases.
Similar with more cases:
- Organic, including symptomatic, mental disorders
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 618 | 287 | 325 |
| Only index persons | 392 | 179 | 213 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 61.45 | 66.15 | 57.14 |
| Only index persons | 58.87 | 62.16 | 56.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 44 | 14 | 30 |
| Unadjusted period prevalence (%) | 0.01 | 0.00 | 0.01 |
| Median age at first event (years) | 56.85 | 58.26 | 56.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
TimeCodeWAS
↥TimeCodeWAS is a tool for exploring time-dependent associations between an endpoint and health codes (diagnoses, lab tests, procedures, etc.).
The TimeCodeWAS analysis is done in three steps:
- Build a matched case-control set for this endpoint. Each case is matched to 5–10 controls on sex and year of birth, and controls must be at risk at the same age as the case's age of onset. TimeCodeWAS allows for controls to be reused.
- Count cases and controls. For each health code, and for each time window: tally the counts into a 2×2 table. To be eligible in a time window, a case or control must have data coverage for at least 50% of that time window.
- Perform association tests. If all cells of the 2×2 table have N≥10, then a χ² test is performed, otherwise a Fisher's exact test is done. The corresponding p-value and confidence interval are reported below, along with the standard odds ratio when a χ² test is done, or Fisher's MLE odds ratio otherwise.
TimeCodeWAS currently uses the same default set of time windows for all the endpoints. Please reach out to us if you have suggestions for better time windows for some endpoints.
The default time windows are:
LabWAS
↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
5
7
7.84
2.61
7.4
3.6
17.82
16.23
%
—
5
7
13
61
2.59
1.94
3.3
1.7
—
—
—
0
0
5
18
2.99
1.32
4.8
2.0
—
—
—
0
0
0
34
0.00
1.22
0.0
1.4
—
—
—
0
0
8
40
2.21
1.19
4.1
3.8
—
—
—
0
0
20
143
1.72
0.92
7.5
4.6
0.00
0.00
estimate
—
7
42
25
191
1.70
0.90
6.4
6.5
11.56
11.69
umol/l
0.03
25
181
6
31
2.08
0.88
2.3
1.3
—
—
—
0
0
20
147
1.65
0.81
2.9
2.6
—
—
estimate
—
0
0
27
318
0.62
0.72
4.0
4.4
1.42
1.24
mmol/l
0.33
21
288
18
134
1.57
0.67
5.2
3.5
—
—
—
0
0
31
352
0.62
0.67
16.6
12.3
30.19
24.85
u/l
0.38
31
341
15
108
1.58
0.64
8.5
4.7
0.00
0.00
estimate
—
6
43
32
359
0.62
0.62
50.6
25.5
131.72
136.43
g/l
0.86
32
354
32
359
0.62
0.62
50.3
25.9
38.64
40.71
%
0.75
32
354
6
35
1.82
0.60
13.2
12.2
—
—
—
0
0
9
61
1.59
0.59
4.2
7.7
99.89
104.61
mmol/l
—
9
61
7
45
1.66
0.52
4.6
1.7
—
—
—
0
0
7
47
1.58
0.50
4.6
1.7
—
—
—
0
0
22
184
1.38
0.42
7.0
4.4
0.00
0.00
estimate
—
7
50
22
185
1.37
0.40
7.1
4.5
0.00
0.00
estimate
—
7
52
14
111
1.38
0.35
5.8
3.4
0.16
0.25
e6/l
0.38
14
79
22
188
1.33
0.35
7.1
4.5
0.00
0.00
estimate
—
6
49
18
152
1.31
0.30
2.3
2.0
90.92
94.09
pmol/l
0.13
13
82
23
258
0.78
0.29
41.3
22.8
331.52
331.91
g/l
0.09
23
258
20
175
1.26
0.24
8.8
7.1
1.21
1.20
mmol/l
0.21
14
151
32
342
0.78
0.23
36.3
20.6
4.05
4.01
mmol/l
0.50
32
337
32
341
0.79
0.22
35.9
20.6
138.88
139.77
mmol/l
0.79
32
335
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
17
154
1.17
0.12
3.4
2.6
—
—
—
0
0
15
135
1.17
0.11
3.8
4.8
24.90
23.45
%
—
5
75
12
113
1.08
0.02
6.4
3.9
0.00
0.00
estimate
—
6
37
12
123
0.97
0.00
3.2
2.0
196.25
322.81
u/l
0.38
12
117
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
9.78
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint F5_ORGAMN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ORGAMN | 2.828 [1.83, 4.37] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.35 |
During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 182 females with F5_ORGAMN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ORGAMN | 3.338 [2.2, 5.06] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.056 |
During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 217 males with F5_ORGAMN died.
Mortality risk
Mortality risk for people of age
years, who have F5_ORGAMN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.201% | 0.622% |
| 5 | 1.661% | 3.742% |
| 10 | 4.01% | 10.027% |
| 15 | 7.3% | 18.649% |
| 20 | 13.199% | 29.477% |
Relationships between endpoints
↥Index endpoint: F5_ORGAMN – Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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