Gastric ulcer - Acute with haemorrhage, drug-induced

GASTRIC_ULCER_ACUTE_W_HAEMORRHAGE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs ANY
  • Hospital discharge: ICD-10 K25.0#

1 out of 7 registries used, show all original rules.

66

4. Check minimum number of events

None

66

5. Include endpoints

None

66

6. Filter based on genotype QC (FinnGen only)

66

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 66 17 49
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 61.85 58.27 63.09

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
60
Matched controls
601
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K25.0
ICD-10 Finland
Gastric ulcer, Acute with haemorrhage
+∞
80.2
60
*
UJD02
NOMESCO Finland
Gastroscopy
17.7
11.0
17
13
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.3
10.3
37
121
K92.0
ICD-10 Finland
Haematemesis
24.5
8.9
12
6
A02BC01
ATC
omeprazole; systemic
4.8
7.7
34
128
JDA32
NOMESCO Finland
Endoscopic injection in stomach or pylorus
+∞
6.4
6
*
A02BC03
ATC
lansoprazole; oral
4.0
6.0
32
133

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
8
32
2.70
1.66
3.5
1.4
—
—
—
0
0
8
162
0.42
1.66
2.5
3.0
2.3
2.3
mmol/l
—
8
132
6
21
3.04
1.54
1.2
1.4
—
—
—
0
0
31
406
0.55
1.52
5.3
5.0
6.7
6.2
mmol/l
0.24
25
354
7
28
2.67
1.50
3.3
1.6
—
—
—
0
0
0
33
0.00
1.20
0.0
1.4
—
—
—
0
0
8
41
2.08
1.13
3.4
1.6
—
—
—
0
0
12
68
1.93
1.09
1.7
2.0
—
—
—
0
0
14
85
1.82
1.04
6.9
5.1
—
—
—
0
0
7
36
2.05
1.00
2.6
3.9
—
—
—
0
0
30
373
0.64
0.96
4.3
4.2
1.8
2.1
mu/l
0.83
24
315
34
405
0.67
0.81
5.3
5.3
2.2
2.5
mmol/l
0.91
29
358
22
284
0.66
0.78
3.6
3.4
14.9
15.1
pmol/l
0.18
17
243
37
432
0.67
0.78
29.1
20.2
102.1
87.6
umol/l
0.38
37
432
9
57
1.67
0.75
1.9
1.6
—
—
—
0
0
9
58
1.64
0.73
1.2
1.3
—
—
—
0
0
5
29
1.78
0.65
5.2
3.8
—
—
—
0
0
0
19
0.00
0.61
0.0
1.3
—
—
—
0
0
0
21
0.00
0.61
0.0
5.1
—
—
—
0
0
24
195
1.36
0.51
5.2
5.4
58.9
58.9
%
0.01
24
177
23
187
1.35
0.48
1.9
2.4
88.8
88.9
pmol/l
—
10
103
38
425
0.75
0.48
25.9
15.7
—
—
—
0
0
5
31
1.66
0.44
1.2
1.6
—
—
—
0
0
13
168
0.72
0.42
2.4
2.3
—
—
—
0
0
5
33
1.56
0.42
2.6
2.2
0.2
0.2
g/l
—
5
28
24
200
1.31
0.42
5.3
5.4
27.6
26.1
%
0.17
24
180
0
15
0.00
0.42
0.0
3.5
—
—
—
0
0
17
138
1.31
0.35
3.5
3.4
—
—
—
0
0
6
46
1.33
0.34
2.3
2.1
65.9
66.9
g/l
—
6
40
7
97
0.69
0.34
1.4
1.3
—
—
—
0
0
23
196
1.27
0.33
5.5
5.5
9.6
9.0
%
0.46
23
180
8
108
0.71
0.32
3.6
3.6
—
—
—
0
0
26
291
0.82
0.26
4.5
4.5
—
—
—
0
0
9
76
1.21
0.26
6.4
2.6
2.0
2.3
g/l
—
9
68
22
192
1.22
0.25
5.3
5.3
0.6
0.6
%
0.01
22
175
14
116
1.26
0.24
4.3
3.8
0.0
0.0
estimate
—
6
30
16
135
1.24
0.24
9.5
3.9
7.4
7.4
ph
—
8
24
13
107
1.27
0.24
7.6
7.4
—
—
—
0
0
33
302
1.19
0.22
4.7
4.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
22
195
1.19
0.21
5.2
5.3
2.7
2.9
%
0.19
22
178
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
31
336
0.85
0.20
31.1
20.3
14.6
13.9
%
1.29
31
328
17
148
1.20
0.19
4.4
4.3
—
—
—
0
0
9
81
1.13
0.16
6.4
2.7
8.8
12.4
umol/l
—
9
75
13
112
1.20
0.16
4.5
3.6
—
—
—
0
0
19
210
0.87
0.15
3.9
4.3
0.0
0.0
estimate
—
6
33
32
341
0.88
0.15
22.3
20.1
38.5
38.4
%
0.03
18
214
12
138
0.84
0.14
1.3
2.0
109.5
156.9
u/l
0.75
12
131
23
212
1.13
0.12
11.0
8.6
1.1
1.4
inr
—
9
54
13
116
1.15
0.10
3.2
3.3
—
—
—
0
0
5
44
1.15
0.10
1.6
1.1
—
—
—
0
0
15
136
1.13
0.09
2.7
3.2
132.1
517.2
mg/l
—
10
98
7
68
1.03
0.08
17.9
5.6
1.1
1.0
mmol/l
—
7
60
8
91
0.86
0.07
3.6
4.1
—
1.0
—
0
11
13
142
0.89
0.07
3.1
4.9
—
—
—
0
0
15
140
1.09
0.05
4.9
5.0
—
—
—
0
0
20
210
0.93
0.04
3.9
4.3
0.0
0.0
estimate
—
6
36
24
249
0.94
0.03
4.2
5.6
1.9
2.5
ug/l
0.59
19
210
10
108
0.91
0.03
4.2
4.6
—
—
—
0
0
20
208
0.94
0.02
4.6
6.1
0.0
0.0
estimate
—
7
36
15
144
1.05
0.00
2.9
2.3
—
—
—
0
0
11
109
1.01
0.00
2.9
3.0
397.8
3885.7
umol/l
0.49
11
92
15
148
1.02
0.00
4.1
4.0
36.3
17.9
mg/mmol
—
10
101
32
318
1.01
0.00
3.4
4.1
16.3
14.7
mm/h
0.19
27
284
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
305.8
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
13.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
7.2
—
0
5
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
5
50
1.00
0.00
2.4
2.3
4.8
10.0
umol/l
—
5
42
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
61.4
—
0
8
0
6
0.00
0.00
0.0
3.0
—
4.5
—
0
6
0
7
0.00
0.00
0.0
1.4
—
7.1
—
0
7
5
50
1.00
0.00
1.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
5
58
0.85
0.00
2.4
2.1
4.4
4.9
ug/l
—
5
52
0
7
0.00
0.00
0.0
2.3
—
111.3
—
0
7

Mortality – FinRegistry

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

Index endpoint: GASTRIC_ULCER_ACUTE_W_HAEMORRHAGE – Gastric ulcer - Acute with haemorrhage, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).