Other and unspecified disorders of skin and subcutaneous tissue related to radiation

L12_SKINRADINAS

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L59.8, L59.9 Cause of death: ICD-10 — L59.8, L59.9 2 out of 7 registries used, show all original rules.	34
4. Check minimum number of events None	34
5. Include endpoints None	34
6. Filter based on genotype QC (FinnGen only)	34

Control definitions (FinnGen only)

Control exclude: L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	L12_SKINRADINAS
CONTROL_EXCLUDE	L12_RADIATIONRELATEDSKIN
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L59[8-9]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L59[8-9]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other and unspecified disorders of skin and subcutaneous tissue related to radiation based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	241	149	92
Only index persons	190	127	63
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	64.16	58.12
Only index persons	62.58	65.65	56.38

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	34	27	7
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	58.62	58.32	59.78

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019060) Gas panel - Arterial blood

5.43

3.27

2.9

3.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.57

2.28

3.8

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

3.22

2.15

10.6

9.3

—

(40768443) Skin Pathology biopsy report

4.31

2.03

1.3

1.1

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

4.05

1.93

2.5

3.4

28.6

25.3

mmol/l

—

(42870588) Differential panel, method unspecified - Blood

2.55

1.82

8.1

4.9

—

(3000991) Gas panel - Venous blood

2.88

1.55

7.4

3.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

120

2.32

1.54

4.7

3.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.44

1.29

1.3

1.9

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.58

1.24

1.8

2.4

22.0

39.7

u/l

—

(3006315) Basophils [#/volume] in Blood

148

2.10

1.20

10.0

5.4

0.0

e9/l

0.08

130

(3012544) pH of Venous blood

2.58

1.19

8.0

2.6

—

(3001604) Monocytes [#/volume] in Blood

149

2.07

1.17

9.5

5.3

0.6

e9/l

0.00

129

(3042936) Bacteria identified in Isolate by Culture

2.29

1.15

3.1

2.0

—

(3019198) Lymphocytes [#/volume] in Blood

150

2.05

1.13

10.0

5.4

1.5

1.7

e9/l

0.73

134

(3001122) Ferritin [Mass/volume] in Serum or Plasma

114

1.98

1.08

2.6

2.8

75.7

86.9

ug/l

0.23

102

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.48

1.07

2.6

3.0

129.0

133.7

g/l

—

(3000492) Spirometry study

2.48

1.07

1.8

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.38

0.97

1.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

2.02

0.96

2.1

1.6

2.3

1.2

mg/l

0.46

(3023368) Bacteria identified in Blood by Culture

1.95

0.96

8.1

4.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.99

0.86

1.2

1.8

—

(40758558) Short blood count panel - Blood

1.83

0.81

16.2

6.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.82

0.81

1.2

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.06

0.80

1.1

1.6

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

2.00

0.78

2.9

2.0

6.3

6.2

umol/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.89

0.75

1.7

1.5

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.08

0.74

2.0

1.7

29.4

65.5

ng/l

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.84

0.74

4.0

102.6

103.3

mmol/l

—

(3044889) 12 lead EKG panel

196

1.76

0.70

4.8

4.1

—

(40768804) Tissue Pathology biopsy report

108

1.70

0.69

2.6

2.0

—

(3012516) Albumin [Mass/volume] in Urine

1.74

0.69

2.7

3.2

12.7

52.4

mg/l

—

(3026008) Bacteria identified in Urine by Culture

118

1.67

0.67

4.9

2.7

—

(3002385) Erythrocyte distribution width [Ratio]

243

1.86

0.64

33.9

18.5

14.3

13.9

0.36

238

(40761535) Cells panel - Urine sediment

1.81

0.60

5.2

3.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.75

0.59

1.8

2.2

—

(3044640) Blood type and Crossmatch panel - Blood

1.62

0.57

3.2

2.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.65

0.52

21.0

19.9

—

1.5

—

(3009542) Hematocrit [Volume Fraction] of Blood

249

1.70

0.51

32.7

15.4

36.3

38.0

0.27

168

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

135

1.52

0.49

4.4

4.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

135

1.52

0.49

2.4

2.2

85.9

81.4

nmol/l

0.33

114

(3026493) Urate [Moles/volume] in Serum or Plasma

1.61

0.48

2.3

3.2

29677.6

5401.6

umol/l

—

(3018418) pH of Serum or Plasma

109

0.65

0.47

4.6

4.2

—

7.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.78

0.46

3.8

4.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

156

1.49

0.46

2.5

3.4

—

(3002256) Pathology report gross observation

1.72

0.45

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.49

0.43

5.4

6.8

—

(3022145) Colonoscopy Study observation

1.45

0.40

1.0

1.2

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

279

0.71

0.31

5.3

4.6

4.3

4.6

mmol/l

0.73

250

(3000494) Fungus identified in Specimen by Culture

1.41

0.25

1.2

1.6

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.33

0.24

8.0

4.0

1.0

1.1

mmol/l

—

(40768797) Stomach Pathology biopsy report

1.26

0.23

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.33

0.22

8.3

4.1

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.22

0.0

1.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.22

0.0

1.9

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.6

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.22

0.0

1.9

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.21

0.0

2.8

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

120

1.28

0.21

2.4

2.0

91.0

103.1

pmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.17

0.18

3.5

2.3

—

(3021960) Folate [Moles/volume] in Serum or Plasma

0.76

0.18

2.5

1.7

14.3

22.0

nmol/l

—

(36304419) Bacteria [Presence] in Urine

1.27

0.17

5.8

2.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.74

0.17

8.1

3.1

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.08

0.08

5.1

3.1

2.6

2.5

mmol/l

—

(1761868) Lipid panel - Serum or Plasma

1.08

0.08

2.7

3.5

—

(3013512) EKG study

1.16

0.06

2.8

3.9

—

(3015736) pH of Urine

123

1.09

0.02

7.4

3.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

125

1.06

0.00

9.0

4.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

132

0.98

0.00

2.8

4.1

46.6

40.7

ng/l

—

100

(3037467) Urinalysis macro (dipstick) panel - Urine

208

1.03

0.00

7.0

4.5

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.1

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

2.7

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

1.4

—

72.0

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

3.8

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.4

—

92.2

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.6

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

1.4

—

7.4

—

(3003694) ABO and Rh group [Type] in Blood

0.95

0.00

1.3

1.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.4

—

27.9

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.9

—

44.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

264

1.11

0.00

9.3

6.3

42.0

40.9

mmol/mol

0.20

241

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

1.2

—

0.8

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

2.2

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

2.0

—

197.7

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

2.3

—

39.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.2

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

2.5

—

334.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_SKINRADINAS and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_SKINRADINAS	1.805 [1.08, 3.01]	0.024
Birth year	0.99 [0.98, 1.0]	0.033

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 128 females with L12_SKINRADINAS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_SKINRADINAS.

N-year risk	Females	Males
1	0.114%	No data
5	0.848%	No data
10	2.234%	No data
15	4.074%	No data
20	7.251%	No data

Relationships between endpoints

↥

Index endpoint: L12_SKINRADINAS – Other and unspecified disorders of skin and subcutaneous tissue related to radiation

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other and unspecified disorders of skin and subcutaneous tissue related to radiation

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints