Other disorders of skin and subcutaneous tissue related to radiation

L12_SKINRADIOTH

photosensitivity disease: Photosensitivity refers to various symptoms, diseases and conditions caused or aggravated by exposure to sunlight.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L59 Cause of death: ICD-10 — L59 2 out of 7 registries used, show all original rules.	59
4. Check minimum number of events None	59
5. Include endpoints L12_ABIGNE L12_SKINRADINAS	59
6. Filter based on genotype QC (FinnGen only)	59

Control definitions (FinnGen only)

Control exclude: L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L55-L59
Name in latin: Aliae morbositates cutis et telae subcutaneae e radiatione

NAME	L12_SKINRADIOTH
CONTROL_EXCLUDE	L12_RADIATIONRELATEDSKIN
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	L12_ABIGNE\|L12_SKINRADINAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L59
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L59
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other disorders of skin and subcutaneous tissue related to radiation based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	422	251	168
Only index persons	350	224	126
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	56.02	58.38	52.65
Only index persons	54.89	57.35	50.54

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	59	46	13
Unadjusted period prevalence (%)	0.01	0.02	0.01
Median age at first event (years)	55.42	55.70	54.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
56: Matched controls
558

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L59.9

ICD-10 Finland

Disorder of skin and subcutaneous tissue related to radiation, unspecified

+∞

29.9

L59.0

ICD-10 Finland

Erythema ab igne [dermatitis ab igne]

+∞

27.3

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

7.6

6.8

L95.9

ICD-10 Finland

Vasculitis limited to skin, unspecified

78.4

6.6

L59.8

ICD-10 Finland

Other specified disorders of skin and subcutaneous tissue related to radiation

+∞

6.4

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42870588) Differential panel, method unspecified - Blood

158

2.83

3.73

9.3

5.0

—

(3019060) Gas panel - Arterial blood

4.13

3.68

2.5

4.4

—

(3000991) Gas panel - Venous blood

3.61

3.30

4.9

6.1

—

(3003396) Base excess in Arterial blood by calculation

3.07

3.08

2.6

6.1

2.7

1.5

mmol/l

—

(3009508) Creatinine [Moles/volume] in Urine

140

2.53

2.95

3.5

2.6

7.1

7.8

mmol/l

0.35

107

(40768443) Skin Pathology biopsy report

4.05

2.70

1.4

1.1

—

(3012544) pH of Venous blood

2.95

2.45

5.3

2.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.81

2.40

3.0

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

180

2.20

2.26

4.3

2.9

—

(3012516) Albumin [Mass/volume] in Urine

130

2.26

2.24

3.3

2.8

82.9

41.6

mg/l

0.22

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.53

2.18

2.3

4.2

27.6

25.3

mmol/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

306

2.29

2.16

14.5

9.4

4.4

4.0

e9/l

0.68

268

(3020682) Albumin/Creatinine [Ratio] in Urine

141

2.18

2.11

4.9

3.4

19.5

5.4

mg/mmol

0.45

(3002032) Base excess in Venous blood by calculation

2.78

2.07

5.7

2.5

4.1

2.6

mmol/l

0.71

(3004588) Protein electrophoresis panel - Serum or Plasma

3.14

1.94

1.1

1.2

—

(3026493) Urate [Moles/volume] in Serum or Plasma

121

2.14

1.91

3.1

2.8

14319.1

3223.8

umol/l

0.35

105

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.80

1.89

1.2

1.1

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

3.59

1.79

2.5

1.3

0.3

0.2

g/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

3.17

1.78

1.9

1.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.82

1.73

2.1

2.9

128.1

131.6

g/l

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

3.03

1.71

2.3

2.8

0.7

0.8

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.39

1.71

1.8

1.3

1.2

g/l

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.80

1.65

1.6

1.3

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.91

1.64

2.6

3.1

26.5

25.0

mmol/l

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.53

1.63

2.3

23.5

35.4

u/l

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

208

1.90

1.59

2.5

2.7

71.6

86.0

ug/l

0.50

187

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.80

1.57

2.3

2.7

1.0

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.30

1.56

10.2

8.6

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

3.54

1.55

1.2

1.1

0.1

0.0

g/l

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

3.54

1.55

1.2

1.1

0.0

g/l

—

(3026008) Bacteria identified in Urine by Culture

175

1.87

1.48

4.4

2.9

—

(3000492) Spirometry study

2.41

1.45

1.6

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

111

1.89

1.32

6.9

3.7

—

(3020891) Body temperature

2.94

1.31

4.2

5.4

—

(40768804) Tissue Pathology biopsy report

210

1.75

1.26

2.7

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.89

1.22

1.3

1.7

—

(3042936) Bacteria identified in Isolate by Culture

1.97

1.18

3.6

2.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.51

1.17

1.6

1.5

—

(3023368) Bacteria identified in Blood by Culture

124

1.79

1.15

6.8

3.8

—

(3031040) Bacteria [#/volume] in Urine by Automated count

344

1.77

1.13

7.3

4.4

—

585.0

—

(3044889) 12 lead EKG panel

334

1.75

1.12

4.3

3.8

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.85

1.10

3.9

3.2

2.6

2.5

mmol/l

1.14

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.03

1.06

1.7

1.5

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.03

1.06

1.8

382.2

349.4

nmol/l

—

(3018095) Leukocytes [#/volume] in Urine

181

1.66

1.04

5.5

3.3

9.5

77.9

e6/l

2.27

122

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.82

1.02

1.9

2.1

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.92

0.98

2.5

2.1

5.1

6.8

umol/l

0.56

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.36

0.96

1.7

1.6

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.27

0.94

2.5

9.3

92.9

95.5

—

(3022145) Colonoscopy Study observation

1.95

0.94

1.0

1.2

—

(3027945) Reticulocytes/100 erythrocytes in Blood

1.95

0.94

1.7

3.2

1.6

1.8

—

(3000494) Fungus identified in Specimen by Culture

1.95

0.94

1.6

1.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.88

0.94

37.6

22.3

—

1.4

—

(3044640) Blood type and Crossmatch panel - Blood

158

1.63

0.93

3.0

2.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.19

0.92

2.3

6.8

—

(40761535) Cells panel - Urine sediment

1.99

0.92

7.3

3.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.97

0.84

2.3

1.7

—

(4035726)

1.77

0.82

1.8

1.1

—

(40768797) Stomach Pathology biopsy report

1.79

0.82

1.1

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

348

1.58

0.82

5.3

4.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

248

1.53

0.81

9.5

4.7

0.0

estimate

—

(1002224) Polysomnography panel

0.00

0.80

0.0

1.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.80

0.78

7.4

3.7

1.1

1.0

mmol/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.80

0.78

1.3

1.6

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

2.18

0.76

2.4

3.1

0.1

0.2

e6/l

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.85

0.74

1.1

1.5

—

(3019225) pH of Specimen

1.75

0.71

6.9

4.0

—

(40758558) Short blood count panel - Blood

140

1.53

0.70

16.8

7.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.93

0.70

3.4

54.0

39.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.69

0.65

2.8

3.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

116

1.52

0.63

3.9

5.2

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.73

0.63

8.0

2.7

4.8

4.4

pmol/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

228

1.43

0.62

4.0

4.2

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.74

0.59

2.8

3.1

105.0

166.8

ng/l

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.62

0.58

1.2

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.56

0.57

1.3

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.56

0.57

1.4

1.7

—

(3015736) pH of Urine

194

1.40

0.54

5.8

3.4

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.55

0.52

8.9

3.0

0.7

0.8

mmol/l

1.92

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.52

0.52

1.6

—

(36304419) Bacteria [Presence] in Urine

140

1.41

0.50

4.7

2.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

113

1.44

0.49

2.9

2.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

190

1.35

0.44

2.3

2.0

92.8

103.4

pmol/l

0.41

(3009542) Hematocrit [Volume Fraction] of Blood

443

1.45

0.44

28.8

14.6

36.8

39.1

0.63

320

(3002256) Pathology report gross observation

1.41

0.43

1.1

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.42

0.0

1.2

—

4.2

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.42

0.0

1.3

—

466.9

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.42

0.0

1.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

2.0

—

(3029937) Albumin [Presence] in Urine by Test strip

128

1.34

0.37

6.3

4.1

0.0

estimate

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

298

1.24

0.29

2.8

3.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

193

1.22

0.24

2.8

3.8

30.4

35.8

ng/l

0.15

138

(40761536) Microorganisms panel - Urine sediment

1.38

0.24

2.2

2.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

194

1.21

0.23

7.3

3.7

—

(3013512) EKG study

146

1.23

0.22

3.0

3.8

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.5

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.7

—

52.7

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

4.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.3

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.20

0.0

2.8

—

(3021960) Folate [Moles/volume] in Serum or Plasma

114

0.85

0.10

1.9

1.7

14.9

22.2

nmol/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

467

1.15

0.09

18.3

12.9

79.3

80.8

ml/min/173m2

0.14

371

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.04

0.08

1.8

—

(3003694) ABO and Rh group [Type] in Blood

137

1.03

0.00

1.4

—

(1761868) Lipid panel - Serum or Plasma

174

0.97

0.00

2.5

3.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

144

0.96

0.00

4.9

3.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.6

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.3

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

3.0

—

13.1

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.4

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.4

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.4

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.4

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

2.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

14.2

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.0

—

14.9

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.4

—

92.6

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

67.6

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.93

0.00

1.6

1.4

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.8

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(4211845)

0.00

0.0

1.8

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.98

0.00

2.3

2.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

3.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_SKINRADIOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_SKINRADIOTH	1.687 [1.14, 2.49]	0.009
Birth year	0.999 [0.99, 1.01]	0.785

During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 227 females with L12_SKINRADIOTH died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_SKINRADIOTH.

N-year risk	Females	Males
1	0.147%	No data
5	1.144%	No data
10	2.755%	No data
15	5.425%	No data
20	9.691%	No data

Relationships between endpoints

↥

Index endpoint: L12_SKINRADIOTH – Other disorders of skin and subcutaneous tissue related to radiation

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other disorders of skin and subcutaneous tissue related to radiation

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints