Conditions involving the integument and temperature regulation of fetus and newborn

P16_COND_INVOLVI_INTEG_TEMPE_REGULAT_FETUS_NEWBO

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P80-P83 Cause of death: ICD-10 — P80-P83 2 out of 7 registries used, show all original rules.	43
4. Check minimum number of events None	43
5. Include endpoints P16_HYPOTHE_NEWBO P16_OTH_DISTU_TEMPE_REGULAT_NEWBO P16_OTH_COND_INTEG_SPECIFIC_FETUS_NEWBO	43
6. Filter based on genotype QC (FinnGen only)	43

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 2
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P
Name in latin: Condiciones ad integumentum et moderationem caloris fetus et neonati pertinentes

NAME	P16_COND_INVOLVI_INTEG_TEMPE_REGULAT_FETUS_NEWBO
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	P16_HYPOTHE_NEWBO\|P16_OTH_DISTU_TEMPE_REGULAT_NEWBO\|P16_OTH_COND_INTEG_SPECIFIC_FETUS_NEWBO
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P8
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P8
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Conditions involving the integument and temperature regulation of fetus and newborn based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3406	881	2525
Only index persons	1772	380	1392
Unadjusted period prevalence (%)
Whole population	0.06	0.03	0.07
Only index persons	0.04	0.01	0.05
Median age at first event (years)
Whole population	-	0.02	0.12
Only index persons	0.21	0.03	0.26

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	43	16	27
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	0.28	0.53	0.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

6.11

2.27

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

6.11

2.27

1.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

4.46

2.12

1.3

1.4

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

4.98

2.00

50.4

10.3

21.60

24.36

mmol/l

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

3.15

1.90

15.0

19.4

1.10

1.14

mg/l

—

(3035637) Corticotropin [Mass/volume] in Plasma

3.89

1.66

1.0

2.7

—

(3027801) Oxygen [Partial pressure] in Arterial blood

3.62

1.57

50.4

8.1

16.96

16.70

kpa

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

3.62

1.57

50.4

8.0

4.60

5.07

kpa

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.45

1.54

3.2

4.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.51

1.48

2.0

2.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.68

1.46

2.3

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.68

1.46

1.9

1.8

—

(3016879) Cocaine [Presence] in Urine

2.38

1.41

1.2

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.06

1.15

4.4

5.4

—

(3027008) Opiates [Presence] in Urine

2.26

1.14

1.4

1.5

—

(3028300) Cannabinoids [Presence] in Urine

2.26

1.14

1.4

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

2.26

1.14

1.4

1.5

—

(3000991) Gas panel - Venous blood

2.03

1.10

29.3

8.5

—

(3015736) pH of Urine

1.86

1.02

3.2

3.7

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.06

0.99

1.3

1.5

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

2.06

0.99

1.0

1.3

—

10.86

—

(3026008) Bacteria identified in Urine by Culture

1.97

0.97

3.1

2.8

—

(3022313) Gas panel - Capillary blood

1.98

0.93

10.3

11.9

—

(3012544) pH of Venous blood

1.80

0.82

9.0

9.6

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.82

0.0

2.6

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

2.13

0.75

1.4

1.3

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.13

0.75

9.4

8.1

63.60

44.48

ng/l

—

(3044640) Blood type and Crossmatch panel - Blood

1.77

0.74

3.6

4.0

—

(3027944) Amphetamines [Presence] in Urine

1.75

0.71

1.3

1.5

—

(3013512) EKG study

1.77

0.67

3.7

2.9

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.82

0.66

10.8

6.6

97.00

92.90

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.60

0.59

10.6

9.2

23.68

24.38

mmol/l

—

(36304419) Bacteria [Presence] in Urine

1.53

0.51

5.6

3.7

—

(3018095) Leukocytes [#/volume] in Urine

125

1.45

0.46

6.1

4.8

17.96

27.86

e6/l

0.32

(3011288) Drugs identified in Urine by Screen method

1.69

0.45

1.6

1.7

—

(1761868) Lipid panel - Serum or Plasma

1.49

0.42

1.6

2.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.42

0.0

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.45

0.42

4.5

4.8

—

(3019198) Lymphocytes [#/volume] in Blood

205

1.39

0.41

8.4

8.5

2.04

2.33

e9/l

0.66

174

(3021960) Folate [Moles/volume] in Serum or Plasma

1.44

0.39

1.4

1.3

20.96

18.72

nmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

111

1.39

0.36

6.9

4.2

—

(3021589) Normoblasts [#/volume] in Blood

202

0.74

0.36

8.9

11.7

0.00

e9/l

0.00

157

(3023368) Bacteria identified in Blood by Culture

1.35

0.32

4.1

4.6

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.41

0.31

14.0

14.1

22.60

25.14

mmol/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

208

0.77

0.29

11.0

9.2

93.29

105.04

ml/min/173m2

—

149

(3041096) Erythrocytes [Presence] in Urine by Automated

1.29

0.28

2.6

4.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.71

0.25

3.0

2.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

340

1.36

0.25

2.8

3.9

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

340

1.36

0.25

15.0

11.6

19.18

23.54

mg/l

0.30

229

(3044889) 12 lead EKG panel

144

0.77

0.25

2.8

2.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.40

0.24

2.6

1.8

—

(3037522) Nuclear Ab [Titer] in Serum

1.36

0.24

2.2

1.6

—

360.00

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

2.1

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.21

0.0

3.1

—

51.50

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.21

0.0

3.1

—

3.53

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3041008) Bicarbonate [Moles/volume] standard in Arterial cord blood

0.00

0.21

0.0

1.0

—

18.55

—

(3006598) pH of Arterial cord blood

0.00

0.21

0.0

1.0

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.20

0.0

1.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

212

0.81

0.20

3.7

3.0

2.18

2.70

mmol/l

2.36

194

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.27

0.19

2.4

1.5

—

(3032080) INR in Blood by Coagulation assay

1.18

0.17

7.8

8.2

—

1.24

—

(40761511) CBC panel - Blood by Automated count

332

1.29

0.15

12.2

9.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

182

1.18

0.15

7.0

4.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

207

0.85

0.13

3.7

2.9

1.46

1.36

mmol/l

0.49

190

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

154

1.17

0.12

2.5

1.9

—

(3003694) ABO and Rh group [Type] in Blood

1.21

0.12

1.5

1.8

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

195

0.87

0.11

3.7

2.9

0.93

1.15

mmol/l

1.35

182

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.07

0.10

1.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.08

0.09

1.8

1.9

0.96

1.09

mmol/l

—

(36660697) Celiac disease serology panel - Serum

1.07

0.08

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

128

1.14

0.08

1.7

1.6

1.52

g/l

—

(42870588) Differential panel, method unspecified - Blood

148

1.13

0.07

9.2

10.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.15

0.07

3.0

4.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.90

0.07

2.4

2.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

190

0.91

0.05

6.1

3.5

38.48

36.81

mmol/mol

0.22

174

(3020564) Creatinine [Moles/volume] in Serum or Plasma

319

0.90

0.04

13.5

11.5

72.61

65.14

umol/l

0.30

319

(40758558) Short blood count panel - Blood

121

1.11

0.04

5.3

8.9

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.3

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

0.0

5.1

—

452.14

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(40768804) Tissue Pathology biopsy report

0.94

0.00

1.3

2.0

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

26.33

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

2.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

2.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(44813793)

0.00

0.0

1.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.4

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

210

1.00

0.00

3.7

3.1

3.93

4.39

mmol/l

1.57

195

(21494429) FMR1 gene CGG repeat analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.2

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.0

3.0

—

20.71

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.00

0.00

2.2

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.92

0.00

2.2

2.9

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

0.33

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.2

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

2.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.00

0.00

4.1

3.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.04

0.00

2.7

1.6

—

(3013336) Amino acids [Identifier] in Serum or Plasma

0.00

0.0

1.1

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.0

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

0.00

0.0

1.0

—

169.60

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_COND_INVOLVI_INTEG_TEMPE_REGULAT_FETUS_NEWBO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_COND_INVOLVI_INTEG_TEMPE_REGULAT_FETUS_NEWBO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_COND_INVOLVI_INTEG_TEMPE_REGULAT_FETUS_NEWBO – Conditions involving the integument and temperature regulation of fetus and newborn

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Conditions involving the integument and temperature regulation of fetus and newborn

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints