Haemolytic disease of fetus and newborn

P16_HAEMOLYTIC_DISEA_FETUS_NEWBO

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P55 Cause of death: ICD-10 — P55 2 out of 7 registries used, show all original rules.	38
4. Check minimum number of events None	38
5. Include endpoints None	38
6. Filter based on genotype QC (FinnGen only)	38

Control definitions (FinnGen only)

Control exclude: P16_HAEMORRHAGIC_HAEMATOL_DISORD_FETUS_NEWBO

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P[5-6]
Name in latin: Morbus haemolyticus fetus sive neonati

NAME	P16_HAEMOLYTIC_DISEA_FETUS_NEWBO
CONTROL_EXCLUDE	P16_HAEMORRHAGIC_HAEMATOL_DISORD_FETUS_NEWBO
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P55
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P55
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Haemolytic disease of fetus and newborn based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2935	1428	1507
Only index persons	1452	693	759
Unadjusted period prevalence (%)
Whole population	0.04	0.04	0.04
Only index persons	0.03	0.03	0.03
Median age at first event (years)
Whole population	-	0.01	0.01
Only index persons	0.00	0.01	0.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	38	23	15
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	0.01	0.02	0.01

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020961) Endomysium IgA Ab [Titer] in Serum

2.20

1.17

1.0

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.22

1.06

3.1

1.7

—

(3022096) Basophils/100 leukocytes in Blood

193

1.86

0.96

17.3

11.1

0.9

0.6

1.97

187

(42870588) Differential panel, method unspecified - Blood

155

1.79

0.92

15.8

13.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

101

1.80

0.88

26.5

8.2

47.6

31.4

umol/l

0.32

(3006504) Eosinophils/100 leukocytes in Blood

197

1.79

0.85

17.4

10.9

3.2

0.00

188

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.82

0.0

1.5

—

(3019069) Monocytes/100 leukocytes in Blood

200

1.73

0.78

17.4

10.9

8.4

0.03

194

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

134

1.65

0.71

24.7

7.7

117.6

117.0

ml/min/173m2

0.03

(40758558) Short blood count panel - Blood

125

1.65

0.71

13.2

9.3

—

(3018010) Neutrophils/100 leukocytes in Blood

204

1.66

0.68

16.7

10.7

47.5

0.00

197

(36660697) Celiac disease serology panel - Serum

1.76

0.66

1.1

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.61

0.62

10.8

4.5

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.62

0.0

2.2

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.84

0.61

1.0

1.1

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.84

0.61

6.0

23.2

106.5

105.2

mmol/l

—

(3026008) Bacteria identified in Urine by Culture

1.70

0.60

1.7

2.8

—

(3002030) Lymphocytes/100 leukocytes in Blood

209

1.57

0.57

17.4

10.6

38.3

37.3

0.18

204

(3022948) Iron [Moles/volume] in Serum or Plasma

1.59

0.54

9.3

3.2

15.1

14.7

umol/l

—

(40761511) CBC panel - Blood by Automated count

299

1.79

0.53

13.8

7.5

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.6

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.42

0.0

1.3

—

0.4

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.41

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.41

0.0

1.4

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.41

0.0

1.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.63

0.38

1.7

2.1

—

(3018095) Leukocytes [#/volume] in Urine

120

1.41

0.38

10.7

4.5

244.2

71.6

e6/l

—

(3007164) IgA [Mass/volume] in Serum or Plasma

140

1.39

0.36

1.5

1.8

1.2

1.6

g/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

107

0.68

0.35

21.6

4.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

306

1.59

0.29

22.2

11.6

17.0

23.8

mg/l

0.96

207

(3022313) Gas panel - Capillary blood

1.38

0.27

29.0

6.6

—

(36304419) Bacteria [Presence] in Urine

1.35

0.27

7.4

3.5

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

0.00

0.22

0.0

1.4

—

317.2

—

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

0.00

0.22

0.0

1.0

—

165.5

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.22

0.0

1.6

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.22

0.0

1.1

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.22

0.0

1.6

—

(40768804) Tissue Pathology biopsy report

1.30

0.21

2.3

1.4

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

9.3

—

(40761535) Cells panel - Urine sediment

0.00

0.21

0.0

4.8

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.21

0.0

9.3

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(3022621) pH of Urine by Test strip

0.00

0.21

0.0

2.3

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

8.6

—

224.0

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

0.21

0.0

8.6

—

3.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.20

0.0

1.9

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

170

0.81

0.19

18.7

4.9

112.8

131.9

u/l

0.45

162

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.71

0.19

1.2

1.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.20

0.18

2.0

3.4

—

(3003694) ABO and Rh group [Type] in Blood

107

0.79

0.15

1.8

1.7

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

104

1.22

0.14

6.2

3.0

36.9

36.1

mmol/mol

0.08

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.22

0.12

15.8

6.4

24.0

24.2

mmol/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.19

0.09

1.6

2.5

—

(3044889) 12 lead EKG panel

108

1.16

0.08

2.2

2.3

—

(3000991) Gas panel - Venous blood

1.11

0.08

12.9

7.7

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.08

0.08

30.7

10.2

1.5

1.4

mmol/l

—

(3002032) Base excess in Venous blood by calculation

0.86

0.07

12.7

12.9

0.1

0.6

mmol/l

—

(3012544) pH of Venous blood

0.84

0.07

12.9

12.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

103

0.83

0.07

18.9

15.0

23.9

24.9

mmol/l

—

103

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

109

1.15

0.07

10.4

4.0

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

149

0.90

0.04

8.9

3.2

66.4

59.9

ug/l

0.07

140

(3037467) Urinalysis macro (dipstick) panel - Urine

171

1.10

0.04

8.9

3.8

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.12

0.03

1.8

2.6

—

(3015736) pH of Urine

1.06

0.00

10.1

3.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

164

0.96

0.00

1.8

2.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

108

1.03

0.00

1.5

1.9

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

0.0

1.5

—

92.7

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

5.2

—

3.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.8

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3016038) Potassium [Moles/volume] in Urine

0.00

0.0

2.7

—

35.0

—

(3022411) Androstenedione [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

3.8

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

1.2

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.4

—

(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(3018993) Complement total hemolytic CH100 [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

2.6

—

1.7

—

(4268621)

0.00

0.0

2.0

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

328

1.05

0.00

5.2

3.8

—

(3022229) Phosphate [Moles/volume] in Urine

0.00

0.0

4.2

—

14.8

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.0

—

26.4

—

(3042299) inFLIXimab [Mass/volume] in Serum or Plasma

0.00

0.0

10.6

—

7.1

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(4198724)

0.00

0.0

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.4

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(3016616) Dehydroepiandrosterone sulfate (DHEA-S) [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

4.3

—

(40768453) Hazelnut native (nCor a) 9 IgE Ab [Units/volume] in Serum

0.00

0.0

1.4

—

1.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

0.3

—

(3016031) Almond IgE Ab [Units/volume] in Serum

0.00

0.0

1.2

—

5.2

—

(3018133) Calcium [Moles/volume] in Urine

0.00

0.0

3.1

—

2.0

—

(3017115) Methotrexate [Moles/volume] in Serum or Plasma

0.00

0.0

28.9

—

0.7

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.4

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

11.8

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

16.4

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

0.0

5.6

—

457.3

—

(3044640) Blood type and Crossmatch panel - Blood

0.95

0.00

22.3

3.8

—

(3032352) Blasts [#/volume] in Cerebral spinal fluid

0.00

0.0

7.1

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.2

—

(4062490)

0.00

0.0

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3023368) Bacteria identified in Blood by Culture

1.00

0.00

3.8

4.7

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.00

0.00

23.3

4.1

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

0.0

1.1

—

74.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_HAEMOLYTIC_DISEA_FETUS_NEWBO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_HAEMOLYTIC_DISEA_FETUS_NEWBO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_HAEMOLYTIC_DISEA_FETUS_NEWBO – Haemolytic disease of fetus and newborn

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Haemolytic disease of fetus and newborn

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints