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Haemorrhagic and haematological disorders of fetus and newborn

P16_HAEMORRHAGIC_HAEMATOL_DISORD_FETUS_NEWBO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P50-P61
  • Cause of death: ICD-10 P50-P61

2 out of 7 registries used, show all original rules.

708

4. Check minimum number of events

None

708

5. Include endpoints

708

6. Filter based on genotype QC (FinnGen only)

708

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P
Name in latin
Morbositates haemorrhagicae et haematologicae fetus et neonati

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 708 379 329
Unadjusted period prevalence (%) 0.14 0.13 0.15
Median age at first event (years) 0.01 0.01 0.01

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
613
Matched controls
5832
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P59.9
ICD-10 Finland
Neonatal jaundice, unspecified
2485.5
315.9
283
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
+∞
186.3
172
*
P07.3
ICD-10 Finland
Other preterm infants
19.1
124.2
202
146
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
8.4
60.8
147
212
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
13.9
20.9
36
26
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
6.2
20.8
58
97
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
13.5
20.1
35
26
P59.3
ICD-10 Finland
Neonatal jaundice from breast milk inhibitor
+∞
19.5
19
*
P55.1
ICD-10 Finland
ABO isoimmunization of fetus and newborn
+∞
19.5
19
*
P52.0
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 1, of fetus and newborn
+∞
16.4
16
*
P07.2
ICD-10 Finland
Extreme immaturity
13.7
14.7
25
18
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
3.4
14.3
71
214
P61.1
ICD-10 Finland
Polycythaemia neonatorum
+∞
13.3
13
*
P61.0
ICD-10 Finland
Transient neonatal thrombocytopenia
+∞
13.3
13
*
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
+∞
13.3
13
*
602
Kela drug reimbursment
Children's severe malnutrition
3.5
13.1
62
180
P61.4
ICD-10 Finland
Other congenital anaemias, not elsewhere classified
+∞
12.3
12
*
P55.0
ICD-10 Finland
Rh isoimmunization of fetus and newborn
+∞
12.3
12
*
WX722
NOMESCO Finland
PEEP
4.4
12.3
45
104
P59.8
ICD-10 Finland
Neonatal jaundice from other specified causes
+∞
11.3
11
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
10.3
11.0
21
20
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
13.8
10.2
17
12
WX882
NOMESCO Finland
High dependency care
2.3
10.2
102
469
P22.8
ICD-10 Finland
Other respiratory distress of newborn
9.3
10.0
20
21
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
8.5
9.5
20
23
Z2446
NOMESCO Finland
Social worker
1.9
9.2
147
816
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
3.6
8.4
37
103
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
8.3
208
1336
P07.1
ICD-10 Finland
Other low birth weight
19.4
8.3
12
6
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
6.7
8.3
20
29
P61.2
ICD-10 Finland
Anaemia of prematurity
+∞
8.2
8
*
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
14.0
8.0
13
9
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
4.5
8.0
27
59
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
7.9
143
830
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
7.6
188
1198
R4110
NOMESCO Finland
Physiotherapy
1.7
7.4
166
1026
Z3226
NOMESCO Finland
Physiotherapist
1.7
7.3
177
1120
P61.3
ICD-10 Finland
Congenital anaemia from fetal blood loss
+∞
7.2
7
*
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
7.4
7.1
16
21
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
7.1
77
364
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
7.0
133
779
JKD50
NOMESCO Finland
Hepatoportoenterostomy
13.3
6.7
11
8
Q44.29
ICD-10 Finland
Atresia of bile ducts
13.3
6.7
11
8
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
13.3
6.7
11
8
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
5.0
6.7
20
39
H35.1
ICD-10 Finland
Retinopathy of prematurity
9.0
6.6
13
14
WW805
NOMESCO Finland
Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse
9.0
6.6
13
14
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
11.8
6.4
11
9
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
9.7
6.3
12
12
Z3231
NOMESCO Finland
Registered nurse
1.6
6.3
252
1807
ZXE00
NOMESCO Finland
One hour or less
1.5
6.0
247
1772

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: P16_HAEMORRHAGIC_HAEMATOL_DISORD_FETUS_NEWBO – Haemorrhagic and haematological disorders of fetus and newborn

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).