Other perinatal haematological disorders

P16_OTH_PERINA_HAEMATOL_DISORD

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P61 Cause of death: ICD-10 — P61 2 out of 7 registries used, show all original rules.	62
4. Check minimum number of events None	62
5. Include endpoints None	62
6. Filter based on genotype QC (FinnGen only)	62

Control definitions (FinnGen only)

Control exclude: P16_HAEMORRHAGIC_HAEMATOL_DISORD_FETUS_NEWBO

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P[5-6]
Name in latin: Aliae morbositates haematologicae perinatales

NAME	P16_OTH_PERINA_HAEMATOL_DISORD
CONTROL_EXCLUDE	P16_HAEMORRHAGIC_HAEMATOL_DISORD_FETUS_NEWBO
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P61
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P61
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other perinatal haematological disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3857	1614	2243
Only index persons	2091	866	1225
Unadjusted period prevalence (%)
Whole population	0.06	0.05	0.06
Only index persons	0.04	0.03	0.05
Median age at first event (years)
Whole population	-	0.00	0.00
Only index persons	0.00	0.00	0.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	62	34	28
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	0.00	0.00	0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
54: Matched controls
539

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

Z87.6

ICD-10 Finland

Personal history of certain conditions arising in the perinatal period

35.1

18.0

P61.0

ICD-10 Finland

Transient neonatal thrombocytopenia

+∞

14.2

P61.1

ICD-10 Finland

Polycythaemia neonatorum

+∞

14.2

P61.4

ICD-10 Finland

Other congenital anaemias, not elsewhere classified

+∞

13.0

P07.3

ICD-10 Finland

Other preterm infants

13.2

9.7

P61.2

ICD-10 Finland

Anaemia of prematurity

+∞

8.5

P61.3

ICD-10 Finland

Congenital anaemia from fetal blood loss

+∞

7.5

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020630) Protein [Mass/volume] in Serum or Plasma

3.30

1.46

1.2

3.3

64.8

59.6

g/l

—

(21494755) Public health laboratory ask at order entry panel

3.30

1.46

1.4

1.1

—

(40761511) CBC panel - Blood by Automated count

479

1.99

1.11

8.8

8.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

524

0.57

0.95

4.0

3.9

—

(3022313) Gas panel - Capillary blood

113

1.69

0.95

6.2

10.3

—

(3021589) Normoblasts [#/volume] in Blood

301

1.57

0.91

6.7

11.7

0.0

e9/l

0.00

229

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.80

0.0

1.3

—

(3000494) Fungus identified in Specimen by Culture

1.95

0.76

1.6

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.52

0.74

1.2

2.1

—

(4035726)

1.85

0.67

1.0

1.8

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.61

0.0

1.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

0.00

0.61

0.0

1.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.53

0.61

2.1

3.7

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

0.00

0.59

0.0

15.0

—

0.3

—

(3022621) pH of Urine by Test strip

0.00

0.59

0.0

2.1

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

128

1.45

0.55

6.8

10.2

1.2

mmol/l

0.03

(46235355) HIV 1 and 2 tests - Meaningful Use set

140

0.66

0.50

2.8

2.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.57

0.50

2.8

1.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

101

0.65

0.44

1.7

2.3

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.42

0.0

1.1

—

135.0

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

0.00

0.42

0.0

1.1

—

(3024928) Oxygen saturation in Venous blood

0.00

0.42

0.0

37.3

—

(3011897) Casein IgE Ab [Units/volume] in Serum

0.00

0.42

0.0

1.7

—

1.8

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.40

0.0

1.1

—

(42870560) Thyrotropin [Units/volume] in Cord blood

1.47

0.40

1.0

12.8

8.9

mu/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.36

0.39

2.0

1.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

144

0.71

0.39

3.9

2.7

—

(40768804) Tissue Pathology biopsy report

1.38

0.35

1.4

1.7

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.37

0.35

4.7

9.0

1239.0

1571.1

ng/l

—

(3027944) Amphetamines [Presence] in Urine

1.42

0.35

1.0

1.7

—

(3000764) Benzodiazepines [Presence] in Urine

1.42

0.35

1.0

1.7

—

(3028300) Cannabinoids [Presence] in Urine

1.40

0.32

1.0

1.7

—

(3027008) Opiates [Presence] in Urine

1.40

0.32

1.0

1.7

—

(3009542) Hematocrit [Volume Fraction] of Blood

511

1.44

0.32

12.8

17.1

38.9

39.1

0.11

459

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

137

0.76

0.28

3.3

2.5

—

(3016879) Cocaine [Presence] in Urine

1.31

0.27

1.0

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

157

0.78

0.26

2.0

—

(3023368) Bacteria identified in Blood by Culture

0.72

0.26

2.2

4.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

241

1.21

0.25

9.8

14.0

1.2

mmol/l

0.38

227

(3007164) IgA [Mass/volume] in Serum or Plasma

228

0.82

0.24

2.2

1.6

1.5

1.6

g/l

—

114

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.73

0.24

1.3

1.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

496

1.30

0.24

7.6

11.4

29.0

21.4

mg/l

0.54

325

(3013115) Eosinophils [#/volume] in Blood

312

1.20

0.23

6.5

10.8

0.2

e9/l

1.15

257

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

102

0.75

0.23

2.5

1.8

—

(3000991) Gas panel - Venous blood

117

1.25

0.23

5.6

15.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

1.24

0.22

1.2

1.5

—

(3029493) Herpes virus 6 DNA [Presence] in Blood by NAA with probe detection

0.00

0.21

0.0

6.4

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.21

0.0

2.1

—

18.5

—

(4198724)

0.00

0.21

0.0

2.3

—

(3026285) Alpha 1 antitrypsin [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.0

—

1.5

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

2.5

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.21

0.0

7.2

—

(3024932) HLA-DR beta [Type]

0.00

0.21

0.0

1.1

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

6.2

—

2.5

—

(3024471) HLA-A [Type]

0.00

0.21

0.0

1.0

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.21

0.0

1.3

—

0.7

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

45.3

—

11.2

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.21

0.0

2.2

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.20

0.0

1.0

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.20

0.0

2.1

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.20

0.0

3.6

—

1.9

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.20

0.0

39.5

—

71.8

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

121

0.79

0.20

3.0

4.0

—

(3044640) Blood type and Crossmatch panel - Blood

119

1.23

0.20

2.4

3.6

—

(3003694) ABO and Rh group [Type] in Blood

152

0.82

0.19

1.6

1.7

—

(3044889) 12 lead EKG panel

183

0.83

0.19

1.5

2.1

—

(42870588) Differential panel, method unspecified - Blood

237

1.17

0.18

6.1

11.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

263

0.86

0.18

1.7

2.2

—

(3002032) Base excess in Venous blood by calculation

130

1.20

0.18

4.2

13.2

-0.4

1.1

mmol/l

0.51

(3012544) pH of Venous blood

131

1.19

0.16

4.3

13.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

0.81

0.15

1.4

4.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

152

1.16

0.14

7.1

15.8

24.7

24.8

mmol/l

0.05

152

(3013650) Neutrophils [#/volume] in Blood by Automated count

332

1.12

0.12

7.7

11.5

3.7

3.3

e9/l

0.21

274

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.19

0.12

1.4

3.3

48.0

62.5

u/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

176

0.88

0.11

3.3

5.0

—

(3013512) EKG study

1.12

0.10

4.2

3.5

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

235

0.90

0.09

2.2

1.9

2.1

3.0

u/ml

—

(3011288) Drugs identified in Urine by Screen method

1.12

0.09

1.0

2.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

275

1.10

0.09

3.6

4.3

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

127

1.13

0.08

4.2

11.5

22.9

23.5

mmol/l

0.29

122

(3001604) Monocytes [#/volume] in Blood

306

1.09

0.08

6.3

10.0

0.6

0.5

e9/l

0.29

249

(3006315) Basophils [#/volume] in Blood

306

1.09

0.08

6.3

10.0

0.0

e9/l

0.07

249

(40758558) Short blood count panel - Blood

183

0.90

0.07

9.2

8.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.88

0.07

1.1

2.9

—

(3033658) Prothrombin time (PT) actual/Normal

129

1.11

0.06

3.4

10.5

84.4

86.2

0.08

129

(3018095) Leukocytes [#/volume] in Urine

191

1.07

0.03

4.0

5.7

5.6

26.7

e6/l

2.13

128

(36304419) Bacteria [Presence] in Urine

157

0.94

0.01

3.5

4.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

163

1.06

0.01

2.5

4.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

126

0.94

0.01

1.1

3.7

—

(3026008) Bacteria identified in Urine by Culture

113

0.97

0.00

1.5

2.9

—

(3015736) pH of Urine

163

0.98

0.00

2.3

3.7

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

213

0.98

0.00

2.6

6.5

19.1

28.2

u/l

0.99

206

(36660697) Celiac disease serology panel - Serum

106

1.05

0.00

1.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.00

0.00

1.5

1.9

—

(4062490)

0.00

0.0

1.1

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

2.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

2.0

—

94.2

—

(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3003633) Ovomucoid IgE Ab [Units/volume] in Serum

0.00

0.0

2.8

—

4.2

—

(3014038) Collagen crosslinked N-telopeptide [Moles/volume] in Urine

0.00

0.0

2.0

—

(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma

0.00

0.0

2.8

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

3.7

—

2.7

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

0.0

1.2

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

23.7

—

(3032185) JC virus DNA [#/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

7.7

—

(3010464) Parainfluenza virus 1 Ag [Presence] in Specimen

0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.0

2.7

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.4

—

37.8

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.1

—

(3027135) IgG subclass 1 [Mass/volume] in Serum

0.00

0.0

1.1

—

5.8

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

3.7

—

51.3

—

(3032390) JC virus DNA [#/volume] (viral load) in Urine by NAA with probe detection

0.00

0.0

5.5

—

(42869858) Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

0.00

0.0

1.4

—

(3040151) Glucose [Moles/volume] in Capillary blood

0.00

0.0

1.4

—

6.1

—

(3021578) Parainfluenza virus 2 Ag [Presence] in Specimen

0.00

0.0

1.0

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.5

—

151.2

—

(3041806) Other cells [#/volume] in Blood by Manual count

0.00

0.0

1.7

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

2.6

—

57.4

—

(3021513) Carbon dioxide [Partial pressure] in Mixed venous blood

0.00

0.0

2.0

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

0.0

1.0

—

113.7

—

(3041082) Glomerular basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3005880) Parainfluenza virus 3 Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3008092) Baker's yeast IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3002621) Streptococcal DNAse B [Units/volume] in Serum

0.00

0.0

1.0

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

1.8

—

4.8

—

(3028192) IgG subclass 2 [Mass/volume] in Serum

0.00

0.0

1.1

—

2.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.4

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

0.0

1.1

—

92.3

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

1.5

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.2

—

91.6

—

(3036035) von Willebrand factor (vWf) Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

143.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

4.7

—

(3016273) Islet cell 512 Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

2.3

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3003752) BK virus DNA [Units/volume] (viral load) in Urine by NAA with probe detection

0.00

0.0

5.5

—

(3042299) inFLIXimab [Mass/volume] in Serum or Plasma

0.00

0.0

15.4

—

8.0

—

(3018993) Complement total hemolytic CH100 [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3038071) Oxygen [Partial pressure] in Mixed venous blood

0.00

0.0

2.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.00

0.00

1.0

1.7

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

1.9

—

2.1

—

(3001820) Epstein Barr virus nuclear Ab [Presence] in Serum

0.00

0.0

1.6

—

(3016031) Almond IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

2.8

—

(3017115) Methotrexate [Moles/volume] in Serum or Plasma

0.00

0.0

38.6

—

0.7

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

1.8

—

8.7

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

8.8

—

24.1

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

121.9

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.02

0.00

1.0

1.4

1.1

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_OTH_PERINA_HAEMATOL_DISORD and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_OTH_PERINA_HAEMATOL_DISORD.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_OTH_PERINA_HAEMATOL_DISORD – Other perinatal haematological disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other perinatal haematological disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints