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Intracranial nontraumatic haemorrhage of fetus and newborn

P16_INTRACR_NONTRAU_HAEMORRHAGE_FETUS_NEWBO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P52
  • Cause of death: ICD-10 P52

2 out of 7 registries used, show all original rules.

50

4. Check minimum number of events

None

50

5. Include endpoints

None

50

6. Filter based on genotype QC (FinnGen only)

50

Control definitions (FinnGen only)

Control exclude
P16_HAEMORRHAGIC_HAEMATOL_DISORD_FETUS_NEWBO

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P[5-6]
Name in latin
Haemorrhagia intracranialis non traumatica fetus sive neonati

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2780 1110 1670
Only index persons 1118 439 679
Unadjusted period prevalence (%)
Whole population 0.04 0.03 0.05
Only index persons 0.02 0.02 0.03
Median age at first event (years)
Whole population - 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 50 28 22
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
12
22
6.86
6.65
4.4
8.4
651.3
341.6
mg/l
0.64
12
22
11
21
6.43
5.82
4.8
8.9
—
—
—
0
0
10
21
5.70
4.76
4.8
8.9
—
—
—
0
0
15
46
4.23
4.63
2.6
1.2
100.1
101.4
pmol/l
—
7
25
10
22
5.43
4.53
4.5
8.4
2.7
3.3
mmol/l
—
10
22
26
125
3.25
4.04
27.5
9.1
—
—
—
0
0
13
40
4.04
3.95
2.9
2.0
713.5
204.6
u/l
0.85
13
40
18
70
3.46
3.92
7.8
4.7
—
—
—
0
0
8
13
7.09
3.66
2.3
2.2
—
—
—
0
0
26
134
2.96
3.46
28.8
9.0
23.7
24.2
mmol/l
0.35
26
134
8
16
5.73
3.20
4.4
7.5
—
—
—
0
0
7
12
6.58
3.14
1.0
1.2
—
—
—
0
0
9
22
4.75
3.05
1.8
2.4
—
—
—
0
0
9
22
4.75
3.05
1.8
2.4
—
—
—
0
0
9
22
4.75
3.05
1.8
2.4
—
—
—
0
0
9
22
4.75
3.05
1.8
2.4
—
—
—
0
0
7
13
6.06
2.98
1.9
2.2
—
—
—
0
0
11
37
3.53
2.90
2.4
1.6
—
—
—
0
0
5
6
9.07
2.81
4.0
10.2
21.0
10.5
mg/l
—
5
6
33
212
2.64
2.64
12.5
14.0
—
—
—
0
0
6
11
6.02
2.62
4.0
4.5
1.4
1.4
umol/l
—
6
11
5
7
7.77
2.61
3.2
5.6
21.3
13.8
mmol/l
—
5
7
10
34
3.43
2.58
2.4
1.3
—
—
—
0
0
9
27
3.83
2.54
1.7
2.1
—
—
—
0
0
5
9
6.02
2.27
5.2
3.4
476.2
415.4
umol/l
—
5
9
9
31
3.31
2.20
1.9
1.5
—
—
—
0
0
5
10
5.41
2.12
4.4
4.3
4.2
2.6
mmol/l
—
5
10
18
95
2.40
2.10
4.8
4.6
—
—
—
0
0
13
59
2.63
2.05
3.3
1.6
—
—
—
0
0
19
107
2.25
1.89
3.1
4.9
2.5
2.6
mg/l
0.09
19
92
26
170
2.10
1.76
10.3
12.2
—
—
—
0
0
36
269
2.21
1.69
12.8
13.7
0.2
0.2
e9/l
0.31
31
216
20
121
2.09
1.63
11.8
12.8
—
—
—
0
0
8
33
2.69
1.62
2.1
1.4
—
—
—
0
0
5
15
3.58
1.56
1.2
1.7
—
—
—
0
0
7
29
2.64
1.45
1.3
2.3
—
—
—
0
0
12
62
2.23
1.42
1.4
1.9
—
—
—
0
0
50
463
+∞
1.41
32.6
17.7
86.0
84.7
fl
0.88
50
457
50
463
+∞
1.41
32.6
17.7
29.1
28.5
pg
0.99
50
457
50
463
+∞
1.41
33.4
18.0
132.3
129.1
g/l
0.56
50
457
5
17
3.15
1.39
1.0
1.0
—
—
—
0
0
19
119
1.96
1.38
2.1
1.7
—
—
—
0
0
5
18
2.97
1.31
2.0
1.7
—
—
—
0
0
5
19
2.81
1.24
3.8
5.5
—
—
—
0
0
30
226
1.82
1.19
9.2
4.4
—
—
—
0
0
22
151
1.82
1.19
3.6
2.8
0.9
1.1
mmol/l
1.91
22
143
5
20
2.66
1.18
3.8
5.3
64.4
69.6
%
—
5
20
10
54
2.06
1.05
3.6
5.0
11.1
7.6
g/l
—
10
54
33
265
1.72
0.97
12.6
12.3
0.5
0.6
e9/l
0.69
27
205
33
265
1.72
0.97
12.6
12.3
0.0
0.0
e9/l
0.21
27
205
20
141
1.70
0.95
13.6
5.3
1.1
0.1
e6/l
0.44
12
104
14
89
1.80
0.94
9.5
3.0
—
—
—
0
0
28
217
1.66
0.93
10.8
4.1
—
—
—
0
0
45
403
2.16
0.90
25.6
11.7
29.2
25.3
mg/l
0.24
29
271
6
31
2.06
0.87
1.7
1.4
—
—
—
0
0
22
162
1.64
0.87
39.4
16.8
25.1
24.7
mmol/l
0.29
22
162
33
270
1.65
0.86
12.7
12.2
2.3
2.8
e9/l
1.04
28
219
34
281
1.66
0.84
14.0
14.2
2.7
3.4
e9/l
1.29
28
223
33
272
1.63
0.81
14.8
13.5
0.0
0.1
e9/l
0.46
28
193
18
128
1.63
0.81
12.1
14.0
5.1
5.3
kpa
0.20
18
128
20
149
1.57
0.74
13.6
5.1
16.6
55.0
e6/l
0.90
12
111
22
168
1.55
0.73
15.2
6.1
90.5
25.2
e6/l
0.39
12
112
19
142
1.55
0.68
14.1
5.2
—
—
—
0
0
7
44
1.69
0.68
3.7
22.4
107.7
105.8
mmol/l
—
7
44
0
20
0.00
0.62
0.0
1.4
—
—
—
0
0
6
35
1.81
0.60
1.2
1.4
—
—
—
0
0
17
128
1.50
0.58
11.3
12.5
24.2
23.3
mmol/l
1.13
17
120
14
102
1.52
0.55
4.8
3.9
—
—
—
0
0
10
67
1.62
0.54
10.0
4.1
—
—
—
0
0
16
121
1.47
0.53
5.1
3.9
—
—
—
0
0
8
60
1.40
0.43
11.9
2.4
—
—
—
0
0
0
16
0.00
0.42
0.0
1.4
—
4.2
—
0
5
0
17
0.00
0.41
0.0
2.4
—
7.9
—
0
5
9
67
1.42
0.41
1.9
1.7
—
—
—
0
0
18
150
1.31
0.32
3.7
2.9
32.7
35.7
mmol/mol
0.89
11
136
7
55
1.32
0.31
1.1
1.4
—
—
—
0
0
9
72
1.30
0.28
1.6
1.7
—
—
—
0
0
8
101
0.75
0.24
1.0
1.2
—
—
—
0
0
5
42
1.21
0.22
6.6
4.6
15.4
20.9
nmol/l
—
5
42
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
36.4
—
0
10
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
44.0
—
11.4
—
0
13
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
0.7
—
0
13
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
11
92
1.25
0.18
1.7
1.9
—
—
—
0
0
26
242
1.15
0.13
5.1
4.7
7.0
8.4
mm/h
0.33
21
222
15
134
1.17
0.12
1.8
1.5
—
—
—
0
0
13
141
0.89
0.06
2.8
2.1
—
—
—
0
0
19
201
0.91
0.06
2.1
1.8
1.6
1.3
g/l
—
10
87
0
6
0.00
0.00
0.0
1.7
—
0.8
—
0
6
0
6
0.00
0.00
0.0
7.5
—
1.7
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
175.7
—
0
7
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
3.4
—
0
8
0
8
0.00
0.00
0.0
2.1
—
67.0
—
0
8
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
2.4
—
0
8
5
57
0.86
0.00
2.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
5.2
—
0
8
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint P16_INTRACR_NONTRAU_HAEMORRHAGE_FETUS_NEWBO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_INTRACR_NONTRAU_HAEMORRHAGE_FETUS_NEWBO.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: P16_INTRACR_NONTRAU_HAEMORRHAGE_FETUS_NEWBO – Intracranial nontraumatic haemorrhage of fetus and newborn

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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