Defect, injury or illness of face

Z21_DEFECT_INJURY_ILLNE_FACE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — ZA8.1 Cause of death: ICD-10 — ZA8.1 2 out of 7 registries used, show all original rules.	55
4. Check minimum number of events None	55
5. Include endpoints None	55
6. Filter based on genotype QC (FinnGen only)	55

Control definitions (FinnGen only)

Control exclude: Z21_ADDIT_CODES_LOCAT_DEFECT_INJURY_ILLNE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: Z[AB]

NAME	Z21_DEFECT_INJURY_ILLNE_FACE
CONTROL_EXCLUDE	Z21_ADDIT_CODES_LOCAT_DEFECT_INJURY_ILLNE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	ZA81
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	ZA81
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Defect, injury or illness of face based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	55	31	24
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	47.94	50.72	44.35

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020779) Urea [Moles/volume] in Serum or Plasma

4.84

4.40

11.2

8.6

6.80

6.20

mmol/l

0.15

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

5.55

2.83

3.3

1.9

—

(3026008) Bacteria identified in Urine by Culture

116

2.49

2.59

3.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.90

2.50

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

177

2.35

2.45

3.5

3.7

—

(3023520) Reticulocytes [#/volume] in Blood

2.93

1.64

11.0

3.2

69.49

78.45

e9/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.20

1.56

6.6

2.5

1.50

3.30

e6/l

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

2.14

1.54

5.0

3.2

49.54

166.91

ng/l

—

(3018418) pH of Serum or Plasma

114

2.02

1.54

8.3

3.5

7.40

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.13

1.46

6.6

2.3

0.14

1.20

e6/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

101

1.99

1.40

4.1

3.6

—

(3035350) Ketones [Presence] in Urine by Test strip

226

1.85

1.39

4.0

3.6

0.00

estimate

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.99

1.36

6.9

2.1

—

(36304419) Bacteria [Presence] in Urine

119

1.91

1.35

6.7

2.6

—

(3030467) Casts [#/volume] in Urine by Automated count

119

1.91

1.35

6.8

2.6

0.24

0.15

e6/l

0.22

(3009261) Glucose [Presence] in Urine by Test strip

228

1.82

1.33

4.3

3.7

0.00

estimate

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

403

2.14

1.28

16.5

11.3

86.00

87.99

ml/min/173m2

0.19

321

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

158

1.78

1.21

3.8

3.5

24.48

46.46

ng/l

0.47

(3029937) Albumin [Presence] in Urine by Test strip

123

1.83

1.21

4.2

3.9

0.00

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

223

1.76

1.20

5.3

4.9

0.00

estimate

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.99

1.19

1.8

2.2

—

(3002582) Erythrocytes [#/volume] in Urine

133

1.79

1.16

6.7

2.9

803.99

45.18

e6/l

0.45

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

108

1.83

1.14

2.2

1.6

—

(3045414) Leukocytes [Presence] in Urine

2.51

1.11

2.2

1.6

—

(3044640) Blood type and Crossmatch panel - Blood

136

1.74

1.07

2.8

2.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.08

1.01

1.7

1.6

—

(3022621) pH of Urine by Test strip

2.02

0.98

4.6

2.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

132

1.67

0.93

1.7

1.8

109.03

100.25

pmol/l

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.00

0.92

1.6

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

133

1.65

0.90

2.9

3.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.77

0.88

2.1

2.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.78

0.83

4.4

1.6

—

(3021589) Normoblasts [#/volume] in Blood

191

1.57

0.82

11.0

8.8

0.00

e9/l

0.50

153

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.74

0.79

1.1

1.5

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

221

1.54

0.79

7.9

6.3

10.03

10.56

umol/l

0.15

207

(3022948) Iron [Moles/volume] in Serum or Plasma

1.77

0.79

3.2

2.1

12.59

12.39

umol/l

0.04

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.72

0.77

2.3

1.6

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.19

0.76

1.4

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

203

1.53

0.76

15.0

3.9

—

(3009542) Hematocrit [Volume Fraction] of Blood

420

1.82

0.75

23.0

14.1

39.85

40.15

0.18

331

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

166

1.54

0.75

11.0

7.2

1.22

1.21

mmol/l

0.26

157

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.10

0.75

10.2

6.4

23.88

25.06

mmol/l

—

(40758558) Short blood count panel - Blood

104

1.61

0.72

4.2

7.8

—

(3031040) Bacteria [#/volume] in Urine by Automated count

289

1.46

0.62

8.1

4.3

—

557.71

—

(40768443) Skin Pathology biopsy report

0.00

0.61

0.0

1.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.61

0.0

3.1

—

52.17

—

(21494755) Public health laboratory ask at order entry panel

1.56

0.60

1.5

1.4

—

(4035726)

1.80

0.60

1.2

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.65

0.56

2.8

1.6

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

156

1.44

0.56

2.3

2.9

40.35

28.03

u/l

0.37

144

(3015736) pH of Urine

169

1.39

0.49

4.0

3.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

151

1.39

0.47

6.2

2.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.46

0.47

5.0

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

298

1.37

0.46

5.5

4.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.53

0.46

1.4

2.0

—

(3000991) Gas panel - Venous blood

1.67

0.44

4.2

15.8

—

(3012544) pH of Venous blood

1.52

0.41

7.4

4.6

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.41

0.0

4.4

—

19.65

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.48

0.40

4.0

1.9

—

(3042936) Bacteria identified in Isolate by Culture

1.34

0.39

3.6

1.6

—

(3025941) Bacteria identified in Stool by Culture

1.43

0.39

2.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.44

0.36

1.8

1.5

—

(3023368) Bacteria identified in Blood by Culture

111

1.35

0.34

9.1

3.9

—

(42870588) Differential panel, method unspecified - Blood

130

1.33

0.34

8.6

6.0

—

(3044889) 12 lead EKG panel

289

1.26

0.29

3.7

3.3

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

152

1.27

0.28

2.5

2.1

181.78

52.27

u/l

0.47

142

(3032080) INR in Blood by Coagulation assay

162

1.26

0.28

6.4

8.2

1.90

1.30

inr

—

(3013512) EKG study

106

1.30

0.26

4.1

4.0

—

(40761536) Microorganisms panel - Urine sediment

1.31

0.23

5.0

2.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

365

1.24

0.23

4.3

3.5

—

(40768804) Tissue Pathology biopsy report

185

0.81

0.23

2.0

1.9

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.0

—

13.64

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.21

0.0

7.3

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.21

0.0

1.3

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.21

0.0

3.3

—

7.90

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.21

0.0

3.3

—

1.20

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.20

0.0

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.27

0.18

2.4

1.8

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

259

1.17

0.16

12.8

8.3

3.97

4.37

e9/l

0.43

231

(46235355) HIV 1 and 2 tests - Meaningful Use set

132

1.19

0.15

2.5

2.0

—

(3026493) Urate [Moles/volume] in Serum or Plasma

107

0.81

0.14

3.1

3.0

331.33

345.20

umol/l

—

(3003694) ABO and Rh group [Type] in Blood

143

1.17

0.13

1.8

1.6

—

(3000494) Fungus identified in Specimen by Culture

1.12

0.10

1.6

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.15

0.08

2.8

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.11

0.08

3.3

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.14

0.07

11.9

3.2

—

(1761868) Lipid panel - Serum or Plasma

168

1.11

0.07

1.8

2.7

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(4034850)

0.00

0.0

14.9

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

6.5

—

0.00

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

0.39

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.5

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(4062490)

0.00

0.0

1.0

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

5.4

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

11.06

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3002256) Pathology report gross observation

1.02

0.00

1.6

1.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.7

—

104.86

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.4

—

13.80

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

120

1.00

0.00

1.2

1.3

0.81

1.28

u/ml

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.90

0.00

1.2

1.7

—

(3007368) IgG [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

48.16

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.7

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

7.3

—

0.00

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.6

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.1

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

338.40

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.7

—

3.96

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.6

—

34.92

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

0.0

1.0

—

421.40

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.3

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.8

—

79.50

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.4

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.4

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3026285) Alpha 1 antitrypsin [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

1.33

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

5.9

—

0.77

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.2

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

0.0

1.4

—

1.20

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

7.3

—

0.00

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: Z21_DEFECT_INJURY_ILLNE_FACE – Defect, injury or illness of face

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Defect, injury or illness of face

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Defect, injury or illness of face (Z21_DEFECT_INJURY_ILLNE_FACE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints