Burkitt lymphoma

C3_BURKITT

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions HLP_C3_BURKITT	30
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Cause of death: ICD-10 — C83.70, C83.71 Cause of death: ICD-9 — 2002A Cancer registry: Topography ICD-O-3 — C42\|C77 Cancer registry: Morphology ICD-O-3 — 9687\|9826 Cancer registry: Behaviour codes — 3 2 out of 7 registries used, show all original rules.	30
4. Check minimum number of events None	30
5. Include endpoints HLP_C3_BURKITT	30
6. Filter based on genotype QC (FinnGen only)	29

Control definitions (FinnGen only)

Control exclude: C3_CANCER, C3_CANCER_WIDE
Control conditions: not HLP_C3_BURKITT

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF8
Parent code in ICD-10: C81-C96
Name in latin: Lymphoma non-Hodgkin diffusum

NAME	C3_BURKITT
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS	!HLP_C3_BURKITT
SEX
INCLUDE	HLP_C3_BURKITT
PRE_CONDITIONS
CONDITIONS	HLP_C3_BURKITT
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	C837
COD_ICD_9	2002A
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C42\|C77
CANC_TOPO_EXCL
CANC_MORPH	9687\|9826
CANC_MORPH_EXCL
CANC_BEHAV	3

Similar endpoints

↥

List of similar endpoints to Burkitt lymphoma based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	29	7	22
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	41.00	39.74	41.41

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

12.28

11.10

1.8

1.5

—

(4035726) Immunohistochemistry procedure

27.16

8.98

1.4

1.3

—

(3017115) Methotrexate [Moles/volume] in Serum or Plasma

+∞

8.74

12.8

0.0

0.22

—

umol/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

9.07

8.46

1.7

2.1

—

(3023368) Bacteria identified in Blood by Culture

8.85

8.26

9.7

4.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

10.81

7.77

1.6

1.5

—

(3032352) Blasts [#/volume] in Cerebral spinal fluid

+∞

7.59

2.9

0.0

—

(21494434) Karyotype in Bone marrow

+∞

7.59

1.0

0.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

11.34

7.42

1.5

1.4

—

(3028026) IgM [Mass/volume] in Serum or Plasma

15.70

7.37

2.9

1.2

1.23

1.19

g/l

0.04

(3026493) Urate [Moles/volume] in Serum or Plasma

6.24

5.75

12.9

2.0

315.37

12992.90

umol/l

0.79

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

15.34

5.73

1.4

1.3

—

(3026008) Bacteria identified in Urine by Culture

5.82

5.30

1.7

3.0

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

14.93

5.12

3.9

1.3

306.13

571.29

mg/l

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

14.93

5.12

3.6

1.1

3.77

3.64

mmol/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

114

6.49

4.99

25.9

4.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

5.25

4.72

7.7

2.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

6.96

4.71

2.5

1.3

—

(3013115) Eosinophils [#/volume] in Blood

130

6.51

4.55

21.2

5.9

0.13

0.22

e9/l

2.79

110

(3048929) Epstein Barr virus Ab [Presence] in Serum

8.64

4.37

1.4

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

12.52

4.25

1.3

1.1

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

12.52

4.25

2.3

1.9

3.41

4.40

g/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

9.42

4.16

3.0

1.5

—

(3042936) Bacteria identified in Isolate by Culture

6.31

4.14

2.3

4.5

—

(3044640) Blood type and Crossmatch panel - Blood

4.64

4.11

8.3

2.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

4.86

4.08

6.5

3.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

6.28

3.58

2.9

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

6.28

3.58

2.7

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

116

4.34

3.46

4.5

2.9

0.00

estimate

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

9.00

3.21

1.3

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

9.00

3.21

5.0

1.3

4.05

1.90

ug/l

—

(3021589) Normoblasts [#/volume] in Blood

121

4.05

3.11

32.8

7.8

0.01

0.00

e9/l

0.60

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

11.61

3.09

2.2

1.0

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

7.98

3.02

2.3

1.4

90.17

90.78

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

3.66

2.98

5.6

2.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

116

3.69

2.83

6.5

4.2

0.00

estimate

—

(3025941) Bacteria identified in Stool by Culture

5.73

2.78

1.4

1.0

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

3.48

2.76

1.8

2.6

57.76

73.42

nmol/l

1.81

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

6.50

2.68

1.2

1.5

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

7.21

2.47

2.8

1.4

171.00

193.25

—

(3036489) Thrombin time

7.21

2.47

2.8

1.3

21.20

20.88

—

(3018095) Leukocytes [#/volume] in Urine

3.20

2.43

7.4

3.2

7.03

16.15

e6/l

0.67

(3011397) Hemoglobin [Presence] in Urine by Test strip

3.26

2.39

4.3

2.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

151

3.23

2.17

6.0

3.5

—

(36304419) Bacteria [Presence] in Urine

2.99

2.13

5.6

2.3

—

(3000991) Gas panel - Venous blood

3.51

2.04

15.4

14.1

—

(3003694) ABO and Rh group [Type] in Blood

2.94

2.03

2.2

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

5.21

2.02

1.2

1.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

175

3.56

2.01

7.1

3.6

13.28

9.72

mm/h

0.74

160

(3019832) Treponema pallidum Ab [Presence] in Serum

3.64

1.94

1.4

2.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

4.76

1.90

1.2

—

(40758558) Short blood count panel - Blood

2.82

1.89

31.6

5.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

3.14

1.87

4.8

2.6

0.00

1.18

e6/l

—

(3022313) Gas panel - Capillary blood

4.38

1.79

2.6

5.9

—

(40761535) Cells panel - Urine sediment

4.06

1.68

4.0

2.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.83

1.68

4.8

2.5

0.20

0.61

e6/l

—

(40768804) Tissue Pathology biopsy report

2.67

1.67

2.1

1.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.06

1.63

18.6

7.0

23.90

25.98

mmol/l

—

(3000494) Fungus identified in Specimen by Culture

3.06

1.63

3.3

2.5

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.83

1.50

9.1

11.6

102.29

103.93

mmol/l

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

3.00

1.45

20.7

4.4

26.83

24.39

mmol/l

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

3.31

1.42

3.4

4.9

4.61

5.20

kpa

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

2.33

1.38

4.3

2.8

—

(3012544) pH of Venous blood

2.50

1.31

15.9

4.4

—

(3002032) Base excess in Venous blood by calculation

2.50

1.31

16.0

3.8

5.30

1.59

mmol/l

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

129

2.29

1.28

11.1

9.0

6.28

6.66

mmol/l

0.36

118

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.62

1.25

24.7

3.4

—

(3026782) Osmolality of Urine

2.42

1.19

3.9

2.6

586.11

550.85

mosm/kgh2o

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.09

0.81

2.6

2.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.88

0.73

4.0

2.9

—

(1761868) Lipid panel - Serum or Plasma

0.52

0.69

2.2

2.6

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.63

0.0

1.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.62

0.0

1.0

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.77

0.60

2.3

1.7

1137.33

1276.04

nmol/l

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

241

0.67

0.46

4.3

4.1

2.74

2.72

mmol/l

0.04

223

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.42

0.0

1.1

—

5.48

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.42

0.0

1.1

—

9.15

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.42

0.0

1.1

—

6.82

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

170

1.53

0.41

3.4

3.7

121.50

52.32

u/l

0.85

164

(3013512) EKG study

1.48

0.35

5.7

3.7

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

239

0.70

0.32

4.0

3.7

4.38

4.50

mmol/l

0.25

220

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

210

1.41

0.27

32.7

10.3

98.16

86.67

ml/min/173m2

0.97

167

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

190

1.35

0.26

3.4

3.8

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.22

0.0

1.2

—

0.91

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.22

0.0

4.6

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

0.22

0.0

1.2

—

4.85

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.7

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.5

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.20

0.0

1.2

—

(3008898) HLA-B27 [Presence]

0.00

0.20

0.0

1.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

0.70

0.19

1.0

1.8

1.63

1.27

mmol/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

223

0.81

0.18

4.1

3.6

1.37

1.30

mmol/l

0.18

202

(3044889) 12 lead EKG panel

152

1.27

0.18

4.8

3.3

—

(3002385) Erythrocyte distribution width [Ratio]

217

1.26

0.17

58.2

14.6

15.96

13.77

0.85

212

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

205

1.27

0.17

4.5

4.2

2.14

2.00

mu/l

0.18

183

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.19

0.11

1.4

2.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.4

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(4034850) Laboratory test

0.00

0.0

6.3

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

2.6

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

3.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.4

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.05

-0.00

1.8

2.2

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

2.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.02

-0.00

1.0

2.5

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.5

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(3021788) Differential panel - Synovial fluid

0.00

-0.00

0.0

1.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

2.2

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: C3_BURKITT – Burkitt lymphoma

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

R13

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Burkitt lymphoma

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Burkitt lymphoma (C3_BURKITT)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Relationships between endpoints