Benign neoplasm: Cornea

CD2_BENIGN_CORNEA

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D31.1& Hospital discharge: ICD-9 — 2244 Hospital discharge: ICD-8 — 22401 Cause of death: ICD-10 — D31.1& Cause of death: ICD-9 — 2244 Cause of death: ICD-8 — 22401 2 out of 7 registries used, show all original rules.	53
4. Check minimum number of events None	53
5. Include endpoints None	53
6. Filter based on genotype QC (FinnGen only)	53

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D31
Name in latin: Neoplasma benignum corneae

NAME	CD2_BENIGN_CORNEA
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D311
HD_ICD_9	2244
HD_ICD_8	22401
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D311
COD_ICD_9	2244
COD_ICD_8	22401
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Cornea based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Benign neoplasm: Cornea

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	410	229	180
Only index persons	371	214	157
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	57.52	59.46	55.18
Only index persons	57.43	59.16	55.08

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	53	27	26
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	58.47	60.52	56.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044889) 12 lead EKG panel

311

1.96

1.31

3.9

4.0

—

(40768804) Tissue Pathology biopsy report

185

1.80

1.24

2.0

1.9

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.21

0.0

1.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

186

1.78

1.21

6.4

3.9

33.47

35.39

g/l

0.94

178

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.20

1.12

2.0

1.5

—

(21494755) Public health laboratory ask at order entry panel

2.22

1.07

1.1

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.05

1.07

2.0

1.6

—

(3021589) Normoblasts [#/volume] in Blood

191

1.71

1.07

10.8

11.0

0.00

e9/l

0.50

166

(3009542) Hematocrit [Volume Fraction] of Blood

393

1.96

1.02

23.7

15.1

39.76

40.71

0.55

293

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.92

1.01

5.1

3.6

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.20

0.92

36.5

6.8

25.00

25.67

mmol/l

—

(40761535) Cells panel - Urine sediment

2.05

0.87

2.2

4.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.29

0.78

2.4

2.0

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

405

1.73

0.76

4.2

4.6

2.13

2.01

mu/l

0.36

366

(3042936) Bacteria identified in Isolate by Culture

1.79

0.75

2.5

1.8

—

(3012544) pH of Venous blood

1.80

0.65

8.0

5.7

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.80

0.65

1.6

1.4

—

(40768797) Stomach Pathology biopsy report

1.57

0.60

1.4

1.3

—

(3013115) Eosinophils [#/volume] in Blood

233

1.43

0.56

6.4

6.6

0.19

e9/l

0.09

214

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

423

1.66

0.56

4.3

4.6

5.78

5.97

mmol/l

0.78

391

(3032080) INR in Blood by Coagulation assay

185

1.43

0.55

9.8

9.0

1.00

1.23

inr

—

(3000492) Spirometry study

1.61

0.55

1.5

—

(3001604) Monocytes [#/volume] in Blood

224

1.42

0.55

6.3

6.1

0.65

0.60

e9/l

0.30

204

(4035726)

1.56

0.53

1.3

—

(3006315) Basophils [#/volume] in Blood

225

1.41

0.53

6.3

6.2

0.04

e9/l

0.11

205

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.53

0.49

2.4

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.49

0.48

5.9

7.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

429

1.55

0.45

16.6

14.8

24.30

22.31

mg/l

0.14

333

(3037522) Nuclear Ab [Titer] in Serum

1.47

0.45

1.5

—

354.67

—

(3019198) Lymphocytes [#/volume] in Blood

230

1.35

0.44

6.4

1.90

1.81

e9/l

0.25

214

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

172

1.37

0.44

2.0

1.9

84.34

98.13

pmol/l

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.42

0.0

1.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.42

0.0

1.4

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.42

0.0

1.2

—

(40758558) Short blood count panel - Blood

108

1.40

0.41

2.1

8.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

146

1.35

0.39

4.2

2.9

—

(3031040) Bacteria [#/volume] in Urine by Automated count

276

1.30

0.34

4.5

4.2

—

79.13

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.41

0.33

2.3

1.8

—

(3002256) Pathology report gross observation

1.40

0.33

1.1

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.34

0.32

2.1

1.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.31

0.31

13.4

23.9

—

1.03

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

268

1.28

0.31

6.4

10.7

4.15

4.29

e9/l

0.15

240

(40760892) CBC W Ordered Manual Differential panel - Blood

113

1.32

0.31

2.9

4.6

—

(3023368) Bacteria identified in Blood by Culture

127

0.74

0.30

9.4

4.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.29

0.29

4.6

1.5

—

(40761511) CBC panel - Blood by Automated count

458

1.51

0.28

13.2

14.4

—

(3003694) ABO and Rh group [Type] in Blood

106

1.30

0.26

1.5

1.4

—

(40761536) Microorganisms panel - Urine sediment

1.31

0.23

4.8

3.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.21

0.22

1.2

1.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.21

0.0

1.4

—

(3008898) HLA-B27 [Presence]

0.00

0.21

0.0

1.0

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.21

0.0

2.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.31

0.21

2.8

1.6

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.2

—

(4094501)

0.00

0.21

0.0

1.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

(4034850)

0.00

0.20

0.0

16.7

—

(3000494) Fungus identified in Specimen by Culture

1.21

0.19

1.6

1.3

—

(3015736) pH of Urine

159

1.20

0.18

4.6

3.7

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

133

1.18

0.14

5.7

5.4

21.17

19.51

—

(3013512) EKG study

126

0.84

0.13

3.0

4.5

—

(42870588) Differential panel, method unspecified - Blood

155

1.14

0.11

4.9

5.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

416

1.18

0.10

18.5

14.6

77.87

80.60

ml/min/173m2

0.30

338

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

126

1.15

0.10

2.3

2.2

697.86

237.82

u/l

0.35

119

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

195

1.13

0.10

3.5

3.8

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

1.17

0.10

4.8

3.1

1.39

0.69

ug/l

—

(3044640) Blood type and Crossmatch panel - Blood

144

0.87

0.10

2.7

2.4

—

(36304419) Bacteria [Presence] in Urine

117

1.15

0.09

5.1

2.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

284

0.90

0.08

4.6

4.0

—

(3019309) Folate [Moles/volume] in Red Blood Cells

0.86

0.08

3.1

1.7

1859.57

1286.77

nmol/l

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

447

1.22

0.07

4.8

5.2

2.76

2.72

mmol/l

0.09

410

(3019150) Specific gravity of Urine by Refractometry

1.12

0.07

5.3

4.7

—

1.02

—

(3026008) Bacteria identified in Urine by Culture

132

0.88

0.07

2.7

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

429

1.15

0.07

3.7

4.2

1.21

1.30

mmol/l

0.70

391

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

262

1.06

0.02

2.2

2.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

153

1.07

0.02

4.8

4.2

—

(3012516) Albumin [Mass/volume] in Urine

114

1.07

0.01

3.2

25.81

74.10

mg/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

116

0.93

0.01

2.9

3.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

186

0.95

0.00

3.6

4.8

22.69

71.69

ng/l

1.06

129

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.01

0.00

2.1

1.8

475.40

411.06

pmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.01

0.00

3.0

2.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.06

0.00

6.8

3.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

124

0.96

0.00

3.8

4.0

4.37

9.87

mg/mmol

—

(3009261) Glucose [Presence] in Urine by Test strip

206

1.03

0.00

4.8

3.9

—

0.08

estimate

—

(1761868) Lipid panel - Serum or Plasma

174

0.97

0.00

2.5

3.2

—

(3026493) Urate [Moles/volume] in Serum or Plasma

108

1.02

0.00

2.1

3.2

358.91

4892.11

umol/l

0.49

(3018095) Leukocytes [#/volume] in Urine

152

0.98

0.00

6.5

3.5

20.00

47.97

e6/l

—

118

(3003458) Phosphate [Moles/volume] in Serum or Plasma

0.95

0.00

18.2

6.0

1.40

1.04

mmol/l

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.0

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.0

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

2.2

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3011412) CD3 cells [#/volume] in Blood

0.00

0.0

1.8

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.2

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.2

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

1.2

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.92

0.00

1.2

1.3

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.7

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

5.4

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

3.6

—

4.08

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

1.9

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

2.7

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

1.9

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

466

1.08

0.00

19.9

17.4

85.40

80.27

umol/l

0.19

466

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

2.2

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

3.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

3.6

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

5.4

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.7

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

2.7

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

3.1

—

0.61

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

2.7

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

440

1.00

0.00

4.2

4.7

1.43

1.47

mmol/l

0.29

405

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

3.6

—

104.00

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_CORNEA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CORNEA.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_CORNEA – Benign neoplasm: Cornea

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Cornea

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints