Carcinoma in situ of larynx

CD2_INSITU_LARYNX

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions not C3_LARYNX	519371
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D02.0& Hospital discharge: ICD-9 — 2310 Cause of death: ICD-10 — D02.0& Cause of death: ICD-9 — 2310 Cancer registry: Topography ICD-O-3 — C32 Cancer registry: Morphology ICD-O-3 — ANY Cancer registry: Behaviour codes — 2 3 out of 7 registries used, show all original rules.	61
4. Check minimum number of events None	61
5. Include endpoints None	61
6. Filter based on genotype QC (FinnGen only)	61

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF9
Parent code in ICD-10: D02
Name in latin: Carcinoma in situ bronchi

NAME	CD2_INSITU_LARYNX
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS	!C3_LARYNX
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D020
HD_ICD_9	2310
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D020
COD_ICD_9	2310
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C32
CANC_TOPO_EXCL
CANC_MORPH	ANY
CANC_MORPH_EXCL
CANC_BEHAV	2

Similar endpoints

↥

List of similar endpoints to Carcinoma in situ of larynx based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	61	12	49
Unadjusted period prevalence (%)	0.02	0.00	0.02
Median age at first event (years)	66.13	47.82	70.62

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
61: Matched controls
610

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

UDQ12

NOMESCO Finland

Flexible laryngoscopy

35.3

43.5

DQB10

NOMESCO Finland

Endoscopic excision of lesion of larynx

371.3

37.3

C32.0

ICD-10 Finland

Malignant neoplasm: Glottis

128.4

23.7

D02.0

ICD-10 Finland

Carcinoma in situ: Larynx

+∞

23.4

D14.1

ICD-10 Finland

Benign neoplasm: Larynx

119.9

22.5

DQA10

NOMESCO Finland

Biopsy of larynx

167.7

22.3

D38.0

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Larynx

145.2

19.9

C320, 8077, 2

ICD-O-3

+∞

17.5

8070/2-C32.0

ICD-O-3

Squamous cell carcinoma in situ, NOS, of glottis

+∞

17.5

ZXC10

NOMESCO Finland

Use of laser

44.8

16.0

J37.0

ICD-10 Finland

Chronic laryngitis

24.0

14.2

J38.3

ICD-10 Finland

Other diseases of vocal cords

42.4

13.4

UDQ22

NOMESCO Finland

Microlaryngoscopy

40.4

10.8

WX404

NOMESCO Finland

Intravenous generell anesthesy

5.5

9.0

EP1AE

NOMESCO Finland

Neck ultrasound examination

12.8

8.6

C32.9

ICD-10 Finland

Malignant neoplasm: Larynx, unspecified

+∞

7.4

2310A

ICD-9 Finland

Carcinoma in situ of respiratory system, Larynx

+∞

7.4

WX734

NOMESCO Finland

JET-ventilation

+∞

7.4

YA1BD

NOMESCO Finland

Extensive CT examination of head and neck for dose design of radiotherapy

77.6

6.6

8070/2-C32.9

ICD-O-3

Squamous cell carcinoma in situ, NOS, of larynx, NOS

+∞

6.3

UDH02

NOMESCO Finland

Rhinopharyngoscopy

8.8

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768804) Tissue Pathology biopsy report

181

3.65

5.76

4.0

2.1

—

(3019225) pH of Specimen

3.74

3.94

2.5

5.2

—

(3013512) EKG study

147

2.85

3.87

7.4

5.0

—

(3042936) Bacteria identified in Isolate by Culture

3.24

3.68

2.0

2.1

—

(3022217) INR in Platelet poor plasma by Coagulation assay

261

2.74

3.37

14.4

15.4

1.31

inr

0.01

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

208

2.43

2.89

3.3

2.6

—

(4035726) Immunohistochemistry procedure

3.10

2.84

1.6

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

222

2.35

2.68

5.8

4.5

73.62

42.45

ng/l

0.43

175

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

179

2.33

2.63

3.4

3.5

896.33

1419.84

ng/l

0.49

152

(3000492) Spirometry study

3.53

2.58

2.0

1.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

316

2.41

2.43

4.9

4.2

—

(3044640) Blood type and Crossmatch panel - Blood

147

2.19

3.2

2.7

—

(3027945) Reticulocytes/100 erythrocytes in Blood

2.54

2.14

2.4

2.6

1.61

1.83

0.42

(3007853) Bacteria identified in Skin by Aerobe culture

2.53

2.01

1.8

—

(40761511) CBC panel - Blood by Automated count

465

2.85

1.99

26.9

16.1

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

4.84

1.98

2.2

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

424

2.53

1.95

23.9

17.2

73.77

74.17

ml/min/173m2

0.04

345

(3023368) Bacteria identified in Blood by Culture

163

2.04

1.89

5.3

4.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

202

1.95

1.75

2.4

2.5

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

475

2.60

1.67

30.2

21.5

91.36

87.85

umol/l

0.16

475

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.63

1.60

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

490

2.74

1.60

35.4

25.4

39.13

39.77

0.25

458

(40761536) Microorganisms panel - Urine sediment

2.46

1.56

4.3

3.8

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.53

1.55

1.6

1.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.53

1.55

2.2

1.4

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.53

1.55

2.0

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

155

1.90

1.55

4.2

3.9

2.45

11.70

mg/mmol

2.11

(40760892) CBC W Ordered Manual Differential panel - Blood

200

1.86

1.53

6.5

7.1

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.31

1.47

1.2

1.7

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

288

1.85

1.46

5.7

5.4

7.73

6.89

mmol/l

0.70

269

(3026493) Urate [Moles/volume] in Serum or Plasma

134

1.86

1.39

2.2

3.4

362.63

3199.61

umol/l

0.50

114

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.11

1.38

1.4

2.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.28

1.37

1.9

3.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

197

1.78

1.35

2.3

2.1

95.69

86.20

pmol/l

0.73

119

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.93

1.31

1.8

2.5

—

(3012516) Albumin [Mass/volume] in Urine

145

1.81

1.30

3.1

3.3

54.92

86.37

mg/l

0.29

(3020630) Protein [Mass/volume] in Serum or Plasma

2.20

1.24

1.9

4.4

68.24

66.16

g/l

—

(3002256) Pathology report gross observation

2.09

1.21

1.5

1.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

342

1.73

1.13

4.8

4.1

14.94

14.01

mm/h

0.10

305

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.81

1.06

5.2

4.1

0.79

0.80

mmol/l

0.10

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.84

1.05

2.6

2.1

—

(3044889) 12 lead EKG panel

336

1.67

1.04

4.5

4.6

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.94

1.02

1.8

2.7

25.67

7.70

umol/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.06

1.00

1.0

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.86

0.97

7.4

3.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

122

1.67

0.94

3.5

3.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

106

1.69

0.90

3.7

2.6

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

2.11

0.89

1.0

1.7

1.45

2.50

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.11

0.89

2.2

3.3

136.50

123.80

g/l

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.80

0.89

2.7

7.1

1.04

1.01

mmol/l

0.17

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

440

1.76

0.87

4.7

4.9

4.19

4.36

mmol/l

0.52

393

(3002032) Base excess in Venous blood by calculation

1.77

0.82

3.1

4.3

3.29

2.40

mmol/l

—

(3035350) Ketones [Presence] in Urine by Test strip

237

1.52

0.82

2.8

4.1

0.00

estimate

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.83

0.81

1.9

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.91

0.81

1.0

1.5

—

(3000494) Fungus identified in Specimen by Culture

1.86

0.81

1.2

1.6

—

(3049717) Cytology report of Urine Cyto stain

2.27

0.78

4.0

3.1

—

(3022313) Gas panel - Capillary blood

2.18

0.76

3.6

4.0

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.18

0.76

2.4

4.0

28.42

24.58

mmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

195

1.48

0.70

3.9

3.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

235

1.45

0.67

3.3

5.3

0.00

estimate

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

440

1.58

0.65

4.7

4.8

1.43

1.38

mmol/l

0.29

388

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.79

0.65

2.4

2.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.72

0.63

2.4

2.0

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

453

1.58

0.62

5.3

5.4

2.24

2.57

mmol/l

1.84

402

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.61

0.0

1.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.61

0.0

1.1

—

(4034850) Laboratory test

0.00

0.60

0.0

19.4

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

127

1.47

0.58

2.6

2.0

2.77

3.23

mg/l

0.45

113

(3009261) Glucose [Presence] in Urine by Test strip

240

1.40

0.57

2.8

4.1

0.00

estimate

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.53

0.56

2.2

1.9

—

(3018095) Leukocytes [#/volume] in Urine

187

1.37

0.49

4.8

3.9

186.27

66.69

e6/l

0.31

137

(3019060) Gas panel - Arterial blood

1.52

0.49

2.3

4.6

—

(36304419) Bacteria [Presence] in Urine

142

1.38

0.45

4.9

3.0

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

430

1.41

0.45

4.4

4.3

1.34

1.27

mmol/l

0.17

378

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

181

1.34

0.43

3.2

4.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

120

0.71

0.40

1.6

4.1

—

(3029937) Albumin [Presence] in Urine by Test strip

145

1.34

0.40

3.4

4.2

0.00

estimate

—

(1761868) Lipid panel - Serum or Plasma

129

1.33

0.35

3.9

3.3

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

159

1.28

0.32

3.3

2.2

313.37

173.21

u/l

0.56

150

(3002385) Erythrocyte distribution width [Ratio]

378

1.26

0.30

25.9

20.8

16.86

15.45

0.53

373

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.31

0.29

1.6

2.6

4.29

5.88

ug/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.24

0.22

1.0

1.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.21

0.0

1.7

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3018418) pH of Serum or Plasma

139

1.20

0.18

6.0

5.3

7.39

7.40

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.74

0.18

1.4

4.6

5.56

65.80

ug/l

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

0.74

0.16

3.7

7.4

102.83

103.96

mmol/l

—

(3026008) Bacteria identified in Urine by Culture

142

1.17

0.14

2.9

3.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

247

0.89

0.11

6.5

4.7

24.85

21.66

0.34

130

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

175

0.88

0.10

3.2

0.98

0.71

ug/l

—

132

(3000991) Gas panel - Venous blood

1.05

0.09

3.0

9.1

—

(40768797) Stomach Pathology biopsy report

1.13

0.08

1.6

1.2

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.07

0.07

1.9

2.8

10.03

11.50

umol/l

—

(3003694) ABO and Rh group [Type] in Blood

109

1.01

0.00

2.4

1.3

—

(40758558) Short blood count panel - Blood

121

0.99

0.00

9.3

7.5

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.3

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.2

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.5

—

11.17

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.2

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.2

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

2.2

—

6.62

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.3

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

6.2

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

-0.00

0.0

1.2

—

(3007368) IgG [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

49.80

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

1.2

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(40761535) Cells panel - Urine sediment

0.96

-0.00

1.2

3.9

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.5

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

198.20

—

(3027944) Amphetamines [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

5.9

—

(40759040) C peptide [Moles/volume] in Serum or Plasma --post meal

0.00

-0.00

0.0

1.2

—

2.46

—

(3028300) Cannabinoids [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.97

-0.00

3.4

11.5

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.6

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

0.99

-0.00

1.9

2.8

2.27

2.22

g/l

—

(3016879) Cocaine [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.8

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.6

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

15.29

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

-0.00

0.0

1.0

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(3027008) Opiates [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

2.2

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_LARYNX – Carcinoma in situ of larynx

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

R13

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Carcinoma in situ of larynx

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Carcinoma in situ of larynx (CD2_INSITU_LARYNX)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints