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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart CD2_INSITU_LARYNX_EXALLC for full statistics.

Carcinoma in situ of larynx

DOID Endpoint Browser

CD2_INSITU_LARYNX

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • not C3_LARYNX
519637

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D02.0&
  • Hospital discharge: ICD-9 — 2310
  • Cause of death: ICD-10 — D02.0&
  • Cause of death: ICD-9 — 2310
  • Cancer registry: Topography ICD-O-3 — C32
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 2

3 out of 7 registries used, show all original rules.

58

4. Check minimum number of events

None

58

5. Include endpoints

None

58

6. Filter based on genotype QC (FinnGen only)

58

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D02
Name in latin
Carcinoma in situ bronchi

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 58 11 47
Unadjusted period prevalence (%) 0.02 0.00 0.02
Median age at first event (years) 64.56 38.69 70.62

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
56
Matched controls
558
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
DQB10
NOMESCO Finland
Endoscopic excision of lesion of larynx
580.4
32.3
29
*
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
+∞
26.1
23
*
C32.0
ICD-10 Finland
Malignant neoplasm: Glottis
352.1
23.5
22
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
38.6
23.4
30
16
DQA10
NOMESCO Finland
Biopsy of larynx
+∞
22.4
20
*
8070/2-C32.0
ICD-O-3
Squamous cell carcinoma in situ, NOS, of glottis
+∞
18.8
17
*
D02.0
ICD-10 Finland
Carcinoma in situ: Larynx
258.6
18.7
18
*
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
+∞
17.6
16
*
C320, 8077, 2
ICD-O-3
NA
+∞
15.3
14
*
J37.0
ICD-10 Finland
Chronic laryngitis
39.6
13.9
17
6
J38.3
ICD-10 Finland
Other diseases of vocal cords
60.9
12.5
14
*
ZXC10
NOMESCO Finland
Use of laser
31.1
12.4
16
7
UDQ22
NOMESCO Finland
Microlaryngoscopy
149.5
11.9
12
*
2310A
ICD-9 Finland
Carcinoma in situ of respiratory system, Larynx
+∞
7.4
7
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
5.8
7.1
22
56
EP1AE
NOMESCO Finland
Neck ultrasound examination
10.9
7.0
13
15
C32.9
ICD-10 Finland
Malignant neoplasm: Larynx, unspecified
78.4
6.6
7
*
8070/2-C32.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of larynx, NOS
+∞
6.4
6
*
WX734
NOMESCO Finland
JET-ventilation
+∞
6.4
6
*

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: CD2_INSITU_LARYNX – Carcinoma in situ of larynx

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).