info icon

This is a non-core endpoint: only basic statistics are computed.

See its core counterpart CD2_INSITU_EAR_RESP_EXALLC for full statistics.

Carcinoma in situ of middle ear and respiratory system

CD2_INSITU_EAR_RESP

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D02
  • Cause of death: ICD-10 D02

2 out of 7 registries used, show all original rules.

83

4. Check minimum number of events

None

83

5. Include endpoints

165

6. Filter based on genotype QC (FinnGen only)

165

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D00-D09
Name in latin
Carcinoma in situ auris mediae sive systematis respiratorii

Similar endpoints

List of similar endpoints to Carcinoma in situ of middle ear and respiratory system based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 165 44 121
Unadjusted period prevalence (%) 0.04 0.01 0.05
Median age at first event (years) 68.56 66.30 69.39

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
158
Matched controls
1581
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D02.0
ICD-10 Finland
Carcinoma in situ: Larynx
+∞
52.0
47
*
C32.0
ICD-10 Finland
Malignant neoplasm: Glottis
214.2
46.6
46
*
DQB10
NOMESCO Finland
Endoscopic excision of lesion of larynx
58.2
39.9
46
11
DQA10
NOMESCO Finland
Biopsy of larynx
73.4
27.1
30
5
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
61.2
26.3
30
6
ZXC10
NOMESCO Finland
Use of laser
34.6
24.3
31
11
UDQ12
NOMESCO Finland
Flexible laryngoscopy
15.8
24.0
40
33
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
84.4
20.3
22
*
C32.9
ICD-10 Finland
Malignant neoplasm: Larynx, unspecified
+∞
20.2
19
*
J38.3
ICD-10 Finland
Other diseases of vocal cords
53.4
19.8
23
5
UDQ22
NOMESCO Finland
Microlaryngoscopy
60.1
18.5
21
*
8070/3-C32.9
ICD-O-3
Squamous cell carcinoma, NOS, of larynx, NOS
75.7
18.2
20
*
8070/2-C32.0
ICD-O-3
Squamous cell carcinoma in situ, NOS, of glottis
+∞
18.1
17
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.2
16.9
50
109
8140/2-C34.1
ICD-O-3
Adenocarcinoma in situ, NOS, of upper lobe, lung
+∞
15.9
15
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.3
15.3
44
91
8070/3-C32.0
ICD-O-3
Squamous cell carcinoma, NOS, of glottis
+∞
14.8
14
*
C320, 8077, 2
ICD-O-3
NA
+∞
14.8
14
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
9.5
14.4
30
38
J37.0
ICD-10 Finland
Chronic laryngitis
14.0
13.6
23
19
WF002
NOMESCO Finland
Radical radiotherapy
8.1
13.5
31
46
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
19.4
12.9
19
11
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
25.2
11.8
16
7
D02.3
ICD-10 Finland
Carcinoma in situ: Other parts of respiratory system
+∞
11.6
11
*
D02.2
ICD-10 Finland
Carcinoma in situ: Bronchus and lung
+∞
11.6
11
*
DQB70
NOMESCO Finland
Total excision of vocal cord
+∞
11.6
11
*
XX3DW
NOMESCO Finland
Time consuming IT work
5.9
11.1
32
65
GDC01
NOMESCO Finland
Thoracoscopic lobectomy of lung
64.5
10.8
12
*
130
Kela drug reimbursment
Malignant tumour
4.7
10.3
37
97
GD1AD
NOMESCO Finland
Thorax CT examination
10.6
10.1
19
20
UJC01
NOMESCO Finland
Scopy of lower throat
21.8
10.0
14
7
EP1AE
NOMESCO Finland
Neck ultrasound examination
8.1
9.9
22
31
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
6.3
9.4
25
46
UDH02
NOMESCO Finland
Rhinopharyngoscopy
7.3
9.4
22
34
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.0
9.3
70
329
C34.90
ICD-10 Finland
Malignant tumor in unspecified location in bronchus and lung without histology
20.1
9.1
13
7
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
15.2
8.9
14
10
2310A
ICD-9 Finland
Carcinoma in situ of respiratory system, Larynx
+∞
8.4
8
*
DQB30
NOMESCO Finland
Laryngectomy
+∞
8.4
8
*
WX734
NOMESCO Finland
JET-ventilation
83.9
7.5
8
*
UDQ02
NOMESCO Finland
Direct laryngoscopy
83.9
7.5
8
*
DQE00
NOMESCO Finland
Implantation of prosthetic replacement for larynx
83.9
7.5
8
*
8070/2-C32.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of larynx, NOS
+∞
7.3
7
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
16.8
7.3
11
7
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.0
6.9
42
168
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.1
6.7
38
145
WZC30
NOMESCO Finland
Teaching
3.5
6.7
31
102
UJC02
NOMESCO Finland
Rigid oesophagoscopy
72.7
6.5
7
*
C32.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of larynx
+∞
6.3
6
*
8070/2-C34.3
ICD-O-3
Squamous cell carcinoma in situ, NOS, of lower lobe, lung
+∞
6.3
6
*
8140/2-C34.3
ICD-O-3
Adenocarcinoma in situ, NOS, of lower lobe, lung
+∞
6.3
6
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
6.0
6.2
16
29
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
6.1
54
266

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_EAR_RESP – Carcinoma in situ of middle ear and respiratory system

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).