This is a non-core endpoint: only basic statistics are computed.
Carcinoma in situ of middle ear and respiratory system
CD2_INSITU_EAR_RESP
No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
89 |
4. Check minimum number of eventsNone |
89 |
5. Include endpoints |
170 |
6. Filter based on genotype QC (FinnGen only) |
167 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D00-D09
- Name in latin
- Carcinoma in situ auris mediae sive systematis respiratorii
Carcinoma in situ of middle ear and respiratory system
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 167 | 48 | 119 |
| Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.05 |
| Median age at first event (years) | 68.52 | 66.17 | 69.47 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 170
- Matched controls
- 1700
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D02.0
ICD-10 Finland
Carcinoma in situ: Larynx
+∞
58.8
53
*
C32.0
ICD-10 Finland
Malignant neoplasm: Glottis
148.3
51.2
52
5
DQB10
NOMESCO Finland
Endoscopic excision of lesion of larynx
105.9
49.3
52
7
UDQ12
NOMESCO Finland
Flexible laryngoscopy
10.5
36.0
46
58
DQA10
NOMESCO Finland
Biopsy of larynx
84.2
31.2
34
5
ZXC10
NOMESCO Finland
Use of laser
37.6
28.6
36
12
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
53.7
26.6
31
7
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
10.2
24.4
30
35
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
63.7
23.8
27
5
8070/3-C32.9
ICD-O-3
Squamous cell carcinoma, NOS, of larynx, NOS
264.1
23.2
23
*
C32.9
ICD-10 Finland
Malignant neoplasm: Larynx, unspecified
+∞
22.4
21
*
UDQ22
NOMESCO Finland
Microlaryngoscopy
41.5
20.5
25
7
J38.3
ICD-10 Finland
Other diseases of vocal cords
28.9
20.3
27
11
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
5.1
19.5
51
131
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.7
19.0
42
93
8140/2-C34.1
ICD-O-3
Adenocarcinoma in situ, NOS, of upper lobe, lung
+∞
18.0
17
*
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
56.3
17.4
20
*
8070/2-C32.0
ICD-O-3
Squamous cell carcinoma in situ, NOS, of glottis
+∞
17.0
16
*
C320, 8077, 2
ICD-O-3
+∞
17.0
16
*
WF002
NOMESCO Finland
Radical radiotherapy
6.1
16.8
33
65
J37.0
ICD-10 Finland
Chronic laryngitis
13.2
16.0
28
25
EP1AE
NOMESCO Finland
Neck ultrasound examination
7.0
14.6
24
39
D02.2
ICD-10 Finland
Carcinoma in situ: Bronchus and lung
+∞
13.7
13
*
D02.3
ICD-10 Finland
Carcinoma in situ: Other parts of respiratory system
+∞
12.7
12
*
DQB70
NOMESCO Finland
Total excision of vocal cord
139.9
12.6
13
*
8070/3-C32.0
ICD-O-3
Squamous cell carcinoma, NOS, of glottis
139.9
12.6
13
*
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
17.6
12.5
19
12
UDH02
NOMESCO Finland
Rhinopharyngoscopy
5.4
12.1
26
55
WZC00
NOMESCO Finland
Treatment plan or consultation
3.1
11.8
81
386
DQB30
NOMESCO Finland
Laryngectomy
69.9
11.8
13
*
DQE00
NOMESCO Finland
Implantation of prosthetic replacement for larynx
128.3
11.6
12
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
17.5
10.6
16
10
130
Kela drug reimbursment
Malignant tumour
3.7
10.4
38
122
XX3DW
NOMESCO Finland
Time consuming IT work
3.6
10.4
40
133
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.7
10.0
25
60
UJC01
NOMESCO Finland
Scopy of lower throat
14.6
9.9
16
12
WX734
NOMESCO Finland
JET-ventilation
+∞
9.5
9
*
C32.1
ICD-10 Finland
Malignant neoplasm: Supraglottis
94.6
8.5
9
*
2310A
ICD-9 Finland
Carcinoma in situ of respiratory system, Larynx
+∞
8.4
8
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
8.3
58
270
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
26.4
7.7
10
*
WX402
NOMESCO Finland
General anaesthesia
2.9
7.6
41
166
GDC01
NOMESCO Finland
Thoracoscopic lobectomy of lung
14.2
7.5
12
9
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.8
7.4
44
187
8070/2-C32.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of larynx, NOS
+∞
7.3
7
*
C34.90
ICD-10 Finland
Malignant tumor in unspecified location in bronchus and lung without histology
12.8
7.2
12
10
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
14.6
7.0
11
8
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.8
6.8
22
64
WZC30
NOMESCO Finland
Teaching
2.8
6.7
39
163
C32.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of larynx
72.5
6.5
7
*
8140/2-C34.3
ICD-O-3
Adenocarcinoma in situ, NOS, of lower lobe, lung
+∞
6.3
6
*
GDB21
NOMESCO Finland
Thoracoscopic segmental resection of lung
+∞
6.3
6
*
A07AA02
ATC
nystatin; oral
4.0
6.1
18
49
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
11
17
6.84
4.86
1.0
1.1
—
—
—
0
0
14
37
4.03
4.00
1.1
1.3
—
—
—
0
0
16
55
3.11
3.85
2.6
3.1
—
—
—
0
0
96
705
1.83
3.64
17.3
16.0
1.37
1.33
inr
0.17
28
198
82
596
1.73
3.05
3.1
2.9
—
—
—
0
0
10
26
4.02
3.03
1.5
1.6
14.62
14.40
ug/l
—
10
26
10
26
4.02
3.03
1.7
2.0
—
—
—
0
0
65
446
1.74
2.95
3.8
3.2
2.34
2.34
mmol/l
0.06
57
382
89
670
1.69
2.85
6.2
6.8
1.21
1.21
mmol/l
0.03
80
564
82
613
1.65
2.64
5.8
6.1
1.21
1.20
mmol/l
0.43
77
548
7
15
4.82
2.62
1.9
1.5
—
—
—
0
0
11
36
3.19
2.62
1.5
1.5
—
—
—
0
0
7
16
4.51
2.50
2.0
1.5
—
—
—
0
0
8
21
3.94
2.49
1.1
1.3
—
—
—
0
0
8
24
3.44
2.21
1.8
1.4
—
—
—
0
0
47
318
1.66
2.16
3.1
2.9
—
—
—
0
0
10
37
2.81
2.11
1.6
1.9
—
—
—
0
0
10
37
2.81
2.11
1.7
1.9
—
—
—
0
0
5
10
5.11
2.08
2.4
1.4
—
—
—
0
0
5
11
4.65
1.95
2.4
1.4
—
—
—
0
0
89
713
1.52
1.95
10.9
10.1
4.47
4.25
e9/l
0.36
81
623
5
14
3.65
1.62
2.2
1.4
—
—
—
0
0
17
95
1.88
1.49
2.5
3.2
56.00
58.41
ml/min/173m2
—
7
39
24
163
1.55
1.09
7.0
4.7
3.76
47.32
ug/l
0.84
24
137
28
198
1.50
1.06
4.3
4.7
32.44
32.57
%
0.02
18
130
10
53
1.94
1.03
4.7
3.0
4.21
4.20
pmol/l
—
10
43
22
154
1.49
0.89
1.8
1.9
—
—
—
0
0
60
506
1.29
0.80
2.8
3.3
—
—
—
0
0
0
24
0.00
0.80
0.0
1.3
—
1.74
—
0
7
51
423
1.29
0.77
4.2
3.7
3.03
8.13
mg/mmol
1.93
31
272
30
231
1.36
0.74
2.3
2.1
—
—
—
0
0
96
863
1.26
0.74
5.0
3.7
15.40
14.96
pmol/l
0.88
86
748
5
26
1.95
0.71
1.4
1.2
—
—
—
0
0
82
727
1.25
0.71
4.7
3.2
58.04
58.81
u/l
0.03
75
664
5
27
1.88
0.69
2.4
1.6
—
—
—
0
0
5
27
1.88
0.69
2.2
1.6
—
—
—
0
0
68
593
1.24
0.67
4.9
5.4
0.00
0.00
estimate
-0.00
18
115
58
498
1.25
0.66
1.8
2.2
81.20
76.72
nmol/l
0.46
51
429
21
157
1.39
0.63
1.9
2.0
—
—
—
0
0
5
30
1.69
0.62
2.2
1.6
—
—
—
0
0
68
599
1.23
0.60
3.8
4.1
0.00
0.01
estimate
0.50
18
123
7
113
0.60
0.60
1.4
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
8
52
1.56
0.60
2.1
3.4
41.73
37.42
g/l
—
8
46
30
240
1.30
0.59
3.3
1.9
29.77
29.78
s
0.00
30
230
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
63
553
1.22
0.58
2.1
2.1
99.78
92.72
pmol/l
0.60
41
296
68
604
1.21
0.55
3.7
4.1
0.00
0.00
estimate
-0.00
17
106
9
62
1.48
0.54
1.4
2.2
—
—
—
0
0
99
913
1.20
0.53
4.7
4.2
14.91
13.54
mm/h
0.33
88
828
21
165
1.31
0.48
6.1
3.6
—
—
—
0
0
36
304
1.23
0.47
1.9
1.7
1168.61
1142.88
nmol/l
0.07
30
224
127
1206
1.21
0.46
23.8
18.0
28.58
27.48
mg/l
0.14
116
993
16
122
1.34
0.44
1.7
3.2
68.21
66.16
g/l
0.59
16
110
8
56
1.45
0.43
2.1
3.3
1.26
0.26
g/l
—
8
49
5
32
1.58
0.42
2.2
1.6
—
—
—
0
0
8
59
1.37
0.41
2.0
3.2
2.73
3.05
g/l
—
8
53
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
8
60
1.35
0.41
2.0
3.1
8.85
10.52
g/l
—
8
53
14
106
1.35
0.40
2.1
3.2
4.35
4.27
kpa
0.07
14
99
12
158
0.74
0.39
1.2
1.3
54.12
11.15
u/ml
—
5
58
65
593
1.16
0.37
5.5
4.4
51.54
42.04
ng/l
0.21
57
455
63
574
1.16
0.36
2.3
2.4
—
—
—
0
0
41
361
1.18
0.36
1.4
1.7
20.84
21.30
nmol/l
0.06
33
298
114
1193
0.87
0.35
5.2
5.4
2.39
2.59
mmol/l
1.39
101
1073
40
354
1.17
0.33
4.1
4.3
0.00
0.00
estimate
-0.00
14
103
107
1120
0.88
0.31
4.4
4.3
1.27
1.25
mmol/l
0.07
94
998
10
130
0.75
0.30
1.1
1.3
—
—
—
0
0
43
386
1.15
0.30
3.1
3.2
1.52
0.49
e6/l
0.53
34
296
111
1157
0.88
0.29
4.8
4.8
1.44
1.43
mmol/l
0.11
99
1039
31
272
1.17
0.28
2.0
1.7
1.08
1.51
mg/l
0.81
23
213
114
1093
1.13
0.28
6.0
4.4
1.94
2.00
mu/l
0.17
100
953
8
64
1.26
0.28
2.0
3.1
—
—
—
0
0
8
64
1.26
0.28
2.0
3.1
6.67
7.39
g/l
—
8
58
8
64
1.26
0.28
2.0
3.1
3.41
3.62
g/l
—
8
58
13
104
1.27
0.27
2.4
1.6
1.82
1.84
%
0.03
13
80
13
104
1.27
0.27
1.8
2.0
7.79
12.86
nmol/l
1.89
13
89
14
170
0.81
0.26
1.1
1.2
48.02
43.31
iu/ml
—
6
63
51
550
0.90
0.23
5.7
4.6
23.42
21.20
%
0.49
34
284
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
19
218
0.86
0.21
2.3
3.2
1.85
2.01
e6/l
0.05
11
125
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
52
485
1.10
0.20
3.5
3.3
770.33
1556.38
ng/l
1.68
43
405
113
1164
0.91
0.18
4.7
4.8
4.34
4.44
mmol/l
0.40
101
1056
50
468
1.10
0.18
4.5
4.4
—
—
—
0
0
37
342
1.10
0.17
2.4
3.0
361.32
7291.49
umol/l
1.49
28
286
121
1179
1.09
0.16
5.5
5.1
6.29
6.14
mmol/l
0.58
108
1051
117
1140
1.08
0.15
22.7
16.6
74.86
74.46
ml/min/173m2
0.08
102
926
7
87
0.80
0.15
1.7
3.4
0.98
0.19
e6/l
—
7
87
19
212
0.88
0.15
2.1
2.4
2.27
2.27
g/l
0.01
19
193
37
395
0.92
0.13
3.4
3.2
0.92
0.77
ug/l
0.65
29
280
28
299
0.92
0.10
2.0
1.8
427.18
457.33
pmol/l
0.21
22
245
72
698
1.05
0.09
5.8
5.4
2.41
2.85
ug/l
0.35
64
602
5
47
1.07
0.09
1.2
1.5
—
—
—
0
0
11
97
1.14
0.09
1.2
1.5
—
—
—
0
0
5
62
0.80
0.08
2.6
3.9
10.40
1398.77
u/ml
—
5
53
21
225
0.92
0.08
2.2
3.0
0.53
0.96
e6/l
0.80
13
130
7
84
0.83
0.07
2.0
1.8
—
—
—
0
0
19
178
1.08
0.06
4.8
9.6
—
—
—
0
0
99
997
0.98
0.01
27.7
20.9
16.33
15.61
%
0.45
99
979
113
1136
0.98
0.00
8.4
6.4
41.83
41.20
mmol/mol
0.31
101
1040
130
1305
0.98
0.00
35.3
25.8
39.26
39.41
%
0.09
118
1207
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
0.31
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.7
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
88
0.90
-0.00
2.4
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: CD2_INSITU_EAR_RESP – Carcinoma in situ of middle ear and respiratory system
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).