Risteys · CD2_INSITU

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions not C3_BRONCHUS_LUNG	510818
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D02.2& Hospital discharge: ICD-9 — 2312 Cause of death: ICD-10 — D02.2& Cause of death: ICD-9 — 2312 Cancer registry: Topography ICD-O-3 — C34 Cancer registry: Morphology ICD-O-3 — ANY Cancer registry: Behaviour codes — 2 3 out of 7 registries used, show all original rules.	43
4. Check minimum number of events None	43
5. Include endpoints None	43
6. Filter based on genotype QC (FinnGen only)	41

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	41	16	25
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	68.98	68.22	69.47

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(4035726) Immunohistochemistry procedure

6.39

5.28

1.6

1.2

—

(3022217) INR in Platelet poor plasma by Coagulation assay

186

4.94

5.10

12.5

14.5

1.48

1.30

inr

—

(40768804) Tissue Pathology biopsy report

129

3.94

4.56

2.8

2.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.92

4.53

3.0

2.0

—

(4200892) Spirometry reversibility

5.74

4.35

1.4

1.3

—

(3002256) Pathology report gross observation

4.81

4.21

1.5

1.3

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

3.93

3.83

8.2

4.8

3.59

91.78

ug/l

0.52

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

158

3.57

3.77

3.2

2.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

5.12

3.20

4.4

10.4

26.06

25.01

mmol/l

—

(3042631) Mycobacterium sp identified in Specimen

11.06

3.05

2.6

6.8

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

11.06

3.05

1.0

1.2

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

157

2.93

2.87

5.2

4.8

35.28

34.52

g/l

0.38

148

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

192

2.86

2.55

10.5

7.1

19.54

11.28

umol/l

0.41

182

(3044640) Blood type and Crossmatch panel - Blood

114

2.65

2.45

3.2

2.1

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

206

2.81

2.38

10.4

12.3

4.38

4.29

e9/l

0.07

176

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

291

3.62

2.32

14.8

8.0

76.16

80.58

u/l

0.32

269

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

4.79

2.23

1.2

1.1

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

4.79

2.23

4.0

1.4

—

(3018418) pH of Serum or Plasma

119

2.49

2.19

3.4

4.9

7.39

7.40

—

(3049717) Cytology report of Urine Cyto stain

3.97

2.16

2.1

2.8

—

(3019225) pH of Specimen

3.15

1.90

3.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

162

2.30

1.85

5.8

6.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.28

1.81

9.6

8.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

111

2.28

1.78

4.4

2.8

25.84

29.92

u/l

0.80

106

(3042936) Bacteria identified in Isolate by Culture

2.50

1.61

1.7

2.0

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

3.62

1.57

9.8

4.3

0.84

0.94

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

2.57

1.51

8.4

11.9

114.67

118.58

g/l

—

(3033658) Prothrombin time (PT) actual/Normal

2.14

1.42

4.3

3.2

89.60

87.19

0.16

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.25

1.23

4.3

10.4

105.90

103.63

mmol/l

—

(3018010) Neutrophils/100 leukocytes in Blood

163

1.88

1.17

5.9

5.3

61.43

58.44

0.59

151

(3037467) Urinalysis macro (dipstick) panel - Urine

243

1.99

1.15

5.5

4.6

—

(3002030) Lymphocytes/100 leukocytes in Blood

164

1.87

1.14

6.1

5.4

24.62

26.77

0.48

152

(3022096) Basophils/100 leukocytes in Blood

155

1.86

1.13

6.5

5.2

0.74

0.64

0.47

141

(3003396) Base excess in Arterial blood by calculation

2.15

1.11

8.4

10.9

2.28

1.65

mmol/l

—

(40768797) Stomach Pathology biopsy report

2.10

1.09

1.6

1.1

—

(3023368) Bacteria identified in Blood by Culture

120

1.86

1.09

3.2

4.4

—

(3000494) Fungus identified in Specimen by Culture

2.05

1.07

1.2

1.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.43

1.06

2.6

1.4

—

(3000492) Spirometry study

2.43

1.06

1.2

1.5

—

(3019069) Monocytes/100 leukocytes in Blood

161

1.75

0.96

6.5

5.6

9.12

8.55

0.35

149

(3006504) Eosinophils/100 leukocytes in Blood

161

1.75

0.96

6.3

5.3

3.03

2.59

0.58

149

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.90

0.89

4.0

3.6

2.47

mmol/l

0.00

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

345

0.57

0.81

5.7

2.37

2.55

mmol/l

0.49

307

(3011397) Hemoglobin [Presence] in Urine by Test strip

0.49

0.78

5.6

3.9

—

(3019060) Gas panel - Arterial blood

1.89

0.68

11.0

5.1

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.89

0.68

5.6

14.7

96.56

93.78

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

332

0.61

0.67

5.3

5.1

4.23

4.37

mmol/l

0.32

296

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

331

0.62

0.65

5.6

5.1

1.45

1.44

mmol/l

0.02

290

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

155

1.54

0.63

2.1

3.6

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.62

0.0

6.1

—

(36660697) Celiac disease serology panel - Serum

0.00

0.62

0.0

1.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.62

0.0

2.1

—

(3000991) Gas panel - Venous blood

1.72

0.58

4.0

12.1

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.72

0.58

5.2

5.6

1.19

1.21

mmol/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

318

0.66

0.54

5.1

4.5

1.12

1.25

mmol/l

0.97

279

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.42

0.0

2.0

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.42

0.0

1.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

156

1.39

0.41

2.1

1.9

104.67

93.75

pmol/l

0.39

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.41

0.0

1.0

—

(3003338) MCHC [Mass/volume]

263

0.73

0.38

45.1

23.3

329.26

331.07

g/l

0.47

263

(3003694) ABO and Rh group [Type] in Blood

1.42

0.34

1.4

—

(3021589) Normoblasts [#/volume] in Blood

163

1.30

0.28

15.2

11.9

0.00

e9/l

0.47

134

(3018095) Leukocytes [#/volume] in Urine

144

1.30

0.28

2.6

3.9

714.19

72.85

e6/l

0.44

108

(3001122) Ferritin [Mass/volume] in Serum or Plasma

135

1.29

0.27

2.8

101.13

150.22

ug/l

0.60

120

(3041096) Erythrocytes [Presence] in Urine by Automated

1.29

0.23

6.7

4.8

—

(40761535) Cells panel - Urine sediment

1.21

0.22

4.8

3.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.21

0.22

1.2

1.6

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.21

0.0

1.9

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.21

0.0

1.2

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.21

0.0

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.21

0.0

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.29

0.21

3.2

9.7

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.21

0.0

3.3

—

123.71

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.21

0.0

1.5

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.21

0.0

3.8

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.20

0.0

1.0

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.20

0.0

7.2

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.20

0.20

3.3

4.8

—

33.54

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

365

1.35

0.18

34.1

20.0

85.24

83.76

umol/l

0.11

365

(40758558) Short blood count panel - Blood

103

1.23

0.16

9.0

6.4

—

(1761868) Lipid panel - Serum or Plasma

105

0.82

0.15

4.4

3.3

—

(36304419) Bacteria [Presence] in Urine

114

1.20

0.14

2.5

3.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.13

0.10

1.4

1.8

—

(3013512) EKG study

107

1.17

0.10

4.2

4.6

—

(3027945) Reticulocytes/100 erythrocytes in Blood

1.15

0.09

2.2

1.9

1.52

1.75

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

369

1.26

0.09

30.2

19.4

139.29

139.88

mmol/l

0.47

357

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

366

1.33

0.09

20.1

11.8

24.05

23.79

u/l

0.06

349

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

161

1.09

0.04

2.4

2.3

—

(3026008) Bacteria identified in Urine by Culture

136

0.94

0.01

4.4

3.2

—

(3015736) pH of Urine

146

0.94

0.01

6.5

4.3

—

5.94

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

323

0.96

0.00

6.9

4.5

1.68

2.08

mu/l

1.21

271

(3009508) Creatinine [Moles/volume] in Urine

127

1.03

0.00

3.2

8.04

7.60

mmol/l

—

103

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

335

0.94

0.00

7.2

6.7

42.33

41.68

mmol/mol

0.13

305

(3020682) Albumin/Creatinine [Ratio] in Urine

135

0.95

0.00

3.8

4.0

0.65

11.25

mg/mmol

—

(3012516) Albumin [Mass/volume] in Urine

125

1.06

0.00

3.2

3.3

7.92

77.77

mg/l

—

(3035350) Ketones [Presence] in Urine by Test strip

185

0.95

0.00

6.1

4.5

0.00

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

186

1.04

0.00

8.5

6.1

0.00

estimate

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

148

1.02

0.00

7.0

5.0

—

(3009261) Glucose [Presence] in Urine by Test strip

187

1.03

0.00

5.8

4.5

0.00

estimate

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.0

—

(40761511) CBC panel - Blood by Automated count

355

1.09

0.00

29.4

16.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.96

0.00

2.8

4.3

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3000963) Hemoglobin [Mass/volume] in Blood

375

1.11

0.00

41.7

24.7

132.53

134.10

g/l

0.29

366

(3008898) HLA-B27 [Presence]

0.00

0.0

1.1

—

(3010813) Leukocytes [#/volume] in Blood

375

1.11

0.00

41.7

24.7

7.15

6.69

e9/l

0.81

362

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3026361) Erythrocytes [#/volume] in Blood

375

1.11

0.00

41.5

24.7

4.32

4.44

e12/l

0.82

362

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.4

—

(3035941) MCH [Entitic mass]

375

1.11

0.00

41.3

24.5

30.84

30.46

0.63

366

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.0

1.3

—

(3024731) MCV [Entitic volume]

375

1.11

0.00

41.4

24.6

92.76

91.82

0.70

366

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3007461) Platelets [#/volume] in Blood

375

1.11

0.00

41.6

24.7

246.55

240.16

e9/l

0.26

364

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

372

1.18

-0.00

30.3

19.2

4.01

3.99

mmol/l

0.10

360

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

-0.00

0.0

1.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.8

—

106.50

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

-0.00

0.0

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

-0.00

0.0

2.0

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

1.19

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.05

-0.00

1.4

1.8

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

0.97

-0.00

9.0

3.2

13.71

168.50

ng/l

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

3.40

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.6

—

167.32

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.8

—

4.03

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.02

-0.00

1.7

2.9

2.63

2.32

g/l

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

7.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

3.8

—

19.00

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

-0.00

0.0

1.1

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

-0.00

0.0

1.6

—

(3044889) 12 lead EKG panel

270

1.00

-0.00

5.7

4.2

—

(3022948) Iron [Moles/volume] in Serum or Plasma

0.98

-0.00

1.8

2.8

8.47

12.92

umol/l

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

377.60

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

-0.00

0.0

1.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

0.98

-0.00

1.8

1.9

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

374.60

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

0.29

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

6.3

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

-0.00

0.0

1.1

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.8

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

5.0

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.8

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

-0.00

0.0

2.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

(3021901) Oxygen saturation in Capillary blood

0.00

-0.00

0.0

3.8

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_BRONCHUSLUNG – Carcinoma in situ of bronchus and lung

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

NAME	CD2_INSITU_BRONCHUSLUNG
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS	!C3_BRONCHUS_LUNG
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D022
HD_ICD_9	2312
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D022
COD_ICD_9	2312
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C34
CANC_TOPO_EXCL
CANC_MORPH	ANY
CANC_MORPH_EXCL
CANC_BEHAV	2

≡ Risteys

R13

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Carcinoma in situ of bronchus and lung

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Carcinoma in situ of bronchus and lung (CD2_INSITU_BRONCHUSLUNG)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Relationships between endpoints