Thyroid crisis or storm

E4_THYCRISIS

Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E05.5 Cause of death: ICD-10 — E05.5 2 out of 7 registries used, show all original rules.	89
4. Check minimum number of events None	89
5. Include endpoints None	89
6. Filter based on genotype QC (FinnGen only)	89

Control definitions (FinnGen only)

Control exclude: E4_THYROID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E05
Name in latin: Crisis thyreotoxica

NAME	E4_THYCRISIS
CONTROL_EXCLUDE	E4_THYROID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E055
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E055
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Thyroid crisis or storm based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	550	428	119
Only index persons	515	401	114
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	50.42	49.11	55.48
Only index persons	49.42	47.76	55.28

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	89	70	19
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	49.16	47.50	55.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
79: Matched controls
789

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E05.5

ICD-10 Finland

Thyroid crisis or storm

+∞

105.7

E05.0

ICD-10 Finland

Thyrotoxicosis with diffuse goitre

+∞

85.7

H03BB01

ATC

carbimazole; oral

2180.6

84.1

H03AA01

ATC

levothyroxine sodium; systemic

270.5

72.3

E05.9

ICD-10 Finland

Thyrotoxicosis, unspecified

+∞

53.2

BAA60

NOMESCO Finland

Total thyroidectomy

+∞

42.6

104

Kela drug reimbursment

Thyroid insufficiency

+∞

40.0

E89.01

ICD-10 Finland

Postsurgical hypothyroidism

+∞

28.9

H06.2*E05.9

ICD-10 Finland

Dysthyroid exophthalmos

+∞

23.0

E03.9

ICD-10 Finland

Hypothyroidism, unspecified

60.7

13.4

E05.2

ICD-10 Finland

Thyrotoxicosis with toxic multinodular goitre

139.3

11.8

E89.00

ICD-10 Finland

Postirradiation hypothyroidism

+∞

11.7

H062, E050

ICD-10 Finland

+∞

10.6

E03.89

ICD-10 Finland

Other specified hypothyroidism

+∞

10.6

C07AA05

ATC

propranolol; systemic

5.7

10.4

E03

ICD-10 Finland

Other hypothyroidism

50.1

7.9

E05

ICD-10 Finland

Thyrotoxicosis [hyperthyroidism]

50.1

7.9

BA1AE

NOMESCO Finland

Thyroiid ultrasound examination

+∞

7.4

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.7

6.9

171

H05.2

ICD-10 Finland

Exophthalmic conditions

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

5.48

8.59

1.5

1.2

352.3

96.3

iu/ml

—

(42868691) Thyroxine (T4) free [Moles/volume] in Serum or Plasma by Dialysis

+∞

6.32

2.3

0.0

38.5

—

pmol/l

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

334

2.82

5.27

7.5

5.6

1.2

mmol/l

0.41

279

(3018418) pH of Serum or Plasma

214

2.58

4.50

3.8

3.5

7.4

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

5.76

3.61

1.0

1.1

—

16.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

290

2.12

3.00

3.9

3.5

34.9

35.9

g/l

0.57

276

(3022096) Basophils/100 leukocytes in Blood

324

2.05

2.76

7.3

5.1

0.7

0.6

0.12

299

(3002030) Lymphocytes/100 leukocytes in Blood

347

2.01

2.62

7.3

5.0

25.2

27.9

0.81

330

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

267

1.99

2.56

1.8

101.7

97.2

pmol/l

0.24

127

(3019309) Folate [Moles/volume] in Red Blood Cells

106

2.28

2.52

1.3

1.7

932.9

1316.8

nmol/l

1.82

(3019225) pH of Specimen

2.76

2.49

3.8

3.5

—

(3006504) Eosinophils/100 leukocytes in Blood

333

1.96

2.47

7.3

5.0

2.6

2.7

0.07

312

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.35

2.18

2.3

2.0

25.9

27.8

u/l

0.22

(3018010) Neutrophils/100 leukocytes in Blood

337

1.84

2.08

7.7

4.9

58.1

57.7

0.07

322

(42870588) Differential panel, method unspecified - Blood

231

1.85

2.00

7.1

4.7

—

(40758558) Short blood count panel - Blood

186

1.83

1.79

6.5

7.8

—

(3032080) INR in Blood by Coagulation assay

256

1.76

1.78

14.0

6.4

1.4

1.1

inr

0.60

(3022145) Colonoscopy Study observation

2.15

1.64

1.2

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.83

1.61

1.1

—

(3001604) Monocytes [#/volume] in Blood

356

1.68

1.59

7.6

5.3

0.6

0.5

e9/l

0.52

317

(3013650) Neutrophils [#/volume] in Blood by Automated count

435

1.69

1.57

10.5

9.7

4.2

e9/l

0.01

380

(3007164) IgA [Mass/volume] in Serum or Plasma

161

1.77

1.50

1.5

1.3

2.1

g/l

0.00

100

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

689

2.07

1.44

15.0

11.6

85.5

85.6

ml/min/173m2

0.02

555

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

172

1.72

1.42

1.5

1.2

1.4

1.2

u/ml

—

(3013115) Eosinophils [#/volume] in Blood

373

1.62

1.42

7.7

5.8

0.2

e9/l

0.02

334

(3006315) Basophils [#/volume] in Blood

354

1.62

1.41

7.7

5.4

0.0

e9/l

0.24

315

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

123

1.81

1.39

5.8

2.8

60.5

70.3

ng/l

0.06

(40768443) Skin Pathology biopsy report

2.72

1.39

1.0

1.3

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

2.60

1.32

2.5

1.7

251.4

230.7

ug/l

—

(3044640) Blood type and Crossmatch panel - Blood

237

1.62

1.32

1.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

508

1.64

1.32

3.8

3.9

—

(4010399)

2.16

1.31

1.7

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

763

2.30

1.29

15.1

11.8

18.8

21.4

mg/l

0.33

576

(36660697) Celiac disease serology panel - Serum

2.10

1.28

1.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.50

1.26

1.2

2.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.50

1.26

1.2

2.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.50

1.26

2.3

1.6

—

(3023368) Bacteria identified in Blood by Culture

169

1.67

1.26

3.0

3.7

—

(4035726)

1.98

1.20

1.8

1.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

137

1.70

1.20

1.2

1.3

53.0

8.3

u/ml

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

165

1.62

1.12

1.7

1.5

1.3

1.1

mg/l

0.10

132

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

246

1.54

1.10

3.3

3.7

37.9

24.2

ng/l

0.47

160

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.46

1.10

1.0

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

2.11

1.09

2.7

1.4

—

(40768804) Tissue Pathology biopsy report

314

1.50

1.04

2.0

1.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.73

0.90

1.6

1.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.94

0.90

1.1

2.4

—

(3044889) 12 lead EKG panel

483

1.43

0.83

4.1

3.6

—

(3021589) Normoblasts [#/volume] in Blood

316

1.42

0.82

11.2

9.8

0.0

e9/l

0.53

262

(3020630) Protein [Mass/volume] in Serum or Plasma

1.73

0.81

1.0

2.6

64.6

69.1

g/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.88

0.80

2.0

1.5

—

(3000492) Spirometry study

1.73

0.79

1.3

1.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

666

1.53

0.77

5.7

5.3

38.7

39.0

mmol/mol

0.12

629

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

310

1.39

0.76

2.2

2.1

74.3

75.3

nmol/l

0.07

275

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

172

1.45

0.74

1.8

1.9

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.81

0.73

1.3

1.6

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.72

0.70

1.0

—

(3000991) Gas panel - Venous blood

1.68

0.68

11.9

5.4

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.83

0.67

1.2

1.4

—

(3015736) pH of Urine

288

1.35

0.65

2.9

3.3

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.77

0.65

1.4

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.69

0.64

1.4

1.7

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.61

0.0

1.3

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.60

0.0

1.3

—

19.0

—

(3020891) Body temperature

0.00

0.60

0.0

4.1

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.60

0.0

1.2

—

1.9

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.71

0.58

14.0

2.9

22.8

24.5

mmol/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

171

1.38

0.57

1.3

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.56

0.56

1.3

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

172

1.37

0.55

2.0

3.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

746

1.52

0.54

4.8

4.6

2.8

mmol/l

0.25

691

(40768793) Breast Pathology biopsy report

1.58

0.54

1.8

1.2

—

(1002224) Polysomnography panel

1.54

0.52

1.0

1.1

—

(3035350) Ketones [Presence] in Urine by Test strip

365

1.29

0.51

3.1

3.6

0.0

estimate

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

715

1.43

0.51

4.7

4.2

5.8

mmol/l

0.02

657

(3013512) EKG study

185

1.33

0.48

4.0

3.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

183

0.72

0.46

8.6

5.0

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.50

0.41

2.4

1.9

4.7

5.1

kpa

—

(3009261) Glucose [Presence] in Urine by Test strip

373

1.24

0.40

3.1

3.5

0.0

estimate

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

144

1.31

0.39

1.7

1.5

—

(3000494) Fungus identified in Specimen by Culture

1.41

0.38

1.6

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

716

1.30

0.33

18.9

12.3

39.6

39.4

0.08

545

(40761511) CBC panel - Blood by Automated count

793

1.43

0.33

16.2

10.8

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.40

0.32

1.1

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

350

1.20

0.32

3.7

—

(3022621) pH of Urine by Test strip

1.38

0.32

1.7

2.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

370

1.20

0.32

4.7

5.0

0.0

estimate

—

(1761868) Lipid panel - Serum or Plasma

277

0.82

0.31

3.0

2.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.28

0.27

3.1

3.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

106

1.27

0.25

2.1

1.7

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

3.7

—

3.9

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

3.7

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

3.7

—

108.5

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

3.4

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.3

—

(4281824)

0.00

0.21

0.0

1.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.21

0.0

1.2

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.20

0.0

2.1

—

9.5

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.20

0.0

1.3

—

(3012544) pH of Venous blood

1.25

0.19

2.4

3.0

—

(40761536) Microorganisms panel - Urine sediment

1.17

0.17

3.8

3.4

—

(3029937) Albumin [Presence] in Urine by Test strip

192

0.86

0.16

3.7

3.6

0.0

estimate

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.79

0.16

2.5

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.74

0.16

2.2

6.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.17

0.16

1.4

1.7

—

(3030467) Casts [#/volume] in Urine by Automated count

201

0.87

0.15

2.7

2.6

0.6

0.4

e6/l

0.31

145

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.77

0.15

1.4

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.20

0.13

1.9

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

116

0.84

0.12

2.1

—

(3042936) Bacteria identified in Isolate by Culture

1.18

0.12

1.8

1.9

—

(36304419) Bacteria [Presence] in Urine

197

0.89

0.11

2.7

2.6

—

(21494755) Public health laboratory ask at order entry panel

1.17

0.11

1.2

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

213

1.11

0.10

3.7

3.3

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.07

0.09

1.4

1.5

—

(3012516) Albumin [Mass/volume] in Urine

166

1.11

0.08

3.5

3.0

12.0

54.9

mg/l

1.49

108

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

245

0.92

0.08

2.8

2.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

544

0.94

0.07

3.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

288

1.06

0.05

3.7

3.6

—

(3003694) ABO and Rh group [Type] in Blood

221

0.93

0.05

1.3

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

108

0.92

0.03

1.9

2.0

—

(3026008) Bacteria identified in Urine by Culture

238

0.95

0.02

2.6

2.8

—

(40768797) Stomach Pathology biopsy report

1.08

0.02

1.1

1.2

—

(3018095) Leukocytes [#/volume] in Urine

253

1.04

0.01

2.9

3.4

31.1

40.6

e6/l

0.13

169

(3000850) Epithelial cells [#/volume] in Urine

145

1.04

0.00

2.6

2.3

5.0

6.3

e6/l

0.27

129

(46235355) HIV 1 and 2 tests - Meaningful Use set

151

0.99

0.00

2.0

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

121

0.99

0.00

1.6

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.96

0.00

2.3

1.7

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.7

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

257.1

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

3.7

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.4

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

1.6

—

(3004451) EKG impression Narrative

0.00

0.0

1.8

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.8

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.2

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.0

—

15.7

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

26.0

—

2161.2

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.0

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.1

—

274.3

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.8

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.3

—

(4146454)

0.00

0.0

2.4

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

0.0

1.0

—

114.2

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

3.4

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.6

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

6.7

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.00

0.00

1.5

1.8

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.4

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

127.2

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3002385) Erythrocyte distribution width [Ratio]

640

1.00

0.00

23.7

14.9

13.5

13.8

0.97

628

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

2.4

—

12.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.1

—

(3002256) Pathology report gross observation

0.94

0.00

1.1

1.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3012565) Volume of 24 hour Urine

0.00

0.0

3.8

—

2180.0

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

3.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.3

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.0

—

31.8

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.8

—

2.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

4.7

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

9.2

—

1126.8

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.1

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

7.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYCRISIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYCRISIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_THYCRISIS – Thyroid crisis or storm

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Thyroid crisis or storm

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints