Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
89 |
4. Check minimum number of eventsNone |
89 |
5. Include endpointsNone |
89 |
6. Filter based on genotype QC (FinnGen only) |
89 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Crisis thyreotoxica
Similar endpoints
↥List of similar endpoints to
Thyroid crisis or storm
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis, other and/or unspecified
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
- Disorders of the thyroid gland
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 550 | 428 | 119 |
| Only index persons | 515 | 401 | 114 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 50.42 | 49.11 | 55.48 |
| Only index persons | 49.42 | 47.76 | 55.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 89 | 70 | 19 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 49.16 | 47.50 | 55.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 79
- Matched controls
- 789
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.5
ICD-10 Finland
Thyroid crisis or storm
+∞
105.7
76
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
85.7
66
*
H03BB01
ATC
carbimazole; oral
2180.6
84.1
67
*
H03AA01
ATC
levothyroxine sodium; systemic
270.5
72.3
69
19
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
53.2
45
*
BAA60
NOMESCO Finland
Total thyroidectomy
+∞
42.6
37
*
104
Kela drug reimbursment
Thyroid insufficiency
+∞
40.0
35
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
28.9
26
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
23.0
21
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
60.7
13.4
15
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
139.3
11.8
12
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
11.7
11
*
H062, E050
ICD-10 Finland
NA
+∞
10.6
10
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
+∞
10.6
10
*
C07AA05
ATC
propranolol; systemic
5.7
10.4
35
96
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
50.1
7.9
9
*
E03
ICD-10 Finland
Other hypothyroidism
50.1
7.9
9
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
+∞
7.4
7
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.7
6.9
40
171
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYCRISIS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYCRISIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_THYCRISIS – Thyroid crisis or storm
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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