Postpolio syndrome

G6_POSTPOLIO

postpoliomyelitis syndrome: Postpoliomyelitis syndrome (PPS) is a neurologic disorder characterized by the development of new neuromuscular symptoms such as progressive muscular weakness or abnormal muscle fatigability occurring in survivors of the acute paralytic form of poliomyelitis (see this term), 15-40 years after recovery from the disease, and that is unexplained by other medical causes. Other manifestations that can occur gradually include generalized fatigue, muscle atrophy, muscle and joint pain, intolerance to cold, and difficulties sleeping, swallowing or breathing.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G14 Hospital discharge: ICD-9 — 138 Hospital discharge: ICD-8 — 4499 Cause of death: ICD-10 — G14 Cause of death: ICD-9 — 138 Cause of death: ICD-8 — 4499 2 out of 7 registries used, show all original rules.	75
4. Check minimum number of events None	75
5. Include endpoints None	75
6. Filter based on genotype QC (FinnGen only)	75

Control definitions (FinnGen only)

Control exclude: G6_NEUATR

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	G6_POSTPOLIO
CONTROL_EXCLUDE	G6_NEUATR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G14
HD_ICD_9	138
HD_ICD_8	4499
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G14
COD_ICD_9	138
COD_ICD_8	4499
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Postpolio syndrome based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	981	555	407
Only index persons	561	364	197
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	58.18	58.22	57.94
Only index persons	52.38	53.03	51.18

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	75	45	30
Unadjusted period prevalence (%)	0.01	0.02	0.01
Median age at first event (years)	49.07	45.89	53.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
69: Matched controls
689

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

1380A

ICD-9 Finland

Late effects of acute poliomyelitis[SEQUELAE POLIOMYELITIDIS]

+∞

93.7

B91

ICD-10 Finland

Sequelae of poliomyelitis

632.7

51.6

04499

ICD-8 Finland

Late effects of actue poliomyelitis

+∞

22.0

N70

ICPC

Poliomyelitis

+∞

15.1

Z46.8

ICD-10 Finland

Fitting and adjustment of other specified devices

12.9

7.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.75

2.11

1.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

299

1.82

1.74

11.7

6.7

1.2

mmol/l

0.41

246

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.76

1.71

4.4

6.7

—

(40758558) Short blood count panel - Blood

138

1.84

1.48

4.2

6.4

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

2.30

1.26

6.6

3.6

0.1

e6/l

—

(3019060) Gas panel - Arterial blood

2.09

1.24

2.3

3.5

—

(3000991) Gas panel - Venous blood

2.15

1.23

6.5

6.3

—

(40768804) Tissue Pathology biopsy report

226

1.63

1.21

1.8

2.1

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.17

1.19

4.0

6.6

92.7

94.6

—

(3025941) Bacteria identified in Stool by Culture

0.00

1.19

0.0

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.48

1.11

1.2

3.1

—

(3016502) Oxygen saturation in Arterial blood

1.86

1.07

3.3

5.4

94.9

95.4

0.20

(3022621) pH of Urine by Test strip

2.04

1.07

4.3

2.4

—

(3003694) ABO and Rh group [Type] in Blood

126

1.68

1.04

1.2

1.3

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.80

1.03

4.1

4.9

5.3

5.0

kpa

0.56

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.81

0.99

5.8

5.2

1.0

1.1

mmol/l

0.15

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

258

1.50

0.90

2.1

85.9

91.1

pmol/l

0.24

124

(3022948) Iron [Moles/volume] in Serum or Plasma

1.64

0.83

2.5

2.2

12.6

12.9

umol/l

0.06

(4010399)

1.74

0.81

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.79

0.0

1.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.66

0.78

4.8

5.3

102.9

103.4

mmol/l

0.10

(3012544) pH of Venous blood

1.77

0.76

4.3

3.7

—

(3049717) Cytology report of Urine Cyto stain

2.16

0.76

1.6

3.9

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.07

0.74

2.4

1.9

—

(3044640) Blood type and Crossmatch panel - Blood

173

1.48

0.74

2.7

2.2

—

(3022313) Gas panel - Capillary blood

1.99

0.72

5.4

4.4

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.84

0.67

2.4

2.3

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.61

0.0

1.5

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.61

0.0

2.8

—

0.2

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.60

0.57

3.4

2.4

3.2

4.8

ug/l

—

(3042936) Bacteria identified in Isolate by Culture

1.57

0.57

2.1

2.0

—

(3009343) pH of Capillary blood

1.67

0.57

5.0

3.8

—

7.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

219

1.36

0.56

4.6

3.2

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.58

0.54

5.0

3.7

5.0

kpa

—

(3026008) Bacteria identified in Urine by Culture

222

1.34

0.51

4.1

3.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.61

0.50

1.9

1.7

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.46

0.50

2.5

2.2

2.4

2.3

g/l

0.71

(3020630) Protein [Mass/volume] in Serum or Plasma

1.47

0.47

9.6

3.8

62.7

64.8

g/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

104

1.43

0.47

2.3

1.9

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

215

1.32

0.47

3.2

2.5

145.0

124.6

ug/l

0.16

193

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.44

0.46

1.4

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

123

1.38

0.45

3.0

2.1

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

313

1.29

0.45

8.5

9.6

4.4

4.3

e9/l

0.05

274

(3007853) Bacteria identified in Skin by Aerobe culture

1.45

0.44

1.8

1.5

—

(40761535) Cells panel - Urine sediment

1.42

0.43

3.0

3.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.43

0.43

1.2

1.8

2.3

2.8

g/l

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.41

0.0

1.4

—

(40768797) Stomach Pathology biopsy report

1.44

0.41

1.3

1.2

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.41

0.0

3.4

—

7.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.41

0.0

1.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.41

0.0

1.1

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.41

0.0

6.1

—

32.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.8

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.8

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.40

0.0

3.2

—

1.5

—

(36304419) Bacteria [Presence] in Urine

163

1.31

0.39

3.1

3.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

120

0.72

0.39

3.9

6.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.42

0.39

1.6

—

(3018095) Leukocytes [#/volume] in Urine

221

1.27

0.38

5.3

3.9

229.4

70.7

e6/l

0.66

164

(1761868) Lipid panel - Serum or Plasma

144

0.72

0.37

2.0

3.7

—

(3023368) Bacteria identified in Blood by Culture

183

1.29

0.37

4.4

4.1

—

(42870588) Differential panel, method unspecified - Blood

174

1.29

0.37

6.0

4.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.43

0.36

10.7

3.3

—

(3001604) Monocytes [#/volume] in Blood

261

1.25

0.36

6.0

5.5

0.6

e9/l

0.22

229

(3006315) Basophils [#/volume] in Blood

262

1.24

0.34

6.1

5.6

0.0

e9/l

0.07

229

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.36

0.34

2.3

3.3

0.8

mmol/l

0.35

(3013707) Erythrocyte sedimentation rate by Westergren method

407

1.20

0.27

5.8

4.5

19.5

14.6

mm/h

1.05

365

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.69

0.25

7.3

9.2

—

(3000492) Spirometry study

1.38

0.24

1.8

1.4

—

(3013115) Eosinophils [#/volume] in Blood

271

1.18

0.23

6.2

5.7

0.2

e9/l

0.14

237

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

289

0.85

0.23

5.0

30.7

33.9

ng/l

0.12

219

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.21

0.0

1.5

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

3.5

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

3.1

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

3.8

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.1

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

2.8

—

4.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

2.8

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.21

0.0

2.5

—

1.5

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

2.8

—

108.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.21

0.0

1.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

253

1.17

0.21

3.8

4.0

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.21

0.0

1.7

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.21

0.0

3.4

—

16.3

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.5

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

128

1.21

0.20

4.3

—

(3002256) Pathology report gross observation

1.23

0.19

1.4

1.3

—

(3044889) 12 lead EKG panel

396

0.87

0.19

3.2

4.7

—

(3000494) Fungus identified in Specimen by Culture

1.18

0.18

1.6

1.5

—

(3013512) EKG study

203

0.85

0.18

4.2

4.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.22

0.17

2.3

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.18

0.17

2.3

1.7

—

(3030467) Casts [#/volume] in Urine by Automated count

172

1.14

0.13

3.5

3.1

0.5

0.4

e6/l

0.14

134

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

552

1.14

0.12

23.5

16.9

28.3

23.8

mg/l

0.46

441

(3041096) Erythrocytes [Presence] in Urine by Automated

166

0.88

0.11

3.6

4.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

226

0.90

0.10

2.8

2.3

—

(3019225) pH of Specimen

1.12

0.08

14.7

3.8

—

(3037467) Urinalysis macro (dipstick) panel - Urine

415

1.08

0.08

6.4

5.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.83

0.08

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

446

1.08

0.07

21.0

16.6

38.2

38.5

0.08

270

(3032080) INR in Blood by Coagulation assay

257

1.08

0.06

9.3

8.9

1.6

1.3

inr

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

520

1.07

0.04

22.0

16.8

86.2

70.2

ml/min/173m2

3.77

416

(3026493) Urate [Moles/volume] in Serum or Plasma

149

0.93

0.03

4.2

3.6

366.9

8014.5

umol/l

1.05

116

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

138

0.93

0.03

1.5

1.7

1.2

1.3

mmol/l

0.12

110

(3020564) Creatinine [Moles/volume] in Serum or Plasma

572

1.06

0.02

28.1

20.7

72.6

81.8

umol/l

0.72

572

(3015736) pH of Urine

222

1.05

0.02

3.8

4.3

—

(3021589) Normoblasts [#/volume] in Blood

234

1.04

0.00

6.6

11.9

0.0

e9/l

0.71

195

(40761511) CBC panel - Blood by Automated count

559

1.01

0.00

18.8

17.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

131

0.99

0.00

4.6

4.9

23.3

21.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

234

0.98

0.00

4.5

4.8

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.89

0.00

2.2

4.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

2.5

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.1

—

197.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

6.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.8

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.8

—

(3004451) EKG impression Narrative

0.00

0.0

1.7

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.3

—

(44806118)

0.00

0.0

1.5

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

0.99

0.00

3.2

1.9

29.0

29.2

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.6

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.8

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

2.8

—

88.4

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.8

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

2.2

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.8

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.8

—

(4024509)

0.00

0.0

1.2

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.8

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

4.3

—

57.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.8

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

1142.3

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.7

—

31.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.8

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.8

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.5

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.2

—

6.9

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

42.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.8

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.1

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(44790049)

0.00

0.0

1.5

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.4

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(44790047)

0.00

0.0

1.5

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

4.6

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

440.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.2

—

(44790048)

0.00

0.0

1.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_POSTPOLIO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_POSTPOLIO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: G6_POSTPOLIO – Postpolio syndrome

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Postpolio syndrome

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints