No definition available.
Systemic atrophies primarily affecting the central nervous system
DOID EFO Endpoint Browser PheWeb
G6_NEUATR
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1420 |
4. Check minimum number of eventsNone |
1420 |
5. Include endpoints |
1609 |
6. Filter based on genotype QC (FinnGen only) |
1568 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Systemic atrophies primarily affecting the central nervous system
based on the number of shared cases.
Similar with more cases:
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16815 | 7755 | 8724 |
| Only index persons | 10265 | 4914 | 5351 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.22 | 0.24 |
| Only index persons | 0.19 | 0.18 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 61.80 | 62.97 | 60.68 |
| Only index persons | 60.13 | 60.86 | 59.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1568 | 677 | 891 |
| Unadjusted period prevalence (%) | 0.34 | 0.24 | 0.41 |
| Median age at first event (years) | 62.54 | 60.56 | 64.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1609
- Matched controls
- 16090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N99
ICPC
Neurological disease other
49.2
307.7
264
64
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
29.4
307.7
233
92
G12.2
ICD-10 Finland
Motor neuron disease
12927.0
307.7
736
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
30.4
284.5
191
71
R47.1
ICD-10 Finland
Dysarthria and anarthria
33.7
282.3
183
61
J96.1
ICD-10 Finland
Chronic respiratory failure
15.2
246.3
228
173
G11.9
ICD-10 Finland
Hereditary ataxia, unspecified
+∞
243.0
227
*
N07XX02
ATC
riluzole; oral
+∞
225.4
211
*
N28
ICPC
Limited function/disability (N)
18.9
218.9
178
105
R27.0
ICD-10 Finland
Ataxia, unspecified
52.8
196.8
113
23
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.2
174.1
349
693
G12.9
ICD-10 Finland
Spinal muscular atrophy, unspecified
+∞
159.0
150
*
TAB00
NOMESCO Finland
Lumbar puncture
7.3
131.0
206
316
G11.2
ICD-10 Finland
Late-onset cerebellar ataxia
+∞
126.8
120
*
M03BX01
ATC
baclofen; systemic
12.5
123.5
125
108
R4130
NOMESCO Finland
Speech therapy
9.8
121.7
147
164
R13
ICD-10 Finland
Dysphagia
5.2
117.8
276
620
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
7.1
116.9
189
298
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
6.2
113.6
211
383
Z31.5
ICD-10 Finland
Genetic counselling
7.0
112.5
183
290
Z51.5
ICD-10 Finland
Palliative care
4.5
107.9
308
809
G12.8
ICD-10 Finland
Other spinal muscular atrophies and related syndromes
+∞
102.2
97
*
N29
ICPC
Neurological sympt/complt other
10.1
100.3
117
124
N03AE01
ATC
clonazepam; systemic
5.2
93.6
210
451
R1250
NOMESCO Finland
Evaluation of functional capability
8.7
89.9
117
143
B91
ICD-10 Finland
Sequelae of poliomyelitis
31.6
88.8
58
19
TJD20
NOMESCO Finland
Change of gastrostomy tube
31.1
86.8
57
19
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
8.1
86.7
120
158
G72.9
ICD-10 Finland
Myopathy, unspecified
16.1
85.9
74
48
G11.8
ICD-10 Finland
Other hereditary ataxias
+∞
77.7
74
*
1380A
ICD-9 Finland
Late effects of acute poliomyelitis[SEQUELAE POLIOMYELITIDIS]
+∞
76.7
73
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.9
75.9
257
755
L28
ICPC
Limited function/disability (L)
2.9
71.6
451
1925
G12.1
ICD-10 Finland
Other inherited spinal muscular atrophy
696.9
68.5
67
*
SPAT1229
SPAT
Assessment of need for aid
3.7
66.1
239
731
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.2
63.7
186
489
A28
ICPC
Limited function/disability NOS
2.7
62.8
442
1981
WX725
NOMESCO Finland
Noninvasive ventilation
4.3
61.8
172
436
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
6.2
59.2
105
180
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.7
57.9
205
616
NXL00
NOMESCO Finland
Biopsy of muscle
23.3
56.5
41
18
N19
ICPC
Speech disorder
8.5
51.1
67
82
N18
ICPC
Paralysis/weakness
6.1
50.3
89
152
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.8
49.7
302
1242
G11.4
ICD-10 Finland
Hereditary spastic paraplegia
+∞
49.2
47
*
R25.3
ICD-10 Finland
Fasciculation
21.0
48.8
37
18
XG466
NOMESCO Finland
Sleep oxymetry
5.0
47.5
107
228
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.3
47.3
197
654
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
9.0
47.2
59
68
N02AA01
ATC
morphine; systemic, rectal
6.1
46.0
82
141
R1260
NOMESCO Finland
Evaluation of communicative skills
6.4
45.7
77
125
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
4.4
44.2
117
284
G10
ICD-10 Finland
Huntington disease
+∞
44.0
42
*
R4120
NOMESCO Finland
Occupational therapy
3.4
42.6
166
528
R4190
NOMESCO Finland
Nutritional therapy
4.4
41.3
109
264
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
40.9
351
1689
D21
ICPC
Swallowing problem
6.6
39.0
64
101
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.0
36.6
110
293
R5599
NOMESCO Finland
Other rehabilitation service
4.6
36.1
88
200
SPAT1231
SPAT
Assessment of adjustments needed in living environment
5.3
35.8
74
146
G31.0
ICD-10 Finland
Circumscribed brain atrophy
12.8
35.0
34
27
R47.8
ICD-10 Finland
Other and unspecified speech disturbances
7.8
34.5
48
63
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
5.0
33.0
73
153
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.4
29.6
76
180
34899
ICD-8 Finland
Motor neurone disease, Other and unspecified manifestations
+∞
28.2
27
*
XA402
NOMESCO Finland
ENMG
4.5
26.8
66
151
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
23.6
26.2
37
16
R26.0
ICD-10 Finland
Ataxic gait
23.0
25.3
36
16
XG416
NOMESCO Finland
Measurement of maximal airway pressure
+∞
25.1
24
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.5
24.4
60
137
UDQ42
NOMESCO Finland
Endoscopic assessment of swallowing function
29.6
24.1
32
11
F80.1
ICD-10 Finland
Expressive language disorder
7.5
23.8
34
46
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
6.0
23.6
42
72
Z50.5
ICD-10 Finland
Speech therapy
5.7
23.6
44
79
3342A
ICD-9 Finland
Spinocerebellar disease, Primary cerebellar degeneration
+∞
23.0
22
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.4
22.9
168
743
R5110, ,
SPAT
2.6
22.3
138
563
G62.8
ICD-10 Finland
Other specified polyneuropathies
6.4
21.9
36
57
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
5.1
21.7
46
93
04499
ICD-8 Finland
Late effects of actue poliomyelitis
222.9
21.6
22
*
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.6
21.6
137
566
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.1
21.5
91
303
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
5.9
21.1
38
66
G35
ICD-10 Finland
Multiple sclerosis
6.0
20.5
36
61
N03AX12
ATC
[U] gabapentin; oral
1.9
20.3
287
1634
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
6.3
20.2
34
55
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
20.2
343
2069
Z50.1
ICD-10 Finland
Other physical therapy
2.7
20.1
114
445
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
7.4
20.0
29
40
L99
ICPC
Musculoskeletal disease other
4.5
20.0
49
112
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.5
19.9
126
520
XG467
NOMESCO Finland
Nocturnal CO2 monitoring
40.6
19.5
24
6
SPAT1216
SPAT
Assessment of functional ability
1.9
18.9
293
1715
G12.0
ICD-10 Finland
Infantile spinal muscular atrophy, type I [Werdnig-Hoffman]
+∞
18.8
18
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
18.6
132
574
XA800
NOMESCO Finland
Neuropsychological investigation
2.9
17.9
84
297
G11.18
ICD-10 Finland
Early-onset cerebellar ataxia
181.9
17.5
18
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
17.3
526
3702
N70
ICPC
Poliomyelitis
42.5
17.3
21
5
XX9TE
NOMESCO Finland
Compementary ultrasound examination
7.6
17.0
24
32
Z82.0
ICD-10 Finland
Family history of epilepsy and other diseases of the nervous system
25.9
16.9
23
9
JDB01
NOMESCO Finland
Laparoscopic gastrostomy
91.0
16.6
18
*
M62.5
ICD-10 Finland
Muscle wasting and atrophy, not elsewhere classified
23.3
16.4
23
10
R4120, ,
SPAT
6.2
16.4
28
46
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
4.5
16.4
40
91
SPAT1297
SPAT
Other function in accordance with speech therapy nomenclature
12.9
16.2
28
22
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.2
16.1
140
664
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
5.8
15.9
29
51
WPA10
NOMESCO Finland
Proactive palliative care treatment plan
7.3
15.7
23
32
3352A
ICD-9 Finland
Anterior horn cell disease, Motor neuron disease[SCLEROSIS LATERALIS AMYOTROPHICA]
+∞
15.6
15
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
15.6
253
1496
L19
ICPC
Muscle symptom/complaint NOS
3.4
15.1
55
167
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
15.1
267
1620
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.4
15.0
107
467
A98
ICPC
Health maint/preventive medicine
0.6
14.8
1247
13693
XW5WT
NOMESCO Finland
Other blood specimen with radiologicl guidance
32.0
14.8
19
6
G60.0
ICD-10 Finland
Hereditary motor and sensory neuropathy
18.6
14.7
22
12
G11.00
ICD-10 Finland
Cerebellar dysplasia and aplasia
+∞
14.6
14
*
G71.08
ICD-10 Finland
Other muscular dystrophy
36.4
14.4
18
5
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
15.5
14.4
23
15
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
14.3
474
3375
T05
ICPC
Feeding problem of adult
5.5
14.0
27
50
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
5.8
13.7
25
44
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
5.6
13.4
25
45
NJ3BG
NOMESCO Finland
MRI examination of extremities with high intensity magnet
18.4
13.4
20
11
RS314, ,
NOMESCO Finland
26.0
13.4
18
7
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
13.2
449
3209
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
4.4
13.1
33
77
SPAT1234
SPAT
Support of social functional capacity
2.3
13.1
102
462
R26.2
ICD-10 Finland
Difficulty in walking, not elsewhere classified
3.9
13.1
38
99
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
5.5
13.1
25
46
N05BA06
ATC
lorazepam; systemic, sublingual
2.3
12.6
99
450
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
2.4
12.5
87
375
3343A
ICD-9 Finland
Spinocerebellar disease, Other cerebellar ataxia
+∞
12.5
12
*
Z3229
NOMESCO Finland
Other healthcare associate professional
2.0
12.5
148
789
G82.1
ICD-10 Finland
Spastic paraplegia
37.8
12.2
15
*
N06AA09
ATC
amitriptyline; systemic
1.9
12.2
157
861
N02AA05
ATC
oxycodone; systemic
1.6
12.1
313
2092
RS340, ,
NOMESCO Finland
26.9
12.0
16
6
SPAT1167
SPAT
Insertion of urinary catheter
2.6
12.0
70
278
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
5.0
11.7
25
51
WX781
NOMESCO Finland
Remote monitoring, noninvasive ventilation
65.4
11.6
13
*
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
11.2
11.5
21
19
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
11.5
438
3190
G13.0
ICD-10 Finland
Paraneoplastic neuromyopathy and neuropathy
+∞
11.5
11
*
3351X
ICD-9 Finland
Anterior horn cell disease, Spinal muscular atrophy[ATROPHIA MUSCULORUM SPINALIS NUD]
+∞
11.5
11
*
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
4.6
11.4
27
60
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
3.5
11.1
38
111
GX2D5
NOMESCO Finland
Sleep oximetry
8.1
11.1
24
30
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
10.1
11.0
21
21
RS222, ,
NOMESCO Finland
4.1
11.0
30
75
A06AD11
ATC
lactulose; oral
1.6
10.9
262
1717
G61.8
ICD-10 Finland
Other inflammatory polyneuropathies
21.6
10.7
15
7
TNX05
NOMESCO Finland
Simple incision of soft tissue, unspecified region
14.3
10.5
17
12
ABD40
NOMESCO Finland
Implantation of spinal injection device
110.7
10.4
11
*
7812A
ICD-9 Finland
Symptoms involving nervous and musculoskeletal systems, Abnormality of gait
+∞
10.4
10
*
A120_, ,
NOMESCO Finland
+∞
10.4
10
*
34898
ICD-8 Finland
Motor neurone disease, Alii definiti
+∞
10.4
10
*
A210_, ,
NOMESCO Finland
+∞
10.4
10
*
3349X
ICD-9 Finland
Spinocerebellar disease, unspecified
+∞
10.4
10
*
AA1AD
NOMESCO Finland
CT of head and brain
1.5
10.4
435
3220
G71.3
ICD-10 Finland
Mitochondrial myopathy, not elsewhere classified
32.7
10.3
13
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
3.4
10.3
37
112
M54.1
ICD-10 Finland
Radiculopathy
2.4
10.3
67
281
RK110, ,
NOMESCO Finland
4.7
10.3
23
49
R5140
NOMESCO Finland
Monitoring the use of the aid
1.8
10.2
176
1055
R49.08
ICD-10 Finland
Other specified dysphonia
3.2
9.9
39
125
SPAT1245
SPAT
Provision of support and information to patient’s family members
2.2
9.9
81
376
RS221, ,
NOMESCO Finland
3.7
9.8
31
86
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.7
9.8
52
197
U04
ICPC
Incontinence urine
2.1
9.7
92
452
N94
ICPC
Peripheral neuritis/neuropathy
17.6
9.4
14
8
G11
ICD-10 Finland
Hereditary ataxia
+∞
9.4
9
*
F02.29*G10
ICD-10 Finland
Dementia in Huntington's disease without information on additional symptoms
+∞
9.4
9
*
G11.02
ICD-10 Finland
Dysequilibrium syndrome
+∞
9.4
9
*
Z3226
NOMESCO Finland
Physiotherapist
1.5
9.3
278
1913
Z02.4
ICD-10 Finland
Examination for driving licence
0.6
9.3
237
3436
N81
ICPC
Injury nervous system other
10.7
9.3
17
16
N03AF01
ATC
carbamazepine; oral, rectal
2.1
9.3
89
440
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.5
9.1
30
86
XKD06
NOMESCO Finland
Physiologic investigation of micturition
2.4
9.0
59
248
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
3.7
9.0
28
77
RS142, ,
NOMESCO Finland
18.7
8.9
13
7
G04BD12
ATC
mirabegron; oral
1.7
8.9
187
1181
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
3.3
8.9
33
102
JDB00
NOMESCO Finland
Gastrostomy
24.1
8.9
12
5
G71.9
ICD-10 Finland
Primary disorder of muscle, unspecified
24.1
8.9
12
5
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
4.4
8.9
22
51
J96.9
ICD-10 Finland
Respiratory failure, unspecified
4.5
8.8
21
47
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.4
8.8
60
257
N05BA01
ATC
diazepam; systemic, rectal
1.6
8.8
199
1283
SPAT1254
SPAT
Administration of medicine
1.6
8.7
229
1528
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
7.2
8.7
20
28
M41.4
ICD-10 Finland
Neuromuscular scoliosis
50.3
8.7
10
*
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
3.2
8.7
34
109
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.7
8.7
147
877
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
2.3
8.6
66
298
Z99.8
ICD-10 Finland
Dependence on other enabling machines and devices
16.4
8.6
13
8
XKC03
NOMESCO Finland
Water cystometry
2.5
8.5
52
212
N06AX21
ATC
duloxetine; oral
1.7
8.5
157
959
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
2.7
8.5
45
171
OAB43, ,
SPAT
0.5
8.4
97
1728
R42
ICD-10 Finland
Dizziness and giddiness
1.5
8.4
335
2445
R25.1
ICD-10 Finland
Tremor, unspecified
2.5
8.4
50
202
G13.2*E03.9
ICD-10 Finland
Systemic atrophy primarily affecting central nervous system in myxoedema
+∞
8.3
8
*
RP120, ,
NOMESCO Finland
+∞
8.3
8
*
A220_, ,
NOMESCO Finland
+∞
8.3
8
*
NGA20
NOMESCO Finland
Exploration of soft tissue knee or lower leg, open
10.8
8.3
15
14
SPAT1262
SPAT
Handing over of treatment supplies
1.5
8.3
269
1882
Z46.9
ICD-10 Finland
Fitting and adjustment of unspecified device
3.5
8.3
27
77
XG410
NOMESCO Finland
Flow-volume spirometry
2.2
8.2
69
324
N05BA04
ATC
oxazepam; oral
1.4
8.2
367
2735
N06AB04
ATC
citalopram; systemic
1.5
8.1
289
2059
N04BB01
ATC
amantadine; oral
3.5
8.1
27
78
Z73.6
ICD-10 Finland
Limitation of activities due to disability
4.2
8.0
21
51
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
2.0
8.0
80
403
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
7.9
318
2321
Z2446
NOMESCO Finland
Social worker
1.9
7.9
103
568
ZY010
NOMESCO Finland
Hospital outpatient
2.1
7.9
69
330
M62.9
ICD-10 Finland
Disorder of muscle, unspecified
10.9
7.8
14
13
N05BA09
ATC
clobazam; oral
7.0
7.8
18
26
WPA40
NOMESCO Finland
Individual-centered psychosocial intervention in palliative care
45.2
7.7
9
*
N87
ICPC
Parkinsonism
3.2
7.7
29
91
TNH33
NOMESCO Finland
Custom moulded brace, ankle or foot
3.3
7.7
28
86
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.0
7.6
79
402
Z93.1
ICD-10 Finland
Gastrostomy status
18.4
7.6
11
6
G82.2
ICD-10 Finland
Paraplegia, unspecified
8.1
7.6
16
20
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.7
7.5
127
756
N06AB10
ATC
escitalopram; oral
1.5
7.4
240
1675
N04BC05
ATC
pramipexole; oral
1.8
7.4
115
669
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.0
7.3
78
401
34800
ICD-8 Finland
Motor neurone disease, Amyotrophic lateral sclerosis
+∞
7.3
7
*
G72.8
ICD-10 Finland
Other specified myopathies
2.8
7.3
34
121
XA421
NOMESCO Finland
Nocturnal polygraphy
9.4
7.3
14
15
RT274, ,
NOMESCO Finland
15.8
7.2
11
7
UJC01
NOMESCO Finland
Scopy of lower throat
3.6
7.2
23
65
WPA43
NOMESCO Finland
A doctor's home visit to perform palliative care
30.1
7.1
9
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
1.8
7.1
100
564
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
6.1
7.1
18
30
GD1AA, ,
SPAT
0.4
6.9
34
822
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
4.1
6.8
18
44
G60.9
ICD-10 Finland
Hereditary and idiopathic neuropathy, unspecified
40.2
6.8
8
*
WPA13
NOMESCO Finland
Palliative consultation
7.2
6.7
15
21
N86
ICPC
Multiple sclerosis
7.2
6.7
15
21
SPAT1301
SPAT
No procedures
1.4
6.7
439
3478
N02BF01
ATC
gabapentin; oral
1.7
6.7
113
675
R4110
NOMESCO Finland
Physiotherapy
1.4
6.6
395
3082
J96.0
ICD-10 Finland
Acute respiratory failure
2.9
6.6
29
100
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.1
6.6
60
292
RS310, ,
NOMESCO Finland
12.3
6.6
11
9
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
3.5
6.6
22
64
R33
ICD-10 Finland
Retention of urine
1.6
6.5
142
906
W19
ICD-10 Finland
Unspecified fall
1.6
6.5
144
923
RS230, ,
NOMESCO Finland
5.7
6.5
17
30
N07AA02
ATC
pyridostigmine; systemic
5.7
6.5
17
30
GX1P5
NOMESCO Finland
Nocturnal CO2 monitoring
70.1
6.4
7
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.6
6.4
142
910
N03AX16
ATC
[U] pregabalin
1.4
6.4
325
2467
K11.72
ICD-10 Finland
Xerostomia
14.4
6.4
10
7
R1420, ,
SPAT
14.4
6.4
10
7
R53
ICD-10 Finland
Malaise and fatigue
1.4
6.3
328
2497
RS122, ,
NOMESCO Finland
8.2
6.3
13
16
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
3.6
6.3
20
56
TJD10
NOMESCO Finland
Insertion of other tube into stomach or duodenum
11.1
6.3
11
10
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
2.8
6.3
31
114
S12
ICPC
Insect bite/sting
0.4
6.3
29
721
R63.4
ICD-10 Finland
Abnormal weight loss
2.1
6.3
60
298
3348X
ICD-9 Finland
Spinocerebellar disease, Other spinocerebellar diseases
+∞
6.3
6
*
33098
ICD-8 Finland
Hereditary neuromuscular disorders, Alii definiti
+∞
6.3
6
*
A222_, ,
NOMESCO Finland
+∞
6.3
6
*
3350A
ICD-9 Finland
Anterior horn cell disease, Werdnig-Hoffmann disease[MORBUS WERDNIG-HOFFMANN]
+∞
6.3
6
*
M89.6
ICD-10 Finland
Osteopathy after poliomyelitis
+∞
6.3
6
*
A211_, ,
NOMESCO Finland
+∞
6.3
6
*
SPAT1125
SPAT
Stoma care and guidance
2.8
6.2
30
109
Z99.1
ICD-10 Finland
Dependence on respirator
26.8
6.2
8
*
N06DX01
ATC
memantine; oral
0.4
6.2
36
815
A06AH03
ATC
naloxegol; oral
2.9
6.2
28
98
OAA67, ,
SPAT
0.4
6.2
37
828
G81.9
ICD-10 Finland
Hemiplegia, unspecified
3.3
6.1
22
67
R26
ICD-10 Finland
Abnormalities of gait and mobility
12.6
6.1
10
8
WX320
NOMESCO Finland
Spinalanesthesy
0.7
6.1
192
2690
Z2445
NOMESCO Finland
Psychologist
2.2
6.1
51
241
6BA02, ,
NOMESCO Finland
10.1
6.0
11
11
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.6
6.0
153
2241
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
107
79
14.44
116.05
1.1
1.0
—
—
—
0
0
108
83
13.88
114.44
1.2
1.1
38.12
42.55
mg/l
0.32
91
71
106
80
14.11
113.50
1.1
1.1
277.20
286.91
mg/l
0.13
94
70
187
322
6.44
105.95
1.5
1.4
561.23
526.44
mg/l
0.13
181
299
113
117
10.31
98.52
1.0
1.1
—
—
—
0
0
117
137
9.13
92.98
1.1
1.1
—
—
—
0
0
161
285
6.17
88.36
1.5
1.4
3.73
3.85
mmol/l
0.73
151
266
91
85
11.29
85.08
1.1
1.1
0.09
5.10
nmol/l
1.36
11
15
154
273
6.13
84.32
1.7
1.6
495.16
936.05
e6/l
0.36
127
223
154
273
6.13
84.32
1.6
1.5
6.28
40.96
e6/l
0.94
122
218
275
805
3.91
81.93
2.6
2.5
16.42
23.84
au/ml
—
9
45
254
721
4.00
78.89
1.4
1.3
54.86
57.25
au/ml
—
7
46
759
4083
2.63
77.06
2.6
2.2
257.82
234.19
u/l
0.30
725
3818
71
65
11.38
67.14
1.1
1.1
1.08
1.09
u/l
0.08
31
36
61
65
9.72
51.80
1.1
1.5
5.39
8.64
u/l
0.63
50
51
41
28
15.00
46.04
1.0
1.1
—
—
—
0
0
230
959
2.63
36.12
4.7
4.7
2.81
1.85
mmol/l
3.35
205
720
238
1013
2.58
35.83
5.0
4.6
5.55
5.15
kpa
8.50
233
968
265
1199
2.45
34.98
2.2
2.9
67.56
66.41
g/l
2.02
246
1089
35
43
8.30
26.55
1.3
1.2
144.88
117.78
nmol/l
0.29
25
32
1084
12644
0.56
23.92
4.6
5.1
2.77
2.67
mmol/l
2.76
956
11543
132
516
2.70
23.29
1.4
2.7
2.44
2.96
g/l
8.93
123
463
138
553
2.64
23.17
1.4
2.7
3.39
3.60
g/l
1.08
128
501
138
554
2.63
23.09
1.4
2.7
6.80
7.36
g/l
4.53
129
501
138
554
2.63
23.09
1.4
2.7
—
—
—
0
0
1056
12372
0.57
22.97
4.2
4.6
4.65
4.55
mmol/l
2.57
940
11367
1046
12268
0.58
22.49
4.2
4.5
1.46
1.43
mmol/l
0.96
934
11190
124
505
2.58
20.12
1.7
2.2
852.81
482.59
ug/l
0.25
116
475
196
980
2.14
19.85
2.2
3.0
10.69
10.67
g/l
0.02
172
904
123
519
2.48
18.52
1.3
2.7
9.77
10.62
g/l
1.30
113
465
280
1631
1.87
18.30
5.7
7.6
5.60
5.11
kpa
7.74
268
1562
279
1632
1.86
17.97
5.7
7.6
10.93
11.86
kpa
3.29
265
1563
1023
11873
0.62
17.68
3.8
4.1
1.32
1.30
mmol/l
0.37
907
10738
1014
11791
0.62
17.65
6.0
6.1
40.16
40.38
mmol/mol
0.28
921
10817
1073
12298
0.62
17.25
4.6
4.8
5.96
6.03
mmol/l
1.09
962
11090
275
1635
1.82
16.72
5.6
7.6
2.93
1.15
mmol/l
11.30
231
1297
30
55
5.54
15.74
1.1
1.1
17.18
296.35
ng/l
—
5
14
117
537
2.27
14.58
1.6
1.9
38.08
38.80
u/l
0.17
106
466
24
41
5.93
13.54
1.1
1.1
—
—
—
0
0
24
42
5.79
13.22
1.1
1.1
—
—
—
0
0
163
902
1.90
12.29
6.2
7.7
26.56
24.61
mmol/l
5.98
155
859
219
3418
0.58
12.19
1.7
1.7
1.37
1.37
mmol/l
0.00
191
2832
1288
13933
0.62
12.14
25.4
23.2
6.91
6.79
e9/l
0.47
1244
13478
1288
13930
0.62
12.07
25.4
23.2
250.29
244.18
e9/l
2.82
1252
13526
1289
13936
0.62
12.01
25.6
23.3
133.95
134.91
g/l
1.51
1268
13683
45
140
3.28
11.96
1.0
1.9
—
1744.00
—
0
5
1289
13934
0.62
11.96
25.4
23.2
4.43
4.47
e12/l
1.39
1244
13483
1289
13923
0.63
11.68
25.5
23.3
39.58
39.95
%
1.13
1180
12906
90
414
2.24
11.18
1.5
2.6
0.00
0.02
g/l
0.72
81
381
728
5885
1.43
11.06
4.4
5.0
35.55
35.06
g/l
1.52
681
5475
818
6758
1.43
10.99
7.0
7.2
1.22
1.21
mmol/l
3.76
699
5737
231
1463
1.68
10.98
6.0
8.0
94.36
95.30
%
1.03
222
1414
15
7
21.61
10.68
1.1
1.0
—
—
—
0
0
97
474
2.11
10.38
1.5
2.8
0.65
1.41
g/l
1.00
85
414
22
27
8.25
10.32
1.0
1.4
—
—
—
0
0
89
437
2.10
9.43
1.3
2.6
39.68
37.58
g/l
3.18
80
384
1072
11889
0.71
9.38
16.0
14.7
86.38
77.42
ml/min/173m2
25.55
899
9826
21
45
4.72
9.30
1.1
1.2
—
—
—
0
0
20
42
4.81
9.07
1.2
1.1
—
—
—
0
0
681
5573
1.38
9.04
2.0
2.1
92.79
93.58
pmol/l
0.16
379
2913
68
307
2.27
8.88
2.7
2.5
18.13
15.96
%
5.08
52
160
25
64
3.95
8.88
1.3
1.2
—
—
—
0
0
1243
13399
0.68
8.86
11.3
10.9
27.61
26.40
u/l
1.24
1199
12891
81
393
2.12
8.86
1.4
2.7
0.00
0.00
g/l
-0.00
72
361
368
2719
1.46
8.67
1.7
1.8
1144.24
1162.97
nmol/l
0.14
296
2039
79
389
2.08
8.33
1.4
2.7
0.00
0.00
g/l
-0.00
71
360
308
2228
1.47
8.03
3.1
3.7
0.82
0.82
mmol/l
0.19
287
2085
323
2365
1.46
7.90
1.8
1.9
—
—
—
0
0
221
3151
0.65
7.83
2.7
3.1
0.80
0.77
ug/l
0.25
157
2139
66
311
2.17
7.81
2.4
2.2
138.79
128.83
g/l
2.47
57
234
1253
13416
0.70
7.56
20.1
18.5
71.48
81.14
umol/l
14.12
1253
13411
19
46
4.17
7.28
1.2
1.1
—
—
—
0
0
186
1239
1.57
7.12
5.8
7.1
1.23
1.43
mmol/l
2.57
176
1207
974
10792
0.75
6.86
20.3
18.9
14.90
15.12
%
0.63
961
10574
723
6165
1.31
6.62
6.6
6.4
1.22
1.21
mmol/l
1.83
662
5611
81
438
1.89
6.62
1.3
1.2
7.33
1.06
u/ml
—
6
31
34
131
2.63
6.32
1.2
1.2
—
—
—
0
0
20
57
3.54
6.17
1.0
1.0
—
—
—
0
0
339
4315
0.73
6.16
4.2
3.9
14.64
8.57
mg/mmol
0.82
225
2754
374
2922
1.36
6.15
1.6
1.7
62112257.71
22869448.12
pmol/l
0.42
322
2405
33
129
2.59
5.97
1.2
1.2
—
—
—
0
0
350
4375
0.74
5.53
4.4
4.4
21.66
21.69
%
0.01
186
2182
341
4269
0.74
5.42
4.2
3.2
7.24
7.54
mmol/l
0.69
282
3566
23
82
2.83
4.99
2.5
2.2
—
—
—
0
0
401
3262
1.31
4.88
1.6
1.6
19.78
20.39
nmol/l
0.39
358
2751
1253
13220
0.76
4.60
20.7
18.7
3.94
3.99
mmol/l
8.18
1223
12846
24
93
2.60
4.48
1.1
1.0
29.21
45.54
ng/l
1.39
16
50
11
19
5.82
4.44
1.1
1.1
—
—
—
0
0
11
19
5.82
4.44
1.1
1.1
—
—
—
0
0
871
7841
1.24
4.39
5.4
5.1
6.73
6.80
mmol/l
0.42
825
7386
334
4089
0.77
4.35
3.4
3.3
4184.00
310.66
mg/l
5.01
228
2665
1252
13189
0.77
4.33
20.7
18.5
139.56
139.64
mmol/l
0.41
1227
12836
179
1311
1.41
4.30
2.3
2.3
0.21
0.21
g/l
0.50
167
1222
10
16
6.28
4.29
1.1
1.3
—
—
—
0
0
11
20
5.53
4.29
1.1
1.1
—
—
—
0
0
21
78
2.71
4.26
1.1
1.1
—
—
—
0
0
740
6564
1.24
4.22
14.9
17.3
1.23
1.32
inr
1.92
193
1870
9
13
6.95
4.16
1.1
1.2
—
—
—
0
0
21
80
2.65
4.07
1.6
1.4
—
—
—
0
0
21
80
2.65
4.07
1.6
1.4
—
—
—
0
0
185
1376
1.39
4.07
4.3
4.4
3.19
1.94
mmol/l
4.38
171
1113
23
93
2.49
3.97
1.1
1.0
271.75
304.42
ng/l
0.31
16
53
12
27
4.47
3.93
1.1
1.1
—
—
—
0
0
466
5427
0.80
3.91
4.6
5.1
9.33
3.79
ug/l
0.92
405
4826
17
59
2.90
3.90
1.2
1.2
—
—
—
0
0
217
1667
1.35
3.90
1.8
1.8
—
—
—
0
0
63
376
1.70
3.84
2.0
1.8
—
—
—
0
0
14
38
3.71
3.79
1.1
1.1
—
—
—
0
0
57
332
1.74
3.79
2.9
3.1
31.57
37.17
umol/l
0.97
50
294
19
72
2.66
3.73
1.1
1.2
—
—
—
0
0
52
871
0.58
3.66
1.7
1.8
—
—
—
0
0
108
746
1.48
3.57
6.9
9.4
25.76
24.33
mmol/l
4.30
102
728
22
93
2.38
3.49
1.1
1.0
795.70
599.04
ng/l
—
10
52
35
184
1.92
3.25
1.0
1.1
21.00
80.71
iu/ml
0.72
15
34
7
11
6.39
3.18
1.1
1.0
—
—
—
0
0
145
1912
0.73
3.15
1.2
1.2
5.26
12.57
u/ml
1.91
56
706
79
526
1.53
3.14
1.9
1.8
—
—
—
0
0
85
580
1.49
3.02
1.8
2.0
—
—
—
0
0
629
6979
0.84
2.99
2.7
2.7
—
—
—
0
0
16
63
2.56
2.96
1.6
1.4
—
—
—
0
0
7
13
5.40
2.87
1.0
1.1
—
—
—
0
0
297
3528
0.81
2.85
3.1
2.9
5332.83
6371.02
umol/l
0.16
259
3061
685
6191
1.19
2.84
5.8
6.4
26.39
27.09
%
0.83
649
5773
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
19
84
2.28
2.77
1.1
1.1
—
—
—
0
0
209
1678
1.28
2.76
1.8
1.8
—
—
—
0
0
28
145
1.95
2.76
1.3
1.4
—
—
—
0
0
66
436
1.54
2.76
1.5
1.3
—
—
—
0
0
99
710
1.42
2.75
4.6
5.2
25.47
24.01
mmol/l
4.00
99
690
670
6083
1.17
2.56
5.6
6.1
58.49
57.67
%
0.95
638
5667
6
11
5.47
2.54
1.2
2.2
—
—
—
0
0
27
143
1.90
2.51
1.5
1.5
273.55
279.02
mosm/kgh2o
0.42
20
102
7
16
4.39
2.47
1.0
1.1
—
—
—
0
0
131
1003
1.33
2.47
1.7
1.6
—
—
—
0
0
15
63
2.39
2.46
1.6
1.4
—
—
—
0
0
300
2551
1.22
2.38
1.3
1.2
1.47
1.75
u/ml
0.14
72
642
19
91
2.10
2.33
1.3
1.5
1.52
1.18
promille
0.31
14
70
6
13
4.63
2.27
1.2
1.1
—
—
—
0
0
44
278
1.60
2.27
1.4
1.4
—
—
—
0
0
1214
12624
0.84
2.23
18.4
15.9
26.08
25.92
mg/l
0.05
1029
10115
37
226
1.65
2.19
1.3
1.2
38.68
42.04
u/ml
—
5
21
47
305
1.56
2.18
1.3
1.2
1.99
8.61
u/ml
—
9
47
457
4069
1.17
2.16
3.6
3.3
32.92
38.86
u/l
0.77
437
3867
95
710
1.36
2.13
3.7
3.3
26.07
25.18
mmol/l
1.35
89
685
11
43
2.57
2.08
1.3
1.1
1778.91
1682.72
miu/ml
0.06
11
43
7
20
3.51
2.05
1.3
1.3
—
—
—
0
0
798
7451
1.14
1.90
7.5
9.4
4.21
4.21
e9/l
0.00
697
6499
45
300
1.51
1.89
1.3
1.2
2.81
2.67
u/ml
—
7
27
54
375
1.46
1.86
1.5
1.6
0.27
17.00
iu/ml
0.49
15
71
35
538
0.64
1.85
3.0
3.4
5444.17
7631.43
u/ml
0.11
29
454
570
5211
1.15
1.85
2.4
2.3
77.88
77.70
nmol/l
0.05
504
4599
117
1468
0.78
1.83
3.1
4.2
12.44
21.45
ug/l
0.52
95
1220
109
1375
0.78
1.78
1.4
1.4
—
—
—
0
0
191
1605
1.22
1.74
3.0
4.1
228.08
248.88
u/l
1.50
183
1517
44
298
1.49
1.73
1.1
1.1
—
—
—
0
0
8
30
2.67
1.72
1.0
1.1
—
—
—
0
0
6
19
3.17
1.66
1.2
1.3
—
—
—
0
0
25
403
0.61
1.65
1.6
1.6
3.57
2.91
mg/l
0.12
17
306
221
1894
1.19
1.64
5.8
6.1
1.06
1.05
mmol/l
0.20
206
1740
82
1052
0.77
1.55
2.1
2.2
13.08
13.01
nmol/l
0.02
69
926
16
85
1.89
1.55
1.4
1.9
—
—
—
0
0
77
589
1.32
1.55
4.6
6.1
1.49
1.62
%
0.89
69
555
8
33
2.43
1.54
1.3
1.8
—
—
—
0
0
13
65
2.01
1.48
2.3
4.0
—
—
—
0
0
27
171
1.59
1.46
1.3
1.8
—
—
—
0
0
311
2768
1.15
1.46
4.6
4.1
1.02
1.02
kg/l
0.06
58
410
45
323
1.40
1.37
1.3
1.4
—
—
—
0
0
45
323
1.40
1.37
1.3
1.4
—
—
—
0
0
5
17
2.95
1.36
1.8
1.6
—
—
—
0
0
144
1704
0.83
1.35
1.3
1.4
—
—
—
0
0
12
222
0.54
1.35
1.2
1.1
—
—
—
0
0
23
145
1.59
1.29
3.0
2.6
—
—
—
0
0
8
34
2.36
1.29
1.0
1.1
—
—
—
0
0
114
1368
0.82
1.25
2.4
2.3
148.16
139.29
ug/g
0.13
86
1093
8
36
2.23
1.24
1.3
1.9
—
—
—
0
0
132
1112
1.20
1.22
2.7
3.8
1.22
1.22
mmol/l
0.41
107
959
5
20
2.50
1.15
4.6
5.5
—
—
—
0
0
0
35
0.00
1.15
0.0
1.3
—
—
—
0
0
108
900
1.21
1.13
1.8
1.6
—
—
—
0
0
891
8539
1.10
1.09
5.5
4.6
73.71
2052.25
e6/l
2.00
14
136
13
74
1.76
1.06
2.0
2.4
—
—
—
0
0
6
122
0.49
1.05
1.2
1.6
—
—
—
0
0
136
1168
1.18
1.05
2.0
2.2
380.66
365.67
nmol/l
0.43
120
1077
5
22
2.28
1.03
1.2
1.1
—
—
—
0
0
5
22
2.28
1.03
1.4
1.2
—
—
—
0
0
256
2306
1.13
1.03
1.4
1.5
2.33
2.55
g/l
0.82
155
1358
104
1231
0.83
1.02
3.3
2.4
30.69
77.62
u/l
0.64
86
1048
19
286
0.66
1.01
1.3
1.6
—
—
—
0
0
23
156
1.48
0.98
1.3
1.8
—
—
—
0
0
57
714
0.79
0.97
1.6
1.8
—
—
—
0
0
166
1459
1.15
0.97
4.1
3.5
—
—
—
0
0
0
31
0.00
0.96
0.0
1.3
—
—
—
0
0
66
804
0.81
0.89
1.6
1.9
—
—
—
0
0
8
44
1.82
0.86
2.6
2.8
—
—
—
0
0
8
44
1.82
0.86
2.6
2.8
—
—
—
0
0
31
230
1.35
0.85
1.7
1.7
4.67
4.78
mmol/24h
0.07
25
201
38
292
1.31
0.83
1.2
1.3
—
—
—
0
0
1119
11460
0.92
0.78
4.6
4.6
1.89
2.08
mu/l
1.06
1028
10349
722
6928
1.08
0.77
5.7
6.4
11.78
12.08
umol/l
0.19
687
6574
23
313
0.73
0.75
1.2
1.3
—
—
—
0
0
154
1375
1.13
0.75
1.9
1.7
1.60
1.53
%
0.39
138
1181
12
75
1.60
0.75
1.3
1.2
—
—
—
0
0
12
75
1.60
0.75
1.3
1.2
—
—
—
0
0
25
333
0.75
0.72
4.1
3.2
0.86
0.84
nmol/l
0.07
20
260
477
4524
1.08
0.69
2.6
3.4
2.37
2.35
mmol/l
1.76
411
3932
72
613
1.18
0.68
2.3
2.0
0.59
2.04
ug/l
2.03
63
541
182
1997
0.90
0.67
1.3
1.3
34.94
34.12
iu/ml
0.03
47
645
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
43
527
0.81
0.66
3.0
3.7
0.36
0.35
u/ml
0.03
23
312
46
555
0.82
0.62
1.5
1.3
—
—
—
0
0
16
113
1.42
0.61
5.6
1.8
2.21
4.54
mg/l
4.74
16
108
0
20
0.00
0.60
0.0
1.0
—
25.18
—
0
20
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
22
166
1.33
0.58
1.7
1.5
—
—
—
0
0
22
166
1.33
0.58
1.7
1.5
—
—
—
0
0
8
53
1.51
0.58
1.1
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.6
—
2.08
—
0
9
13
185
0.70
0.58
1.2
1.1
1.63
1.52
g/l
0.82
13
166
504
5266
0.94
0.58
2.8
2.8
157.41
146.55
ug/l
0.24
462
4787
22
167
1.32
0.57
1.7
1.5
—
—
—
0
0
22
167
1.32
0.57
1.6
1.4
—
—
—
0
0
137
1242
1.11
0.56
2.6
3.3
161.97
223.93
ng/l
1.04
131
1146
10
65
1.54
0.55
1.3
1.4
—
—
—
0
0
61
708
0.86
0.55
1.2
1.3
337.12
205.86
u/ml
0.60
55
641
8
126
0.63
0.54
1.1
1.3
—
—
—
0
0
22
169
1.31
0.53
1.7
1.4
—
—
—
0
0
22
169
1.31
0.53
1.7
1.4
—
—
—
0
0
179
1652
1.09
0.52
8.6
7.6
—
—
—
0
0
965
9434
1.06
0.51
4.3
4.2
12.39
13.12
mm/h
0.79
899
8660
307
2900
1.07
0.51
3.2
2.7
6.13
5.24
e6/l
0.42
278
2627
95
850
1.13
0.50
1.5
1.5
—
—
—
0
0
12
167
0.72
0.49
1.4
1.5
—
—
—
0
0
11
76
1.45
0.48
1.1
1.9
—
—
—
0
0
11
76
1.45
0.48
1.1
1.9
—
—
—
0
0
599
6192
0.95
0.47
5.8
5.1
0.00
0.00
estimate
-0.00
116
1172
19
244
0.78
0.47
1.1
1.3
279.75
203.89
miu/ml
—
8
101
23
288
0.80
0.47
1.3
1.3
—
—
—
0
0
404
4219
0.94
0.46
2.8
3.1
1457.94
1622.76
ng/l
0.23
334
3604
230
2162
1.07
0.45
2.5
2.4
29.82
29.97
s
0.18
222
2092
14
104
1.35
0.43
1.3
1.2
—
—
—
0
0
26
316
0.82
0.42
1.4
1.4
—
—
—
0
0
5
33
1.52
0.41
1.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
24
195
1.23
0.40
5.4
5.1
377.23
359.01
umol/l
0.20
19
175
16
123
1.30
0.40
1.1
1.1
—
—
—
0
0
5
34
1.47
0.40
1.4
1.4
—
—
—
0
0
8
61
1.31
0.39
1.1
2.0
—
—
—
0
0
8
61
1.31
0.39
1.1
2.0
—
—
—
0
0
29
345
0.84
0.38
1.4
1.7
—
—
—
0
0
17
133
1.28
0.38
1.1
1.7
—
—
—
0
0
17
133
1.28
0.38
1.1
1.7
—
—
—
0
0
17
133
1.28
0.38
1.1
1.7
—
—
—
0
0
72
648
1.12
0.37
2.4
3.3
4.32
4.47
pmol/l
0.55
64
565
141
1513
0.93
0.37
3.4
3.1
6.92
8.62
umol/l
0.94
119
1334
605
6218
0.96
0.37
4.3
3.8
0.00
0.00
estimate
0.75
124
1253
14
107
1.31
0.37
1.3
1.4
11.79
13.84
u/l
0.75
14
101
5
37
1.35
0.37
1.0
1.5
—
—
—
0
0
272
2593
1.06
0.36
2.7
3.1
2.47
2.45
mmol/l
0.93
231
2259
34
396
0.86
0.36
1.6
1.7
—
—
—
0
0
5
79
0.63
0.35
6.2
3.6
—
—
—
0
0
9
123
0.73
0.35
2.1
2.2
—
—
—
0
0
9
125
0.72
0.35
1.3
1.1
94.22
95.49
%
—
9
119
16
200
0.80
0.34
1.8
1.5
—
—
—
0
0
351
3377
1.05
0.34
4.9
4.0
0.00
0.00
estimate
0.69
112
1115
6
87
0.69
0.33
2.8
1.4
0.91
0.99
g/l
—
6
87
6
87
0.69
0.33
1.3
1.3
—
—
—
0
0
612
6273
0.96
0.33
4.4
3.8
0.00
0.01
estimate
0.80
109
1129
25
295
0.85
0.32
2.6
3.4
444.85
1295.16
u/ml
0.44
25
278
33
379
0.87
0.31
1.3
1.4
—
—
—
0
0
19
156
1.22
0.31
1.1
1.0
—
—
—
0
0
57
514
1.11
0.30
1.9
2.8
—
—
—
0
0
35
398
0.88
0.29
1.4
1.5
250.96
279.11
ug/g
0.43
23
241
42
373
1.13
0.29
1.5
1.6
—
—
—
0
0
29
334
0.87
0.29
1.7
1.7
14231.29
17749.72
e6/l
0.17
21
246
35
396
0.88
0.27
2.2
3.7
90.43
89.75
%
0.05
35
384
8
66
1.21
0.26
1.3
1.2
—
—
—
0
0
19
225
0.84
0.26
1.6
1.7
—
—
—
0
0
29
253
1.15
0.26
1.3
1.8
—
—
—
0
0
29
253
1.15
0.26
1.3
1.8
—
—
—
0
0
5
75
0.67
0.26
1.6
3.8
4.00
24.77
umol/l
—
5
50
19
224
0.85
0.25
5.4
3.9
2.79
1.41
%
0.52
19
206
215
2240
0.95
0.25
3.7
3.1
2.85
1.90
e6/l
0.54
138
1279
49
539
0.91
0.25
1.1
1.1
—
—
—
0
0
32
361
0.88
0.25
1.8
1.7
—
—
—
0
0
23
198
1.16
0.24
1.6
1.5
—
—
—
0
0
6
83
0.72
0.24
2.5
1.6
—
—
—
0
0
13
158
0.82
0.23
1.1
1.3
0.73
0.64
nmol/l
0.55
13
148
51
467
1.10
0.22
3.4
3.8
33.24
54.82
mg/l
0.90
41
384
29
326
0.89
0.22
1.9
1.9
—
—
—
0
0
11
135
0.81
0.22
1.1
1.1
1.42
2.38
u/ml
—
5
72
10
124
0.81
0.21
1.9
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
487
4768
1.03
0.21
4.6
4.0
—
—
—
0
0
388
3785
1.03
0.21
3.8
3.3
0.54
0.50
e6/l
0.13
313
2928
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.04
—
0
6
8
103
0.78
0.21
1.4
1.3
—
—
—
0
0
8
103
0.78
0.21
1.4
1.4
—
—
—
0
0
8
103
0.78
0.21
1.4
1.3
—
—
—
0
0
8
103
0.78
0.21
1.4
1.4
—
—
—
0
0
110
1043
1.06
0.21
4.5
4.2
94.42
93.97
ng/l
0.02
98
908
225
2174
1.04
0.20
2.4
2.6
13.48
12.72
umol/l
0.72
203
2023
946
9354
1.03
0.20
3.8
3.8
15.24
14.91
pmol/l
3.37
870
8376
402
4114
0.97
0.20
3.0
2.6
53.90
79.20
u/l
0.71
374
3794
9
113
0.80
0.20
1.6
1.3
—
—
—
0
0
131
1252
1.05
0.19
2.5
2.7
65.63
69.94
e9/l
0.93
106
965
338
3463
0.97
0.18
2.2
2.2
3.05
3.03
mg/l
0.05
284
2918
6
53
1.13
0.18
1.8
1.1
115.00
181.97
iu/ml
—
6
53
13
109
1.19
0.18
1.2
1.2
8.77
13.67
u/l
0.84
13
100
7
62
1.13
0.17
1.1
2.0
—
—
—
0
0
342
3344
1.03
0.17
5.0
4.3
87.88
86.75
%
0.41
336
3260
5
66
0.76
0.17
1.2
1.2
122.74
438.90
u/l
—
5
58
49
456
1.08
0.16
3.2
3.8
2.87
1.69
ratio
—
5
38
50
466
1.08
0.16
3.5
3.8
43.49
66.49
mg/l
0.86
41
382
8
73
1.10
0.15
1.1
1.2
73.63
85.76
u/l
—
8
66
64
677
0.94
0.15
1.7
1.9
1.45
1.52
g/l
0.29
59
593
7
89
0.79
0.14
1.0
1.2
—
—
—
0
0
13
112
1.16
0.14
1.1
1.4
28.05
29.88
u/l
0.07
13
87
1015
10074
1.02
0.14
7.4
7.7
77.45
80.02
u/l
1.06
957
9446
34
367
0.92
0.14
4.0
3.5
3.16
3.58
g/l
0.87
34
346
8
96
0.83
0.13
1.3
2.4
12.50
18.97
nmol/l
—
8
87
18
201
0.89
0.13
1.1
1.1
—
—
—
0
0
28
257
1.09
0.13
1.5
1.5
—
—
—
0
0
16
180
0.89
0.13
1.2
1.2
1.60
3.17
u/ml
—
5
64
19
211
0.90
0.13
2.7
3.8
—
481.15
—
0
20
9
109
0.82
0.13
1.4
1.5
—
—
—
0
0
531
5241
1.02
0.13
4.4
3.9
45.32
60.19
ng/l
0.57
436
3852
21
190
1.11
0.12
5.0
7.1
11.51
11.99
mg/l
0.19
21
176
100
1037
0.96
0.12
3.6
2.8
74.67
64.15
ml/min/173m2
0.30
39
431
131
1271
1.03
0.11
2.7
2.4
7.20
6.96
ug/l
0.03
117
1102
274
2690
1.02
0.11
3.7
4.0
520.35
428.68
ng/l
0.10
222
2210
21
229
0.92
0.10
1.7
1.5
—
—
—
0
0
18
163
1.11
0.10
1.1
1.1
—
—
—
0
0
23
249
0.92
0.10
1.5
1.4
—
—
—
0
0
24
259
0.93
0.10
2.0
1.9
—
—
—
0
0
171
1672
1.03
0.10
2.3
2.7
1.69
1.78
%
0.82
154
1474
5
47
1.06
0.09
1.0
2.0
14.68
201.81
ug/l
—
5
38
28
298
0.94
0.08
5.6
3.6
22.21
27.48
mg/l
0.49
17
193
160
1633
0.98
0.08
4.1
4.7
32.01
32.52
%
0.25
107
1086
419
4145
1.01
0.08
4.1
3.5
43.27
86.34
e6/l
1.43
334
3250
5
62
0.81
0.08
1.4
1.2
—
—
—
0
0
5
65
0.77
0.08
1.0
1.2
—
—
—
0
0
10
88
1.14
0.08
1.0
1.2
—
—
—
0
0
7
67
1.04
0.08
7.3
18.2
1389.86
1520.69
nmol/l
—
7
67
16
174
0.92
0.07
1.2
1.2
1.57
4.86
u/ml
—
7
80
7
80
0.87
0.07
1.0
1.5
—
—
—
0
0
7
83
0.84
0.07
2.3
1.6
—
—
—
0
0
39
373
1.05
0.07
1.5
1.7
—
—
—
0
0
9
85
1.06
0.07
1.0
1.1
—
—
—
0
0
9
85
1.06
0.07
1.0
1.1
—
—
—
0
0
9
85
1.06
0.07
1.4
1.4
117.38
168.87
pmol/l
—
9
85
9
88
1.02
0.07
1.0
1.1
—
—
—
0
0
9
88
1.02
0.07
1.0
1.1
—
—
—
0
0
9
88
1.02
0.07
1.0
1.1
—
—
—
0
0
36
376
0.96
0.06
1.5
1.2
—
—
—
0
0
317
3203
0.99
0.06
2.2
2.5
—
—
—
0
0
17
158
1.08
0.06
2.8
4.2
—
—
—
0
0
239
2362
1.01
0.06
3.3
2.9
0.99
1.04
e6/l
0.11
161
1393
272
2748
0.99
0.05
1.8
1.8
1.35
1.32
mg/l
0.05
211
2129
34
353
0.96
0.04
2.7
2.3
89.94
83.27
ug/min
0.03
18
213
36
373
0.96
0.04
1.5
1.2
—
—
—
0
0
27
259
1.04
0.04
1.5
1.8
5.93
5.36
iu/l
0.08
11
87
11
119
0.92
0.04
1.8
1.7
—
—
—
0
0
69
677
1.02
0.03
1.1
1.2
145.45
154.77
iu/ml
0.06
21
266
35
361
0.97
0.03
1.5
1.8
—
—
—
0
0
604
6063
0.99
0.03
2.4
2.7
—
—
—
0
0
10
92
1.09
0.03
1.3
1.5
77.00
87.55
umol/l
—
10
92
27
279
0.97
0.02
1.2
1.4
11.28
9.13
u/l
0.32
21
216
191
1896
1.01
0.02
2.5
2.6
24.21
22.55
%
0.90
165
1617
20
208
0.96
0.02
1.5
1.5
—
—
—
0
0
24
232
1.04
0.02
1.3
1.3
267.93
288.78
u/ml
0.22
14
127
26
252
1.03
0.02
3.3
3.2
4.26
4.33
e9/l
0.05
26
252
27
262
1.03
0.02
3.7
3.5
59.37
58.71
%
0.09
27
262
19
183
1.04
0.01
1.9
2.4
29.17
26.09
mg/l
—
6
46
21
203
1.03
0.01
1.2
1.2
—
—
—
0
0
800
8011
1.00
0.01
3.7
3.3
46.59
53.54
u/l
0.97
744
7396
33
323
1.02
0.01
1.3
1.3
—
—
—
0
0
17
176
0.97
0.00
1.7
1.8
—
—
—
0
0
38
384
0.99
0.00
6.9
5.3
1.62
1.64
mg/l
0.04
38
353
12
118
1.02
0.00
1.1
1.0
—
—
—
0
0
14
138
1.01
0.00
1.0
1.0
1.00
2.67
u/ml
—
6
48
17
172
0.99
0.00
1.3
1.6
38.11
63.10
%
—
9
108
18
178
1.01
0.00
1.4
1.7
—
—
—
0
0
18
178
1.01
0.00
1.4
1.7
—
—
—
0
0
27
272
0.99
0.00
1.5
1.8
—
—
—
0
0
201
2006
1.00
0.00
2.4
2.5
2.24
2.29
g/l
0.60
180
1856
17
169
1.01
0.00
1.2
1.1
7.19
2.27
u/ml
—
10
95
18
175
1.03
0.00
1.2
1.4
14860.77
107005.32
e6/l
1.55
13
106
25
245
1.02
0.00
1.2
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
24.06
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.0
—
382.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
7.60
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
21.43
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
10.0
—
—
—
0
0
9
99
0.91
-0.00
2.0
1.5
—
—
—
0
0
17
170
1.00
-0.00
1.2
1.1
—
—
—
0
0
7
69
1.01
-0.00
1.1
1.2
13.29
17.02
u/l
—
7
61
8
84
0.95
-0.00
1.4
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1745.20
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
38.90
—
0
7
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
8
84
0.95
-0.00
1.4
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_NEUATR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_NEUATR | 7.442 [6.44, 8.6] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.176 |
During the follow-up period (1.1.1998 — 31.12.2019), 2750 out of 4587 females with G6_NEUATR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_NEUATR | 5.431 [4.76, 6.19] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 3012 out of 5076 males with G6_NEUATR died.
Mortality risk
Mortality risk for people of age
years, who have G6_NEUATR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.823% | 0.863% |
| 5 | 3.911% | 5.649% |
| 10 | 10.404% | 14.121% |
| 15 | 19.039% | 26.114% |
| 20 | 31.816% | 40.692% |
Relationships between endpoints
↥Index endpoint: G6_NEUATR – Systemic atrophies primarily affecting the central nervous system
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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