motor neuron disease: A disease involving the motor neuron.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
759 |
4. Check minimum number of eventsNone |
759 |
5. Include endpointsNone |
759 |
6. Filter based on genotype QC (FinnGen only) |
747 |
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G12
- Name in latin
- Morbus motoneuronalis
Similar endpoints
↥List of similar endpoints to
Motor neuron disease
based on the number of shared cases.
Similar with more cases:
- Motor neuron disease (with DMD)
- Systemic atrophies primarily affecting the central nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8362 | 3928 | 4249 |
| Only index persons | 4490 | 2114 | 2376 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.11 | 0.12 |
| Only index persons | 0.08 | 0.08 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 66.30 | 67.33 | 65.35 |
| Only index persons | 67.14 | 68.36 | 66.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 747 | 307 | 440 |
| Unadjusted period prevalence (%) | 0.16 | 0.11 | 0.20 |
| Median age at first event (years) | 67.96 | 67.79 | 68.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 759
- Matched controls
- 7590
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J96.1
ICD-10 Finland
Chronic respiratory failure
42.5
317.6
199
63
G12.2
ICD-10 Finland
Motor neuron disease
+∞
307.7
734
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
116.0
307.7
178
20
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
119.5
307.7
221
26
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
23.7
246.8
191
106
N07XX02
ATC
riluzole; oral
+∞
224.4
204
*
R13
ICD-10 Finland
Dysphagia
17.0
220.0
204
161
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
28.9
203.7
142
60
N99
ICPC
Neurological disease other
803.3
195.3
184
*
Z51.5
ICD-10 Finland
Palliative care
10.5
188.4
256
352
TAB00
NOMESCO Finland
Lumbar puncture
43.6
184.5
112
30
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
21.0
183.7
147
86
R4130
NOMESCO Finland
Speech therapy
46.5
181.0
108
27
R47.1
ICD-10 Finland
Dysarthria and anarthria
961.1
163.0
154
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
45.1
146.9
88
22
G47.3
ICD-10 Finland
Sleep apnoea
15.1
129.3
121
94
XG466
NOMESCO Finland
Sleep oxymetry
26.9
119.8
84
35
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
9.0
118.3
165
227
SPAT1229
SPAT
Assessment of need for aid
11.6
117.4
131
134
A28
ICPC
Limited function/disability NOS
6.2
111.6
243
534
N03AE01
ATC
clonazepam; systemic
20.5
103.4
81
44
R5140
NOMESCO Finland
Monitoring the use of the aid
12.1
99.0
105
99
N28
ICPC
Limited function/disability (N)
132.2
97.7
103
9
WX725
NOMESCO Finland
Noninvasive ventilation
9.2
96.0
127
162
L28
ICPC
Limited function/disability (L)
5.7
95.3
221
508
R1250
NOMESCO Finland
Evaluation of functional capability
31.1
95.1
63
22
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
43.1
92.8
56
14
N29
ICPC
Neurological sympt/complt other
52.3
84.8
49
10
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
11.3
77.2
85
84
R4190
NOMESCO Finland
Nutritional therapy
11.2
75.4
83
82
R4120
NOMESCO Finland
Occupational therapy
8.9
71.8
95
120
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
9.2
70.7
91
111
R1260
NOMESCO Finland
Evaluation of communicative skills
23.7
70.0
51
23
S06.0
ICD-10 Finland
Concussion
16.1
69.8
61
41
D21
ICPC
Swallowing problem
30.5
69.2
46
16
N02AA01
ATC
morphine; systemic, rectal
11.3
66.0
72
70
R5599
NOMESCO Finland
Other rehabilitation service
13.1
65.9
65
54
N05AH04
ATC
quetiapine; oral
9.3
65.5
83
99
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
31.7
63.9
42
14
SPAT1231
SPAT
Assessment of adjustments needed in living environment
24.4
63.9
46
20
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
6.7
63.3
109
185
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.6
62.6
179
478
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
21.7
59.6
45
22
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
8.1
59.2
84
115
AA1AD
NOMESCO Finland
CT of head and brain
4.3
57.6
183
527
G12.9
ICD-10 Finland
Spinal muscular atrophy, unspecified
+∞
57.0
54
*
N06AB10
ATC
escitalopram; oral
5.5
56.8
121
251
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
10.5
55.2
63
65
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
12.3
54.8
56
49
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
6.2
53.7
99
179
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
13.6
53.3
51
40
M03BX01
ATC
baclofen; systemic
72.2
53.0
60
9
N06AX11
ATC
mirtazapine; oral
3.7
52.2
217
749
SPAT1216
SPAT
Assessment of functional ability
4.3
51.8
158
439
XA402
NOMESCO Finland
ENMG
20.1
51.3
40
21
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
139.3
49.4
52
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
8.7
49.3
65
81
TJD20
NOMESCO Finland
Change of gastrostomy tube
111.5
48.4
52
5
SPAT1245
SPAT
Provision of support and information to patient’s family members
9.7
46.5
56
62
UDQ12
NOMESCO Finland
Flexible laryngoscopy
6.8
45.4
75
121
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
43.8
158
491
N05BA04
ATC
oxazepam; oral
3.6
43.4
177
597
N19
ICPC
Speech disorder
159.2
43.3
45
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
15.3
42.8
38
26
N18
ICPC
Paralysis/weakness
116.6
41.2
44
*
SPAT1215
SPAT
Assessment of need for medical rehabilitation
8.8
41.1
53
64
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
13.2
40.3
39
31
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.8
40.3
140
423
N05BA06
ATC
lorazepam; systemic, sublingual
8.2
40.0
55
72
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
111.0
39.1
42
*
SPAT1234
SPAT
Support of social functional capacity
7.4
36.9
55
79
G72.9
ICD-10 Finland
Myopathy, unspecified
+∞
33.6
32
*
F51.0
ICD-10 Finland
Nonorganic insomnia
+∞
33.6
32
*
R47.8
ICD-10 Finland
Other and unspecified speech disturbances
58.6
33.5
39
7
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.8
33.3
112
329
R5110, ,
SPAT
4.9
32.7
76
168
N06AB04
ATC
citalopram; systemic
3.7
32.5
115
349
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
5.3
30.6
65
133
G12.8
ICD-10 Finland
Other spinal muscular atrophies and related syndromes
+∞
30.4
29
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
29.3
29.2
39
14
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
10.4
28.4
32
32
G56.0
ICD-10 Finland
Carpal tunnel syndrome
6.8
28.0
45
70
R25.3
ICD-10 Finland
Fasciculation
104.0
27.8
30
*
N02AA05
ATC
oxycodone; systemic
2.7
26.4
170
728
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
+∞
26.2
25
*
N03AX12
ATC
[U] gabapentin; oral
3.2
25.9
112
385
UDQ42
NOMESCO Finland
Endoscopic assessment of swallowing function
139.8
25.8
27
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
25.4
242
1245
XA800
NOMESCO Finland
Neuropsychological investigation
31.3
25.2
33
11
G31.0
ICD-10 Finland
Circumscribed brain atrophy
+∞
25.1
24
*
XG416
NOMESCO Finland
Measurement of maximal airway pressure
+∞
25.1
24
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
24.7
221
1104
A06AD11
ATC
lactulose; oral
3.0
24.6
125
471
SPAT1254
SPAT
Administration of medicine
3.0
24.3
118
433
SPAT1297
SPAT
Other function in accordance with speech therapy nomenclature
+∞
24.1
23
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.4
23.7
214
1071
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
30.1
22.0
29
10
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
+∞
22.0
21
*
T05
ICPC
Feeding problem of adult
44.7
21.5
26
6
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
21.2
215
1124
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
+∞
20.9
20
*
G12.1
ICD-10 Finland
Other inherited spinal muscular atrophy
+∞
20.9
20
*
XG467
NOMESCO Finland
Nocturnal CO2 monitoring
215.7
20.7
21
*
G20
ICD-10 Finland
Parkinson disease
215.7
20.7
21
*
F80.1
ICD-10 Finland
Expressive language disorder
215.7
20.7
21
*
NXL00
NOMESCO Finland
Biopsy of muscle
215.7
20.7
21
*
Z31.5
ICD-10 Finland
Genetic counselling
4.7
20.6
49
110
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
20.8
20.5
30
15
SPAT1240
SPAT
Therapeutic discussion
5.2
20.2
42
84
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
21.5
20.1
29
14
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
+∞
19.9
19
*
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
29.8
19.7
26
9
N06AX21
ATC
duloxetine; oral
4.2
19.7
55
140
GX2D5
NOMESCO Finland
Sleep oximetry
107.9
19.7
21
*
N03AF01
ATC
carbamazepine; oral, rectal
6.3
19.5
33
54
S01.0
ICD-10 Finland
Open wound of scalp
3.7
19.4
65
189
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.9
19.3
58
156
JDB01
NOMESCO Finland
Laparoscopic gastrostomy
+∞
18.8
18
*
ACC51
NOMESCO Finland
Release of median nerve
45.2
18.3
22
5
Z50.5
ICD-10 Finland
Speech therapy
22.4
18.3
26
12
N06AA09
ATC
amitriptyline; systemic
3.8
18.1
58
163
G30.1
ICD-10 Finland
Alzheimer disease with late onset
53.9
18.0
21
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
68.3
17.8
20
*
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
97.4
17.6
19
*
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
5.7
17.6
33
60
XW5WT
NOMESCO Finland
Other blood specimen with radiologicl guidance
64.8
16.8
19
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
4.0
16.8
49
129
R53
ICD-10 Finland
Malaise and fatigue
2.4
16.6
129
595
XX9TE
NOMESCO Finland
Compementary ultrasound examination
28.3
16.6
22
8
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
28.3
16.6
22
8
N05BA01
ATC
diazepam; systemic, rectal
2.9
15.9
80
298
3352A
ICD-9 Finland
Anterior horn cell disease, Motor neuron disease[SCLEROSIS LATERALIS AMYOTROPHICA]
+∞
15.7
15
*
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
+∞
15.7
15
*
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
4.3
15.5
41
100
N05CF01
ATC
zopiclone; oral
2.0
15.4
200
1133
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.2
15.3
63
209
Z50.1
ICD-10 Finland
Other physical therapy
3.7
15.1
49
139
WX722
NOMESCO Finland
PEEP
5.1
15.1
32
65
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
14.3
15.1
25
18
R49.08
ICD-10 Finland
Other specified dysphonia
6.7
15.0
24
37
R06.0
ICD-10 Finland
Dyspnoea
2.1
14.9
184
1022
XG410
NOMESCO Finland
Flow-volume spirometry
4.1
14.8
41
104
N04BC05
ATC
pramipexole; oral
3.8
14.8
46
127
N06AX16
ATC
venlafaxine; oral
3.7
14.7
48
137
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
12.2
14.7
26
22
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
14.7
141
711
30041
ICD-8 Finland
Neuroses, Depressiva
+∞
14.6
14
*
N05AX08
ATC
risperidone; systemic
11.2
14.6
27
25
R47.0
ICD-10 Finland
Dysphasia and aphasia
152.8
14.5
15
*
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.8
14.4
44
120
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
22.8
14.3
20
9
N06DA02
ATC
donepezil; oral
30.7
13.9
18
6
G62.8
ICD-10 Finland
Other specified polyneuropathies
76.5
13.6
15
*
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
13.6
13
*
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
+∞
13.6
13
*
U04
ICPC
Incontinence urine
3.7
13.5
44
125
G40.9
ICD-10 Finland
Epilepsy, unspecified
142.5
13.5
14
*
M62.5
ICD-10 Finland
Muscle wasting and atrophy, not elsewhere classified
142.5
13.5
14
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
13.1
13.5
23
18
N03AG01
ATC
valproic acid; systemic, rectal
18.6
13.4
20
11
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
26.3
13.4
18
7
SPAT1167
SPAT
Insertion of urinary catheter
4.3
13.3
35
85
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
14.1
13.3
22
16
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
14.1
13.3
22
16
K90
ICPC
Stroke/cerebrovascular accident
40.8
13.2
16
*
R4120, ,
SPAT
40.8
13.2
16
*
L19
ICPC
Muscle symptom/complaint NOS
5.6
13.1
25
46
SPAT1262
SPAT
Handing over of treatment supplies
2.2
12.9
127
645
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
15.8
12.7
20
13
RS314, ,
NOMESCO Finland
+∞
12.5
12
*
N87
ICPC
Parkinsonism
+∞
12.5
12
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
20.4
12.5
18
9
SPAT1301
SPAT
No procedures
1.9
12.4
204
1242
Z3229
NOMESCO Finland
Other healthcare associate professional
2.7
12.3
69
271
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
14.6
12.3
20
14
M48.0
ICD-10 Finland
Spinal stenosis
2.4
12.2
85
372
Z2445
NOMESCO Finland
Psychologist
27.2
12.1
16
6
WYA20
NOMESCO Finland
Home visit
15.0
11.8
19
13
ZY010
NOMESCO Finland
Hospital outpatient
4.7
11.7
27
59
N05AH03
ATC
olanzapine; systemic
16.7
11.7
18
11
J96.9
ICD-10 Finland
Respiratory failure, unspecified
16.7
11.7
18
11
L99
ICPC
Musculoskeletal disease other
5.8
11.5
21
37
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
+∞
11.5
11
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
+∞
11.5
11
*
RS310, ,
NOMESCO Finland
+∞
11.5
11
*
WX723
NOMESCO Finland
CPAP therapy
+∞
11.5
11
*
SPAT1139
SPAT
Nutrition survey
4.4
11.3
28
65
G56.2
ICD-10 Finland
Lesion of ulnar nerve
20.4
11.2
16
8
J96.0
ICD-10 Finland
Acute respiratory failure
8.7
11.1
23
27
RS340, ,
NOMESCO Finland
44.0
10.9
13
*
N05AN01
ATC
lithium; oral
44.0
10.9
13
*
N06AX26
ATC
vortioxetine; oral
5.5
10.9
21
39
UJC01
NOMESCO Finland
Scopy of lower throat
9.8
10.8
21
22
N07AA02
ATC
pyridostigmine; systemic
60.9
10.6
12
*
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.7
10.6
60
237
N03AX16
ATC
[U] pregabalin
2.0
10.6
123
662
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.5
10.6
26
60
WPA10
NOMESCO Finland
Proactive palliative care treatment plan
9.4
10.6
21
23
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
0.3
10.5
38
1027
N06AB06
ATC
sertraline; oral
3.5
10.5
37
111
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.7
10.5
33
92
RS122, ,
NOMESCO Finland
111.5
10.4
11
*
Z99.8
ICD-10 Finland
Dependence on other enabling machines and devices
111.5
10.4
11
*
A210_, ,
NOMESCO Finland
+∞
10.4
10
*
G35
ICD-10 Finland
Multiple sclerosis
+∞
10.4
10
*
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
+∞
10.4
10
*
A120_, ,
NOMESCO Finland
+∞
10.4
10
*
85000
ICD-8 Finland
Concussion, Current or unspecified
+∞
10.4
10
*
WX781
NOMESCO Finland
Remote monitoring, noninvasive ventilation
+∞
10.4
10
*
K11.72
ICD-10 Finland
Xerostomia
+∞
10.4
10
*
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
10.8
10.3
19
18
N06DX01
ATC
memantine; oral
23.7
10.3
14
6
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
10.1
120
650
F03
ICD-10 Finland
Unspecified dementia
17.0
9.9
15
9
A98
ICPC
Health maint/preventive medicine
0.6
9.9
557
6289
SPAT1276
SPAT
Outlining of treatment with patient or their family members
5.2
9.9
20
39
M54.1
ICD-10 Finland
Radiculopathy
3.9
9.8
29
77
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
20.3
9.8
14
7
R26.2
ICD-10 Finland
Difficulty in walking, not elsewhere classified
5.4
9.7
19
36
EB1VA, ,
NOMESCO Finland
0.2
9.6
7
411
W19
ICD-10 Finland
Unspecified fall
2.6
9.5
57
232
RS313, ,
NOMESCO Finland
101.3
9.4
10
*
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
101.3
9.4
10
*
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
9.4
9
*
WPA44
NOMESCO Finland
Nursing home for palliative care
+∞
9.4
9
*
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
+∞
9.4
9
*
ACC53
NOMESCO Finland
Release of ulnar nerve
+∞
9.4
9
*
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
+∞
9.4
9
*
TJD10
NOMESCO Finland
Insertion of other tube into stomach or duodenum
+∞
9.4
9
*
G81.9
ICD-10 Finland
Hemiplegia, unspecified
+∞
9.4
9
*
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.1
9.3
92
466
R41.0
ICD-10 Finland
Disorientation, unspecified
7.4
9.3
21
29
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
37.2
9.0
11
*
RK110, ,
NOMESCO Finland
12.7
8.9
15
12
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
5.0
8.9
19
39
RS221, ,
NOMESCO Finland
10.9
8.8
16
15
Z3226
NOMESCO Finland
Physiotherapist
1.9
8.8
115
644
RS311, ,
NOMESCO Finland
50.6
8.7
10
*
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
50.6
8.7
10
*
RS222, ,
NOMESCO Finland
11.7
8.6
15
13
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
16.5
8.6
13
8
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
9.1
8.6
17
19
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
27.9
8.5
11
*
G72.8
ICD-10 Finland
Other specified myopathies
91.0
8.4
9
*
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
91.0
8.4
9
*
WPA43
NOMESCO Finland
A doctor's home visit to perform palliative care
91.0
8.4
9
*
N05AX12
ATC
aripiprazole; systemic
91.0
8.4
9
*
N06DA03
ATC
rivastigmine; oral, transdermal
91.0
8.4
9
*
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
91.0
8.4
9
*
Z93.1
ICD-10 Finland
Gastrostomy status
91.0
8.4
9
*
SPAT1172
SPAT
Guidance concerning hydration
5.0
8.4
18
37
A04
ICPC
Weakness/tiredness general
2.2
8.3
73
352
G61.8
ICD-10 Finland
Other inflammatory polyneuropathies
+∞
8.3
8
*
A220_, ,
NOMESCO Finland
+∞
8.3
8
*
3472A
ICD-9 Finland
Cataplexy and narcolepsy[OBSTRUKTIIVINEN UNIAPNEA]
+∞
8.3
8
*
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
+∞
8.3
8
*
130
Kela drug reimbursment
Malignant tumour
0.2
8.3
14
579
Z02.4
ICD-10 Finland
Examination for driving licence
0.5
8.2
107
1779
WPA13
NOMESCO Finland
Palliative consultation
14.7
8.2
13
9
A29
ICPC
General symptom/complaint other
2.1
8.2
86
445
R06.5
ICD-10 Finland
Mouth breathing
2.9
8.1
38
136
Z75.5
ICD-10 Finland
Holiday relief care
33.7
8.1
10
*
XA421
NOMESCO Finland
Nocturnal polygraphy
33.7
8.1
10
*
TNX05
NOMESCO Finland
Simple incision of soft tissue, unspecified region
33.7
8.1
10
*
G44.2
ICD-10 Finland
Tension-type headache
2.7
8.1
43
165
Z73.3
ICD-10 Finland
Stress, not elsewhere classified
22.3
8.0
11
5
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.9
8.0
23
60
Z2446
NOMESCO Finland
Social worker
2.9
8.0
38
137
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
4.7
7.9
18
39
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.6
7.8
45
180
N06AB03
ATC
fluoxetine; oral
2.5
7.7
48
199
RS230, ,
NOMESCO Finland
15.2
7.7
12
8
Z43.1
ICD-10 Finland
Attention to gastrostomy
45.4
7.7
9
*
JDB00
NOMESCO Finland
Gastrostomy
45.4
7.7
9
*
A06AH03
ATC
naloxegol; oral
4.6
7.7
18
40
R4110
NOMESCO Finland
Physiotherapy
1.7
7.7
183
1220
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
18.6
7.6
11
6
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
12.0
7.6
13
11
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
7.6
88
472
G04BD12
ATC
mirabegron; oral
2.1
7.5
73
368
RS211, ,
NOMESCO Finland
80.9
7.4
8
*
N81
ICPC
Injury nervous system other
80.9
7.4
8
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
80.9
7.4
8
*
P29
ICPC
Psychological sympt/compl other
6.1
7.4
19
32
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
+∞
7.3
7
*
WX780
NOMESCO Finland
Remote monitoring CPAP
+∞
7.3
7
*
34800
ICD-8 Finland
Motor neurone disease, Amyotrophic lateral sclerosis
+∞
7.3
7
*
R27.0
ICD-10 Finland
Ataxia, unspecified
+∞
7.3
7
*
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
+∞
7.3
7
*
G12.0
ICD-10 Finland
Infantile spinal muscular atrophy, type I [Werdnig-Hoffman]
+∞
7.3
7
*
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
+∞
7.3
7
*
G99.2*M47.1
ICD-10 Finland
Spondylogenic compression of spinal cord
+∞
7.3
7
*
N03AX09
ATC
lamotrigine; oral
15.9
7.2
11
7
OAB50
NOMESCO Finland
Delivery of care equipment and instruction on their use
30.3
7.2
9
*
F34.1
ICD-10 Finland
Dysthymia
30.3
7.2
9
*
V700A
ICD-9 Finland
General medical examination, Routine general medical examination at a health care facility
4.1
7.1
19
47
N06AX03
ATC
mianserin; oral
4.1
7.1
19
47
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.0
7.1
74
383
N05AA02
ATC
levomepromazine; systemic
10.2
7.1
13
13
N05CD07
ATC
temazepam; oral
2.1
7.0
65
321
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
8.4
6.8
14
17
S62.3
ICD-10 Finland
Fracture of other metacarpal bone
4.2
6.8
18
44
M03BX02
ATC
tizanidine; oral
1.5
6.8
362
2874
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
6.8
6.8
16
24
H02AB02
ATC
dexamethasone; systemic
0.3
6.8
19
590
WPA40
NOMESCO Finland
Individual-centered psychosocial intervention in palliative care
40.4
6.8
8
*
WPA42
NOMESCO Finland
Family-centered psychosocial intervention in palliative care
40.4
6.8
8
*
G30.8
ICD-10 Finland
Other Alzheimer disease
22.7
6.7
9
*
N05CD08
ATC
midazolam; nasal, systemic
4.2
6.6
17
41
Z73.6
ICD-10 Finland
Limitation of activities due to disability
10.1
6.5
12
12
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
6.9
6.5
15
22
L01BC06
ATC
capecitabine; oral
0.1
6.5
*
218
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
0.6
6.5
121
1843
SPAT1252
SPAT
Overall medication plan or its review
2.3
6.5
46
203
S01.1
ICD-10 Finland
Open wound of eyelid and periocular area
3.7
6.5
20
55
R63.4
ICD-10 Finland
Abnormal weight loss
2.9
6.5
30
107
GX1P5
NOMESCO Finland
Nocturnal CO2 monitoring
70.4
6.4
7
*
IGY02
NOMESCO Finland
Psychiatric monitoring contact
70.4
6.4
7
*
N04BD01
ATC
selegiline; oral
70.4
6.4
7
*
N04AA02
ATC
biperiden; systemic
70.4
6.4
7
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
70.4
6.4
7
*
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
70.4
6.4
7
*
Z43.0
ICD-10 Finland
Attention to tracheostomy
70.4
6.4
7
*
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
70.4
6.4
7
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
4.1
6.4
17
42
G51.0
ICD-10 Finland
Bell palsy
18.2
6.3
9
5
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
18.2
6.3
9
5
A123_, ,
NOMESCO Finland
+∞
6.3
6
*
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
+∞
6.3
6
*
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
+∞
6.3
6
*
A222_, ,
NOMESCO Finland
+∞
6.3
6
*
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
+∞
6.3
6
*
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
+∞
6.3
6
*
OAB73, ,
SPAT
+∞
6.3
6
*
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
+∞
6.3
6
*
N05BA09
ATC
clobazam; oral
+∞
6.3
6
*
N86
ICPC
Multiple sclerosis
+∞
6.3
6
*
RS142, ,
NOMESCO Finland
+∞
6.3
6
*
A211_, ,
NOMESCO Finland
+∞
6.3
6
*
G61.9
ICD-10 Finland
Inflammatory polyneuropathy, unspecified
+∞
6.3
6
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
+∞
6.3
6
*
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
+∞
6.3
6
*
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.3
6.2
44
194
WPA41
NOMESCO Finland
Psychosocial conversational support in palliative care
26.9
6.2
8
*
P20
ICPC
Memory disturbance
2.1
6.2
55
267
R42
ICD-10 Finland
Dizziness and giddiness
1.7
6.2
118
738
F06.7
ICD-10 Finland
Mild cognitive disorder
7.8
6.1
13
17
WW200, ,
SPAT
0.5
6.1
58
1074
SPAT1125
SPAT
Stoma care and guidance
5.2
6.0
17
33
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
5.6
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
94
17
62.97
168.44
1.1
1.1
8.17
38.67
e6/l
0.42
70
12
399
1163
6.12
137.64
2.5
1.7
244.56
199.50
u/l
0.97
383
1066
181
239
9.63
134.91
2.6
2.3
16.47
22.60
au/ml
—
8
15
167
217
9.58
125.67
1.3
1.2
67.80
50.64
au/ml
—
5
18
148
211
8.47
102.33
4.7
4.2
3.55
1.80
mmol/l
4.67
135
160
82
6
152.93
78.68
1.0
1.0
—
—
—
0
0
78
6
144.62
74.46
1.1
1.0
—
—
—
0
0
79
9
97.88
72.51
1.0
1.1
—
—
—
0
0
155
406
4.54
55.08
1.6
2.9
67.88
66.05
g/l
2.59
142
371
87
167
5.75
44.15
1.3
2.3
2.41
3.12
g/l
7.39
81
150
89
180
5.47
42.64
1.3
2.2
3.31
3.62
g/l
1.52
82
163
89
180
5.47
42.64
1.3
2.2
—
—
—
0
0
89
180
5.47
42.64
1.3
2.2
6.54
7.45
g/l
6.29
83
163
169
584
3.44
39.61
5.5
6.6
5.81
5.06
kpa
9.04
164
549
168
584
3.41
38.96
5.5
6.6
10.57
12.39
kpa
7.34
162
549
82
173
5.19
37.36
1.2
2.3
10.20
10.33
g/l
0.08
75
155
164
588
3.28
35.96
5.5
6.6
3.93
0.78
mmol/l
18.01
144
451
106
307
3.85
32.08
1.8
3.4
10.67
10.60
g/l
0.06
91
284
34
5
70.97
30.14
1.1
1.2
—
—
—
0
0
63
143
4.71
26.19
1.2
1.7
40.22
37.44
g/l
3.10
57
126
59
135
4.65
24.27
1.4
1.7
0.00
0.03
g/l
0.75
53
122
64
159
4.30
23.73
1.4
2.0
0.71
1.22
g/l
0.32
56
131
57
133
4.55
22.88
1.2
1.7
0.00
0.00
g/l
-0.00
51
120
56
132
4.50
22.19
1.3
1.7
0.00
0.00
g/l
-0.00
50
120
56
134
4.43
21.77
1.7
2.3
191.70
466.24
ug/l
0.93
49
126
67
187
3.83
21.19
1.7
1.9
38.06
38.96
u/l
0.14
62
157
344
2162
2.08
21.13
3.4
4.9
35.71
34.93
g/l
1.86
323
2008
172
834
2.37
20.10
1.7
1.6
1158.22
1135.26
nmol/l
0.12
135
619
163
772
2.42
20.08
1.7
1.8
—
—
—
0
0
375
2492
2.00
19.16
5.4
6.5
1.22
1.21
mmol/l
4.00
312
2119
43
98
4.59
17.75
2.7
2.3
18.51
15.69
%
4.91
32
46
479
5822
0.52
15.82
3.9
4.8
2.81
2.76
mmol/l
0.61
410
5267
467
5697
0.53
15.06
3.7
4.2
4.75
4.65
mmol/l
1.15
398
5190
333
2267
1.84
14.57
5.7
5.6
1.22
1.21
mmol/l
1.26
304
2064
465
5656
0.54
14.31
3.7
4.2
1.49
1.47
mmol/l
0.59
397
5121
105
472
2.42
14.25
1.8
2.3
0.23
0.21
g/l
2.05
100
448
149
778
2.14
14.15
2.5
3.5
0.83
0.83
mmol/l
0.35
131
725
23
37
6.38
13.81
1.0
1.8
—
—
—
0
0
113
534
2.31
13.67
1.7
1.6
—
—
—
0
0
38
97
4.07
13.58
2.5
2.0
143.58
128.26
g/l
3.43
33
62
404
2956
1.78
13.57
4.8
4.1
6.48
6.81
mmol/l
3.54
388
2749
303
2045
1.80
13.33
1.8
1.8
94.16
93.93
pmol/l
0.03
167
1024
350
2479
1.76
12.95
14.3
16.3
1.23
1.37
inr
1.96
91
668
109
536
2.21
11.93
1.7
1.7
—
—
—
0
0
454
5469
0.58
11.71
3.4
3.8
1.24
1.25
mmol/l
0.11
384
4912
65
1426
0.40
11.48
1.6
1.6
1.30
1.28
mmol/l
0.07
58
1161
173
1035
1.87
10.93
1.4
1.6
453.15
38308286.27
pmol/l
1.25
144
851
15
9
16.98
9.90
1.0
1.6
33.97
31.78
umol/l
—
15
9
13
7
18.86
8.95
1.3
1.9
4.64
3.76
mmol/l
—
13
7
446
5257
0.63
8.41
4.8
5.4
38.53
39.88
mmol/mol
2.92
396
4786
165
1065
1.70
7.82
1.4
1.5
20.27
20.02
nmol/l
0.09
150
871
14
13
10.95
7.82
1.0
1.1
—
—
—
0
0
316
2399
1.54
7.62
4.8
5.9
26.48
27.11
%
0.42
299
2234
487
5590
0.64
7.56
4.0
4.4
5.87
5.95
mmol/l
0.94
434
5010
578
6369
0.61
7.18
22.5
18.2
243.91
241.95
e9/l
0.34
562
6130
85
461
1.95
7.10
3.2
3.5
4.48
1.64
mmol/l
6.92
78
365
579
6374
0.61
7.09
22.6
18.3
135.58
136.04
g/l
0.33
573
6228
578
6364
0.62
7.05
22.9
18.4
40.16
40.09
%
0.09
529
5874
579
6372
0.61
7.04
22.5
18.2
4.45
4.49
e12/l
1.34
559
6107
308
2357
1.52
7.00
4.7
5.6
59.09
57.61
%
1.28
294
2192
60
288
2.18
6.95
6.7
8.7
26.93
24.48
mmol/l
6.14
55
277
120
1828
0.59
6.45
3.1
3.7
8.53
7.77
mg/mmol
0.09
69
1145
10
7
14.45
6.41
1.1
1.0
—
—
—
0
0
10
7
14.45
6.41
1.1
1.0
—
—
—
0
0
478
5425
0.68
5.94
13.7
12.4
90.55
76.04
ml/min/173m2
29.55
397
4346
242
1817
1.49
5.79
4.2
3.1
58.88
86.56
ng/l
0.46
216
1297
31
120
2.65
5.78
1.5
1.6
—
—
—
0
0
454
3850
1.45
5.67
3.9
3.6
11.07
13.35
mm/h
3.04
425
3511
92
550
1.77
5.66
4.1
2.7
—
—
—
0
0
101
621
1.72
5.63
3.4
5.4
0.99
1.04
mmol/l
1.15
91
577
557
6121
0.66
5.62
9.7
9.6
28.49
25.52
u/l
4.32
538
5830
9
8
11.37
5.30
1.1
1.0
—
—
—
0
0
121
1737
0.64
4.84
2.5
3.0
7.55
7.53
mmol/l
0.01
92
1432
8
7
11.53
4.79
1.3
1.0
—
—
—
0
0
110
1597
0.64
4.61
2.5
3.2
0.83
0.84
ug/l
0.04
81
1103
8
8
10.09
4.52
1.1
1.0
—
—
—
0
0
215
1649
1.42
4.42
2.6
4.1
2.37
2.35
mmol/l
1.19
189
1437
9
12
7.57
4.36
1.0
1.0
—
—
—
0
0
40
201
2.05
4.20
1.7
2.0
—
—
—
0
0
200
1527
1.42
4.19
2.8
3.2
35.20
41.23
u/l
0.39
193
1450
23
91
2.58
4.16
1.1
1.1
—
—
—
0
0
56
317
1.83
4.16
1.6
2.4
428.83
399.19
nmol/l
0.60
48
296
357
3004
1.36
4.12
6.2
9.3
4.06
4.08
e9/l
0.05
314
2564
36
176
2.10
4.07
1.6
1.9
—
—
—
0
0
7
7
10.08
4.01
1.1
1.0
—
—
—
0
0
390
3335
1.35
4.01
5.1
3.7
46.00
2859.19
e6/l
—
8
48
29
131
2.26
3.97
1.4
1.2
—
—
—
0
0
52
295
1.82
3.85
1.7
1.5
—
—
—
0
0
7
8
8.82
3.78
1.0
1.0
—
—
—
0
0
6
5
12.08
3.77
1.0
1.0
—
—
—
0
0
56
329
1.76
3.70
9.3
8.4
91.39
94.05
%
1.42
56
329
128
1712
0.70
3.43
2.5
3.2
9762.85
205.77
mg/l
4.93
83
1089
12
32
3.79
3.40
1.3
1.0
—
—
—
0
0
55
330
1.72
3.40
1.5
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
7
8.63
3.27
1.0
1.0
—
—
—
0
0
56
349
1.65
3.03
1.5
1.5
1.40
1.37
%
0.12
48
301
420
3720
1.29
2.99
3.4
3.4
15.21
14.97
pmol/l
1.24
391
3293
7
13
5.42
2.87
1.0
1.2
—
—
—
0
0
315
2724
1.27
2.60
4.8
7.0
11.33
12.41
umol/l
1.52
301
2581
8
20
4.03
2.57
1.1
1.1
—
—
—
0
0
5
7
7.18
2.55
1.0
1.0
—
—
—
0
0
355
3123
1.26
2.51
3.2
2.6
39.18
51.77
u/l
4.06
331
2846
180
2182
0.77
2.42
3.9
4.5
22.20
21.70
%
0.21
100
1177
19
90
2.14
2.40
1.4
1.2
—
—
—
0
0
227
2671
0.79
2.39
3.9
5.4
5.94
3.75
ug/l
0.38
195
2399
19
92
2.09
2.28
1.3
1.2
—
—
—
0
0
19
92
2.09
2.28
1.3
1.2
—
—
—
0
0
229
1931
1.27
2.28
1.9
2.1
79.29
79.68
nmol/l
0.06
196
1702
6
14
4.31
2.15
1.7
2.1
—
—
—
0
0
563
5956
0.79
2.13
18.5
14.6
3.93
4.00
mmol/l
7.00
549
5743
47
694
0.66
2.11
2.6
5.0
12.80
42.40
ug/l
1.03
38
586
562
5942
0.79
2.08
18.6
14.4
139.76
139.76
mmol/l
0.01
552
5742
38
239
1.62
2.05
3.2
4.0
27.20
23.79
mmol/l
5.53
38
234
9
32
2.83
2.00
2.0
4.5
—
—
—
0
0
26
435
0.58
1.99
1.8
1.7
—
—
—
0
0
16
77
2.10
1.97
2.1
4.0
57.44
56.83
%
0.05
16
77
7
21
3.35
1.97
1.3
1.9
—
—
—
0
0
58
408
1.46
1.92
2.3
3.5
1.22
1.23
mmol/l
0.76
46
360
51
350
1.49
1.91
2.6
3.7
74.04
95.50
ng/l
1.21
44
315
12
52
2.33
1.88
1.2
1.8
—
—
—
0
0
9
34
2.67
1.87
1.8
1.3
—
—
—
0
0
14
66
2.14
1.83
2.6
1.8
1.45
1.62
mmol/l
0.68
14
66
9
35
2.59
1.80
1.8
1.3
—
—
—
0
0
15
75
2.02
1.70
1.9
3.6
3.92
3.97
e9/l
0.04
15
75
126
1025
1.27
1.67
1.7
1.6
1.27
1.39
mg/l
0.23
103
790
10
40
2.52
1.67
1.1
1.1
—
—
—
0
0
6
145
0.41
1.66
1.5
3.2
12.85
993.74
u/ml
—
6
135
5
132
0.37
1.63
1.6
1.2
—
—
—
0
0
117
1429
0.79
1.62
2.6
2.7
9637.93
7424.37
umol/l
0.16
99
1251
105
838
1.29
1.62
1.3
1.2
0.78
1.25
u/ml
1.20
21
213
11
50
2.22
1.57
1.2
1.8
—
—
—
0
0
17
92
1.87
1.57
1.2
1.2
—
—
—
0
0
12
57
2.12
1.55
1.1
1.6
—
—
—
0
0
12
57
2.12
1.55
1.1
1.6
—
—
—
0
0
12
57
2.12
1.55
1.1
1.6
—
—
—
0
0
8
33
2.44
1.54
1.1
1.8
—
—
—
0
0
8
33
2.44
1.54
1.1
1.8
—
—
—
0
0
23
138
1.69
1.53
1.4
1.6
—
—
—
0
0
5
15
3.35
1.52
1.2
2.5
61.32
49.61
ug/l
—
5
15
39
267
1.49
1.52
1.4
1.4
—
—
—
0
0
28
179
1.59
1.47
1.8
2.4
—
—
—
0
0
113
925
1.26
1.44
2.8
3.4
2.47
2.46
mmol/l
0.37
97
813
17
95
1.81
1.44
1.7
1.4
—
—
—
0
0
6
22
2.74
1.43
1.5
1.7
196.67
210.41
u/l
—
6
22
10
46
2.19
1.40
1.3
1.3
—
—
—
0
0
6
23
2.62
1.37
1.2
1.9
—
—
—
0
0
6
23
2.62
1.37
1.2
1.9
—
—
—
0
0
6
24
2.51
1.30
1.2
1.8
—
—
—
0
0
5
18
2.79
1.28
3.2
1.9
—
—
—
0
0
5
18
2.79
1.28
3.2
1.9
—
—
—
0
0
11
55
2.01
1.28
1.0
1.1
—
—
—
0
0
8
35
2.30
1.27
1.0
1.1
—
—
—
0
0
21
131
1.62
1.24
1.5
1.6
—
—
—
0
0
17
100
1.72
1.24
1.3
1.7
—
—
—
0
0
17
100
1.72
1.24
1.3
1.7
—
—
—
0
0
120
1007
1.23
1.24
3.5
3.3
825.66
745.15
ng/l
0.04
104
846
5
19
2.64
1.21
1.0
1.2
—
—
—
0
0
5
19
2.64
1.21
1.0
1.1
—
—
—
0
0
506
4794
1.17
1.21
4.0
3.9
1.91
2.35
mu/l
1.02
467
4229
12
64
1.89
1.18
2.3
1.9
89.13
89.72
%
0.13
12
64
13
72
1.82
1.15
1.8
1.4
—
—
—
0
0
181
1592
1.18
1.14
3.3
3.2
49.00
76.07
e6/l
0.52
139
1221
41
547
0.74
1.12
1.4
1.4
—
—
—
0
0
5
21
2.39
1.09
1.2
2.2
—
—
—
0
0
16
97
1.66
1.07
1.5
1.6
—
—
—
0
0
9
46
1.97
1.04
3.4
2.4
—
—
—
0
0
56
441
1.29
1.01
2.8
2.2
11.47
7.53
ug/l
0.29
49
400
164
1453
1.16
0.95
3.3
3.1
0.70
0.57
e6/l
0.24
127
1095
14
86
1.64
0.91
1.9
1.4
—
—
—
0
0
88
743
1.21
0.89
1.2
1.2
34.91
43.49
iu/ml
0.16
23
228
211
1914
1.14
0.89
3.5
3.1
—
—
—
0
0
6
30
2.01
0.87
1.0
1.2
—
—
—
0
0
57
697
0.80
0.85
1.2
1.2
9.38
18.07
u/ml
0.72
22
260
441
4199
1.12
0.82
6.0
7.5
72.27
80.31
u/l
5.82
413
3918
82
695
1.20
0.81
7.6
6.2
—
—
—
0
0
119
1045
1.16
0.79
3.1
2.5
7.45
5.77
e6/l
0.37
106
934
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
12
77
1.57
0.69
1.9
1.4
—
—
—
0
0
5
92
0.54
0.67
1.6
1.5
—
—
—
0
0
8
127
0.63
0.64
1.3
1.2
—
—
—
0
0
5
29
1.73
0.64
2.8
1.5
—
—
—
0
0
5
29
1.73
0.64
2.8
1.5
—
—
—
0
0
5
30
1.67
0.61
1.8
1.3
—
—
—
0
0
16
113
1.42
0.61
1.4
1.3
—
—
—
0
0
148
1346
1.12
0.61
4.1
3.3
0.00
0.01
estimate
0.50
50
409
176
1618
1.11
0.60
2.9
2.8
1032.63
1560.21
ng/l
1.34
146
1405
15
106
1.42
0.58
4.7
2.9
70.74
62.43
%
1.13
15
106
6
36
1.67
0.56
2.5
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
24
186
1.30
0.55
2.8
2.5
0.35
0.31
u/ml
0.30
15
103
197
1833
1.10
0.54
3.8
3.5
101.50
171.69
e6/l
0.50
142
1300
6
39
1.54
0.53
1.8
1.4
—
—
—
0
0
9
65
1.39
0.50
1.1
1.4
—
—
—
0
0
239
2532
0.92
0.50
5.1
4.3
0.00
0.00
estimate
-0.00
51
435
7
46
1.53
0.48
1.1
1.1
—
—
—
0
0
5
31
1.62
0.43
1.6
2.1
—
—
—
0
0
6
93
0.64
0.42
2.2
5.5
—
421.67
—
0
12
13
96
1.36
0.41
1.3
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
8
59
1.36
0.41
1.9
1.5
—
—
—
0
0
0
17
0.00
0.40
0.0
1.3
—
0.94
—
0
5
5
34
1.47
0.40
1.2
1.1
—
—
—
0
0
5
36
1.39
0.38
1.0
1.3
—
—
—
0
0
9
69
1.31
0.37
1.4
1.6
—
—
—
0
0
9
69
1.31
0.37
1.4
1.6
—
—
—
0
0
5
37
1.35
0.37
1.0
1.4
—
100.00
—
0
6
5
76
0.66
0.36
1.0
1.1
—
—
—
0
0
38
437
0.86
0.35
1.9
2.8
121.92
59.18
ml/min/173m2
0.69
12
170
6
42
1.43
0.35
1.0
1.1
—
—
—
0
0
87
799
1.10
0.34
1.8
2.4
14.25
12.71
umol/l
0.83
76
752
116
1083
1.08
0.32
3.7
3.3
1.01
1.02
kg/l
0.79
23
145
20
165
1.22
0.31
1.9
1.3
—
—
—
0
0
7
97
0.72
0.31
1.1
1.5
—
—
—
0
0
10
75
1.34
0.30
1.7
1.5
—
—
—
0
0
15
121
1.24
0.28
1.9
1.4
—
—
—
0
0
28
242
1.16
0.28
1.1
1.2
103.31
151.07
iu/ml
—
8
83
39
438
0.88
0.28
2.6
2.3
30.52
35.85
u/l
0.67
31
375
8
63
1.27
0.28
2.9
4.5
—
—
—
0
0
198
1900
1.06
0.26
2.4
2.6
142.88
172.52
ug/l
1.45
180
1734
22
188
1.18
0.25
1.9
1.4
—
—
—
0
0
249
2571
0.95
0.24
3.8
3.1
0.00
0.00
estimate
-0.00
50
429
157
1503
1.06
0.23
2.3
2.3
52.72
62.69
u/l
1.99
143
1370
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
245
2524
0.96
0.21
3.8
3.1
0.00
0.00
estimate
0.50
54
465
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.25
0.20
1.2
1.3
5.50
13.93
u/l
—
6
43
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
10
81
1.24
0.19
1.2
1.2
—
—
—
0
0
57
532
1.08
0.18
2.3
2.8
7.28
9.52
umol/l
0.63
49
469
7
59
1.19
0.18
2.6
1.2
—
—
—
0
0
10
121
0.82
0.18
1.2
1.6
—
—
—
0
0
552
5463
1.04
0.16
16.3
12.3
25.73
28.33
mg/l
0.83
477
4127
8
72
1.11
0.16
2.4
1.3
—
—
—
0
0
201
1956
1.04
0.15
3.9
3.3
—
—
—
0
0
15
132
1.14
0.13
1.3
1.1
—
—
—
0
0
15
132
1.14
0.13
1.3
1.1
—
—
—
0
0
96
928
1.04
0.11
2.7
2.8
1.38
1.04
e6/l
0.44
65
550
10
86
1.16
0.11
1.1
1.9
14.26
28.15
ug/l
—
10
86
128
1315
0.97
0.10
2.0
2.5
—
—
—
0
0
6
73
0.82
0.07
1.0
1.4
—
172.84
—
0
14
15
137
1.10
0.07
3.0
2.4
3.62
3.67
g/l
0.03
15
129
12
132
0.91
0.06
1.8
1.7
—
—
—
0
0
73
710
1.03
0.06
1.7
2.3
23.61
22.88
%
0.18
64
620
87
887
0.98
0.05
2.8
2.9
1.74
1.64
e6/l
0.07
55
512
76
744
1.02
0.04
1.6
2.3
2.23
2.25
g/l
0.14
64
696
126
1242
1.02
0.04
2.1
2.1
3.13
2.89
mg/l
0.47
100
1042
13
140
0.93
0.04
1.5
1.4
—
—
—
0
0
19
180
1.06
0.04
1.9
4.4
37.83
41.43
mg/l
0.10
14
155
21
200
1.05
0.03
1.3
1.2
—
—
—
0
0
255
2532
1.01
0.03
2.1
2.6
—
—
—
0
0
16
153
1.05
0.01
4.1
3.1
24.20
30.38
mg/l
—
10
93
69
682
1.01
0.01
3.7
4.2
34.34
32.58
%
0.59
41
410
57
564
1.01
0.00
1.4
1.3
—
—
—
0
0
270
2706
1.00
0.00
2.6
2.2
—
—
—
0
0
13
125
1.04
0.00
2.2
1.8
—
—
—
0
0
11
106
1.04
0.00
1.5
1.6
52.45
41.48
nmol/l
0.64
11
100
14
137
1.02
0.00
2.4
2.3
13.80
70.23
ug/min
—
5
79
13
129
1.01
0.00
1.1
1.4
—
—
—
0
0
18
181
0.99
0.00
2.0
4.4
35.36
85.59
mg/l
0.80
13
153
20
201
0.99
0.00
1.2
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
11.58
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
7.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
67
0.89
-0.00
1.5
1.4
—
—
—
0
0
6
67
0.89
-0.00
1.5
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
22.72
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
36.92
—
0
6
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
123.67
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
67
0.89
-0.00
1.5
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.7
—
6.44
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
23.83
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
-0.00
1.5
1.4
—
—
—
0
0
6
68
0.88
-0.00
1.5
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
78
0.90
-0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
0.00
—
0
6
6
67
0.89
-0.00
1.5
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
9.12
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint G6_ALS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALS | 18.515 [14.27, 24.02] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.318 |
During the follow-up period (1.1.1998 — 31.12.2019), 2037 out of 2507 females with G6_ALS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALS | 9.357 [7.48, 11.7] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.04 |
During the follow-up period (1.1.1998 — 31.12.2019), 1983 out of 2612 males with G6_ALS died.
Mortality risk
Mortality risk for people of age
years, who have G6_ALS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.608% | 1.809% |
| 5 | 9.35% | 11.766% |
| 10 | 22.668% | 26.493% |
| 15 | 41.38% | 44.597% |
| 20 | 62.462% | 65.032% |
Relationships between endpoints
↥Index endpoint: G6_ALS – Motor neuron disease
GWS hits: 9
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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