amyotrophic lateral sclerosis: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
64 |
4. Check minimum number of eventsNone |
64 |
5. Include endpointsNone |
64 |
6. Filter based on genotype QC (FinnGen only) |
64 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEUATR
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G12
- Name in latin
- Alia atrophia musculorum spinalis congenita
Similar endpoints
↥List of similar endpoints to
Other inherited muscular atrophy
based on the number of shared cases.
Similar with more cases:
- Systemic atrophies primarily affecting the central nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 493 | 224 | 266 |
| Only index persons | 366 | 165 | 201 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 54.54 | 53.40 | 55.54 |
| Only index persons | 52.81 | 50.63 | 54.60 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 64 | 28 | 36 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 53.12 | 51.80 | 54.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 56
- Matched controls
- 562
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G12.1
ICD-10 Finland
Other inherited spinal muscular atrophy
+∞
77.5
55
*
G12.2
ICD-10 Finland
Motor neuron disease
+∞
16.4
15
*
G12.8
ICD-10 Finland
Other spinal muscular atrophies and related syndromes
+∞
13.0
12
*
G12.9
ICD-10 Finland
Spinal muscular atrophy, unspecified
+∞
11.9
11
*
Z31.5
ICD-10 Finland
Genetic counselling
19.7
11.4
17
12
G12.0
ICD-10 Finland
Infantile spinal muscular atrophy, type I [Werdnig-Hoffman]
+∞
7.4
7
*
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
35.0
7.4
9
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
19.8
7.0
10
6
J96.1
ICD-10 Finland
Chronic respiratory failure
26.2
6.9
9
*
M41.4
ICD-10 Finland
Neuromuscular scoliosis
+∞
6.4
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3022313) Gas panel - Capillary blood
12
26
5.45
5.52
5.1
7.2
—
—
—
0
0
(3004490) Bicarbonate [Moles/volume] standard in Capillary blood
11
28
4.54
4.17
5.6
5.9
mmol/l
25.1
25.1
0.02
11
28
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
22
98
2.90
3.65
3.6
2.3
e6/l
0.6
1.1
0.41
16
55
(3016018) Differential panel - Cerebral spinal fluid
6
6
10.85
3.57
8.0
1.0
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
7
13
5.90
2.95
8.1
1.1
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
19
87
2.68
2.94
3.8
2.3
e6/l
3.3
0.6
0.95
13
44
(3023410) Appearance of Cerebral spinal fluid
6
10
6.48
2.76
9.3
1.2
—
—
—
0
0
(3019473) Protein [Mass/volume] in Cerebral spinal fluid
7
15
5.10
2.68
7.9
1.3
mg/l
325.7
385.0
—
7
15
(3007853) Bacteria identified in Skin by Aerobe culture
14
62
2.61
2.27
3.1
1.7
—
—
—
0
0
(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma
0
55
0.00
2.19
0.0
1.6
—
1.3
—
0
49
(3030366) Cystatin C [Mass/volume] in Serum or Plasma
6
16
4.02
1.98
11.8
8.6
mg/l
0.8
1.1
—
6
16
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
6
20
3.20
1.62
4.8
6.8
—
—
—
0
0
(3015736) pH of Urine
28
188
1.87
1.60
3.5
3.7
—
—
—
0
0
(3037121) Protein [Mass/volume] in Urine
6
22
2.90
1.47
11.8
3.3
g/l
0.2
0.2
—
6
11
(4034850)
5
17
3.10
1.38
8.8
11.9
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
5
18
2.92
1.31
1.4
3.9
—
—
—
0
0
(3014576) Chloride [Moles/volume] in Serum or Plasma
11
58
2.08
1.21
4.4
6.6
mmol/l
105.9
104.6
0.32
11
58
(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma
0
34
0.00
1.20
0.0
1.2
—
212.2
—
0
15
(3026008) Bacteria identified in Urine by Culture
19
123
1.77
1.17
3.7
2.9
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
17
112
1.71
0.98
2.2
3.2
—
—
—
0
0
(3028026) IgM [Mass/volume] in Serum or Plasma
7
37
2.00
0.97
1.1
2.0
g/l
0.9
1.2
—
7
32
(3005719) IgG [Mass/volume] in Serum or Plasma
8
43
1.98
0.91
1.5
2.4
g/l
13.8
9.7
—
8
37
(3013742) Prealbumin [Mass/volume] in Serum or Plasma
8
47
1.80
0.84
1.7
2.7
g/l
0.2
0.2
—
8
42
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
22
161
1.56
0.84
4.0
3.1
u/l
32.4
28.3
0.40
22
148
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
17
117
1.62
0.83
1.4
2.5
—
—
—
0
0
(3020891) Body temperature
0
24
0.00
0.81
0.0
4.5
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
24
183
1.50
0.75
4.7
3.2
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
7
40
1.84
0.74
17.7
9.0
mmol/l
24.1
25.4
—
7
40
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
23
175
1.49
0.72
1.9
1.7
pmol/l
94.0
97.2
0.10
12
80
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
5
26
2.00
0.72
1.2
1.5
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
5
27
1.92
0.70
11.0
3.7
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
21
160
1.47
0.65
1.6
2.5
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
20
151
1.47
0.64
5.0
2.9
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
17
124
1.51
0.64
4.4
3.6
—
—
—
0
0
(3012544) pH of Venous blood
8
50
1.68
0.64
8.6
5.6
—
—
—
0
0
(3002032) Base excess in Venous blood by calculation
8
52
1.61
0.62
8.6
5.5
mmol/l
2.0
1.4
—
8
40
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
20
0.00
0.61
0.0
1.3
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
0
20
0.00
0.61
0.0
1.5
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
0
19
0.00
0.61
0.0
1.5
—
—
—
0
0
(3043409) Potassium [Moles/volume] in Arterial blood
0
19
0.00
0.61
0.0
3.4
—
4.0
—
0
19
(3013139) Helicobacter pylori Ag [Presence] in Stool
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
9
62
1.52
0.56
1.3
1.6
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
28
231
1.38
0.55
2.7
4.0
—
—
—
0
0
(40761535) Cells panel - Urine sediment
6
39
1.59
0.54
1.7
3.8
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
22
175
1.39
0.53
3.0
3.8
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
39
341
1.37
0.53
5.0
4.0
—
—
—
0
0
(3022145) Colonoscopy Study observation
7
48
1.51
0.49
1.4
1.4
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
17
131
1.41
0.49
1.4
1.3
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
38
424
0.74
0.48
21.6
16.9
%
13.8
13.6
0.47
38
416
(3000991) Gas panel - Venous blood
7
49
1.48
0.48
15.7
8.4
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
30
344
0.76
0.45
3.3
3.4
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
15
115
1.40
0.44
3.3
5.2
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
0
15
0.00
0.42
0.0
1.4
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
0
15
0.00
0.42
0.0
1.2
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
17
0.00
0.41
0.0
3.0
—
—
—
0
0
(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
17
0.00
0.41
0.0
3.0
—
3.7
—
0
12
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
16
126
1.36
0.40
1.2
1.5
u/ml
0.6
0.7
—
5
28
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
15
183
0.76
0.33
6.6
4.4
ug/l
1.4
1.7
0.54
15
156
(3012095) Magnesium [Moles/volume] in Serum or Plasma
10
75
1.40
0.32
1.9
5.3
mmol/l
0.8
0.8
—
10
70
(3000492) Spirometry study
7
54
1.33
0.32
1.3
1.6
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
6
82
0.70
0.26
1.8
1.6
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
7
93
0.72
0.24
1.1
1.8
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
17
197
0.81
0.24
2.5
3.5
ng/l
44.1
55.1
—
10
136
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
5
39
1.31
0.23
2.0
2.0
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
5
39
1.31
0.23
1.0
1.7
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
5
40
1.27
0.23
1.2
1.4
—
—
—
0
0
(3016650) Hepatitis A virus Ab [Presence] in Serum
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
(44806118)
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
(3050449) Albumin [Mass/time] in Urine collected for unspecified duration
0
11
0.00
0.21
0.0
2.1
—
94.6
—
0
6
(44790049)
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
11
0.00
0.21
0.0
3.3
—
76.2
—
0
11
(44790047)
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(44790048)
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3039162) Centromere protein B Ab [Units/volume] in Serum
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(40759836) Histone Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(3029634) Reagin Ab [Titer] in Serum by VDRL
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3006184) Hemoglobin [Mass/volume] in Capillary blood
0
12
0.00
0.21
0.0
1.3
—
124.4
—
0
5
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
0
12
0.00
0.21
0.0
3.4
—
0.0
—
0
12
(3000475) Leukocytes [#/volume] in Synovial fluid
0
12
0.00
0.21
0.0
1.4
—
4068.2
—
0
5
(3019225) pH of Specimen
6
48
1.28
0.21
2.8
4.4
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
(1001926) Buprenorphine [Presence] in Urine by Screen method
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
17
193
0.84
0.19
2.5
2.1
—
—
—
0
0
(3002256) Pathology report gross observation
7
59
1.21
0.19
1.3
1.3
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
5
66
0.74
0.18
1.4
1.2
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
45
469
0.86
0.14
18.1
15.0
%
40.5
40.8
0.08
33
360
(40758558) Short blood count panel - Blood
16
142
1.17
0.14
3.3
7.9
—
—
—
0
0
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
13
147
0.85
0.13
1.8
3.0
u/l
57.2
56.0
0.04
13
137
(40760892) CBC W Ordered Manual Differential panel - Blood
11
95
1.19
0.12
9.5
6.3
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
5
44
1.15
0.10
1.6
1.8
—
—
—
0
0
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
48
494
0.89
0.09
4.4
4.8
mmol/l
3.1
2.7
2.24
43
450
(3017143) Hepatitis C virus Ab [Presence] in Serum
7
64
1.11
0.08
1.4
1.4
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
7
66
1.07
0.08
4.7
7.9
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
54
528
1.15
0.08
14.7
16.0
umol/l
49.2
76.3
8.55
54
528
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
48
467
1.11
0.08
3.5
3.8
mmol/l
1.8
1.3
1.72
42
423
(3022096) Basophils/100 leukocytes in Blood
24
228
1.08
0.06
6.7
6.1
%
0.6
0.7
0.39
24
208
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
49
480
1.09
0.05
3.9
4.3
mmol/l
5.1
4.6
2.14
44
441
(3044889) 12 lead EKG panel
31
320
0.94
0.04
2.6
3.7
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
49
499
0.92
0.04
16.1
14.6
mg/l
25.6
21.6
0.29
42
383
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
44
449
0.94
0.03
11.9
12.9
ml/min/173m2
101.5
82.1
2.53
37
361
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
47
478
0.94
0.02
4.1
4.3
mmol/l
1.4
1.5
0.72
42
435
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
11
103
1.08
0.02
1.3
1.6
—
—
—
0
0
(3018418) pH of Serum or Plasma
14
133
1.07
0.02
6.2
4.7
—
7.4
—
0
21
(1761868) Lipid panel - Serum or Plasma
17
163
1.06
0.01
3.5
2.6
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
46
467
0.95
0.01
3.7
4.5
mmol/l
5.9
5.9
0.06
40
429
(42870588) Differential panel, method unspecified - Blood
18
173
1.06
0.01
6.9
6.1
—
—
—
0
0
(3019150) Specific gravity of Urine by Refractometry
10
106
0.93
0.01
3.5
4.4
—
1.0
—
0
13
(3006504) Eosinophils/100 leukocytes in Blood
24
234
1.04
0.00
6.6
6.2
%
2.8
3.1
0.26
24
213
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
46
461
0.99
0.00
4.6
5.3
mmol/mol
38.8
39.0
0.06
40
432
(3019069) Monocytes/100 leukocytes in Blood
24
235
1.03
0.00
6.8
6.6
%
8.7
8.5
0.21
24
216
(3018010) Neutrophils/100 leukocytes in Blood
24
238
1.01
0.00
6.7
6.2
%
57.9
56.6
0.20
24
220
(3002030) Lymphocytes/100 leukocytes in Blood
24
244
0.97
0.00
6.9
6.3
%
25.3
28.4
0.88
24
224
(3013512) EKG study
13
128
1.02
0.00
4.1
3.9
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
0.00
0.0
1.3
—
90.3
—
0
6
(3038177) Helicobacter pylori Ab [Presence] in Serum
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(4306422)
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3051611) Lipemic interference index of Serum or Plasma
0
9
0.00
0.00
0.0
3.2
—
—
—
0
0
(3013327) Hepatitis A virus IgM Ab [Presence] in Serum
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
(3022806) Fractional oxyhemoglobin in Capillary blood
0
5
0.00
0.00
0.0
1.6
—
85.4
—
0
5
(3035285) Chloride [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
3.8
—
106.7
—
0
6
(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3051651) Icteric interference index of Serum or Plasma
0
8
0.00
0.00
0.0
3.3
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
3.8
—
4.0
—
0
6
(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
5
52
0.96
0.00
1.0
1.2
—
—
—
0
0
(3019420) Tryptase [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.4
—
8.4
—
0
5
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3028271) Lactate [Moles/volume] in Capillary blood
0
6
0.00
0.00
0.0
1.8
—
1.5
—
0
6
(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
53
530
1.00
0.00
12.5
12.0
—
—
—
0
0
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.6
—
1.2
—
0
7
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(3021788) Differential panel - Synovial fluid
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3028707) Methadone [Presence] in Urine by Screen method
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3053028) Streptococcus sp identified in Specimen by Organism specific culture
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3044927) Protein electrophoresis panel - Urine
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3042975) Streptococcus sp identified in Isolate by Organism specific culture
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3023420) DNA double strand Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3024980) IgG subclass 4 [Mass/volume] in Serum
0
7
0.00
0.00
0.0
1.3
—
0.6
—
0
7
(4268621)
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
0
5
0.00
0.00
0.0
7.8
—
50.8
—
0
5
(3022217) INR in Platelet poor plasma by Coagulation assay
6
60
1.00
0.00
27.2
24.0
—
1.5
—
0
7
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
7
74
0.94
0.00
1.6
1.5
—
—
—
0
0
(40768800) Prostate Pathology biopsy report
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
9
96
0.93
0.00
1.2
3.4
mmol/l
2.4
2.4
—
9
80
(3014051) Protein [Presence] in Urine by Test strip
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3023709) Somatotropin [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
5.1
—
1.7
—
0
8
(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3017817) Protein [Mass] in Urine collected for unspecified duration
0
8
0.00
0.00
0.0
6.0
—
—
—
0
0
(3012494) Peanut IgE Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
2.1
—
0
6
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3003740) Influenza virus B Ag [Presence] in Specimen
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3029075) Extractable nuclear Ab panel - Serum
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3013290) Carbon dioxide [Partial pressure] in Blood
0
8
0.00
0.00
0.0
2.0
—
5.3
—
0
8
(3044941) Cell count panel - Synovial fluid
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(1616796) Gas panel - Central venous blood
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
7
77
0.90
0.00
1.1
2.2
—
—
—
0
0
(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(3030905) Polymorphonuclear cells [#/volume] in Blood
0
5
0.00
0.00
0.0
7.4
—
2.8
—
0
5
(3027315) Oxygen [Partial pressure] in Blood
0
8
0.00
0.00
0.0
2.0
—
6.9
—
0
8
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3012447) Hantavirus puumala IgG Ab [Titer] in Serum
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3025130) Human papilloma virus identified in Specimen
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3047007) Chlamydophila sp Ab [Presence] in Serum
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(4146454)
0
5
0.00
0.00
0.0
3.8
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
6
68
0.87
0.00
1.8
1.3
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
(40768806) Pleura Pathology biopsy report
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3003458) Phosphate [Moles/volume] in Serum or Plasma
7
73
0.95
0.00
3.6
6.2
mmol/l
1.2
1.1
—
7
63
Mortality – FinRegistry
↥Association
Association between endpoint G6_OTHINMUSC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_OTHINMUSC | 7.832 [4.76, 12.89] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.382 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 175 females with G6_OTHINMUSC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_OTHINMUSC | 4.599 [2.98, 7.1] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 221 males with G6_OTHINMUSC died.
Mortality risk
Mortality risk for people of age
years, who have G6_OTHINMUSC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.862% | 0.937% |
| 5 | 4.731% | 4.767% |
| 10 | 12.211% | 12.079% |
| 15 | 21.247% | 21.337% |
| 20 | 34.039% | 34.049% |
Relationships between endpoints
↥Index endpoint: G6_OTHINMUSC – Other inherited muscular atrophy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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