This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Keratopathy (bullous aphakic) following cataract surgery
H7_KERATOPATHY
eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
26 |
4. Check minimum number of eventsNone |
26 |
5. Include endpointsNone |
26 |
6. Filter based on genotype QC (FinnGen only) |
26 |
Control definitions (FinnGen only)
- Control exclude
- H7_EYEPOSTOP
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H59
- Name in latin
- Syndroma corporis vitrei post operationem propter cataractam
Similar endpoints
↥List of similar endpoints to
Keratopathy (bullous aphakic) following cataract surgery
based on the number of shared cases.
Similar with more cases:
- Postprocedural disorders of eye and adnexa, not elsewhere classified
- Other disorders of eye and adnexa
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 334 | 207 | 121 |
| Only index persons | 281 | 180 | 101 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 75.32 | 77.72 | 71.16 |
| Only index persons | 74.34 | 77.04 | 69.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 26 | 15 | 11 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | 71.08 | 74.96 | 65.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3018677) aPTT in Platelet poor plasma by Coagulation assay
9
28
4.35
2.62
1.4
2.4
s
27.8
28.1
—
9
28
(40761511) CBC panel - Blood by Automated count
26
209
+∞
2.18
21.5
16.1
—
—
—
0
0
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
19
119
3.20
1.91
6.7
6.1
umol/l
10.4
10.3
0.03
19
112
(3044889) 12 lead EKG panel
21
152
2.97
1.47
4.4
4.7
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
16
101
2.52
1.38
12.3
9.5
inr
1.4
1.4
—
7
39
(3023368) Bacteria identified in Blood by Culture
13
76
2.42
1.30
5.4
4.1
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
13
77
2.38
1.25
3.7
2.7
—
—
—
0
0
(3013826) Glucose [Moles/volume] in Serum or Plasma
19
138
2.39
1.20
6.0
5.5
mmol/l
7.6
6.9
0.64
19
126
(3013650) Neutrophils [#/volume] in Blood by Automated count
17
120
2.20
1.17
12.3
8.7
e9/l
4.8
4.8
0.02
17
108
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
6
29
2.38
0.97
1.2
1.8
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
12
75
2.11
0.96
4.3
5.8
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
13
85
2.06
0.92
2.8
3.7
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
6
31
2.21
0.91
1.2
1.9
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
20
159
2.11
0.86
4.5
5.5
—
—
—
0
0
(4010399)
0
25
0.00
0.84
0.0
1.2
—
—
—
0
0
(40758558) Short blood count panel - Blood
9
57
1.88
0.83
11.4
8.3
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
5
23
2.44
0.81
3.6
1.5
—
—
—
0
0
(3012544) pH of Venous blood
5
24
2.33
0.79
2.6
2.5
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
5
25
2.23
0.77
1.0
1.6
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
21
173
2.11
0.73
26.8
20.6
%
38.9
38.7
0.06
15
102
(3001604) Monocytes [#/volume] in Blood
14
101
1.84
0.70
7.4
6.0
e9/l
0.6
0.6
0.03
14
87
(3006315) Basophils [#/volume] in Blood
14
102
1.81
0.67
7.4
6.1
e9/l
0.0
0.0
0.16
14
88
(3012516) Albumin [Mass/volume] in Urine
11
75
1.81
0.64
2.9
3.0
mg/l
12.2
32.0
—
5
44
(3019198) Lymphocytes [#/volume] in Blood
14
103
1.78
0.64
7.7
6.1
e9/l
1.6
1.7
0.15
14
90
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
9
63
1.65
0.61
2.0
2.5
mg/l
3.1
3.3
—
9
57
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
0
23
0.00
0.61
0.0
1.3
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
13
95
1.74
0.59
4.1
3.2
—
—
—
0
0
(3022096) Basophils/100 leukocytes in Blood
13
96
1.71
0.56
6.5
6.5
%
0.8
0.6
0.49
13
87
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
13
96
1.71
0.56
4.3
4.0
—
—
—
0
0
(3013707) Erythrocyte sedimentation rate by Westergren method
20
168
1.82
0.55
4.5
5.5
mm/h
9.9
16.0
2.22
20
150
(3013115) Eosinophils [#/volume] in Blood
14
106
1.69
0.55
7.8
6.2
e9/l
0.2
0.2
0.10
14
92
(3031040) Bacteria [#/volume] in Urine by Automated count
19
160
1.69
0.53
5.5
5.6
—
257.0
—
0
7
(3042936) Bacteria identified in Isolate by Culture
5
31
1.75
0.46
1.2
1.4
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
13
100
1.60
0.46
6.5
6.5
%
3.2
2.7
0.25
13
92
(3019069) Monocytes/100 leukocytes in Blood
13
100
1.60
0.46
6.5
6.9
%
8.8
8.5
0.16
13
92
(3000850) Epithelial cells [#/volume] in Urine
9
66
1.55
0.46
2.7
2.5
e6/l
4.4
4.8
—
9
57
(3002030) Lymphocytes/100 leukocytes in Blood
13
101
1.57
0.43
6.8
6.8
%
21.8
24.1
0.33
13
91
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
14
111
1.57
0.43
2.4
2.0
pmol/l
99.1
96.8
—
9
51
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
0
18
0.00
0.41
0.0
1.5
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
5
69
0.66
0.31
1.0
3.2
umol/l
391.0
367.1
—
5
54
(3013512) EKG study
6
79
0.69
0.30
6.2
4.7
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
5
39
1.35
0.24
8.0
5.4
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
6
47
1.36
0.23
1.2
1.9
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
6
48
1.32
0.22
1.5
2.4
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
0
11
0.00
0.22
0.0
2.3
—
—
—
0
0
(3051387) C reactive protein [Mass/volume] in Capillary blood
0
11
0.00
0.22
0.0
4.1
—
24.5
—
0
5
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
0
11
0.00
0.22
0.0
1.9
—
0.9
—
0
11
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
10
0.00
0.22
0.0
1.7
—
—
—
0
0
(3022313) Gas panel - Capillary blood
0
10
0.00
0.22
0.0
3.5
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.22
0.0
2.1
—
—
—
0
0
(3024889) Methemoglobin/Hemoglobin.total in Venous blood
0
10
0.00
0.22
0.0
1.8
—
0.8
—
0
10
(1761482) Bacteria [#/volume] in Urine by Culture
0
10
0.00
0.22
0.0
7.2
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
7
61
1.20
0.20
2.0
1.8
nmol/l
856.4
1177.6
—
7
46
(3044640) Blood type and Crossmatch panel - Blood
8
69
1.23
0.19
1.9
2.5
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
10
84
1.31
0.17
2.2
2.5
ug/l
96.3
106.7
—
10
75
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
5
42
1.23
0.11
1.0
2.0
%
16.0
21.6
—
5
37
(3022948) Iron [Moles/volume] in Serum or Plasma
5
46
1.11
0.10
1.2
2.0
umol/l
8.5
13.3
—
5
41
(3011397) Hemoglobin [Presence] in Urine by Test strip
6
55
1.12
0.09
3.3
3.6
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
5
63
0.75
0.09
2.6
3.9
—
—
—
0
0
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
8
75
1.10
0.08
1.9
2.4
u/l
45.4
53.8
—
8
66
(40768804) Tissue Pathology biopsy report
9
81
1.17
0.08
1.7
2.4
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
8
91
0.83
0.08
4.3
4.6
—
—
—
0
0
(3015736) pH of Urine
10
97
1.05
0.00
1.7
3.9
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
2.3
—
4.0
—
0
6
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3035285) Chloride [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
2.3
—
109.7
—
0
6
(4034850)
0
6
0.00
0.00
0.0
32.5
—
—
—
0
0
(3018010) Neutrophils/100 leukocytes in Blood
10
100
1.00
0.00
8.5
6.4
%
57.2
59.8
—
10
91
(40768793) Breast Pathology biopsy report
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
6
64
0.92
0.00
5.3
4.8
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
5
54
0.91
0.00
1.6
1.2
—
—
—
0
0
(3004490) Bicarbonate [Moles/volume] standard in Capillary blood
0
9
0.00
0.00
0.0
4.1
—
26.7
—
0
9
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3022806) Fractional oxyhemoglobin in Capillary blood
0
5
0.00
0.00
0.0
3.8
—
87.8
—
0
5
(3008757) Leukocyte morphology finding [Identifier] in Blood
0
5
0.00
0.00
0.0
4.2
—
—
—
0
0
(3021901) Oxygen saturation in Capillary blood
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(40768800) Prostate Pathology biopsy report
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
5
50
1.00
0.00
1.4
2.4
mg/l
4.4
1.1
—
5
44
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
10
100
1.00
0.00
1.8
2.2
—
—
—
0
0
(1002224) Polysomnography panel
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_KERATOPATHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_KERATOPATHY | 1.236 [0.93, 1.64] | 0.141 |
| Birth year | 0.999 [0.99, 1.01] | 0.78 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 182 females with H7_KERATOPATHY died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have H7_KERATOPATHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.138% | No data |
| 5 | 0.719% | No data |
| 10 | 2.05% | No data |
| 15 | 3.683% | No data |
| 20 | 6.548% | No data |
Relationships between endpoints
↥Index endpoint: H7_KERATOPATHY – Keratopathy (bullous aphakic) following cataract surgery
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data