eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Postprocedural disorders of eye and adnexa, not elsewhere classified
DOID EFO Endpoint Browser PheWeb
H7_EYEPOSTOP
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
107 |
4. Check minimum number of eventsNone |
107 |
5. Include endpoints |
107 |
6. Filter based on genotype QC (FinnGen only) |
99 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H55-H59
- Name in latin
- Morbositates oculi et organorum accessoriorum post interventiones non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Postprocedural disorders of eye and adnexa, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of eye and adnexa
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 873 | 487 | 378 |
| Only index persons | 737 | 418 | 319 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 72.77 | 74.62 | 70.31 |
| Only index persons | 71.58 | 73.40 | 69.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 99 | 57 | 42 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 72.58 | 74.12 | 70.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 107
- Matched controls
- 1070
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H59.8
ICD-10 Finland
Other postprocedural disorders of eye and adnexa
+∞
42.6
38
*
H59.9
ICD-10 Finland
Postprocedural disorder of eye and adnexa, unspecified
614.5
42.2
39
*
H59.0
ICD-10 Finland
Keratopathy (bullous aphakic) following cataract surgery
+∞
31.9
29
*
WX140
NOMESCO Finland
Parabulbar anesthesy
14.0
30.8
33
33
Z96.1
ICD-10 Finland
Presence of intraocular lens
9.2
30.4
62
140
WX100
NOMESCO Finland
Conjunctival surface anesthesia
7.0
21.6
47
108
S01ED51
ATC
timolol, combinations; ophthalmic
7.6
18.6
32
57
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.3
16.1
24
36
CKD60
NOMESCO Finland
Anterior vitrectomy
38.0
15.4
19
6
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
42.7
15.0
18
5
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
25.3
13.9
19
9
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
5.1
13.8
78
370
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.5
13.0
71
324
CJE99
NOMESCO Finland
Other extracapsular cataract operation using phakoemulsification technique
+∞
12.8
12
*
CJW99
NOMESCO Finland
Other operation on lens
109.3
9.6
10
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
10.8
8.6
16
17
H27.0
ICD-10 Finland
Aphakia
97.4
8.5
9
*
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
+∞
8.4
8
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
10.2
8.4
16
18
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
+∞
7.4
7
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.1
7.3
68
386
H25.8
ICD-10 Finland
Other senile cataract
3.5
7.1
29
102
S01BC03
ATC
diclofenac; ophthalmic
18.2
6.9
10
6
CKD20
NOMESCO Finland
Removal of vitreous body substitute
42.9
6.9
8
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
13.6
6.2
10
8
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
6.1
6.1
16
30
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
28
110
3.09
5.61
4.4
4.9
29.27
32.87
%
0.82
15
62
67
417
2.62
5.45
5.1
5.7
1.23
1.21
mmol/l
1.05
56
377
71
472
2.50
4.77
5.9
6.4
1.23
1.21
mmol/l
1.16
60
384
13
33
4.34
3.95
1.3
2.0
—
—
—
0
0
73
544
2.08
3.06
4.1
4.6
7.00
6.80
mmol/l
0.31
68
507
12
37
3.52
3.05
1.3
2.2
—
—
—
0
0
57
395
1.95
2.88
2.1
2.0
92.20
94.19
pmol/l
0.10
28
176
98
851
2.80
2.73
17.6
17.0
28.60
24.15
mg/l
0.50
88
697
93
790
2.35
2.38
4.9
4.7
2.00
2.00
mu/l
0.01
82
687
82
668
1.97
2.30
5.4
4.3
11.83
13.67
mm/h
0.79
76
595
66
506
1.79
2.21
3.2
3.1
59.11
54.70
u/l
0.10
56
468
65
500
1.76
2.11
7.3
9.4
4.60
4.37
e9/l
0.30
58
437
55
412
1.69
1.90
2.3
2.7
—
—
—
0
0
26
160
1.83
1.77
1.5
2.0
—
—
—
0
0
25
152
1.84
1.77
1.3
1.3
45.71
33.55
iu/ml
—
7
46
12
56
2.29
1.68
1.2
1.9
—
—
—
0
0
92
812
1.95
1.60
16.0
16.5
73.35
74.64
ml/min/173m2
0.23
74
673
49
370
1.60
1.56
2.4
2.3
76.50
77.75
nmol/l
0.09
42
314
18
104
1.88
1.48
5.8
6.1
4.75
5.00
kpa
0.71
13
99
98
896
2.11
1.46
20.4
19.9
79.87
81.94
umol/l
0.33
98
896
93
833
1.89
1.40
5.4
5.2
6.05
6.07
mmol/l
0.05
81
738
18
107
1.82
1.36
5.7
6.1
-1.71
1.22
mmol/l
—
9
88
25
165
1.67
1.33
3.6
3.6
17.05
104.77
ng/l
1.22
20
139
30
208
1.61
1.33
2.0
2.4
—
—
—
0
0
13
70
1.98
1.30
2.1
1.6
—
—
—
0
0
76
653
1.57
1.27
3.6
3.7
15.31
15.11
pmol/l
0.29
65
566
5
20
2.57
1.16
1.2
1.2
0.27
0.20
g/l
—
5
20
5
20
2.57
1.16
1.2
1.2
1.20
1.05
g/l
—
5
20
88
793
1.62
1.08
4.2
4.3
1.31
1.24
mmol/l
0.42
74
700
30
219
1.51
1.05
1.6
1.7
886.20
1285.68
nmol/l
2.75
23
157
51
418
1.42
0.99
4.1
4.2
40.91
46.51
ng/l
0.15
34
319
55
458
1.41
0.97
20.5
16.9
1.53
1.33
inr
0.43
13
146
33
251
1.46
0.95
2.0
2.1
2.84
3.06
mg/l
0.29
28
214
38
299
1.42
0.91
4.4
3.8
15.96
11.30
mg/mmol
0.14
20
181
93
859
1.63
0.90
5.3
5.4
2.62
2.61
mmol/l
0.06
78
757
20
138
1.55
0.90
1.2
1.3
82.70
10.63
u/ml
—
5
56
90
826
1.56
0.89
4.9
4.8
4.60
4.52
mmol/l
0.31
77
738
17
115
1.57
0.83
4.4
7.5
—
—
—
0
0
5
100
0.48
0.82
1.2
1.4
—
—
—
0
0
7
116
0.58
0.73
4.9
3.8
—
—
—
0
0
5
28
1.82
0.67
3.2
2.4
—
—
—
0
0
88
819
1.42
0.65
4.9
4.8
1.51
1.49
mmol/l
0.19
75
725
15
107
1.47
0.59
1.4
1.9
—
—
—
0
0
6
37
1.66
0.56
1.3
1.4
—
—
—
0
0
9
63
1.47
0.54
2.0
1.3
—
—
—
0
0
40
341
1.28
0.53
2.4
3.4
1519.65
1681.61
ng/l
0.12
31
274
6
40
1.53
0.52
1.0
1.0
—
—
—
0
0
22
269
0.77
0.45
5.5
4.4
0.00
0.00
estimate
—
9
95
0
17
0.00
0.41
0.0
1.3
—
—
—
0
0
5
34
1.49
0.41
1.0
1.3
—
—
—
0
0
32
369
0.81
0.40
4.7
4.4
—
—
—
0
0
5
36
1.41
0.38
1.2
2.3
—
—
—
0
0
14
108
1.34
0.37
1.4
2.0
—
—
—
0
0
10
73
1.41
0.36
1.9
1.5
1.59
1.47
%
—
10
60
47
425
1.19
0.34
2.4
2.7
—
—
—
0
0
7
51
1.40
0.32
2.9
4.2
0.01
0.13
e6/l
—
7
51
29
253
1.20
0.30
1.9
1.6
20.60
21.79
nmol/l
0.12
22
203
85
814
1.22
0.29
7.4
6.7
40.74
41.25
mmol/mol
0.19
74
738
39
425
0.87
0.24
4.2
4.3
33.28
34.55
g/l
0.54
33
397
5
42
1.20
0.22
3.0
2.6
—
—
—
0
0
10
123
0.79
0.21
7.3
6.6
109.40
104.05
mmol/l
—
10
123
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
4.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
14
0.00
0.20
0.0
2.2
—
268.46
—
0
14
23
251
0.89
0.13
2.1
1.8
319.50
451.05
pmol/l
2.97
18
200
16
177
0.89
0.11
3.8
3.0
0.42
0.78
ug/l
—
8
113
22
238
0.90
0.11
4.8
4.5
22.08
22.44
%
—
9
116
35
332
1.08
0.09
2.2
3.2
2.39
2.35
mmol/l
1.23
24
284
5
47
1.07
0.09
2.8
2.8
—
—
—
0
0
5
62
0.80
0.08
13.0
7.7
0.48
0.69
%
—
5
62
5
63
0.78
0.08
13.0
7.8
1.78
1.35
%
—
5
63
36
345
1.07
0.07
3.7
3.4
—
—
—
0
0
47
460
1.04
0.03
4.3
4.2
0.00
0.00
estimate
—
9
91
36
369
0.96
0.02
2.3
2.6
125.00
134.40
ug/l
0.13
31
325
46
453
1.03
0.01
4.3
4.2
0.00
0.00
estimate
—
9
103
11
108
1.02
0.00
1.3
1.5
—
—
—
0
0
46
455
1.02
0.00
5.5
5.6
0.00
0.00
estimate
—
9
95
15
145
1.04
0.00
1.7
1.8
28.95
29.44
s
0.14
15
140
13
125
1.05
0.00
3.8
5.2
1.06
1.04
mmol/l
0.13
13
113
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
57
0.87
-0.00
9.2
5.7
22.16
24.65
mmol/l
—
5
57
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
15.94
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
17.00
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
67.20
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
10.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
87.20
—
0
5
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
105.17
—
0
6
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_EYEPOSTOP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EYEPOSTOP | 1.239 [0.99, 1.54] | 0.057 |
| Birth year | 0.994 [0.99, 1.0] | 0.174 |
During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 404 females with H7_EYEPOSTOP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EYEPOSTOP | 1.275 [0.95, 1.71] | 0.102 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 132 out of 311 males with H7_EYEPOSTOP died.
Mortality risk
Mortality risk for people of age
years, who have H7_EYEPOSTOP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.248% |
| 5 | 0.685% | 1.393% |
| 10 | 1.707% | 3.671% |
| 15 | 3.339% | 6.617% |
| 20 | 5.871% | 11.493% |
Relationships between endpoints
↥Index endpoint: H7_EYEPOSTOP – Postprocedural disorders of eye and adnexa, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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