eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Postprocedural disorders of eye and adnexa, not elsewhere classified
DOID EFO Endpoint Browser PheWeb
H7_EYEPOSTOP
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
92 |
4. Check minimum number of eventsNone |
92 |
5. Include endpoints |
92 |
6. Filter based on genotype QC (FinnGen only) |
92 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H55-H59
- Name in latin
- Morbositates oculi et organorum accessoriorum post interventiones non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Postprocedural disorders of eye and adnexa, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of eye and adnexa
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 873 | 487 | 378 |
| Only index persons | 737 | 418 | 319 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 72.77 | 74.62 | 70.31 |
| Only index persons | 71.58 | 73.40 | 69.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 92 | 52 | 40 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 71.47 | 73.67 | 68.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 75
- Matched controls
- 748
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H59.9
ICD-10 Finland
Postprocedural disorder of eye and adnexa, unspecified
+∞
32.7
29
*
H59.8
ICD-10 Finland
Other postprocedural disorders of eye and adnexa
+∞
26.6
24
*
H59.0
ICD-10 Finland
Keratopathy (bullous aphakic) following cataract surgery
+∞
21.9
20
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
13.4
21.1
43
68
CKD60
NOMESCO Finland
Anterior vitrectomy
184.5
15.0
15
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
+∞
14.0
13
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
6.3
12.5
54
216
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
70.3
11.0
12
*
WX140
NOMESCO Finland
Parabulbar anesthesy
14.4
10.8
18
16
WX100
NOMESCO Finland
Conjunctival surface anesthesia
6.4
9.2
26
57
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.7
9.2
48
207
H33.0
ICD-10 Finland
Retinal detachment with retinal break
17.5
8.0
12
8
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
12.8
7.6
13
12
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
+∞
7.4
7
*
CJE99
NOMESCO Finland
Other extracapsular cataract operation using phakoemulsification technique
+∞
7.4
7
*
S01ED51
ATC
timolol, combinations; ophthalmic
6.4
6.9
18
35
CKD20
NOMESCO Finland
Removal of vitreous body substitute
76.0
6.5
7
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
59
350
2.91
5.69
5.3
5.5
1.23
1.21
mmol/l
1.07
49
319
62
400
2.69
4.73
6.2
6.0
1.23
1.21
mmol/l
1.32
52
324
22
94
2.76
3.77
4.1
5.3
29.58
32.82
%
0.62
12
50
10
30
3.62
3.00
1.4
2.1
—
—
—
0
0
85
726
3.24
2.85
16.7
16.8
30.55
23.94
mg/l
0.72
76
599
58
431
1.94
2.37
2.6
3.0
51.48
54.35
u/l
0.06
48
400
49
348
1.87
2.26
3.2
4.2
—
—
—
0
0
25
146
1.98
2.05
3.6
3.6
17.05
113.78
ng/l
1.18
20
123
28
171
1.92
2.02
1.7
2.1
—
—
—
0
0
9
33
2.91
1.99
1.3
2.2
—
—
—
0
0
23
133
1.97
1.93
1.5
2.0
—
—
—
0
0
78
667
2.11
1.81
5.0
4.7
1.99
2.01
mu/l
0.05
69
583
69
570
1.84
1.74
4.5
4.3
11.63
13.60
mm/h
0.79
64
506
55
428
1.71
1.69
7.3
9.2
4.72
4.42
e9/l
0.33
48
375
17
94
1.99
1.60
6.0
6.0
-1.77
1.46
mmol/l
—
8
74
45
339
1.64
1.51
2.2
2.0
85.40
94.49
pmol/l
0.56
21
150
84
761
2.19
1.42
20.5
19.6
80.31
81.31
umol/l
0.13
84
761
65
549
1.63
1.28
3.6
3.8
15.42
15.09
pmol/l
0.48
56
476
71
613
1.69
1.28
17.9
18.0
38.67
39.77
%
0.35
36
382
15
88
1.84
1.20
1.4
1.8
—
—
—
0
0
77
684
1.77
1.19
16.5
16.5
72.61
74.67
ml/min/173m2
0.35
59
563
11
60
1.95
1.08
2.2
1.6
—
—
—
0
0
9
46
2.06
1.07
1.2
1.8
—
—
—
0
0
33
248
1.52
1.05
4.4
4.0
19.45
10.89
mg/mmol
0.22
16
149
78
704
1.71
1.02
5.2
5.2
6.11
6.08
mmol/l
0.08
68
627
40
315
1.48
1.01
2.4
2.3
74.86
77.96
nmol/l
0.23
35
267
44
356
1.45
0.96
3.8
3.9
42.18
47.88
ng/l
0.13
28
265
14
89
1.68
0.87
1.4
1.9
—
—
—
0
0
7
43
1.68
0.68
2.7
3.8
1.17
2.02
mmol/l
—
7
32
35
286
1.36
0.67
2.5
3.4
1653.93
1803.71
ng/l
0.10
28
234
17
229
0.68
0.67
4.3
4.4
0.00
0.00
estimate
—
8
81
7
44
1.64
0.67
9.6
8.6
20.84
24.88
mmol/l
—
7
38
25
314
0.72
0.66
3.8
4.4
—
—
—
0
0
73
670
1.43
0.66
4.0
4.3
1.31
1.24
mmol/l
0.32
62
595
5
29
1.76
0.65
1.0
1.4
—
—
—
0
0
78
728
1.47
0.60
4.9
5.4
2.59
2.60
mmol/l
0.02
66
644
18
134
1.43
0.59
1.3
1.3
51.50
35.56
iu/ml
—
6
41
75
697
1.41
0.57
4.5
4.8
4.55
4.51
mmol/l
0.14
65
626
6
97
0.59
0.55
5.5
3.9
—
—
—
0
0
23
185
1.32
0.48
1.7
1.7
824.26
1273.57
nmol/l
3.26
18
131
8
56
1.47
0.44
2.0
1.3
—
—
—
0
0
5
33
1.54
0.42
1.0
1.0
—
—
—
0
0
5
33
1.54
0.42
1.4
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
3.67
—
0
10
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
13
99
1.36
0.38
4.5
7.5
—
—
—
0
0
26
221
1.25
0.36
1.9
1.5
19.17
22.83
nmol/l
0.60
19
179
73
693
1.26
0.33
4.6
4.9
1.51
1.49
mmol/l
0.15
63
616
27
235
1.21
0.30
3.8
3.2
0.95
0.50
e6/l
0.36
22
178
40
365
1.17
0.26
2.5
2.7
—
—
—
0
0
33
297
1.17
0.25
4.0
3.4
—
—
—
0
0
32
290
1.16
0.22
2.0
3.3
2.41
2.34
mmol/l
2.41
22
247
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
4.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
312.61
—
0
12
7
62
1.14
0.18
1.9
1.5
1.71
1.38
%
—
7
51
12
102
1.20
0.16
3.4
4.8
1.07
1.04
mmol/l
0.13
12
92
71
688
1.14
0.15
7.1
6.8
40.77
41.35
mmol/mol
0.18
62
625
5
48
1.04
0.09
9.2
6.1
22.16
25.00
mmol/l
—
5
48
5
48
1.04
0.09
3.6
4.3
0.00
0.09
e6/l
—
5
48
37
387
0.93
0.09
3.8
4.2
0.00
0.00
estimate
—
8
86
38
390
0.96
0.03
4.8
5.6
0.00
0.00
estimate
—
8
82
15
148
1.02
0.00
3.5
2.9
0.42
0.79
ug/l
—
8
95
10
97
1.03
0.00
1.2
1.5
—
—
—
0
0
36
363
0.99
0.00
4.4
4.2
33.09
34.68
g/l
0.69
31
340
20
201
0.99
0.00
4.8
4.4
21.71
22.50
%
—
8
99
39
394
0.98
0.00
3.7
4.2
0.00
0.00
estimate
—
8
78
5
52
0.96
0.00
13.0
7.8
1.78
1.50
%
—
5
52
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
107.00
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
4.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
4.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
5
51
0.98
0.00
13.0
7.8
0.48
0.71
%
—
5
51
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_EYEPOSTOP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EYEPOSTOP | 1.239 [0.99, 1.54] | 0.057 |
| Birth year | 0.994 [0.99, 1.0] | 0.174 |
During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 404 females with H7_EYEPOSTOP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EYEPOSTOP | 1.275 [0.95, 1.71] | 0.102 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 132 out of 311 males with H7_EYEPOSTOP died.
Mortality risk
Mortality risk for people of age
years, who have H7_EYEPOSTOP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.248% |
| 5 | 0.685% | 1.393% |
| 10 | 1.707% | 3.671% |
| 15 | 3.339% | 6.617% |
| 20 | 5.871% | 11.493% |
Relationships between endpoints
↥Index endpoint: H7_EYEPOSTOP – Postprocedural disorders of eye and adnexa, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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