eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Other and unspecified postprocedural disorders of eye and adnexa
DOID EFO Endpoint Browser PheWeb
H7_POSTOPEYENAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
65 |
4. Check minimum number of eventsNone |
65 |
5. Include endpointsNone |
65 |
6. Filter based on genotype QC (FinnGen only) |
65 |
Control definitions (FinnGen only)
- Control exclude
- H7_EYEPOSTOP
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified postprocedural disorders of eye and adnexa
based on the number of shared cases.
Similar with more cases:
- Postprocedural disorders of eye and adnexa, not elsewhere classified
- Other disorders of eye and adnexa
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 541 | 282 | 257 |
| Only index persons | 456 | 238 | 218 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 71.21 | 72.30 | 70.00 |
| Only index persons | 69.97 | 70.56 | 69.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 65 | 38 | 27 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 71.54 | 71.86 | 71.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 53
- Matched controls
- 530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H59.9
ICD-10 Finland
Postprocedural disorder of eye and adnexa, unspecified
+∞
34.1
29
*
H59.8
ICD-10 Finland
Other postprocedural disorders of eye and adnexa
+∞
27.5
24
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
11.6
14.1
31
57
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
9.3
12.5
40
131
CKD60
NOMESCO Finland
Anterior vitrectomy
37.8
9.9
12
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
40.2
8.4
10
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
5.7
8.3
34
127
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
22.6
8.0
11
6
WX140
NOMESCO Finland
Parabulbar anesthesy
13.9
7.8
13
12
WX100
NOMESCO Finland
Conjunctival surface anesthesia
7.0
7.6
20
42
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
24.1
7.4
10
5
H33.0
ICD-10 Finland
Retinal detachment with retinal break
13.7
7.2
12
11
S01ED51
ATC
timolol, combinations; ophthalmic
10.1
7.2
14
18
Mortality – FinRegistry
↥Association
Association between endpoint H7_POSTOPEYENAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_POSTOPEYENAS | 1.186 [0.87, 1.61] | 0.277 |
| Birth year | 0.998 [0.99, 1.01] | 0.592 |
During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 221 females with H7_POSTOPEYENAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_POSTOPEYENAS | 1.221 [0.89, 1.68] | 0.222 |
| Birth year | 0.987 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 207 males with H7_POSTOPEYENAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_POSTOPEYENAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.158% | 0.267% |
| 5 | 0.729% | 1.541% |
| 10 | 1.938% | 3.612% |
| 15 | 3.787% | 6.642% |
| 20 | 6.666% | 11.455% |
Relationships between endpoints
↥Index endpoint: H7_POSTOPEYENAS – Other and unspecified postprocedural disorders of eye and adnexa
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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