Other and unspecified postprocedural disorders of eye and adnexa

H7_POSTOPEYENAS

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

65

4. Check minimum number of events

None

65

5. Include endpoints

None

65

6. Filter based on genotype QC (FinnGen only)

65

Control definitions (FinnGen only)

Control exclude
H7_EYEPOSTOP

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 541 282 257
Only index persons 456 238 218
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 71.21 72.30 70.00
Only index persons 69.97 70.56 69.33

-FinnGen-

Key figures

All Female Male
Number of individuals 65 38 27
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 71.54 71.86 71.09

-FinRegistry-

Age distribution of first events

0102030405060708090020406080100120140AgeIndividuals

-FinnGen-

Age distribution of first events

04060708002468101214161820AgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220102030405060708090100YearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952005201020152020202302468101214161820YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
53
Matched controls
530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H59.9
ICD-10 Finland
Postprocedural disorder of eye and adnexa, unspecified
+∞
34.1
29
*
H59.8
ICD-10 Finland
Other postprocedural disorders of eye and adnexa
+∞
27.5
24
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
11.6
14.1
31
57
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
9.3
12.5
40
131
CKD60
NOMESCO Finland
Anterior vitrectomy
37.8
9.9
12
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
40.2
8.4
10
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
5.7
8.3
34
127
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
22.6
8.0
11
6
WX140
NOMESCO Finland
Parabulbar anesthesy
13.9
7.8
13
12
WX100
NOMESCO Finland
Conjunctival surface anesthesia
7.0
7.6
20
42
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
24.1
7.4
10
5
H33.0
ICD-10 Finland
Retinal detachment with retinal break
13.7
7.2
12
11
S01ED51
ATC
timolol, combinations; ophthalmic
10.1
7.2
14
18

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
20
45
5.98
9.11
3.4
3.6
—
—
—
0
0
40
247
2.61
3.43
4.8
5.6
1.24
1.21
mmol/l
2.22
32
223
43
280
2.58
3.23
4.9
6.0
1.24
1.21
mmol/l
2.17
38
226
30
169
2.44
3.03
4.6
4.3
—
—
—
0
0
8
172
0.39
1.97
3.8
3.5
—
—
—
0
0
35
240
1.99
1.96
4.1
6.0
25.07
26.05
%
0.16
30
223
9
34
2.91
1.95
1.0
1.1
—
—
—
0
0
27
174
1.94
1.76
1.7
2.2
—
—
—
0
0
6
19
3.37
1.70
2.8
2.5
—
—
—
0
0
35
253
1.83
1.56
4.0
5.5
0.65
0.61
e9/l
0.65
28
224
36
263
1.83
1.55
4.1
5.7
0.15
0.19
e9/l
1.26
28
236
27
181
1.84
1.53
3.3
5.3
—
—
—
0
0
35
255
1.81
1.51
4.1
5.6
0.04
0.04
e9/l
0.02
28
226
7
29
2.58
1.43
2.6
2.5
—
7.45
—
0
6
8
154
0.45
1.37
5.4
7.1
—
—
—
0
0
35
261
1.74
1.35
4.1
5.5
1.83
1.77
e9/l
0.13
29
237
8
38
2.26
1.23
3.3
2.8
—
—
—
0
0
48
398
1.79
1.21
4.4
4.4
12.47
12.99
mm/h
0.11
43
353
58
515
2.17
1.15
12.7
16.6
21.71
24.16
mg/l
0.27
51
423
32
241
1.65
1.13
2.1
2.0
75.14
97.20
pmol/l
1.64
12
109
59
531
2.20
1.07
13.5
16.0
—
—
—
0
0
0
28
0.00
1.00
0.0
1.5
—
—
—
0
0
17
241
0.60
0.97
5.5
11.7
0.00
0.00
e9/l
—
9
206
54
478
1.77
0.90
5.0
4.7
2.11
1.98
mu/l
0.36
47
420
22
160
1.57
0.86
4.5
3.0
74.00
80.88
mg/l
0.04
13
96
8
47
1.80
0.84
1.5
2.8
—
—
—
0
0
9
141
0.58
0.82
1.4
1.7
0.85
1.29
mmol/l
—
9
115
0
25
0.00
0.81
0.0
3.7
—
—
—
0
0
37
306
1.49
0.78
5.2
10.2
4.69
4.54
e9/l
0.11
30
276
50
444
1.55
0.71
13.7
18.0
38.48
39.68
%
0.23
21
287
5
29
1.78
0.65
1.0
1.2
—
—
—
0
0
0
20
0.00
0.61
0.0
1.8
—
—
—
0
0
30
248
1.39
0.59
3.7
3.9
51.15
55.44
ng/l
0.06
18
180
54
496
1.52
0.55
5.0
5.2
5.95
6.03
mmol/l
0.20
44
444
9
63
1.50
0.55
1.4
1.6
—
—
—
0
0
9
63
1.50
0.55
1.2
1.3
—
292.50
—
0
16
22
175
1.39
0.53
4.7
3.8
25.20
11.60
mg/mmol
0.27
12
105
56
523
1.51
0.49
4.5
5.4
2.66
2.60
mmol/l
0.17
45
467
7
49
1.48
0.48
3.1
3.4
—
—
—
0
0
24
197
1.35
0.47
2.1
3.7
2.42
2.35
mmol/l
2.13
14
164
44
395
1.35
0.47
3.5
3.7
15.72
14.98
pmol/l
1.05
36
342
12
160
0.69
0.47
2.6
4.1
—
—
—
0
0
14
181
0.71
0.46
3.6
3.6
—
—
—
0
0
52
480
1.42
0.46
3.8
4.3
1.20
1.23
mmol/l
0.12
42
428
19
151
1.36
0.45
1.8
1.5
20.15
23.10
nmol/l
0.29
12
123
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
3.2
—
16.00
—
0
7
0
16
0.00
0.41
0.0
4.6
—
2.10
—
0
11
0
16
0.00
0.41
0.0
4.6
—
5.08
—
0
16
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
4.6
—
7.84
—
0
16
0
18
0.00
0.40
0.0
2.8
—
56.89
—
0
18
0
18
0.00
0.40
0.0
2.3
—
125.50
—
0
12
57
543
1.40
0.32
16.9
19.1
80.93
80.63
umol/l
0.03
57
543
53
500
1.32
0.31
4.3
4.9
4.58
4.51
mmol/l
0.19
44
453
12
150
0.75
0.31
3.4
3.2
—
—
—
0
0
18
151
1.27
0.29
2.4
4.8
—
—
—
0
0
34
372
0.82
0.28
2.9
4.4
—
—
—
0
0
6
80
0.72
0.26
1.3
1.2
—
—
—
0
0
5
37
1.38
0.24
1.4
1.7
—
—
—
0
0
19
217
0.82
0.23
2.5
2.1
—
—
—
0
0
17
196
0.82
0.22
3.6
4.1
13.19
69.28
e6/l
2.41
12
144
5
41
1.24
0.22
2.2
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.7
—
88.45
—
0
11
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.6
—
1.34
—
0
13
0
14
0.00
0.20
0.0
1.4
—
295.76
—
0
7
0
14
0.00
0.20
0.0
3.9
—
—
—
0
0
52
498
1.22
0.19
4.5
4.9
1.57
1.48
mmol/l
0.66
43
446
11
131
0.81
0.19
1.4
1.4
—
—
—
0
0
7
57
1.26
0.19
2.3
3.3
—
—
—
0
0
7
58
1.23
0.19
1.0
1.2
—
—
—
0
0
7
62
1.14
0.18
1.0
1.5
—
—
—
0
0
8
71
1.14
0.17
4.5
4.6
1.13
1.05
mmol/l
—
8
62
7
89
0.76
0.15
1.3
2.3
—
—
—
0
0
39
371
1.13
0.13
5.9
4.9
—
—
—
0
0
51
493
1.16
0.13
6.5
6.6
39.26
40.91
mmol/mol
0.78
42
450
5
48
1.05
0.09
1.0
2.1
0.23
0.21
g/l
—
5
43
10
113
0.86
0.09
3.6
4.6
—
—
—
0
0
5
60
0.82
0.08
1.0
1.3
—
—
—
0
0
19
178
1.10
0.06
4.7
5.2
1.82
1.99
ug/l
0.07
19
154
11
120
0.90
0.05
3.0
3.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
30.17
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
0.85
—
0
5
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
4.93
—
0
7
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
60.14
—
0
7
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
5
52
0.96
0.00
1.6
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_POSTOPEYENAS and mortality.

Females

Parameter HR [95% CI] p-value
H7_POSTOPEYENAS 1.186 [0.87, 1.61] 0.277
Birth year 0.998 [0.99, 1.01] 0.592

During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 221 females with H7_POSTOPEYENAS died.

Males

Parameter HR [95% CI] p-value
H7_POSTOPEYENAS 1.221 [0.89, 1.68] 0.222
Birth year 0.987 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 207 males with H7_POSTOPEYENAS died.

Mortality risk

Mortality risk for people of age

years, who have H7_POSTOPEYENAS.

N-year risk Females Males
1 0.158% 0.267%
5 0.729% 1.541%
10 1.938% 3.612%
15 3.787% 6.642%
20 6.666% 11.455%

Relationships between endpoints

Index endpoint: H7_POSTOPEYENAS – Other and unspecified postprocedural disorders of eye and adnexa

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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