Palsy of conjugate gaze

H7_PALSYCONJU

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H51.0 Cause of death: ICD-10 — H51.0 2 out of 7 registries used, show all original rules.	30
4. Check minimum number of events None	30
5. Include endpoints None	30
6. Filter based on genotype QC (FinnGen only)	30

Control definitions (FinnGen only)

Control exclude: H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H51
Name in latin: Paresis visus conjugati

NAME	H7_PALSYCONJU
CONTROL_EXCLUDE	H7_OCUMUSCLE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H510
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H510
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Palsy of conjugate gaze based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	305	164	141
Only index persons	273	152	121
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	-	51.43	41.61
Only index persons	45.96	49.43	41.61

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	30	16	14
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	51.12	41.27	62.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018677) aPTT in Platelet poor plasma by Coagulation assay

3.66

2.12

1.9

29.4

29.5

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

4.06

1.68

2.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.31

1.42

1.0

1.5

—

(3019225) pH of Specimen

2.52

1.07

5.8

8.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

2.07

1.06

2.4

1.8

114.8

98.7

pmol/l

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

2.09

0.99

1.6

2.1

272.7

395.2

u/l

0.14

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.77

0.68

3.1

2.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.63

0.0

2.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.63

0.0

1.4

—

(42870588) Differential panel, method unspecified - Blood

1.74

0.62

4.9

5.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

176

0.62

0.55

5.4

3.1

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.55

0.47

2.3

3.8

—

(3013512) EKG study

1.52

0.44

3.3

4.2

—

(3000850) Epithelial cells [#/volume] in Urine

1.38

0.35

4.2

2.0

5.8

6.5

e6/l

—

(3026493) Urate [Moles/volume] in Serum or Plasma

1.42

0.34

3.3

3.2

318.9

329.4

umol/l

—

(3044640) Blood type and Crossmatch panel - Blood

1.47

0.33

3.4

2.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.38

0.33

1.4

1.8

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.35

0.33

1.9

1.5

1.3

1.2

mmol/l

—

(3019069) Monocytes/100 leukocytes in Blood

106

1.40

0.30

5.8

6.0

7.8

8.5

0.29

(3006504) Eosinophils/100 leukocytes in Blood

106

1.40

0.30

5.6

5.5

2.6

2.7

0.11

(3003694) ABO and Rh group [Type] in Blood

1.33

0.29

1.6

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.70

0.27

1.9

4.3

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

118

1.35

0.25

6.1

5.7

10.2

11.2

umol/l

0.39

112

(3044889) 12 lead EKG panel

152

0.74

0.25

4.3

3.4

—

(3042936) Bacteria identified in Isolate by Culture

1.38

0.25

1.0

1.6

—

(3018010) Neutrophils/100 leukocytes in Blood

109

1.34

0.24

5.1

5.4

52.9

57.8

0.62

100

(3002030) Lymphocytes/100 leukocytes in Blood

110

1.32

0.22

5.6

5.7

30.1

27.6

0.33

101

(3011288) Drugs identified in Urine by Screen method

0.00

0.22

0.0

2.4

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.22

0.0

2.5

—

24.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.21

0.0

1.5

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.8

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.21

0.0

1.5

—

(3016879) Cocaine [Presence] in Urine

0.00

0.20

0.0

1.4

—

(3019060) Gas panel - Arterial blood

0.00

0.20

0.0

3.1

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.29

0.19

1.5

2.3

51.8

58.4

u/l

—

(3026008) Bacteria identified in Urine by Culture

0.75

0.18

4.3

2.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

106

1.22

0.12

4.8

4.3

—

(3022096) Basophils/100 leukocytes in Blood

106

1.22

0.12

5.8

5.2

0.7

0.6

0.55

(3023368) Bacteria identified in Blood by Culture

0.82

0.09

4.2

4.7

—

(40758558) Short blood count panel - Blood

0.75

0.09

5.8

5.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

234

0.93

0.09

15.4

13.3

12.7

25.1

mg/l

4.13

168

(40768804) Tissue Pathology biopsy report

1.14

0.08

2.2

2.0

—

(3015736) pH of Urine

1.17

0.06

1.8

4.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

168

1.03

0.00

4.1

4.4

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.02

0.00

1.2

1.8

1415.2

1207.0

nmol/l

—

(1616796) Gas panel - Central venous blood

0.00

0.0

5.4

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

4.0

—

5.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

2.0

—

109.7

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

541.5

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.6

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

3.3

—

1.6

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.7

—

(3020891) Body temperature

0.00

0.0

3.4

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

2.0

—

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

236

1.08

0.00

19.4

15.0

4.0

3.9

mmol/l

0.51

223

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.9

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.6

—

(36304419) Bacteria [Presence] in Urine

1.04

0.00

5.8

2.2

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.93

0.00

6.1

3.1

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

54.4

—

(40761511) CBC panel - Blood by Automated count

248

1.05

0.00

14.2

12.4

—

(4094501)

0.00

0.0

1.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

3.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.5

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.2

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

4.0

—

8.0

—

(3010421) pH of Blood

0.00

0.0

4.2

—

7.4

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

2.0

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

2.5

—

7.7

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.1

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

2.5

—

1.5

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

0.93

0.00

2.0

1.7

673.6

429.9

pmol/l

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

0.95

0.00

1.4

3.7

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

3.8

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

234

1.13

0.00

19.1

15.0

139.4

139.7

mmol/l

0.29

221

Mortality – FinRegistry

↥

Association

Association between endpoint H7_PALSYCONJU and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_PALSYCONJU.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_PALSYCONJU – Palsy of conjugate gaze

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Palsy of conjugate gaze

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints