Risteys · H7_BINOCUMOVOTH

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H51 Cause of death: ICD-10 — H51 2 out of 7 registries used, show all original rules.	848
4. Check minimum number of events None	848
5. Include endpoints H7_PALSYCONJU H7_CONVERGINSUFF H7_INTERNUCOPHTHALMOPLEGIA H7_BINOCUMOVNAS	879
6. Filter based on genotype QC (FinnGen only)	879

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	6549	3902	2630
Only index persons	5992	3644	2348
Unadjusted period prevalence (%)
Whole population	0.10	0.11	0.07
Only index persons	0.12	0.13	0.09
Median age at first event (years)
Whole population	26.83	27.34	25.99
Only index persons	28.28	28.58	27.82

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	879	625	254
Unadjusted period prevalence (%)	0.18	0.21	0.11
Median age at first event (years)	36.37	32.80	45.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
747: Matched controls
7471

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H51.1

ICD-10 Finland

Convergence insufficiency and excess

+∞

323.0

449

H51.2

ICD-10 Finland

Internuclear ophthalmoplegia

+∞

117.9

110

H53.3

ICD-10 Finland

Other disorders of binocular vision

166.4

97.8

101

H51.8

ICD-10 Finland

Other specified disorders of binocular movement

+∞

85.0

H50.52

ICD-10 Finland

Exophoria

456.1

83.7

H53.2

ICD-10 Finland

Diplopia

25.1

77.2

110

H51.9

ICD-10 Finland

Disorder of binocular movement, unspecified

744.7

70.3

H50.31

ICD-10 Finland

Intermittent exotropia

567.1

54.2

H50.1

ICD-10 Finland

Divergent concomitant strabismus

+∞

45.3

XCW99

NOMESCO Finland

Other investigative procedure of eye

5.5

43.4

139

296

AA1AD

NOMESCO Finland

CT of head and brain

3.5

38.1

208

733

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

5.2

35.8

119

261

R51.80

ICD-10 Finland

Headache

3.4

33.4

193

699

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.4

31.3

171

592

TAB00

NOMESCO Finland

Lumbar puncture

7.2

30.6

118

H51.0

ICD-10 Finland

Palsy of conjugate gaze

+∞

27.2

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

4.3

26.9

108

285

CEC10

NOMESCO Finland

Recession and resection of extraocular muscle

+∞

26.2

G35

ICD-10 Finland

Multiple sclerosis

10.8

24.9

N03AX12

ATC

gabapentin; oral

3.1

24.3

147

539

CEC00

NOMESCO Finland

Recession of extraocular muscle

+∞

24.1

H50.2

ICD-10 Finland

Vertical strabismus

129.1

23.7

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

4.0

23.2

275

H50.0

ICD-10 Finland

Convergent concomitant strabismus

+∞

23.0

3788X

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Other disorders of binocular eye movements

+∞

23.0

303

Kela drug reimbursment

Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)

13.4

21.3

109

Kela drug reimbursment

Multiple sclerosis

12.1

20.9

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.9

20.6

140

551

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

4.1

20.6

224

H53.1

ICD-10 Finland

Subjective visual disturbances

4.4

20.2

192

XA800

NOMESCO Finland

Neuropsychological investigation

5.1

20.2

136

Z01.8

ICD-10 Finland

Other specified special examinations

2.5

19.8

185

873

XCK00

NOMESCO Finland

Perimetry

4.6

19.4

161

N03AG01

ATC

valproic acid; systemic, rectal

3.9

18.2

222

H52.0

ICD-10 Finland

Hypermetropia

33.8

18.0

N02CC01

ATC

sumatriptan; nasal, systemic, rectal

2.5

18.0

159

726

H55

ICD-10 Finland

Nystagmus and other irregular eye movements

27.5

17.9

L03AX13

ATC

glatiramer acetate; parenteral

23.5

17.8

WX704

NOMESCO Finland

Intubation

3.7

17.5

235

CS444

NOMESCO Finland

Visual field testing with Octopus automated perimetry

8.0

17.3

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

6.3

17.2

H49.0

ICD-10 Finland

Third [oculomotor] nerve palsy

+∞

16.7

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

3.8

16.7

202

157

Kela drug reimbursment

Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)

11.1

16.6

H52.5

ICD-10 Finland

Disorders of accommodation

173.7

16.6

H50.30

ICD-10 Finland

Intermittent esotropy

173.7

16.6

H52.1

ICD-10 Finland

Myopia

9.1

16.3

TPH04

NOMESCO Finland

Cathetrisation of vein

2.4

16.3

164

797

WX725

NOMESCO Finland

Noninvasive ventilation

4.5

15.9

134

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

5.1

15.8

103

H49.2

ICD-10 Finland

Sixth [abducent] nerve palsy

+∞

15.7

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

3.0

15.1

322

M03BX01

ATC

baclofen; systemic

8.5

14.9

R42

ICD-10 Finland

Dizziness and giddiness

2.3

14.8

155

765

SPAT1028

SPAT

Ultrasound examination of paranasal sinuses

3.4

14.1

220

G43.1

ICD-10 Finland

Migraine with aura [classical migraine]

2.9

14.0

340

SAA03

NOMESCO Finland

Extended examination of mouth

1.8

13.7

326

2220

37301

ICD-8 Finland

Strabismus, Concomitans divergens

+∞

13.6

WX720

NOMESCO Finland

Own respiration

4.8

13.5

UKC02

NOMESCO Finland

Cystoscopy

2.7

13.2

402

A02BC03

ATC

lansoprazole; oral

2.0

12.9

194

1114

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.8

12.6

267

1733

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

2.6

12.6

395

H50.9

ICD-10 Finland

Strabismus, unspecified

+∞

12.5

H50.8

ICD-10 Finland

Other specified strabismus

+∞

12.5

CEC30

NOMESCO Finland

Resection of extraocular muscle

+∞

12.5

L28

ICPC

Limited function/disability (L)

2.4

12.4

108

484

SPAT1301

SPAT

No procedures

1.9

12.4

241

1515

R20.2

ICD-10 Finland

Paraesthesia of skin

3.2

12.4

225

N06AX21

ATC

duloxetine; oral

2.6

12.3

405

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

3.1

12.3

243

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.8

12.3

257

1655

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

3.5

12.2

172

N03AX16

ATC

pregabalin; oral

2.1

12.1

160

867

SPAT1263

SPAT

Sampling

1.8

11.9

334

2358

G37.9

ICD-10 Finland

Demyelinating disease of central nervous system, unspecified

12.8

11.7

N86

ICPC

Multiple sclerosis

30.6

11.7

XKD06

NOMESCO Finland

Physiologic investigation of micturition

6.1

11.3

SHB00

NOMESCO Finland

Prepation and fitting of bite rail to mouth

2.3

10.8

105

496

SPAT1324

SPAT

Screening procedure

1.9

10.8

168

969

L03AB07

ATC

interferon beta-1a; parenteral

11.4

10.6

NA7CG

NOMESCO Finland

Spine and spinal cord extensive MRI examination with high intensity magnet

9.4

10.6

NA7DG

NOMESCO Finland

Spine and spinal cord very extensive MRI examination with high intensity magnet

10.2

10.6

H50.51

ICD-10 Finland

Esophoria

111.5

10.4

H49.1

ICD-10 Finland

Fourth [trochlear] nerve palsy

+∞

10.4

KMAK

NOMESCO Finland

1.7

10.3

405

3106

R03AC02

ATC

salbutamol; inhalant

1.7

10.3

393

2991

N07AA02

ATC

pyridostigmine; systemic

23.7

10.3

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

2.3

10.2

447

SHA02

NOMESCO Finland

Correction of physiology of bite - basic therapy visit

2.6

10.2

289

XKC03

NOMESCO Finland

Water cystometry

4.7

10.1

K07.60

ICD-10 Finland

Snapping jaw

3.0

10.0

199

182

Kela drug reimbursment

Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide

5.3

9.9

N03AE01

ATC

clonazepam; systemic

3.3

9.9

161

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.6

9.9

366

2754

H54.2

ICD-10 Finland

Moderate visual impairment, binocular

26.4

9.8

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

2.3

9.8

420

WX702

NOMESCO Finland

Supraglottic ventilation device

3.1

9.7

180

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

3.8

9.4

107

-1

NOMESCO Finland

1.7

9.4

280

1974

C07AA05

ATC

propranolol; systemic

1.9

9.4

156

919

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.7

9.4

277

1948

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

3.3

9.4

151

G40.20

ICD-10 Finland

Complex partial seizures with only alteration of consciousness

8.8

9.3

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

2.4

9.3

377

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

3.3

9.1

143

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.4

9.1

353

Z3231

NOMESCO Finland

Registered nurse

1.8

9.1

195

1249

G44.2

ICD-10 Finland

Tension-type headache

2.1

9.0

112

590

SPAT1260

SPAT

Consultation of another employee

1.9

8.9

132

743

N01

ICPC

Headache

2.0

8.9

117

627

N06AA09

ATC

amitriptyline; systemic

2.5

8.8

292

G51.0

ICD-10 Finland

Bell palsy

4.8

8.8

J45.9

ICD-10 Finland

Asthma, unspecified

2.0

8.8

122

671

Z2445

NOMESCO Finland

Psychologist

3.0

8.8

174

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

2.4

8.8

324

N03AX14

ATC

levetiracetam; systemic

4.4

8.7

A28

ICPC

Limited function/disability NOS

2.3

8.6

363

R03BA05

ATC

fluticasone; inhalant

1.9

8.5

142

832

M54.4

ICD-10 Finland

Lumbago with sciatica

2.0

8.5

112

602

2AB04

NOMESCO Finland

27.9

8.5

N29

ICPC

Neurological sympt/complt other

6.8

8.4

N99

ICPC

Neurological disease other

12.9

8.4

R03DC03

ATC

montelukast; oral

2.0

8.4

119

660

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.8

8.4

177

1123

CEC90

NOMESCO Finland

Total transposition of extraocular muscle or muscles

+∞

8.3

N03AX09

ATC

lamotrigine; oral

2.8

8.3

193

F32.9

ICD-10 Finland

Depressive episode, unspecified

2.0

8.3

109

587

N02AX02

ATC

tramadol; systemic, rectal

1.6

8.2

246

1725

SPAT1231

SPAT

Assessment of adjustments needed in living environment

7.7

8.2

G43.9

ICD-10 Finland

Migraine, unspecified

2.5

8.1

279

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

4.9

8.1

N05BA01

ATC

diazepam; systemic, rectal

2.1

8.1

458

G70.0

ICD-10 Finland

Myasthenia gravis

33.7

8.1

AEA50

NOMESCO Finland

Adjustment of implanted neurostimulator

17.4

8.1

R96

ICPC

Asthma

2.4

8.1

281

N03AF02

ATC

oxcarbazepine; oral

3.7

8.0

N03AF01

ATC

carbamazepine; oral, rectal

3.2

8.0

129

F83

ICD-10 Finland

Mixed specific developmental disorders

7.3

8.0

N06AX11

ATC

mirtazapine; oral

1.6

7.9

218

1493

H04.10

ICD-10 Finland

Dry eye syndrome

2.3

7.9

332

N03AX11

ATC

topiramate; oral

3.9

7.8

WX400

NOMESCO Finland

Inhalation anesthesy

2.8

7.8

173

B80

ICPC

Iron deficiency anaemia

5.4

7.7

F45.8

ICD-10 Finland

Other somatoform disorders

2.3

7.7

319

R53

ICD-10 Finland

Malaise and fatigue

1.8

7.7

139

836

M25.5

ICD-10 Finland

Pain in joint

1.7

7.6

202

1366

R1250

NOMESCO Finland

Evaluation of functional capability

5.0

7.6

R13

ICD-10 Finland

Dysphagia

2.9

7.6

156

SPAT1097

SPAT

Recording of ECG

2.1

7.6

421

XLD10

NOMESCO Finland

Gynaecological examination

18.6

7.6

G45.9

ICD-10 Finland

Transient cerebral ischaemic attack, unspecified

3.0

7.6

149

S06.0

ICD-10 Finland

Concussion

2.2

7.6

399

A06AC01

ATC

ispaghula (psylla seeds); oral

1.8

7.6

143

875

M01AE03

ATC

ketoprofen; systemic, rectal

1.6

7.6

225

1566

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.1

7.5

402

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

2.4

7.4

266

G40.9

ICD-10 Finland

Epilepsy, unspecified

3.7

7.4

H52.3

ICD-10 Finland

Anisometropia and aniseikonia

80.8

7.4

F43.1

ICD-10 Finland

Post-traumatic stress disorder

3.2

7.3

115

A06AD11

ATC

lactulose; oral

2.2

7.3

375

N28

ICPC

Limited function/disability (N)

6.9

7.3

H53.0

ICD-10 Finland

Amblyopia ex anopsia

9.5

7.3

CEC60

NOMESCO Finland

Transposition of extraocular muscle with adjustable suture

+∞

7.3

3503

FHL

Single muscle retroposition

+∞

7.3

R07.4

ICD-10 Finland

Chest pain, unspecified

1.7

7.3

151

947

R02

ICPC

Shortness of breath/dyspnoea

2.1

7.2

380

R52.2

ICD-10 Finland

Other chronic pain

3.8

7.2

O99.3

ICD-10 Finland

Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium

3.9

7.2

Z3229

NOMESCO Finland

Other healthcare associate professional

2.3

7.2

298

N05BA06

ATC

lorazepam; systemic, sublingual

3.2

7.1

112

183

Kela drug reimbursment

Lamotrigin and topiramate

6.1

7.1

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

2.6

7.0

190

G97.0

ICD-10 Finland

Cerebrospinal fluid leak from spinal puncture

5.5

6.9

SXA05

NOMESCO Finland

6.8

A03FA02

ATC

cisapride; oral, rectal

2.6

6.8

185

A02BC01

ATC

omeprazole; systemic

1.7

6.7

168

1113

A02BC05

ATC

esomeprazole; systemic

1.5

6.7

253

1858

J01DA01

ATC

[U] cefalexin; systemic

1.5

6.7

424

3493

A04

ICPC

Weakness/tiredness general

1.9

6.7

100

562

G46.3*I67.9

ICD-10 Finland

Brain stem stroke syndrome (I60-I67+)

22.7

6.7

G44.8

ICD-10 Finland

Other specified headache syndromes

6.5

6.7

M35.7

ICD-10 Finland

Hypermobility syndrome

4.9

6.6

R56.8

ICD-10 Finland

Other and unspecified convulsions

2.6

6.5

174

R1230

NOMESCO Finland

Neuropsychological evaluation of need and possibilities to rehabilitation

6.3

6.5

H46

ICD-10 Finland

Optic neuritis

6.3

6.5

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

1.6

6.5

174

1175

CE2W4

NOMESCO Finland

Eye movement mapping

70.4

6.4

F02.89*G35

ICD-10 Finland

Dementia in multiple sclerosis

70.4

6.4

N02CC03

ATC

zolmitriptan; nasal, oral

2.4

6.4

218

G91.0

ICD-10 Finland

Communicating hydrocephalus

14.5

6.4

M50.3

ICD-10 Finland

Other cervical disc degeneration

4.5

6.4

A02BA02

ATC

ranitidine; systemic

1.8

6.4

113

673

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.7

6.3

127

787

164

Kela drug reimbursment

Fingolimod

11.1

6.3

H57.1

ICD-10 Finland

Ocular pain

3.1

6.3

106

H52.2

ICD-10 Finland

Astigmatism

9.4

6.3

J45.0

ICD-10 Finland

Predominantly allergic asthma

2.1

6.3

366

WX408

NOMESCO Finland

General anesthesy, balanced

1.6

6.3

171

1158

RS142

NOMESCO Finland

18.2

6.3

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

2.3

6.3

256

R06.0

ICD-10 Finland

Dyspnoea

1.7

6.3

145

940

PA7AD

NOMESCO Finland

CT angiography of head and neck vasculature

4.8

6.3

0148

NOMESCO Finland

+∞

6.3

G23.1

ICD-10 Finland

Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]

+∞

6.3

F95

ICPC

Strabismus

+∞

6.3

3789X

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Unspecified disorder of eye movements

+∞

6.3

G80.1

ICD-10 Finland

Spastic diplegic cerebral palsy

26.9

6.2

108

Kela drug reimbursment

Myasthenia gravis

26.9

6.2

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

2.1

6.2

319

AA5BD

NOMESCO Finland

CT of cerebral ischaemia

5.8

6.2

R44

ICPC

Respiratory, Preventive immunization/medic

5.8

6.2

G43.0

ICD-10 Finland

Migraine without aura [common migraine]

2.2

6.2

272

N04BA02

ATC

levodopa and decarboxylase inhibitor; oral

4.3

6.2

A01

ICPC

Pain general/multiple sites

2.3

6.1

252

NA7BG

NOMESCO Finland

Spine and spinal cord MRI examination with high intensity magnet

8.7

6.1

M03BA52

ATC

carisoprodol, combinations excl. psycholeptics; oral

3.5

6.1

JN3AD

NOMESCO Finland

Abdominal CT examination

2.5

6.1

193

D21

ICPC

Swallowing problem

6.8

6.1

AA1DM

NOMESCO Finland

Very extensive MRI examination of brain with 3 Tesla magnet

10.1

6.0

XKD00

NOMESCO Finland

Uroflowmetry

2.0

6.0

382

N62

ICD-10 Finland

Hypertrophy of breast

2.9

6.0

126

N05CF01

ATC

zopiclone; oral

1.6

6.0

175

1201

N04BB01

ATC

amantadine; oral

5.6

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_BINOCUMOVOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_BINOCUMOVOTH	1.212 [1.03, 1.43]	0.023
Birth year	0.996 [0.99, 1.0]	0.359

During the follow-up period (1.1.1998 — 31.12.2019), 225 out of 3488 females with H7_BINOCUMOVOTH died.

Males

Parameter	HR [95% CI]	p-value
H7_BINOCUMOVOTH	1.596 [1.34, 1.91]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 292 out of 2306 males with H7_BINOCUMOVOTH died.

Mortality risk

Mortality risk for people of age

years, who have H7_BINOCUMOVOTH.

N-year risk	Females	Males
1	0.129%	0.356%
5	0.853%	1.789%
10	1.879%	4.371%
15	3.71%	8.414%
20	6.334%	13.823%

Relationships between endpoints

↥

Index endpoint: H7_BINOCUMOVOTH – Other disorders of binocular movement

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	H7_BINOCUMOVOTH
CONTROL_EXCLUDE	H7_OCUMUSCLE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	H7_PALSYCONJU\|H7_CONVERGINSUFF\|H7_INTERNUCOPHTHALMOPLEGIA\|H7_BINOCUMOVNAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H51
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H51
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Other disorders of binocular movement

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints