Internuclear ophthalmoplegia

H7_INTERNUCOPHTHALMOPLEGIA

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H51.2 Cause of death: ICD-10 — H51.2 2 out of 7 registries used, show all original rules.	129
4. Check minimum number of events None	129
5. Include endpoints None	129
6. Filter based on genotype QC (FinnGen only)	129

Control definitions (FinnGen only)

Control exclude: H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H51
Name in latin: Ophthalmoplegia internuclearis

NAME	H7_INTERNUCOPHTHALMOPLEGIA
CONTROL_EXCLUDE	H7_OCUMUSCLE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H512
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H512
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Internuclear ophthalmoplegia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	744	360	381
Only index persons	703	351	352
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	53.28	49.63	56.83
Only index persons	52.66	49.17	56.15

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	129	75	54
Unadjusted period prevalence (%)	0.02	0.03	0.02
Median age at first event (years)	51.03	44.39	60.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
110: Matched controls
1098

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H51.2

ICD-10 Finland

Internuclear ophthalmoplegia

+∞

158.7

110

G35

ICD-10 Finland

Multiple sclerosis

106.4

29.5

109

Kela drug reimbursment

Multiple sclerosis

159.9

24.7

H53.2

ICD-10 Finland

Diplopia

43.0

23.9

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

17.1

23.7

303

Kela drug reimbursment

Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)

101.1

22.7

157

Kela drug reimbursment

Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)

121.0

19.3

G37.9

ICD-10 Finland

Demyelinating disease of central nervous system, unspecified

185.3

15.9

L03AX13

ATC

glatiramer acetate; parenteral

171.9

14.8

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

10.1

13.7

L03AB07

ATC

interferon beta-1a; parenteral

79.3

12.9

XCK00

NOMESCO Finland

Perimetry

12.2

TAB00

NOMESCO Finland

Lumbar puncture

12.1

11.6

AA1AD

NOMESCO Finland

CT of head and brain

4.8

11.4

133

H49.0

ICD-10 Finland

Third [oculomotor] nerve palsy

+∞

10.6

XCW99

NOMESCO Finland

Other investigative procedure of eye

6.9

10.2

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

7.2

9.4

N86

ICPC

Multiple sclerosis

54.4

8.8

H46

ICD-10 Finland

Optic neuritis

36.3

8.2

N07AA02

ATC

pyridostigmine; systemic

+∞

7.4

2AB04

NOMESCO Finland

+∞

7.4

L03AB08

ATC

interferon beta-1b; parenteral

+∞

7.4

Z01.0

ICD-10 Finland

Examination of eyes and vision

4.0

7.0

M03BX01

ATC

baclofen; systemic

24.3

6.8

353

Kela drug reimbursment

Cladribine and fingolimod

74.0

6.5

164

Kela drug reimbursment

Fingolimod

74.0

6.5

G46.3*I67.9

ICD-10 Finland

Brain stem stroke syndrome (I60-I67+)

74.0

6.5

B01AC30

ATC

platelet aggregation inhibitors excl. heparin - combinations

7.1

6.4

G70.0

ICD-10 Finland

Myasthenia gravis

+∞

6.3

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

13.6

6.2

N04BB01

ATC

amantadine; oral

16.2

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

17.84

29.65

1.1

1.3

713.6

506.9

mg/l

0.33

(3044290) Cell count panel - Cerebral spinal fluid

17.27

20.61

1.1

1.3

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

17.65

19.71

1.1

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

44.07

15.88

1.1

1.4

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

14.01

15.41

1.1

1.2

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

289

3.98

13.68

2.1

2.0

218.4

292.9

u/l

0.34

271

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

36.15

12.91

1.1

1.4

—

(42868647) JC virus Ab [Presence] in Serum or Plasma by Immunoassay

+∞

9.49

2.9

0.0

—

(3023410) Appearance of Cerebral spinal fluid

17.25

9.27

1.1

1.2

—

(42870588) Differential panel, method unspecified - Blood

340

2.93

8.29

7.9

5.1

—

(3016018) Differential panel - Cerebral spinal fluid

21.49

7.25

1.3

1.2

—

(3019309) Folate [Moles/volume] in Red Blood Cells

171

2.94

6.87

1.9

1.6

922.7

1264.4

nmol/l

1.81

135

(3013115) Eosinophils [#/volume] in Blood

540

2.68

6.58

8.3

6.1

0.2

e9/l

0.02

488

(3001604) Monocytes [#/volume] in Blood

525

2.63

6.42

8.3

5.7

0.6

e9/l

0.10

456

(3006315) Basophils [#/volume] in Blood

525

2.63

6.42

8.3

5.7

0.0

e9/l

0.28

458

(3019198) Lymphocytes [#/volume] in Blood

538

2.61

6.28

8.2

5.7

1.8

2.0

e9/l

0.41

486

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

103

3.05

5.58

8.9

7.8

—

(3003129) Base excess in Capillary blood by calculation

+∞

5.24

1.2

0.0

-2.1

—

mmol/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

609

2.32

4.75

8.9

10.0

4.3

4.1

e9/l

0.15

535

(3037467) Urinalysis macro (dipstick) panel - Urine

730

2.43

4.50

5.7

3.9

—

(3031040) Bacteria [#/volume] in Urine by Automated count

668

2.32

4.48

7.2

3.9

—

61.8

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

431

2.09

4.08

4.7

4.2

36.0

36.1

g/l

0.04

403

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

3.59

3.87

3.4

1.8

—

(3022313) Gas panel - Capillary blood

3.50

3.74

6.4

2.8

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

597

2.03

3.59

5.9

4.2

6.8

6.6

mmol/l

0.45

559

(3032080) INR in Blood by Coagulation assay

397

1.90

3.12

11.8

7.8

1.1

1.2

inr

0.31

130

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

4.52

3.05

1.1

1.5

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

110

2.33

3.01

5.6

4.0

33.2

31.4

0.34

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.84

2.90

1.4

1.6

—

(3019225) pH of Specimen

2.52

2.90

8.8

4.7

—

(3013512) EKG study

286

1.88

2.78

4.1

3.7

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

6.23

2.73

1.0

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

4.41

2.72

1.3

1.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

754

1.91

2.70

3.9

2.8

41.6

44.1

u/l

0.13

710

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

168

2.02

2.66

3.8

2.2

1.4

0.9

e6/l

0.35

(3049717) Cytology report of Urine Cyto stain

3.79

2.63

2.0

2.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.78

2.62

1.2

2.9

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

2.84

2.53

2.8

2.0

687.8

7331.6

u/l

—

(3026008) Bacteria identified in Urine by Culture

294

1.81

2.52

4.2

2.4

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

3.50

2.44

1.2

2.2

22.8

22.7

mmol/l

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

241

1.82

2.32

2.9

1.9

3.2

3.0

mg/l

0.24

214

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

429

1.69

2.22

7.9

5.4

1.2

mmol/l

0.38

392

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.70

2.16

1.3

2.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

368

1.69

2.15

5.3

2.8

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.04

2.12

1.2

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

528

1.66

2.11

5.3

3.3

0.0

estimate

0.00

103

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

248

1.75

2.09

3.0

1.9

—

(3013707) Erythrocyte sedimentation rate by Westergren method

793

1.75

2.07

3.6

3.8

10.6

11.1

mm/h

0.15

733

(3021601) Nitrite [Presence] in Urine by Test strip

530

1.65

2.06

6.7

4.6

0.0

estimate

0.00

100

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

183

1.83

2.06

1.4

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

160

1.87

2.02

1.7

1.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.49

2.02

4.1

6.2

25.3

25.1

mmol/l

0.10

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.15

2.01

1.2

1.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

468

1.63

1.96

9.2

6.3

1.2

mmol/l

0.39

394

(40761535) Cells panel - Urine sediment

2.14

1.89

4.7

3.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

388

1.62

1.88

2.3

1.8

84.9

96.8

pmol/l

1.17

192

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

391

1.60

1.81

4.7

3.2

22.7

45.7

ng/l

0.99

260

(3011397) Hemoglobin [Presence] in Urine by Test strip

232

1.70

1.80

5.3

3.4

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

420

1.59

1.78

2.6

2.1

75.3

77.1

nmol/l

0.18

377

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.50

1.72

1.3

2.0

—

(3000991) Gas panel - Venous blood

2.15

1.72

9.2

7.4

—

(3009508) Creatinine [Moles/volume] in Urine

306

1.61

1.68

3.5

2.9

8.4

8.0

mmol/l

0.13

245

(3012516) Albumin [Mass/volume] in Urine

271

1.63

1.68

3.6

3.2

84.4

60.4

mg/l

0.18

176

(40768797) Stomach Pathology biopsy report

130

1.83

1.66

1.2

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

3.09

1.60

4.3

1.8

3.1

4.9

e9/l

—

(3009261) Glucose [Presence] in Urine by Test strip

533

1.53

1.59

5.2

3.4

0.0

estimate

0.00

(3030467) Casts [#/volume] in Urine by Automated count

292

1.59

5.2

2.4

0.2

0.4

e6/l

0.89

210

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.94

1.52

4.5

2.0

64.7

59.7

—

(3017732) Neutrophils [#/volume] in Blood

1.99

1.52

2.4

5.1

3.8

e9/l

—

(36304419) Bacteria [Presence] in Urine

286

1.58

1.52

5.2

2.4

—

(3020779) Urea [Moles/volume] in Serum or Plasma

1.96

1.47

8.7

7.0

14.0

9.2

mmol/l

0.45

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

109

979

1.73

1.44

5.2

4.6

1.8

1.9

mu/l

0.17

103

900

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.27

1.44

1.9

2.6

1.3

1.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

230

1.58

1.39

2.0

1.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

292

1.54

1.38

4.9

3.7

8.1

9.1

mg/mmol

0.05

180

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

116

1064

1.90

1.37

19.1

13.1

20.2

21.6

mg/l

0.18

841

(3017143) Hepatitis C virus Ab [Presence] in Serum

130

1.74

1.37

1.4

1.6

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.17

1.33

2.7

3.3

61.3

50.5

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

215

1.58

1.33

1.7

327.9

468.7

pmol/l

2.16

185

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

108

1.77

1.30

1.9

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

157

1.65

1.29

4.2

2.4

9.8

1.9

e6/l

0.78

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

814

1.51

1.27

6.4

7.5

81.5

75.4

u/l

0.48

752

(3018095) Leukocytes [#/volume] in Urine

379

1.47

1.27

6.1

3.2

104.0

43.7

e6/l

0.42

258

(3029937) Albumin [Presence] in Urine by Test strip

288

1.51

1.26

5.8

3.6

0.0

estimate

0.00

(3012544) pH of Venous blood

1.84

1.25

2.0

3.9

—

(3023368) Bacteria identified in Blood by Culture

262

1.52

1.25

5.0

4.4

—

(3002582) Erythrocytes [#/volume] in Urine

325

1.48

1.25

5.0

2.6

19.1

73.3

e6/l

1.57

238

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

316

1.49

1.24

4.7

2.6

52.3

58.2

u/l

0.75

296

(3021960) Folate [Moles/volume] in Serum or Plasma

247

1.51

1.19

1.7

1.4

22.3

nmol/l

0.00

210

(3007164) IgA [Mass/volume] in Serum or Plasma

213

1.53

1.16

1.9

1.3

2.2

g/l

0.01

129

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

558

1.42

1.14

4.4

6.4

10.7

10.9

umol/l

0.05

527

(1761868) Lipid panel - Serum or Plasma

404

0.66

1.14

3.2

2.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

113

1.69

1.13

2.4

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.18

1.07

1.1

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.91

1.06

1.5

1.7

—

(3021589) Normoblasts [#/volume] in Blood

486

1.39

1.05

9.7

9.0

0.0

e9/l

0.42

402

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

807

1.43

1.05

4.5

3.9

14.9

14.6

pmol/l

0.48

738

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.84

1.04

1.6

1.4

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.96

1.04

2.2

3.4

120.3

130.6

g/l

—

(3010421) pH of Blood

2.32

1.04

1.4

3.4

7.4

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.32

1.04

1.2

1.7

0.0

g/l

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.32

1.04

1.8

1.3

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

2.32

1.04

1.2

1.7

0.0

g/l

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

2.32

1.04

1.2

1.7

0.0

g/l

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.32

1.04

1.4

3.3

5.1

5.0

kpa

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

263

1.45

1.03

3.4

2.6

1556.8

959.9

ng/l

0.43

224

(40761536) Microorganisms panel - Urine sediment

100

1.68

1.02

6.4

3.4

—

(3045414) Leukocytes [Presence] in Urine

2.06

1.01

1.4

1.3

—

(36660697) Celiac disease serology panel - Serum

1.73

0.99

1.4

1.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

127

1.58

0.95

1.3

1.7

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.28

0.95

1.5

1.1

—

(21494755) Public health laboratory ask at order entry panel

130

0.51

0.94

1.1

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

104

0.46

0.94

1.6

1.8

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.12

0.90

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.70

0.88

1.8

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.87

0.87

2.5

3.7

27.0

24.2

mmol/l

—

(3044640) Blood type and Crossmatch panel - Blood

339

1.35

0.82

3.3

2.0

—

(40761511) CBC panel - Blood by Automated count

118

1118

1.65

0.80

19.4

12.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.86

0.80

1.2

1.5

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.80

0.0

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

416

1.33

0.79

5.5

3.4

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.79

0.0

1.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.22

0.77

1.0

1.6

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.89

0.75

1.9

1.7

—

(3052851) Hemolysis interference index of Serum or Plasma

1.89

0.69

3.0

2.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

254

1.35

0.69

6.2

5.3

—

(3018418) pH of Serum or Plasma

301

1.32

0.68

3.8

3.9

7.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

107

1005

1.38

0.65

14.9

11.8

86.8

84.3

ml/min/173m2

0.51

821

(3009214) Lutropin [Units/volume] in Serum or Plasma

1.75

0.64

1.0

1.2

8.7

4.7

u/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.64

0.62

1.0

1.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.60

0.0

1.1

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.61

0.60

1.0

1.2

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.53

0.59

3.2

3.0

60.5

68.3

ml/min/173m2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.61

0.55

2.8

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

109

1.43

0.54

2.1

1.7

—

(3020891) Body temperature

1.56

0.54

5.0

4.9

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

229

1.28

0.49

1.5

1.2

0.7

0.9

u/ml

—

(40768443) Skin Pathology biopsy report

1.64

0.43

1.0

1.2

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

474

1.20

0.42

3.5

2.7

169.5

125.8

ug/l

0.25

449

(3003327) Ova and parasites identified in Stool by Light microscopy

1.54

0.42

1.4

1.6

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.54

0.42

1.0

1.8

54.6

42.9

nmol/l

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.41

0.0

1.1

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.9

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.41

0.0

3.7

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.40

0.0

1.1

—

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

102

972

1.24

0.39

19.7

13.5

41.0

40.6

0.37

740

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.39

0.0

1.1

—

2.9

—

(40768800) Prostate Pathology biopsy report

0.00

0.39

0.0

1.2

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.42

0.38

2.7

4.3

1.2

mmol/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.49

0.36

16.7

7.8

—

(3026493) Urate [Moles/volume] in Serum or Plasma

268

1.21

0.34

2.4

2.7

324.0

5028.5

umol/l

1.08

232

(40758558) Short blood count panel - Blood

278

1.20

0.34

8.1

6.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

728

0.86

0.33

3.3

3.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

103

1066

0.83

0.30

5.7

4.6

2.5

2.8

mmol/l

1.73

987

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.24

0.29

1.0

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

225

0.82

0.29

1.5

1.6

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

321

1.17

0.29

4.9

4.8

8.7

3.1

ug/l

0.43

287

(3025941) Bacteria identified in Stool by Culture

1.31

0.28

1.1

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

120

0.73

0.28

1.9

—

(4035726)

0.75

0.23

1.4

1.3

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.4

—

3.3

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

3.5

—

31.9

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

1.7

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

7.7

—

0.6

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.21

0.0

1.7

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.0

—

(3003694) ABO and Rh group [Type] in Blood

309

1.14

0.21

1.4

1.5

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

2.6

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.7

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.1

—

0.8

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.20

0.0

1.1

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.20

0.0

3.8

—

(3016879) Cocaine [Presence] in Urine

1.21

0.20

2.8

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

498

1.11

0.19

5.6

4.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

257

0.87

0.19

5.7

4.1

20.0

22.1

0.26

118

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

205

1.15

0.18

5.2

3.5

198.2

129.9

ng/l

0.15

148

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

102

1044

0.89

0.16

5.2

4.1

4.4

4.6

mmol/l

2.00

975

(3000494) Fungus identified in Specimen by Culture

129

0.84

0.15

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

122

1.17

0.14

1.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

102

1038

0.92

0.10

5.3

4.1

1.4

1.5

mmol/l

1.05

963

(3022145) Colonoscopy Study observation

106

1.15

0.10

1.3

—

(3000330) Specific gravity of Urine by Test strip

1.17

0.10

7.2

3.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

1006

0.93

0.08

5.4

4.3

6.1

5.9

mmol/l

0.49

927

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

101

995

1.07

0.07

4.8

3.7

1.4

1.3

mmol/l

1.10

922

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.09

0.07

1.3

2.1

10.2

13.4

nmol/l

—

(3048689) Calprotectin [Mass/mass] in Stool

128

1.11

0.07

1.4

1.8

629.9

119.1

ug/g

—

103

(40768804) Tissue Pathology biopsy report

426

1.05

0.06

1.6

2.0

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

953

0.95

0.05

7.8

5.5

40.7

39.7

mmol/mol

0.39

899

(3002385) Erythrocyte distribution width [Ratio]

903

0.95

0.05

20.2

15.9

13.6

13.7

0.29

885

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

108

0.92

0.03

5.6

3.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

152

1.06

0.02

2.4

2.0

—

(3042936) Bacteria identified in Isolate by Culture

147

0.95

0.01

2.4

1.9

—

(3044889) 12 lead EKG panel

726

0.98

0.00

4.6

3.6

—

(3003396) Base excess in Arterial blood by calculation

1.01

0.00

13.1

6.6

1.6

1.3

mmol/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

186

1.03

0.00

1.4

1.5

—

(3002256) Pathology report gross observation

133

0.97

0.00

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

307

1.01

0.00

4.9

3.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

185

0.97

0.00

1.3

1.0

5.0

u/ml

—

(3000492) Spirometry study

1.06

0.00

1.3

1.4

—

(3027944) Amphetamines [Presence] in Urine

0.98

0.00

3.4

1.3

—

(3028300) Cannabinoids [Presence] in Urine

0.98

0.00

3.2

1.3

—

(3027008) Opiates [Presence] in Urine

0.98

0.00

3.2

1.3

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

1.0

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

1.4

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.6

—

12.0

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

0.8

—

(4010399)

0.97

0.00

1.0

1.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.1

—

(3030558) Cytomegalovirus DNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3036035) von Willebrand factor (vWf) Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

145.4

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

2.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

5.7

—

196.5

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(4198724)

0.00

0.0

1.2

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.5

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.6

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

111.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.8

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

1.2

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

11.8

—

800.7

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

79.7

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

2.0

—

8.2

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

2.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

4.7

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.4

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.3

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

4.4

—

51.0

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.7

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood

0.00

0.0

1.4

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

3.6

—

61.4

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.2

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.8

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

58.2

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

1.6

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

142.6

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.97

0.00

1.2

1.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.94

0.00

1.2

1.4

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.2

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

170

1.00

0.00

2.5

2.1

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

19.7

—

1254.9

—

(3000764) Benzodiazepines [Presence] in Urine

1.00

0.00

3.2

1.3

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_INTERNUCOPHTHALMOPLEGIA and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
H7_INTERNUCOPHTHALMOPLEGIA	1.405 [1.03, 1.92]	0.033
Birth year	0.987 [0.98, 1.0]	0.007

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 347 males with H7_INTERNUCOPHTHALMOPLEGIA died.

Mortality risk

Mortality risk for people of age

years, who have H7_INTERNUCOPHTHALMOPLEGIA.

N-year risk	Females	Males
1	No data	0.289%
5	No data	1.514%
10	No data	3.942%
15	No data	7.271%
20	No data	12.622%

Relationships between endpoints

↥

Index endpoint: H7_INTERNUCOPHTHALMOPLEGIA – Internuclear ophthalmoplegia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Internuclear ophthalmoplegia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints