No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
129 |
4. Check minimum number of eventsNone |
129 |
5. Include endpointsNone |
129 |
6. Filter based on genotype QC (FinnGen only) |
129 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H51
- Name in latin
- Ophthalmoplegia internuclearis
Similar endpoints
↥List of similar endpoints to
Internuclear ophthalmoplegia
based on the number of shared cases.
Similar with more cases:
- Other disorders of binocular movement
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 744 | 360 | 381 |
| Only index persons | 703 | 351 | 352 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 53.28 | 49.63 | 56.83 |
| Only index persons | 52.66 | 49.17 | 56.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 129 | 75 | 54 |
| Unadjusted period prevalence (%) | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | 51.03 | 44.39 | 60.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 110
- Matched controls
- 1098
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
+∞
158.7
110
*
G35
ICD-10 Finland
Multiple sclerosis
106.4
29.5
31
*
109
Kela drug reimbursment
Multiple sclerosis
159.9
24.7
25
*
H53.2
ICD-10 Finland
Diplopia
43.0
23.9
29
9
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
17.1
23.7
39
34
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
101.1
22.7
24
*
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
121.0
19.3
20
*
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
185.3
15.9
16
*
L03AX13
ATC
glatiramer acetate; parenteral
171.9
14.8
15
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
10.1
13.7
28
36
L03AB07
ATC
interferon beta-1a; parenteral
79.3
12.9
14
*
XCK00
NOMESCO Finland
Perimetry
12.2
12.2
22
22
TAB00
NOMESCO Finland
Lumbar puncture
12.1
11.6
21
21
AA1AD
NOMESCO Finland
CT of head and brain
4.8
11.4
44
133
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
10.6
10
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.9
10.2
26
47
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
7.2
9.4
23
39
N86
ICPC
Multiple sclerosis
54.4
8.8
10
*
H46
ICD-10 Finland
Optic neuritis
36.3
8.2
10
*
N07AA02
ATC
pyridostigmine; systemic
+∞
7.4
7
*
L03AB08
ATC
interferon beta-1b; parenteral
+∞
7.4
7
*
2AB04
NOMESCO Finland
NA
+∞
7.4
7
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.0
7.0
29
90
M03BX01
ATC
baclofen; systemic
24.3
6.8
9
*
G46.3*I67.9
ICD-10 Finland
Brain stem stroke syndrome (I60-I67+)
74.0
6.5
7
*
353
Kela drug reimbursment
Cladribine and fingolimod
74.0
6.5
7
*
164
Kela drug reimbursment
Fingolimod
74.0
6.5
7
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
7.1
6.4
15
24
G70.0
ICD-10 Finland
Myasthenia gravis
+∞
6.3
6
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
13.6
6.2
10
8
N04BB01
ATC
amantadine; oral
16.2
6.0
9
6
Mortality – FinRegistry
↥Association
Association between endpoint H7_INTERNUCOPHTHALMOPLEGIA and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_INTERNUCOPHTHALMOPLEGIA | 1.405 [1.03, 1.92] | 0.033 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 347 males with H7_INTERNUCOPHTHALMOPLEGIA died.
Mortality risk
Mortality risk for people of age
years, who have H7_INTERNUCOPHTHALMOPLEGIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.289% |
| 5 | No data | 1.514% |
| 10 | No data | 3.942% |
| 15 | No data | 7.271% |
| 20 | No data | 12.622% |
Relationships between endpoints
↥Index endpoint: H7_INTERNUCOPHTHALMOPLEGIA – Internuclear ophthalmoplegia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data