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Internuclear ophthalmoplegia

DOID Endpoint Browser PheWeb

H7_INTERNUCOPHTHALMOPLEGIA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H51.2
  • Cause of death: ICD-10 — H51.2

2 out of 7 registries used, show all original rules.

134

4. Check minimum number of events

None

134

5. Include endpoints

None

134

6. Filter based on genotype QC (FinnGen only)

128

Control definitions (FinnGen only)

Control exclude
H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H51
Name in latin
Ophthalmoplegia internuclearis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 744 360 381
Only index persons 703 351 352
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 53.28 49.63 56.83
Only index persons 52.66 49.17 56.15

-FinnGen-

Key figures

All Female Male
Number of individuals 128 71 57
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 52.30 46.38 59.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
134
Matched controls
1340
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
+∞
193.6
134
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
15.4
45.9
48
47
G35
ICD-10 Finland
Multiple sclerosis
83.3
37.8
41
7
H53.2
ICD-10 Finland
Diplopia
41.9
30.1
37
12
109
Kela drug reimbursment
Multiple sclerosis
56.8
26.9
31
7
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
61.0
25.5
29
6
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
50.6
21.3
25
6
XCK00
NOMESCO Finland
Perimetry
10.0
19.9
25
30
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
73.1
17.2
19
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
6.2
16.7
34
70
L03AX13
ATC
glatiramer acetate; parenteral
68.7
16.2
18
*
TAB00
NOMESCO Finland
Lumbar puncture
14.4
15.9
27
23
L03AB07
ATC
interferon beta-1a; parenteral
51.5
15.5
18
*
AA1AD
NOMESCO Finland
CT of head and brain
4.3
15.3
59
206
N86
ICPC
Multiple sclerosis
167.5
14.8
15
*
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
12.7
12
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.1
12.6
31
75
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.0
11.2
27
64
H46
ICD-10 Finland
Optic neuritis
28.5
10.0
13
5
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.8
9.6
36
119
N04BB01
ATC
amantadine; oral
32.7
9.6
12
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
9.0
33
107
H53.1
ICD-10 Finland
Subjective visual disturbances
4.9
8.5
20
46
N03AX16
ATC
[U] pregabalin
3.1
7.9
44
185
R42
ICD-10 Finland
Dizziness and giddiness
3.0
7.6
43
181
164
Kela drug reimbursment
Fingolimod
84.6
7.5
8
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
17.0
7.4
11
7
G70.0
ICD-10 Finland
Myasthenia gravis
+∞
7.4
7
*
2AB04, ,
NOMESCO Finland
+∞
7.4
7
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
4.8
7.2
17
39
N07AA02
ATC
pyridostigmine; systemic
42.3
6.8
8
*
L03AB08
ATC
interferon beta-1b; parenteral
73.2
6.5
7
*
G36.9
ICD-10 Finland
Acute disseminated demyelination, unspecified
73.2
6.5
7
*
353
Kela drug reimbursment
Cladribine and fingolimod
73.2
6.5
7
*
M03BX01
ATC
baclofen; systemic
11.9
6.4
11
10
108
Kela drug reimbursment
Myasthenia gravis
+∞
6.3
6
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
6.3
6
*
L04AA27
ATC
[U] fingolimod
+∞
6.3
6
*
G46.3*I67.9
ICD-10 Finland
Brain stem stroke syndrome (I60-I67+)
+∞
6.3
6
*
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
18
17.60
16.68
1.1
1.3
713.58
506.89
mg/l
0.33
26
18
71
299
3.92
13.88
2.1
2.0
217.38
292.37
u/l
0.36
66
279
18
12
17.09
11.69
1.1
1.2
—
—
—
0
0
14
9
17.18
9.26
1.1
1.2
—
—
—
0
0
15
13
12.82
8.82
1.1
1.3
—
—
—
0
0
86
503
2.98
8.47
9.0
6.3
—
—
—
0
0
10
5
21.43
7.25
1.3
1.2
—
—
—
0
0
88
555
2.71
6.95
8.8
6.1
0.19
0.19
e9/l
0.13
78
503
86
539
2.66
6.84
8.8
5.7
0.56
0.56
e9/l
0.09
77
473
86
539
2.66
6.84
8.8
5.7
0.04
0.04
e9/l
0.50
77
473
87
552
2.64
6.69
8.7
5.7
1.81
1.96
e9/l
0.49
77
504
40
181
2.72
6.08
1.9
1.6
922.72
1260.01
nmol/l
1.80
29
141
5
0
+∞
5.24
1.2
0.0
-2.12
—
mmol/l
—
5
0
90
628
2.32
4.95
9.3
10.0
4.30
4.14
e9/l
0.21
80
555
102
754
2.48
4.86
5.6
3.8
—
—
—
0
0
95
689
2.30
4.61
7.1
3.9
—
67.78
—
0
9
67
448
1.99
3.74
4.9
4.1
35.88
36.18
g/l
0.17
61
420
13
42
3.32
3.47
6.4
2.8
—
—
—
0
0
84
618
1.96
3.45
6.4
4.2
6.85
6.59
mmol/l
0.47
79
580
48
300
1.93
3.15
4.2
2.4
—
—
—
0
0
67
472
1.84
3.00
19.1
11.8
1.13
1.22
inr
0.46
16
156
5
5
10.31
3.00
5.2
2.6
2.40
4.60
%
—
5
5
18
81
2.41
2.68
8.7
4.7
—
—
—
0
0
46
297
1.84
2.67
4.0
3.7
—
—
—
0
0
12
45
2.83
2.52
2.8
2.0
687.80
7331.59
u/l
—
5
16
8
21
3.98
2.50
1.3
1.2
—
—
—
0
0
9
27
3.50
2.44
1.2
2.2
22.83
23.04
mmol/l
—
9
27
9
27
3.50
2.44
2.0
2.7
—
—
—
0
0
39
246
1.83
2.41
2.9
1.8
3.13
2.96
mg/l
0.16
32
217
13
54
2.56
2.28
1.2
3.2
—
—
—
0
0
72
548
1.68
2.26
5.1
3.3
0.00
0.00
estimate
-0.00
14
113
72
549
1.67
2.24
6.5
4.5
0.00
0.00
estimate
-0.00
13
105
61
449
1.66
2.15
8.5
5.5
1.22
1.21
mmol/l
0.33
56
413
98
822
1.72
2.02
3.6
3.8
10.63
11.05
mm/h
0.12
86
756
55
400
1.64
2.00
2.3
1.8
84.11
96.39
pmol/l
1.26
31
193
64
488
1.60
1.90
9.9
6.4
1.22
1.21
mmol/l
0.34
52
413
30
189
1.76
1.84
1.4
1.6
—
—
—
0
0
36
240
1.68
1.81
5.3
3.4
—
—
—
0
0
70
552
1.56
1.76
5.0
3.3
0.00
0.00
estimate
-0.00
13
99
17
90
2.02
1.74
1.2
1.6
—
—
—
0
0
16
83
2.05
1.73
4.7
3.0
—
—
—
0
0
54
405
1.56
1.67
4.7
3.1
22.36
44.71
ng/l
1.02
45
272
12
56
2.26
1.67
4.1
5.8
25.31
25.02
mmol/l
0.13
12
56
42
298
1.60
1.64
5.1
2.4
—
—
—
0
0
43
307
1.59
1.64
5.2
2.4
0.20
0.44
e6/l
1.27
32
222
16
85
2.00
1.63
8.4
6.9
14.17
9.25
mmol/l
0.51
16
80
45
326
1.57
1.61
4.6
2.6
53.88
72.00
u/l
0.69
40
305
6
20
3.09
1.60
4.3
1.9
3.12
4.92
e9/l
—
6
20
22
132
1.80
1.58
1.2
1.2
—
—
—
0
0
44
319
1.56
1.56
3.4
3.0
8.28
8.10
mmol/l
0.06
30
259
15
79
2.01
1.56
2.4
2.4
4.84
4.60
e9/l
—
10
66
38
267
1.59
1.54
4.9
4.5
—
—
—
0
0
6
21
2.94
1.52
4.5
2.0
64.67
59.71
%
—
6
21
10
45
2.32
1.50
1.9
2.6
0.48
0.65
%
—
10
45
14
73
2.02
1.50
9.2
7.1
—
—
—
0
0
113
1014
1.73
1.50
5.4
4.5
1.83
1.86
mu/l
0.09
107
928
26
167
1.69
1.49
4.2
2.5
9.77
1.84
e6/l
0.80
12
86
40
287
1.56
1.48
3.6
3.2
81.33
57.64
mg/l
0.19
26
189
34
236
1.59
1.44
2.0
1.9
—
—
—
0
0
36
256
1.56
1.38
1.8
1.4
21.85
22.18
nmol/l
0.05
28
217
10
47
2.22
1.37
1.9
2.6
1.25
1.44
%
—
10
47
120
1103
1.84
1.35
19.0
13.0
20.06
21.50
mg/l
0.19
93
872
51
393
1.48
1.34
6.0
3.2
103.98
42.26
e6/l
0.43
33
269
95
828
1.51
1.32
4.5
3.9
14.80
14.63
pmol/l
0.24
89
757
45
339
1.49
1.32
4.9
2.6
19.07
70.34
e6/l
1.54
33
249
11
55
2.09
1.31
2.5
3.4
118.82
129.73
g/l
0.88
11
55
62
501
1.44
1.26
10.4
9.1
0.00
0.01
e9/l
0.42
52
417
32
226
1.55
1.26
1.7
1.7
323.20
466.10
pmol/l
2.34
25
194
41
306
1.49
1.25
4.5
3.7
7.82
8.74
mg/mmol
0.05
24
190
21
134
1.67
1.23
1.4
1.6
—
—
—
0
0
96
845
1.48
1.22
6.4
7.5
81.83
75.33
u/l
0.54
87
782
7
140
0.47
1.17
1.1
1.3
—
—
—
0
0
20
128
1.66
1.17
1.3
1.7
—
—
—
0
0
69
578
1.40
1.11
4.4
6.4
10.72
11.17
umol/l
0.15
64
544
39
297
1.44
1.07
5.8
3.5
0.00
0.00
estimate
-0.00
14
102
32
421
0.68
1.05
3.1
2.8
—
—
—
0
0
7
34
2.12
1.04
1.1
1.3
—
—
—
0
0
30
218
1.48
1.04
1.9
1.3
2.22
2.20
g/l
0.02
21
133
7
36
2.00
0.98
1.4
1.3
—
—
—
0
0
14
86
1.70
0.95
1.4
1.1
—
—
—
0
0
18
120
1.58
0.91
2.4
1.4
—
—
—
0
0
6
29
2.12
0.90
1.2
1.2
—
—
—
0
0
8
45
1.83
0.86
2.5
3.7
27.00
24.15
mmol/l
—
8
45
16
106
1.58
0.83
6.4
3.3
—
—
—
0
0
128
1231
1.89
0.76
30.4
19.2
40.81
40.62
%
0.17
117
1165
5
24
2.12
0.75
1.0
1.5
—
—
—
0
0
5
25
2.04
0.73
1.4
3.2
7.41
7.44
ph
—
5
25
5
25
2.04
0.73
1.4
3.1
5.06
4.94
kpa
—
5
25
39
316
1.33
0.73
3.7
4.0
7.42
7.41
ph
—
9
56
7
40
1.79
0.72
1.9
1.6
—
—
—
0
0
7
42
1.70
0.69
21.1
7.6
—
—
—
0
0
122
1163
1.55
0.69
19.3
12.1
—
—
—
0
0
5
27
1.88
0.69
3.0
2.8
—
—
—
0
0
11
71
1.60
0.64
2.0
4.0
0.40
0.66
%
—
5
25
42
350
1.29
0.64
3.3
2.0
—
—
—
0
0
5
30
1.69
0.62
1.0
1.2
8.73
4.53
u/l
—
5
23
0
20
0.00
0.61
0.0
1.3
—
—
—
0
0
10
65
1.58
0.57
1.0
1.2
—
—
—
0
0
12
82
1.51
0.56
1.8
4.0
0.17
1.09
%
—
6
35
6
38
1.61
0.55
2.8
1.3
—
—
—
0
0
55
484
1.23
0.52
3.4
2.6
165.89
128.53
ug/l
0.22
49
458
6
40
1.52
0.52
5.0
5.1
—
—
—
0
0
34
289
1.24
0.44
8.6
6.8
—
—
—
0
0
5
33
1.53
0.42
1.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
3.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
1.25
—
0
8
5
35
1.44
0.39
1.0
1.9
54.60
41.49
nmol/l
—
5
35
0
19
0.00
0.39
0.0
1.1
—
2.92
—
0
8
28
237
1.23
0.38
1.5
1.2
0.68
0.91
u/ml
—
6
62
9
122
0.72
0.37
1.7
1.9
—
—
—
0
0
107
1111
0.82
0.36
5.6
4.6
2.51
2.76
mmol/l
2.15
95
1029
7
97
0.71
0.32
1.4
1.3
—
—
—
0
0
32
280
1.19
0.31
2.3
2.7
325.32
4816.30
umol/l
1.08
22
243
10
76
1.34
0.29
2.7
4.3
1.22
1.22
mmol/l
—
10
67
8
65
1.25
0.27
1.1
1.2
—
—
—
0
0
5
71
0.69
0.27
1.4
2.0
—
—
—
0
0
100
962
1.16
0.26
19.8
15.6
15.01
14.60
%
0.30
100
948
24
210
1.17
0.24
5.7
3.5
193.11
128.99
ng/l
0.15
19
151
15
125
1.23
0.23
10.1
5.7
105.27
104.10
mmol/l
0.47
15
125
0
11
0.00
0.21
0.0
1.9
—
72.73
—
0
11
0
11
0.00
0.21
0.0
3.4
—
3.28
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
3.5
—
31.90
—
0
10
0
10
0.00
0.21
0.0
10.7
—
720.60
—
0
10
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
17.8
—
1129.40
—
0
10
6
50
1.21
0.20
2.8
1.3
—
—
—
0
0
106
1088
0.88
0.20
5.2
4.2
4.36
4.65
mmol/l
2.35
95
1015
38
350
1.12
0.19
4.7
4.9
8.41
3.01
ug/l
0.43
32
313
15
130
1.17
0.16
1.3
1.5
—
—
—
0
0
97
994
0.91
0.14
7.7
5.5
40.53
39.71
mmol/mol
0.31
90
936
106
1082
0.90
0.14
5.3
4.1
1.40
1.47
mmol/l
0.95
95
1003
12
135
0.88
0.10
1.4
1.3
—
—
—
0
0
34
321
1.08
0.10
1.4
1.5
—
—
—
0
0
103
1048
0.93
0.10
5.3
4.3
6.04
5.91
mmol/l
0.37
87
963
5
47
1.07
0.09
7.2
3.3
—
—
—
0
0
5
60
0.83
0.08
13.2
4.6
—
—
—
0
0
10
89
1.13
0.07
1.4
2.1
10.67
13.30
nmol/l
—
10
83
14
129
1.10
0.06
1.4
1.8
629.89
118.74
ug/g
—
9
104
11
101
1.10
0.04
16.3
6.6
1.75
1.29
mmol/l
0.21
11
80
33
319
1.05
0.04
4.7
2.9
—
—
—
0
0
13
139
0.93
0.03
1.2
1.2
—
—
—
0
0
105
1040
1.04
0.03
4.8
3.7
1.42
1.27
mmol/l
1.25
93
962
12
112
1.08
0.03
1.3
1.3
—
—
—
0
0
76
751
1.03
0.02
4.6
3.6
—
—
—
0
0
44
443
0.99
0.00
1.6
2.0
—
—
—
0
0
10
102
0.98
0.00
1.3
1.4
—
—
—
0
0
15
155
0.96
0.00
2.4
1.9
—
—
—
0
0
18
185
0.97
0.00
1.3
1.3
1.03
5.00
u/ml
—
6
74
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
8.0
—
0.62
—
0
9
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
8.20
—
0
5
0
5
0.00
0.00
0.0
4.4
—
51.00
—
0
5
5
50
1.00
-0.00
3.2
1.4
—
—
—
0
0
8
82
0.97
-0.00
1.0
1.4
—
—
—
0
0
5
51
0.98
-0.00
3.2
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
79.29
—
0
7
5
51
0.98
-0.00
3.2
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
1.56
—
0
8
0
8
0.00
-0.00
0.0
1.6
—
0.86
—
0
8
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
51
0.98
-0.00
3.4
1.4
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_INTERNUCOPHTHALMOPLEGIA and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
H7_INTERNUCOPHTHALMOPLEGIA 1.405 [1.03, 1.92] 0.033
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 347 males with H7_INTERNUCOPHTHALMOPLEGIA died.

Mortality risk

Mortality risk for people of age

years, who have H7_INTERNUCOPHTHALMOPLEGIA.

N-year risk Females Males
1 No data 0.289%
5 No data 1.514%
10 No data 3.942%
15 No data 7.271%
20 No data 12.622%

Relationships between endpoints

↥

Index endpoint: H7_INTERNUCOPHTHALMOPLEGIA – Internuclear ophthalmoplegia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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