No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
540 |
4. Check minimum number of eventsNone |
540 |
5. Include endpointsNone |
540 |
6. Filter based on genotype QC (FinnGen only) |
525 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H51
- Name in latin
- Convergentia insufficiens sive nimia
Similar endpoints
↥List of similar endpoints to
Convergence insufficiency and excess
based on the number of shared cases.
Similar with more cases:
- Other disorders of binocular movement
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3911 | 2548 | 1357 |
| Only index persons | 3670 | 2423 | 1247 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.04 |
| Only index persons | 0.07 | 0.09 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 19.34 | 21.03 | 16.06 |
| Only index persons | 20.89 | 22.48 | 17.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 525 | 408 | 117 |
| Unadjusted period prevalence (%) | 0.12 | 0.14 | 0.05 |
| Median age at first event (years) | 30.69 | 28.70 | 37.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 540
- Matched controls
- 5400
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H51.1
ICD-10 Finland
Convergence insufficiency and excess
+∞
307.7
540
*
H53.3
ICD-10 Finland
Other disorders of binocular vision
163.6
113.2
116
9
H53.2
ICD-10 Finland
Diplopia
21.6
84.5
65
34
H50.52
ICD-10 Finland
Exophoria
201.2
83.8
85
5
H50.31
ICD-10 Finland
Intermittent exotropia
+∞
49.8
47
*
WX704
NOMESCO Finland
Intubation
5.3
41.7
94
206
WX725
NOMESCO Finland
Noninvasive ventilation
6.5
39.4
69
119
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.9
35.1
124
383
R51.80
ICD-10 Finland
Headache
3.3
34.4
170
653
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.8
34.0
85
202
WX720
NOMESCO Finland
Own respiration
6.3
33.6
60
105
H50.1
ICD-10 Finland
Divergent concomitant strabismus
+∞
32.6
31
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.5
30.4
81
202
SPAT1301
SPAT
No procedures
2.8
27.7
218
1066
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.9
26.2
156
655
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
6.1
26.0
47
83
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.1
25.7
128
486
WX702
NOMESCO Finland
Supraglottic ventilation device
4.8
25.5
61
139
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
25.1
142
578
N03AX12
ATC
[U] gabapentin; oral
3.2
24.9
117
428
AA1AD
NOMESCO Finland
CT of head and brain
2.8
23.3
145
619
CEC00
NOMESCO Finland
Recession of extraocular muscle
+∞
22.0
21
*
H52.5
ICD-10 Finland
Disorders of accommodation
+∞
22.0
21
*
H53.1
ICD-10 Finland
Subjective visual disturbances
4.3
22.0
61
156
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
21.8
150
673
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
3.8
21.7
72
210
H52.1
ICD-10 Finland
Myopia
8.4
21.1
28
35
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.2
19.5
86
301
N03AG01
ATC
valproic acid; systemic, rectal
3.8
19.0
61
173
SPAT1263
SPAT
Sampling
2.2
18.3
274
1711
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.8
17.4
56
159
UKC02
NOMESCO Finland
Cystoscopy
3.2
17.2
74
254
SPAT1324
SPAT
Screening procedure
2.4
16.9
158
807
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
16.8
16
*
H52.0
ICD-10 Finland
Hypermetropia
16.3
15.9
25
16
OAB47, ,
SPAT
3.8
15.8
51
145
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.5
15.8
31
59
WX234
NOMESCO Finland
Paracervical blockade
3.7
15.5
52
152
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.2
15.0
64
218
R20.2
ICD-10 Finland
Paraesthesia of skin
3.2
14.5
61
206
A02BC03
ATC
lansoprazole; oral
2.2
13.9
149
796
TAB00
NOMESCO Finland
Lumbar puncture
3.8
13.9
43
119
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
3.4
13.8
52
164
37301
ICD-8 Finland
Strabismus, Concomitans divergens
+∞
13.6
13
*
H50.2
ICD-10 Finland
Vertical strabismus
143.5
13.5
14
*
SPAT1310
SPAT
Counselling related to known health issue
2.0
13.2
201
1223
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.9
13.2
67
252
XKC03
NOMESCO Finland
Water cystometry
5.7
13.2
25
46
XCK00
NOMESCO Finland
Perimetry
4.2
13.0
35
87
XMA22
NOMESCO Finland
General examination of pregnant woman
2.8
13.0
70
272
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.7
13.0
78
321
N01
ICPC
Headache
2.3
13.0
113
553
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.3
12.9
51
166
SPAT1097
SPAT
Recording of ECG
2.7
12.8
75
304
XA800
NOMESCO Finland
Neuropsychological investigation
3.7
12.8
41
116
R03BA05
ATC
fluticasone; inhalant
2.2
12.6
126
652
SPAT1260
SPAT
Consultation of another employee
2.3
12.4
112
556
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.8
12.3
64
244
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.3
12.0
101
486
N02BF01
ATC
gabapentin; oral
3.0
11.7
55
198
K07.60
ICD-10 Finland
Snapping jaw
2.9
11.7
56
204
R03CC03
ATC
terbutaline; systemic
3.9
11.6
35
95
A04
ICPC
Weakness/tiredness general
2.3
11.5
99
480
R02
ICPC
Shortness of breath/dyspnoea
2.5
11.5
76
327
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.7
11.5
65
259
XLD10
NOMESCO Finland
Gynaecological examination
9.2
11.4
23
26
R42
ICD-10 Finland
Dizziness and giddiness
2.2
11.1
111
573
N06AX11
ATC
mirtazapine; oral
1.9
11.0
193
1217
R03AC02
ATC
salbutamol; inhalant
1.9
10.8
328
2455
R96
ICPC
Asthma
2.7
10.7
60
238
A78
ICPC
Infectious disease other/NOS
4.1
10.6
29
73
N06AX21
ATC
duloxetine; oral
2.4
10.6
83
386
N06AA09
ATC
amitriptyline; systemic
2.9
10.6
52
192
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
5.0
10.6
23
48
A45
ICPC
General and Unspecified, Observ/health educat/advice/diet
4.8
10.6
24
52
H50.51
ICD-10 Finland
Esophoria
112.1
10.5
11
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
10.4
104
536
SAA03
NOMESCO Finland
Extended examination of mouth
1.8
10.4
259
1818
R03AC12
ATC
salmeterol; inhalant
4.0
10.1
29
76
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
9.9
228
1555
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
9.8
194
1265
L12
ICPC
Hand/finger symptom/complaint
2.1
9.7
105
556
KMAK, ,
NOMESCO Finland
1.8
9.6
322
2445
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.8
9.4
49
187
M03BX01
ATC
baclofen; systemic
5.0
9.4
20
41
M79.7
ICD-10 Finland
Fibromyalgia
3.6
9.3
31
90
A01
ICPC
Pain general/multiple sites
2.6
9.2
57
237
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
11.7
9.1
16
14
XQ855, ,
SPAT
11.7
9.1
16
14
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
9.1
109
599
SPAT1081
SPAT
Cardiorespiratory global assessment
4.0
9.1
26
68
-45
ICPC
Observ/health educat/advice/diet
4.0
9.0
25
64
WVA20, ,
SPAT
4.5
8.9
22
51
M35.7
ICD-10 Finland
Hypermobility syndrome
5.0
8.9
19
39
A11
ICPC
Chest pain NOS
2.8
8.8
44
164
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.2
8.7
35
115
-1, ,
NOMESCO Finland
1.7
8.7
225
1573
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
8.6
105
580
N03AE01
ATC
clonazepam; systemic
3.2
8.6
35
116
G43.9
ICD-10 Finland
Migraine, unspecified
2.4
8.6
62
278
SPAT1050
SPAT
Extensive neurological examination
4.4
8.5
21
49
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
8.1
8.4
18
23
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
8.4
165
1063
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.1
8.4
81
410
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
8.4
191
1286
HAMTE, ,
NOMESCO Finland
9.7
8.3
16
17
R09
ICPC
Sinus symptom/complaint
2.2
8.3
74
363
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
8.3
57
250
A02BC01
ATC
omeprazole; systemic
1.8
8.2
138
847
O28.8
ICD-10 Finland
Other abnormal findings on antenatal screening of mother
4.5
8.2
20
46
N02CC05
ATC
almotriptan; oral
2.9
8.2
38
136
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.8
8.2
42
159
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
7.0
8.1
19
28
R44
ICPC
Respiratory, Preventive immunization/medic
10.2
8.1
15
15
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.2
8.0
32
105
F16
ICPC
Eyelid symptom/complaint
2.9
7.9
37
133
C07AB07
ATC
bisoprolol; oral
1.7
7.9
172
1140
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
8.6
7.9
16
19
N02AX02
ATC
tramadol; systemic, rectal
1.7
7.7
194
1336
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.6
7.7
18
40
A02BA02
ATC
ranitidine; systemic
2.1
7.7
81
424
N89
ICPC
Migraine
2.7
7.5
42
166
SPAT1101
SPAT
Orthostatic test
4.3
7.5
19
45
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.3
7.5
19
45
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
4.3
7.5
19
45
G04CA02
ATC
tamsulosin; oral
2.4
7.5
54
241
L03
ICPC
Low back symptom/complaint
1.7
7.5
159
1042
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
7.5
106
615
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
7.5
165
1095
H50.9
ICD-10 Finland
Strabismus, unspecified
81.2
7.4
8
*
M54.4
ICD-10 Finland
Lumbago with sciatica
1.9
7.4
103
593
WX402
NOMESCO Finland
General anaesthesia
1.8
7.4
118
710
JAETT, ,
NOMESCO Finland
13.6
7.4
12
9
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.9
7.4
34
121
M25.5
ICD-10 Finland
Pain in joint
1.7
7.4
181
1234
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
4.1
7.4
20
50
N02CC04
ATC
rizatriptan; oral
2.5
7.4
45
186
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.3
7.3
58
270
R52.2
ICD-10 Finland
Other chronic pain
3.4
7.3
26
79
CEC30
NOMESCO Finland
Resection of extraocular muscle
+∞
7.3
7
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
7.3
7
*
MBA20
NOMESCO Finland
Expression of placenta
6.4
7.3
18
29
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.7
7.3
199
1396
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
7.3
123
754
WX400
NOMESCO Finland
Inhalation anesthesy
2.9
7.3
35
128
R03DC03
ATC
montelukast; oral
1.9
7.3
104
605
J45.8
ICD-10 Finland
Mixed asthma
3.8
7.3
22
60
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
7.2
274
2087
R06.0
ICD-10 Finland
Dyspnoea
1.8
7.2
122
747
N03AF01
ATC
carbamazepine; oral, rectal
3.2
7.2
28
90
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
7.5
7.2
16
22
H53.4
ICD-10 Finland
Visual field defects
6.7
7.2
17
26
SPAT1044
SPAT
Tympanometry
3.7
6.9
22
62
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
6.9
47
205
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
6.9
102
600
OAB50, ,
SPAT
2.9
6.8
31
110
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
6.8
222
1624
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
16.9
6.8
10
6
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.3
6.7
53
247
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
6.6
6.7
16
25
N02AC04
ATC
dextropropoxyphene; oral
4.1
6.7
18
45
N03AX09
ATC
lamotrigine; oral
2.5
6.7
43
183
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
3.5
6.6
22
64
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
6.6
121
758
N03AX14
ATC
levetiracetam; systemic
3.9
6.6
19
50
H52.2
ICD-10 Finland
Astigmatism
8.8
6.6
13
15
N05BA01
ATC
diazepam; systemic, rectal
2.1
6.5
68
354
H02AB06
ATC
prednisolone; systemic
1.6
6.5
221
1627
SPAT1053
SPAT
Memory test
2.7
6.5
35
136
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
6.5
36
142
C07AA05
ATC
propranolol; systemic
1.7
6.5
128
819
R01AD58
ATC
fluticasone, combinations; nasal
1.7
6.5
162
1105
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.8
6.5
32
119
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
4.1
6.4
17
42
G43
ICD-10 Finland
Migraine
2.3
6.4
51
239
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
3.3
6.4
24
76
M50.3
ICD-10 Finland
Other cervical disc degeneration
5.6
6.3
17
31
SXA05, ,
NOMESCO Finland
6.1
6.3
16
27
A02BC05
ATC
esomeprazole; systemic
1.6
6.3
192
1373
F45.8
ICD-10 Finland
Other somatoform disorders
2.1
6.3
61
308
M54.5
ICD-10 Finland
Low back pain
1.6
6.3
197
1420
N04BC04
ATC
ropinirole; oral
18.3
6.3
9
5
JN3AD
NOMESCO Finland
Abdominal CT examination
2.2
6.3
53
254
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
6.3
113
704
G44.2
ICD-10 Finland
Tension-type headache
1.9
6.3
91
531
MBC10
NOMESCO Finland
Repair of obstetric laceration of vagina
2.8
6.2
30
110
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.7
6.2
32
122
G20
ICD-10 Finland
Parkinson disease
7.8
6.2
13
17
U07
ICPC
Urine symptom/complaint other
2.5
6.1
37
153
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
2.9
6.1
28
100
N03AF02
ATC
oxcarbazepine; oral
3.0
6.1
26
89
SPAT1153
SPAT
Removal of sutures
1.7
6.1
136
899
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
10.2
6.1
11
11
K01
ICPC
Heart pain
10.2
6.1
11
11
P01AB01
ATC
metronidazole; oral, rectal
1.6
6.0
216
1603
A02BC02
ATC
pantoprazole; systemic
1.6
6.0
308
2479
D07AC01
ATC
betamethasone; topical
1.6
6.0
174
1228
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
141
602
2.82
22.61
3.8
2.8
54.50
268.77
ng/l
2.49
76
369
64
173
4.06
21.41
7.0
7.5
23.74
24.74
mmol/l
1.24
59
164
245
1462
2.24
18.28
5.7
4.1
37.03
36.82
g/l
0.26
229
1369
211
1208
2.23
17.20
2.8
2.3
64.32
55.61
u/l
0.40
198
1129
88
344
2.86
16.28
2.2
1.8
—
—
—
0
0
86
343
2.79
15.29
2.2
1.7
—
—
—
0
0
71
255
3.05
15.25
6.2
8.1
123.42
121.47
g/l
0.31
66
248
175
972
2.18
15.01
3.7
3.3
1.02
1.02
kg/l
0.13
32
126
79
308
2.83
14.63
5.8
7.3
1.15
1.22
mmol/l
0.06
55
235
320
2248
2.04
14.34
6.7
4.1
6.10
6.33
mmol/l
1.32
268
2004
176
998
2.13
14.19
2.4
1.9
211.36
171.40
u/l
0.22
166
938
77
310
2.73
13.38
5.9
7.3
12.74
12.96
kpa
0.13
72
295
77
310
2.73
13.38
5.9
7.3
4.82
5.18
kpa
2.59
72
293
105
497
2.38
13.01
2.3
2.0
27.79
29.37
s
3.10
96
481
254
1702
1.93
12.44
8.1
5.8
1.21
1.22
mmol/l
0.37
222
1450
218
1439
1.86
10.77
10.1
8.1
1.05
1.12
inr
0.70
46
482
35
104
3.53
10.17
1.3
1.1
5.07
3.89
e6/l
0.12
28
80
35
104
3.53
10.17
1.3
1.2
15.14
98.08
e6/l
1.51
29
84
215
1433
1.83
10.15
4.2
3.0
27.31
29.62
u/l
0.56
201
1359
224
1525
1.80
9.77
7.4
5.0
1.21
1.22
mmol/l
1.04
214
1412
336
4045
0.55
9.63
9.5
8.7
93.20
92.65
ml/min/173m2
0.19
261
3197
96
501
2.11
9.22
2.2
1.8
—
—
—
0
0
96
502
2.11
9.17
1.6
1.6
1229.69
1196.54
nmol/l
0.14
80
385
80
395
2.20
8.82
2.6
1.8
383.75
378.23
nmol/l
0.07
72
366
381
3132
1.74
7.70
4.4
3.5
9.66
9.33
mm/h
0.20
374
2911
261
1980
1.62
6.90
5.2
5.2
9.46
10.56
umol/l
1.25
248
1857
371
3070
1.67
6.87
7.2
6.3
73.40
75.34
u/l
0.43
360
2883
190
1339
1.65
6.73
1.8
1.7
96.11
97.02
pmol/l
0.09
87
707
150
1002
1.69
6.49
2.1
2.0
2.11
2.76
mg/l
4.58
137
859
51
240
2.24
6.30
2.2
1.6
—
—
—
0
0
68
364
1.99
6.03
1.8
1.6
—
—
—
0
0
417
3606
1.69
6.02
5.2
4.0
14.47
14.42
pmol/l
0.20
399
3327
26
90
2.98
5.97
2.4
1.7
13.77
13.16
%
0.77
26
90
113
721
1.72
5.73
1.6
1.5
451.53
40852165.23
pmol/l
1.32
101
634
123
807
1.68
5.61
1.3
1.3
13.81
28.82
iu/ml
2.71
41
241
118
774
1.67
5.37
1.3
1.2
2.11
9.12
u/ml
3.74
45
319
307
2511
1.52
5.27
8.7
8.0
4.08
4.02
e9/l
0.13
290
2205
14
26
5.50
5.25
2.0
2.3
—
—
—
0
0
171
1241
1.55
5.10
1.4
1.3
0.57
1.86
u/ml
2.00
41
348
27
105
2.65
5.05
1.7
2.1
—
—
—
0
0
60
329
1.93
4.97
3.0
3.4
4.73
4.67
pmol/l
0.19
55
291
146
1030
1.57
4.91
1.8
1.6
1.30
1.35
mmol/l
0.29
140
896
225
1757
1.48
4.65
3.8
3.1
—
—
—
0
0
114
773
1.60
4.50
1.4
1.4
21.57
20.52
nmol/l
0.31
108
671
37
176
2.18
4.50
1.3
1.2
0.20
2.79
u/ml
—
5
10
17
55
3.16
4.39
1.4
1.4
—
—
—
0
0
17
55
3.16
4.39
1.4
1.4
—
—
—
0
0
282
2321
1.45
4.35
3.4
2.7
73.77
74.65
ug/l
0.04
270
2179
462
4207
1.68
4.34
5.9
4.6
1.65
2.03
mu/l
0.73
446
3932
19
67
2.90
4.26
1.5
1.3
—
—
—
0
0
15
46
3.33
4.21
1.2
1.5
—
—
—
0
0
164
1226
1.48
4.12
1.6
1.5
—
—
—
0
0
263
2151
1.43
4.12
6.0
5.3
30.61
29.75
%
0.67
255
2043
63
1005
0.58
4.10
2.4
1.9
—
—
—
0
0
19
69
2.82
4.06
2.2
1.7
180.53
199.00
pmol/l
0.25
19
64
52
292
1.86
4.03
1.7
1.5
—
—
—
0
0
7
7
10.11
4.02
1.0
1.0
—
—
—
0
0
57
330
1.81
4.01
1.6
1.7
—
—
—
0
0
259
2129
1.42
3.86
5.9
5.2
55.43
56.20
%
0.52
251
2013
14
44
3.24
3.80
1.3
1.1
197.79
202.23
mg/l
0.06
14
39
18
67
2.74
3.69
1.2
1.5
—
—
—
0
0
133
974
1.48
3.65
2.3
1.8
0.60
1.04
mg/l
2.81
105
712
95
648
1.57
3.63
1.9
1.7
—
—
—
0
0
17
405
0.40
3.61
4.1
3.5
29.33
32.14
%
0.51
12
291
270
2254
1.40
3.59
3.8
3.1
0.00
0.00
estimate
-0.00
44
490
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
21
4.83
3.57
1.5
1.1
—
—
—
0
0
11
26
4.30
3.52
1.5
1.3
2.05
1.72
mmol/l
0.73
11
26
15
52
2.94
3.49
1.4
1.1
—
—
—
0
0
72
464
1.64
3.48
3.4
2.4
7221.02
4833.54
u/l
0.28
31
213
48
276
1.81
3.47
10.9
3.9
1.91
1.57
mmol/l
0.32
41
215
20
436
0.44
3.42
1.5
1.5
—
—
—
0
0
19
76
2.55
3.41
1.3
1.5
—
—
—
0
0
19
76
2.55
3.41
1.3
1.5
—
—
—
0
0
258
2160
1.37
3.27
3.1
2.4
—
—
—
0
0
13
43
3.07
3.27
1.2
1.0
—
—
—
0
0
68
439
1.63
3.26
1.8
2.1
21.81
24.95
%
0.91
39
379
18
401
0.43
3.26
1.4
1.4
—
—
—
0
0
9
19
4.80
3.25
1.4
1.1
—
—
—
0
0
18
400
0.43
3.24
1.4
1.4
—
—
—
0
0
18
400
0.43
3.24
1.4
1.4
—
—
—
0
0
18
399
0.43
3.22
1.4
1.4
—
—
—
0
0
112
812
1.48
3.21
1.9
1.9
—
—
—
0
0
15
55
2.78
3.18
1.4
1.1
—
—
—
0
0
53
324
1.70
3.13
1.4
1.3
142.61
251.29
u/ml
0.65
47
299
22
99
2.27
3.10
1.3
1.5
—
—
—
0
0
22
99
2.27
3.10
1.3
1.5
—
—
—
0
0
19
81
2.39
3.02
1.2
1.1
4.27
6.88
u/ml
0.35
11
32
156
1221
1.39
2.93
2.6
2.9
2.32
2.35
mmol/l
3.63
145
1104
14
52
2.74
2.91
1.8
1.1
—
—
—
0
0
498
4718
1.71
2.89
10.1
8.2
24.73
25.20
u/l
0.31
489
4561
6
9
6.73
2.87
1.7
1.3
—
—
—
0
0
265
2260
1.34
2.85
5.2
4.2
0.00
0.00
estimate
0.50
41
472
15
59
2.59
2.81
1.3
1.5
—
—
—
0
0
267
2283
1.34
2.81
3.8
3.1
0.00
0.01
estimate
0.50
42
455
8
19
4.26
2.68
2.3
2.8
81.63
97.16
nmol/l
—
8
19
400
3645
1.38
2.68
4.3
4.3
36.69
37.84
mmol/mol
2.45
386
3434
7
15
4.71
2.60
1.4
1.1
—
—
—
0
0
40
239
1.73
2.59
1.8
1.9
—
—
—
0
0
479
4521
1.53
2.52
15.2
10.1
18.52
19.86
mg/l
0.47
381
3458
26
137
1.94
2.50
16.5
3.3
0.68
0.65
%
0.22
26
137
19
89
2.18
2.47
1.8
1.5
5.63
7.27
mmol/l
4.09
19
79
40
243
1.70
2.45
4.5
7.0
6.49
7.58
mmol/l
0.80
40
232
13
52
2.54
2.37
1.4
1.1
—
—
—
0
0
350
3156
1.31
2.32
3.5
2.8
33.99
36.83
u/l
0.42
338
3008
8
24
3.37
2.18
1.4
1.5
10.00
10.40
umol/l
—
8
24
19
95
2.04
2.13
1.3
1.0
3.05
4.00
u/ml
0.15
13
47
56
384
1.51
2.12
8.1
5.3
—
—
—
0
0
16
75
2.17
2.10
1.3
1.0
0.01
0.39
u/ml
—
9
24
5
10
5.03
2.07
2.8
3.9
188.60
195.40
u/l
—
5
10
0
58
0.00
2.05
0.0
1.1
—
—
—
0
0
6
15
4.03
2.04
2.0
1.8
23.83
16.03
umol/l
—
6
15
44
290
1.56
2.00
2.1
2.6
0.22
0.23
g/l
0.04
39
275
9
33
2.76
1.94
2.1
1.4
4.88
5.22
mmol/l
—
9
33
6
17
3.56
1.84
1.2
1.1
—
—
—
0
0
6
18
3.36
1.75
1.0
2.5
251.33
463.94
u/ml
—
6
18
5
13
3.87
1.72
1.8
1.2
—
—
—
0
0
5
13
3.87
1.72
1.6
1.1
—
—
—
0
0
5
13
3.87
1.72
1.8
1.1
—
—
—
0
0
5
13
3.87
1.72
1.6
1.1
—
—
—
0
0
5
13
3.87
1.72
1.8
1.2
—
—
—
0
0
17
89
1.94
1.71
1.3
1.3
—
—
—
0
0
526
5134
1.95
1.71
21.7
15.1
264.63
261.08
e9/l
0.61
526
5026
526
5136
1.93
1.67
22.1
15.1
40.34
40.12
%
0.40
430
4874
428
4034
1.29
1.65
3.9
3.5
5.54
5.66
mmol/l
1.88
410
3750
49
346
1.46
1.65
13.7
6.9
105.61
104.79
mmol/l
0.52
49
346
5
132
0.37
1.64
1.2
2.0
—
—
—
0
0
23
136
1.72
1.61
1.3
1.1
—
—
—
0
0
15
77
1.98
1.60
2.7
4.8
—
595.10
—
0
10
10
44
2.30
1.56
1.1
1.3
—
—
—
0
0
5
15
3.35
1.52
1.2
1.2
—
—
—
0
0
16
86
1.89
1.52
1.4
1.4
—
—
—
0
0
5
127
0.39
1.51
1.6
1.8
—
—
—
0
0
9
38
2.39
1.46
1.4
1.8
—
—
—
0
0
7
28
2.52
1.45
1.7
2.1
—
—
—
0
0
59
442
1.38
1.45
3.0
2.7
7.07
7.56
umol/l
0.05
47
369
5
16
3.14
1.44
1.2
1.2
—
—
—
0
0
196
1720
1.22
1.40
2.6
2.2
73.86
73.52
nmol/l
0.06
185
1578
5
17
2.96
1.36
1.0
1.1
80.00
96.47
%
—
5
17
5
17
2.96
1.36
1.0
1.0
—
—
—
0
0
16
91
1.78
1.30
1.3
1.1
—
—
—
0
0
53
399
1.36
1.28
4.1
3.9
21.84
21.46
%
0.05
17
177
10
48
2.10
1.28
1.0
1.4
—
—
—
0
0
8
35
2.30
1.27
1.5
1.8
—
—
—
0
0
8
156
0.51
1.27
1.8
1.6
—
—
—
0
0
155
1346
1.21
1.22
1.9
1.7
—
—
—
0
0
19
117
1.65
1.19
1.4
1.1
0.26
1.62
u/ml
2.05
13
67
8
38
2.12
1.19
1.1
1.1
—
—
—
0
0
34
241
1.44
1.17
14.2
3.3
4.93
4.62
kpa
0.35
34
234
8
39
2.07
1.15
1.4
1.2
—
—
—
0
0
34
243
1.43
1.13
1.4
1.5
—
—
—
0
0
21
136
1.57
1.10
1.7
1.7
—
—
—
0
0
29
203
1.45
1.07
1.3
1.4
22.32
10.23
u/l
0.49
29
169
17
105
1.64
1.07
1.5
1.3
235.82
340.70
ug/g
2.38
11
62
12
204
0.58
1.07
1.8
1.4
—
—
—
0
0
124
1067
1.21
1.07
2.5
3.1
7.46
8.04
mmol/l
0.70
116
928
22
146
1.53
1.05
1.9
2.0
1.99
5.18
iu/l
—
10
57
14
84
1.68
0.98
2.9
2.5
—
—
—
0
0
0
29
0.00
0.98
0.0
1.2
—
34.40
—
0
5
0
29
0.00
0.98
0.0
3.6
—
—
—
0
0
44
565
0.76
0.97
2.8
2.4
2.34
3.17
e6/l
0.63
17
285
110
1271
0.83
0.97
1.9
2.2
—
—
—
0
0
17
110
1.56
0.91
1.1
1.9
1.38
1.29
g/l
0.10
12
92
19
128
1.50
0.87
1.5
1.5
0.16
0.39
nmol/l
3.58
12
106
21
146
1.46
0.83
1.2
1.5
0.02
0.44
iu/ml
—
7
25
25
339
0.72
0.81
2.2
1.8
—
—
—
0
0
100
867
1.19
0.81
2.8
3.9
4.29
10.31
mg/mmol
1.76
57
548
28
371
0.74
0.79
3.7
2.7
—
—
—
0
0
0
26
0.00
0.78
0.0
1.6
—
—
—
0
0
138
1238
1.15
0.73
3.3
2.9
13.66
31.53
ng/l
3.35
63
639
7
39
1.81
0.72
1.0
1.1
—
—
—
0
0
7
40
1.76
0.71
1.1
1.3
—
—
—
0
0
14
93
1.52
0.70
1.4
1.9
2.34
2.92
g/l
1.54
14
86
9
58
1.56
0.70
2.2
1.4
—
—
—
0
0
432
4186
1.16
0.69
3.8
3.5
4.77
4.74
mmol/l
0.33
419
3967
396
3819
1.14
0.66
4.1
3.8
—
—
—
0
0
93
1053
0.86
0.65
3.4
2.5
0.11
0.38
e6/l
3.99
67
765
19
137
1.40
0.65
1.3
1.3
—
—
—
0
0
5
29
1.73
0.64
1.8
1.7
—
1224680.00
—
0
5
54
454
1.21
0.62
1.3
1.2
94.87
161.48
iu/ml
1.29
32
191
57
483
1.20
0.61
1.6
1.4
—
—
—
0
0
10
151
0.66
0.60
1.5
1.6
—
—
—
0
0
103
1147
0.87
0.58
1.7
2.1
—
—
—
0
0
13
89
1.47
0.58
1.3
1.5
—
—
—
0
0
38
311
1.24
0.57
1.1
1.0
—
—
—
0
0
19
141
1.36
0.57
1.4
1.1
0.33
3.84
u/ml
3.25
14
84
14
99
1.43
0.54
1.4
1.8
6.74
7.27
g/l
0.92
14
92
9
60
1.51
0.54
1.2
1.1
—
—
—
0
0
6
39
1.54
0.53
1.0
1.2
—
88.57
—
0
7
12
83
1.46
0.52
1.0
1.1
—
—
—
0
0
12
85
1.42
0.47
1.4
1.2
—
—
—
0
0
52
598
0.86
0.47
2.7
2.2
0.60
0.88
e6/l
0.79
24
318
434
4242
1.12
0.45
4.1
3.8
2.86
2.84
mmol/l
0.14
420
3989
98
891
1.12
0.45
2.6
2.4
304.77
5700.47
umol/l
3.40
87
791
12
86
1.40
0.45
8.0
4.2
3.84
3.83
mmol/l
0.02
12
86
8
60
1.34
0.40
1.1
1.3
—
—
—
0
0
8
60
1.34
0.40
1.0
1.6
—
—
—
0
0
8
60
1.34
0.40
1.1
1.3
—
—
—
0
0
5
35
1.43
0.39
1.0
1.2
—
—
—
0
0
426
4173
1.10
0.37
3.6
3.5
1.46
1.49
mmol/l
0.76
412
3940
8
113
0.70
0.37
2.5
4.3
1.08
1.26
mg/l
—
8
104
13
99
1.32
0.35
1.4
1.8
—
—
—
0
0
13
99
1.32
0.35
1.4
1.8
3.05
3.65
g/l
1.94
13
92
23
273
0.84
0.32
2.2
2.4
62.90
76.65
ml/min/173m2
—
10
101
12
92
1.31
0.32
1.4
1.9
9.91
10.73
g/l
0.36
12
84
16
129
1.25
0.30
1.1
1.3
—
25.66
—
0
7
11
141
0.78
0.29
1.6
1.2
—
—
—
0
0
11
140
0.78
0.28
1.6
1.2
—
—
—
0
0
25
214
1.18
0.28
2.2
1.3
—
—
—
0
0
12
94
1.28
0.28
1.1
1.1
—
10.77
—
0
6
24
279
0.85
0.27
1.3
1.3
146.18
255.84
miu/ml
—
8
148
53
582
0.90
0.27
2.4
2.3
2.41
2.42
mmol/l
0.32
48
495
10
128
0.78
0.27
1.0
1.3
—
—
—
0
0
29
329
0.87
0.25
1.3
1.4
—
—
—
0
0
22
255
0.86
0.25
4.0
4.3
2.43
23.34
ug/l
0.64
12
202
20
170
1.18
0.25
9.1
8.8
0.68
0.69
%
0.06
20
170
26
297
0.87
0.25
2.5
2.8
0.41
0.71
ug/l
3.37
12
177
127
1207
1.07
0.24
4.6
3.3
0.00
0.01
estimate
1.08
43
467
5
41
1.22
0.22
1.0
1.3
—
—
—
0
0
405
3990
1.06
0.21
3.1
3.2
1.27
1.21
mmol/l
0.91
391
3753
5
42
1.19
0.21
1.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
1.71
—
0
6
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
14
0.00
0.20
0.0
2.2
—
—
—
0
0
11
90
1.23
0.19
1.0
1.1
—
—
—
0
0
10
82
1.22
0.17
1.9
2.3
742.55
206.63
ug/l
—
10
75
10
82
1.22
0.17
1.7
3.3
3.47
4.52
e9/l
—
10
82
17
194
0.87
0.17
1.4
1.2
—
—
—
0
0
5
69
0.72
0.17
2.4
1.4
—
—
—
0
0
18
204
0.88
0.16
7.6
4.0
5.26
5.12
kpa
0.42
18
194
8
72
1.11
0.16
2.5
2.5
0.91
0.97
nmol/l
—
8
64
22
244
0.90
0.15
1.4
1.4
—
—
—
0
0
51
542
0.93
0.14
1.6
1.5
—
—
—
0
0
7
88
0.79
0.14
1.1
1.2
—
—
—
0
0
137
1327
1.04
0.14
3.5
2.7
—
—
—
0
0
21
189
1.12
0.14
1.5
1.8
—
—
—
0
0
19
171
1.12
0.12
9.5
8.8
1.25
1.51
%
0.67
19
171
10
85
1.18
0.12
1.7
3.6
49.70
57.33
%
—
10
85
68
711
0.95
0.12
2.9
2.8
527.11
720.63
ng/l
0.55
54
568
10
87
1.15
0.09
1.0
1.0
1.26
2.02
u/ml
—
5
44
6
56
1.07
0.08
1.3
2.5
—
—
—
0
0
6
56
1.07
0.08
1.5
1.3
—
—
—
0
0
7
66
1.06
0.08
1.0
1.1
—
—
—
0
0
6
71
0.84
0.07
1.2
1.5
—
—
—
0
0
7
81
0.86
0.07
1.7
1.9
40.73
39.15
g/l
—
7
74
11
122
0.90
0.07
1.2
1.6
—
256.00
—
0
5
74
751
0.98
0.02
1.7
1.5
—
—
—
0
0
16
166
0.96
0.00
1.7
2.2
0.02
0.15
e6/l
3.06
16
160
10
97
1.03
0.00
1.0
1.2
6.00
7.43
u/ml
—
5
42
11
111
0.99
0.00
1.2
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
1.20
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
66
0.91
-0.00
1.8
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
7.63
—
0
6
5
58
0.86
-0.00
1.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
14
140
1.00
-0.00
7.1
9.0
23.31
24.17
mmol/l
0.63
14
132
0
6
0.00
-0.00
0.0
3.0
—
0.67
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint H7_CONVERGINSUFF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONVERGINSUFF | 0.934 [0.75, 1.17] | 0.547 |
| Birth year | 0.992 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 2408 females with H7_CONVERGINSUFF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONVERGINSUFF | 1.371 [1.07, 1.76] | 0.012 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 1274 males with H7_CONVERGINSUFF died.
Mortality risk
Mortality risk for people of age
years, who have H7_CONVERGINSUFF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.065% | 0.274% |
| 5 | 0.501% | 1.774% |
| 10 | 1.179% | 4.347% |
| 15 | 2.336% | 8.311% |
| 20 | 4.254% | 13.689% |
Relationships between endpoints
↥Index endpoint: H7_CONVERGINSUFF – Convergence insufficiency and excess
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data