No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
530 |
4. Check minimum number of eventsNone |
530 |
5. Include endpointsNone |
530 |
6. Filter based on genotype QC (FinnGen only) |
530 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H51
- Name in latin
- Convergentia insufficiens sive nimia
Similar endpoints
↥List of similar endpoints to
Convergence insufficiency and excess
based on the number of shared cases.
Similar with more cases:
- Other disorders of binocular movement
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3911 | 2548 | 1357 |
| Only index persons | 3670 | 2423 | 1247 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.04 |
| Only index persons | 0.07 | 0.09 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 19.34 | 21.03 | 16.06 |
| Only index persons | 20.89 | 22.48 | 17.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 530 | 410 | 120 |
| Unadjusted period prevalence (%) | 0.12 | 0.14 | 0.05 |
| Median age at first event (years) | 30.70 | 28.61 | 37.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 449
- Matched controls
- 4488
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H51.1
ICD-10 Finland
Convergence insufficiency and excess
+∞
323.0
449
*
H53.3
ICD-10 Finland
Other disorders of binocular vision
308.2
99.0
97
*
H50.52
ICD-10 Finland
Exophoria
+∞
78.5
73
*
H53.2
ICD-10 Finland
Diplopia
36.6
43.1
55
17
H50.31
ICD-10 Finland
Intermittent exotropia
+∞
38.1
36
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
+∞
28.4
27
*
R51.80
ICD-10 Finland
Headache
3.6
24.9
135
482
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.2
23.1
76
169
WX704
NOMESCO Finland
Intubation
5.3
21.2
68
146
SPAT1301
SPAT
No procedures
2.7
19.9
177
863
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.6
19.0
95
312
WX725
NOMESCO Finland
Noninvasive ventilation
7.0
18.7
47
74
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.4
18.1
99
347
CEC00
NOMESCO Finland
Recession of extraocular muscle
+∞
17.8
17
*
AA1AD
NOMESCO Finland
CT of head and brain
3.0
17.4
112
441
N03AX12
ATC
gabapentin; oral
3.3
17.3
98
349
WX720
NOMESCO Finland
Own respiration
7.2
17.3
42
63
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
4.5
17.0
63
157
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.8
15.9
123
538
N03AG01
ATC
valproic acid; systemic, rectal
4.4
15.6
58
145
H52.5
ICD-10 Finland
Disorders of accommodation
+∞
14.7
14
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
14.7
14
*
WX702
NOMESCO Finland
Supraglottic ventilation device
4.9
14.4
48
107
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.2
14.2
56
148
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
14.2
107
459
Z01.8
ICD-10 Finland
Other specified special examinations
2.6
13.7
118
544
SPAT1324
SPAT
Screening procedure
2.4
13.5
137
691
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.6
13.5
63
194
SPAT1263
SPAT
Sampling
2.1
13.3
222
1410
H53.1
ICD-10 Finland
Subjective visual disturbances
4.5
12.9
46
111
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.1
12.8
51
136
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.1
12.5
74
271
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
5.8
12.4
35
65
A02BC03
ATC
lansoprazole; oral
2.3
12.1
132
687
H52.1
ICD-10 Finland
Myopia
11.0
11.9
22
21
R03AC02
ATC
salbutamol; inhalant
2.0
11.5
262
1845
SPAT1310
SPAT
Counselling related to known health issue
2.1
11.2
166
984
K07.60
ICD-10 Finland
Snapping jaw
3.7
10.6
46
133
37301
ICD-8 Finland
Strabismus, Concomitans divergens
+∞
10.5
10
*
H50.2
ICD-10 Finland
Vertical strabismus
+∞
10.5
10
*
H52.0
ICD-10 Finland
Hypermetropia
16.5
10.4
16
10
N01
ICPC
Headache
2.5
10.3
85
381
SPAT1097
SPAT
Recording of ECG
2.9
10.2
63
237
SPAT1260
SPAT
Consultation of another employee
2.4
10.1
89
412
UKC02
NOMESCO Finland
Cystoscopy
3.0
10.0
61
226
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
2.5
9.9
80
353
N06AX21
ATC
duloxetine; oral
2.8
9.9
67
264
N06AX11
ATC
mirtazapine; oral
2.0
9.6
148
878
H50.51
ICD-10 Finland
Esophoria
+∞
9.4
9
*
N06AA09
ATC
amitriptyline; systemic
3.2
9.0
48
164
WX400
NOMESCO Finland
Inhalation anesthesy
4.2
9.0
33
83
R03BA05
ATC
fluticasone; inhalant
2.2
8.9
104
550
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
8.8
154
951
SAA03
NOMESCO Finland
Extended examination of mouth
1.8
8.7
205
1405
R20.2
ICD-10 Finland
Paraesthesia of skin
3.2
8.5
45
153
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
8.5
183
1217
R44
ICPC
Respiratory, Preventive immunization/medic
13.1
8.4
14
11
H50.9
ICD-10 Finland
Strabismus, unspecified
+∞
8.4
8
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.9
8.3
51
188
SPAT1050
SPAT
Extensive neurological examination
7.3
8.3
19
27
M25.5
ICD-10 Finland
Pain in joint
1.9
8.3
137
826
HAMTE
NOMESCO Finland
NA
14.8
8.2
13
9
XA800
NOMESCO Finland
Neuropsychological investigation
3.9
8.1
32
86
A02BA02
ATC
ranitidine; systemic
2.4
8.1
72
333
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.5
8.1
23
44
SXA05
NOMESCO Finland
NA
10.3
8.1
15
15
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.6
8.0
60
253
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
11.1
7.8
14
13
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.9
7.8
46
168
TAB00
NOMESCO Finland
Lumbar puncture
3.5
7.8
35
105
F43.1
ICD-10 Finland
Post-traumatic stress disorder
4.1
7.8
29
74
XKC03
NOMESCO Finland
Water cystometry
5.6
7.6
21
39
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
25.5
7.6
10
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
10.3
7.6
14
14
A02BC05
ATC
esomeprazole; systemic
1.8
7.3
165
1101
CEC30
NOMESCO Finland
Resection of extraocular muscle
+∞
7.3
7
*
M54.4
ICD-10 Finland
Lumbago with sciatica
2.2
7.3
79
399
KMAK
NOMESCO Finland
NA
1.7
7.2
264
2035
-1
NOMESCO Finland
NA
1.7
7.2
184
1276
A45
ICPC
General and Unspecified, Observ/health educat/advice/diet
5.5
7.2
20
38
A04
ICPC
Weakness/tiredness general
2.2
7.1
70
341
XCK00
NOMESCO Finland
Perimetry
3.4
7.0
32
98
A02BC01
ATC
omeprazole; systemic
1.9
7.0
111
656
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.8
6.9
28
78
N05BA01
ATC
diazepam; systemic, rectal
2.4
6.9
59
267
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
4.1
6.9
25
63
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.5
6.9
30
89
R42
ICD-10 Finland
Dizziness and giddiness
2.1
6.8
82
432
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.3
6.8
66
319
A06AC01
ATC
ispaghula (psylla seeds); oral
2.0
6.7
89
488
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
3.0
6.7
38
134
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
2.6
6.7
49
204
N02AC04
ATC
dextropropoxyphene; oral
5.6
6.7
18
33
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
6.0
6.7
17
29
R06.0
ICD-10 Finland
Dyspnoea
2.0
6.6
92
517
N03AF02
ATC
oxcarbazepine; oral
4.5
6.4
21
48
R09
ICPC
Sinus symptom/complaint
2.3
6.4
58
268
F45.8
ICD-10 Finland
Other somatoform disorders
2.4
6.4
54
244
R03DC03
ATC
montelukast; oral
2.0
6.4
85
469
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.3
6.4
18
35
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.5
6.4
28
84
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
6.4
47
196
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
4.7
6.4
20
44
A01
ICPC
Pain general/multiple sites
2.8
6.4
40
151
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.8
6.3
38
142
XLD10
NOMESCO Finland
Gynaecological examination
11.2
6.3
11
10
H04.10
ICD-10 Finland
Dry eye syndrome
2.6
6.3
45
186
M03BX01
ATC
baclofen; systemic
7.2
6.3
14
20
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
6.3
6
*
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
3.7
6.2
25
70
H53.4
ICD-10 Finland
Visual field defects
7.8
6.2
13
17
F16
ICPC
Eyelid symptom/complaint
3.3
6.2
29
92
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
6.1
81
443
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.8
6.1
39
149
N05AH04
ATC
quetiapine; oral
2.0
6.1
88
498
C07AA05
ATC
propranolol; systemic
1.9
6.1
103
618
N03AX14
ATC
levetiracetam; systemic
5.0
6.1
18
37
C07AB07
ATC
bisoprolol; oral
1.7
6.0
135
890
R01AD01
ATC
beclometasone; nasal
2.0
6.0
73
389
SPAT1044
SPAT
Tympanometry
4.4
6.0
20
47
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
139
594
2.82
22.27
3.8
2.8
54.5
273.5
ng/l
2.51
76
362
62
170
4.00
20.34
7.2
7.6
23.8
24.8
mmol/l
1.08
57
160
239
1437
2.21
17.37
5.7
4.1
37.0
36.8
g/l
0.20
224
1344
204
1188
2.17
15.70
2.6
2.3
64.8
55.5
u/l
0.42
192
1113
86
339
2.83
15.66
2.2
1.8
—
—
—
0
0
172
955
2.19
14.78
3.7
3.3
1.0
1.0
kg/l
0.16
32
123
84
338
2.76
14.68
2.1
1.7
—
—
—
0
0
314
2214
2.03
13.84
6.6
4.1
6.1
6.3
mmol/l
1.27
262
1973
68
252
2.95
13.81
6.2
7.8
123.4
121.6
g/l
0.28
63
242
76
302
2.77
13.56
5.8
7.1
1.2
1.2
mmol/l
0.00
54
229
103
489
2.37
12.68
2.3
2.0
27.8
29.3
s
2.76
94
473
169
982
2.06
12.57
2.4
2.0
206.6
171.3
u/l
0.19
160
924
19
28
7.00
12.37
1.5
1.3
—
—
—
0
0
74
304
2.67
12.35
5.9
7.1
4.8
5.2
kpa
2.33
69
288
74
304
2.67
12.35
5.9
7.1
12.8
13.0
kpa
0.08
69
290
246
1671
1.88
11.31
8.2
5.8
1.2
1.2
mmol/l
0.48
214
1422
35
103
3.57
10.33
1.3
1.1
5.1
3.0
e6/l
0.23
28
79
35
103
3.57
10.33
1.3
1.2
15.1
99.3
e6/l
1.51
29
83
212
1412
1.84
10.07
4.1
3.0
27.4
29.0
u/l
0.36
198
1338
328
3958
0.55
9.56
8.9
8.7
93.2
92.7
ml/min/173m2
0.16
256
3118
94
495
2.09
8.81
2.1
1.8
—
—
—
0
0
93
489
2.09
8.75
1.6
1.6
1227.3
1194.2
nmol/l
0.13
79
379
216
1498
1.75
8.62
7.5
5.0
1.2
1.2
mmol/l
1.01
205
1381
14
25
5.72
7.58
2.0
2.0
—
—
—
0
0
374
3076
1.73
7.54
4.4
3.5
9.6
9.3
mm/h
0.13
367
2865
452
3938
2.00
7.51
17.2
12.3
13.3
13.4
%
0.44
447
3863
76
394
2.08
7.38
2.7
1.8
375.4
379.0
nmol/l
0.05
68
365
68
359
2.03
6.28
1.8
1.6
—
—
—
0
0
361
3007
1.63
6.26
7.1
6.3
72.7
75.1
u/l
0.63
349
2824
253
1941
1.58
6.22
5.2
5.2
9.6
10.5
umol/l
0.92
241
1823
50
235
2.25
6.21
2.2
1.6
—
—
—
0
0
410
3537
1.70
6.10
5.2
4.0
14.5
14.4
pmol/l
0.26
392
3267
184
1316
1.61
6.05
1.8
1.7
96.4
97.0
pmol/l
0.06
86
700
145
980
1.66
5.96
2.2
2.0
2.1
2.8
mg/l
4.08
132
841
111
704
1.73
5.76
1.6
1.5
452.7
41506841.2
pmol/l
1.32
100
624
121
789
1.69
5.67
1.3
1.3
13.8
28.8
iu/ml
2.57
40
227
26
93
2.89
5.65
2.4
1.7
13.8
13.2
%
0.72
26
93
116
758
1.68
5.37
1.3
1.2
2.1
8.8
u/ml
3.49
44
315
60
326
1.95
5.11
3.0
3.4
4.7
4.7
pmol/l
0.19
55
289
27
106
2.63
4.96
1.7
2.1
—
—
—
0
0
299
2457
1.50
4.92
8.7
8.0
4.1
4.0
e9/l
0.10
282
2157
167
1216
1.55
4.90
1.4
1.3
0.6
1.9
u/ml
2.00
41
343
11
24
4.66
4.80
1.5
1.2
2.1
1.7
mmol/l
0.75
11
24
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
20
5.08
4.79
1.5
1.1
—
—
—
0
0
143
1014
1.56
4.69
1.8
1.6
1.3
1.3
mmol/l
0.28
137
884
19
64
3.04
4.60
1.5
1.3
—
—
—
0
0
37
175
2.20
4.56
1.3
1.2
0.2
2.5
u/ml
—
5
11
220
1725
1.47
4.43
3.7
3.1
—
—
—
0
0
60
984
0.56
4.36
2.4
1.9
—
—
—
0
0
15
45
3.40
4.35
1.2
1.6
—
—
—
0
0
112
764
1.59
4.31
1.4
1.4
21.9
20.6
nmol/l
0.41
106
664
57
325
1.84
4.21
1.6
1.7
—
—
—
0
0
452
4118
1.66
4.18
5.9
4.6
1.7
2.0
mu/l
0.72
437
3857
162
1207
1.49
4.16
1.6
1.5
—
—
—
0
0
52
289
1.89
4.16
1.7
1.5
—
—
—
0
0
80
509
1.67
4.06
3.4
3.0
0.8
0.8
mmol/l
0.07
75
481
19
69
2.82
4.06
2.2
1.7
180.5
199.0
pmol/l
0.25
19
64
472
4358
1.76
4.05
17.4
10.7
39.8
40.1
%
0.41
325
3551
276
2286
1.43
4.03
3.4
2.8
74.4
74.7
ug/l
0.01
264
2149
16
402
0.38
3.83
4.1
3.5
29.2
32.1
%
0.48
11
286
18
66
2.79
3.79
1.2
1.5
—
—
—
0
0
93
637
1.56
3.49
1.8
1.7
—
—
—
0
0
15
52
2.94
3.49
1.4
1.1
—
—
—
0
0
9
18
5.07
3.38
1.4
1.1
—
—
—
0
0
263
2204
1.38
3.37
3.7
3.0
0.0
0.0
estimate
0.00
40
452
20
430
0.44
3.31
1.5
1.5
—
—
—
0
0
13
43
3.07
3.27
1.2
1.0
—
—
—
0
0
22
97
2.32
3.24
1.3
1.5
—
—
—
0
0
22
97
2.32
3.24
1.3
1.5
—
—
—
0
0
46
268
1.78
3.21
11.2
4.0
1.9
1.6
mmol/l
0.21
37
206
15
55
2.78
3.18
1.4
1.1
—
—
—
0
0
18
395
0.44
3.14
1.4
1.4
—
—
—
0
0
70
460
1.60
3.14
3.4
2.4
7221.0
4833.7
u/l
0.28
31
213
18
394
0.44
3.12
1.4
1.4
—
—
—
0
0
18
394
0.44
3.12
1.4
1.4
—
—
—
0
0
18
393
0.44
3.10
1.4
1.4
—
—
—
0
0
128
960
1.44
3.08
2.3
1.8
0.6
1.0
mg/l
2.39
101
703
66
431
1.61
3.04
1.8
2.1
21.5
24.9
%
1.00
38
371
251
2118
1.35
2.95
5.6
3.9
—
—
—
0
0
109
800
1.46
2.93
1.9
1.9
—
—
—
0
0
15
58
2.63
2.89
1.3
1.5
—
—
—
0
0
6
9
6.73
2.87
1.7
1.3
—
—
—
0
0
152
1193
1.38
2.80
2.7
2.9
2.3
2.4
mmol/l
3.23
142
1075
488
4630
1.68
2.70
10.0
8.2
24.8
25.2
u/l
0.24
479
4481
8
19
4.26
2.68
2.3
2.8
81.6
97.2
nmol/l
—
8
19
7
15
4.71
2.60
1.4
1.1
—
—
—
0
0
258
2214
1.32
2.60
5.1
4.2
0.0
0.0
estimate
0.50
39
461
260
2237
1.32
2.56
3.7
3.1
0.0
0.0
estimate
0.50
40
445
19
88
2.20
2.54
1.8
1.5
5.7
7.3
mmol/l
3.11
13
60
50
320
1.62
2.52
1.4
1.3
147.5
253.8
u/ml
0.60
44
295
470
4435
1.53
2.49
14.8
10.1
18.3
19.7
mg/l
0.49
372
3400
13
51
2.59
2.46
1.4
1.1
—
—
—
0
0
391
3582
1.35
2.38
4.3
4.3
36.7
37.8
mmol/mol
2.28
378
3376
13
52
2.54
2.37
1.9
1.1
—
—
—
0
0
8
23
3.52
2.27
1.4
1.5
10.0
10.2
umol/l
—
8
23
38
236
1.66
2.17
4.6
7.0
6.6
7.5
mmol/l
0.60
38
225
38
238
1.64
2.11
1.8
2.0
—
—
—
0
0
5
10
5.04
2.07
2.8
3.9
188.6
195.4
u/l
—
5
10
0
56
0.00
2.07
0.0
1.1
—
—
—
0
0
341
3103
1.28
1.95
3.6
2.8
33.8
36.9
u/l
0.45
329
2960
6
16
3.78
1.94
1.2
1.1
—
—
—
0
0
9
33
2.76
1.94
2.1
1.4
4.9
5.2
mmol/l
—
9
33
42
282
1.53
1.78
2.2
2.7
0.2
0.2
g/l
0.03
37
268
17
88
1.96
1.76
1.3
1.3
—
—
—
0
0
6
18
3.36
1.75
1.0
2.6
251.3
462.3
u/ml
—
6
18
53
376
1.46
1.73
8.2
5.3
—
—
—
0
0
5
13
3.87
1.72
1.8
1.2
—
—
—
0
0
5
13
3.87
1.72
1.6
1.1
—
—
—
0
0
5
13
3.87
1.72
1.8
1.1
—
—
—
0
0
5
13
3.87
1.72
1.6
1.1
—
—
—
0
0
5
13
3.87
1.72
1.8
1.2
—
—
—
0
0
15
76
2.00
1.66
2.7
4.9
—
595.1
—
0
10
7
25
2.82
1.65
1.7
2.2
—
—
—
0
0
5
131
0.38
1.64
1.2
2.0
—
—
—
0
0
5
14
3.59
1.62
1.2
1.2
—
—
—
0
0
16
85
1.91
1.56
1.4
1.4
—
—
—
0
0
22
130
1.72
1.55
1.3
1.1
—
—
—
0
0
10
44
2.30
1.54
1.1
1.4
—
—
—
0
0
5
15
3.35
1.52
1.2
1.2
—
—
—
0
0
5
15
3.35
1.52
2.2
1.8
27.5
16.0
umol/l
—
5
15
5
126
0.39
1.51
1.6
1.8
—
—
—
0
0
9
38
2.39
1.46
1.4
1.8
—
—
—
0
0
7
154
0.45
1.45
1.3
1.6
—
—
—
0
0
14
73
1.94
1.45
1.3
1.0
0.0
0.4
u/ml
—
8
18
418
3959
1.26
1.41
3.9
3.4
5.5
5.7
mmol/l
1.81
401
3682
10
46
2.20
1.40
1.0
1.4
—
—
—
0
0
52
385
1.39
1.38
4.0
3.7
21.6
21.7
%
0.02
16
167
5
17
2.96
1.36
1.0
1.0
—
—
—
0
0
16
90
1.80
1.34
1.3
1.1
—
—
—
0
0
8
35
2.30
1.27
1.5
1.8
—
—
—
0
0
57
435
1.35
1.27
3.1
2.7
7.2
7.6
umol/l
0.04
46
362
11
201
0.54
1.23
1.8
1.4
—
—
—
0
0
8
37
2.18
1.22
2.3
2.1
—
—
—
0
0
41
550
0.72
1.19
2.6
2.4
2.6
3.3
e6/l
0.44
14
277
190
1689
1.19
1.16
2.6
2.2
73.7
73.6
nmol/l
0.03
181
1552
8
39
2.07
1.15
1.4
1.2
—
—
—
0
0
22
144
1.55
1.10
1.9
2.1
2.0
5.2
iu/l
—
10
58
21
136
1.57
1.10
1.8
1.7
—
—
—
0
0
29
202
1.46
1.10
1.3
1.3
22.3
10.1
u/l
0.49
29
169
150
1318
1.19
1.04
1.9
1.7
—
—
—
0
0
33
240
1.40
1.01
1.5
1.5
—
—
—
0
0
108
1251
0.83
0.98
1.9
2.2
—
—
—
0
0
0
29
0.00
0.98
0.0
1.2
—
34.4
—
0
5
17
109
1.58
0.94
1.1
1.9
1.4
1.3
g/l
0.14
12
92
32
235
1.38
0.94
14.9
3.3
4.9
4.6
kpa
0.32
32
228
16
102
1.59
0.91
1.5
1.4
235.5
340.7
ug/g
—
10
62
17
253
0.66
0.90
1.7
1.7
2.3
2.7
mg/l
0.18
12
171
24
333
0.71
0.88
1.9
1.7
—
—
—
0
0
88
1026
0.83
0.86
3.3
2.5
0.1
0.4
e6/l
3.48
62
742
13
80
1.64
0.85
3.1
2.5
—
—
—
0
0
0
25
0.00
0.79
0.0
3.8
—
—
—
0
0
14
90
1.57
0.79
1.4
1.9
2.9
3.0
g/l
—
8
71
0
26
0.00
0.78
0.0
1.6
—
—
—
0
0
7
38
1.85
0.73
1.0
1.1
—
—
—
0
0
9
56
1.62
0.72
2.2
1.5
—
—
—
0
0
7
40
1.76
0.71
1.1
1.3
—
—
—
0
0
20
144
1.40
0.69
1.2
1.6
0.0
0.5
iu/ml
—
6
23
9
59
1.53
0.68
1.2
1.1
—
—
—
0
0
57
477
1.22
0.68
1.6
1.4
—
—
—
0
0
28
361
0.76
0.68
3.7
2.7
—
—
—
0
0
18
128
1.42
0.66
1.5
1.5
0.2
0.4
nmol/l
3.31
11
107
5
29
1.73
0.64
1.8
1.7
—
1224680.0
—
0
5
13
87
1.51
0.64
1.3
1.5
—
—
—
0
0
33
262
1.28
0.62
15.1
6.3
1.5
1.3
mmol/l
1.45
33
246
14
96
1.47
0.62
1.4
1.8
6.8
7.2
g/l
—
8
75
49
583
0.82
0.61
2.5
2.2
0.5
0.8
e6/l
1.44
21
309
101
1129
0.87
0.60
1.7
2.1
—
—
—
0
0
10
151
0.66
0.60
1.5
1.6
—
—
—
0
0
389
3760
1.13
0.59
4.0
3.8
—
—
—
0
0
53
449
1.20
0.58
1.3
1.2
94.9
160.8
iu/ml
1.26
32
190
12
81
1.49
0.57
9.4
4.4
9.7
8.3
kpa
1.84
12
76
423
4115
1.14
0.56
3.7
3.5
4.8
4.7
mmol/l
0.26
411
3893
18
133
1.37
0.55
1.3
1.3
—
—
—
0
0
6
38
1.59
0.54
1.0
1.2
—
88.6
—
0
7
12
83
1.46
0.52
1.4
1.2
—
—
—
0
0
9
64
1.41
0.51
1.4
1.4
19.2
34.7
nmol/l
—
9
57
37
307
1.22
0.51
1.1
1.0
—
—
—
0
0
132
1214
1.12
0.49
3.3
2.9
13.8
32.0
ng/l
3.24
58
617
26
321
0.80
0.48
11.3
15.5
1.3
1.2
inr
—
5
56
96
868
1.13
0.48
2.6
2.4
304.5
5479.9
umol/l
3.16
86
766
62
697
0.87
0.42
3.1
2.8
565.7
726.5
ng/l
0.40
50
557
13
96
1.36
0.42
1.4
1.8
3.5
3.8
g/l
—
6
70
13
96
1.36
0.42
1.4
1.8
—
—
—
0
0
8
58
1.39
0.41
1.0
1.6
—
—
—
0
0
8
58
1.39
0.41
1.1
1.3
—
—
—
0
0
8
58
1.39
0.41
1.1
1.3
—
—
—
0
0
5
33
1.52
0.41
1.0
1.2
—
—
—
0
0
12
89
1.36
0.38
1.4
1.9
11.1
10.8
g/l
—
7
77
22
267
0.82
0.37
2.3
2.4
62.9
76.5
ml/min/173m2
—
10
97
11
81
1.37
0.36
1.0
1.1
—
—
—
0
0
23
276
0.83
0.35
1.3
1.3
146.2
258.7
miu/ml
—
8
146
425
4170
1.10
0.35
4.1
3.8
2.8
2.8
mmol/l
0.02
410
3913
16
196
0.81
0.30
8.3
4.0
5.3
5.1
kpa
0.56
16
182
21
249
0.84
0.29
4.1
4.3
2.4
23.6
ug/l
0.64
12
199
16
130
1.24
0.29
1.1
1.2
—
25.7
—
0
7
52
573
0.90
0.28
2.4
2.3
2.4
2.4
mmol/l
0.33
47
490
417
4103
1.08
0.27
3.6
3.5
1.5
1.5
mmol/l
0.48
403
3868
11
138
0.79
0.26
1.6
1.2
—
—
—
0
0
11
137
0.80
0.24
1.6
1.2
—
—
—
0
0
5
39
1.28
0.23
1.0
1.3
—
—
—
0
0
5
40
1.25
0.22
1.0
1.4
—
—
—
0
0
398
3919
1.06
0.22
3.1
3.2
1.3
1.2
mmol/l
0.75
385
3689
10
124
0.80
0.22
1.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
1.2
—
0
10
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
10
80
1.25
0.20
1.7
3.5
49.7
57.7
%
—
10
80
29
323
0.89
0.20
1.3
1.4
—
—
—
0
0
11
90
1.23
0.19
1.0
1.1
—
—
—
0
0
5
66
0.76
0.17
2.4
1.4
—
—
—
0
0
22
245
0.89
0.16
1.4
1.4
—
—
—
0
0
26
286
0.90
0.15
2.5
2.7
0.4
0.7
ug/l
3.02
12
168
7
89
0.78
0.14
1.1
1.2
—
—
—
0
0
17
190
0.89
0.13
1.4
1.2
—
—
—
0
0
51
539
0.94
0.13
1.6
1.5
—
—
—
0
0
122
1185
1.04
0.11
4.5
3.3
0.0
0.0
estimate
1.08
41
456
23
211
1.09
0.11
2.1
1.3
—
—
—
0
0
20
183
1.10
0.10
1.5
1.8
—
—
—
0
0
15
166
0.90
0.10
1.7
2.2
0.0
0.1
e6/l
2.93
15
159
6
55
1.09
0.09
1.5
1.3
—
—
—
0
0
6
56
1.07
0.08
1.3
2.5
—
—
—
0
0
10
88
1.14
0.08
1.0
1.0
1.3
2.0
u/ml
—
5
44
7
65
1.08
0.08
1.0
1.1
—
—
—
0
0
7
66
1.06
0.08
1.9
2.4
25.2
24.9
mmol/l
—
7
60
18
166
1.09
0.08
9.1
8.4
0.7
0.7
%
0.02
18
166
6
71
0.84
0.07
1.2
1.5
—
—
—
0
0
131
1297
1.01
0.03
3.4
2.7
—
—
—
0
0
11
118
0.93
0.03
1.3
1.6
—
256.0
—
0
5
75
743
1.01
0.01
1.7
1.5
—
—
—
0
0
10
106
0.94
0.01
1.2
1.3
—
—
—
0
0
13
136
0.95
0.00
6.5
8.5
23.3
24.1
mmol/l
0.48
13
124
10
95
1.05
0.00
1.0
1.3
6.0
6.7
u/ml
—
5
41
17
167
1.02
0.00
9.6
8.3
1.3
1.5
%
0.46
17
167
7
72
0.97
0.00
2.7
2.5
0.9
1.0
nmol/l
—
7
64
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
3.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
5
55
0.91
0.00
1.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
7.6
—
0
6
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
0.7
—
0
6
7
78
0.90
0.00
1.7
1.9
40.7
39.1
g/l
—
7
69
Mortality – FinRegistry
↥Association
Association between endpoint H7_CONVERGINSUFF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONVERGINSUFF | 0.934 [0.75, 1.17] | 0.547 |
| Birth year | 0.992 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 2408 females with H7_CONVERGINSUFF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONVERGINSUFF | 1.371 [1.07, 1.76] | 0.012 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 1274 males with H7_CONVERGINSUFF died.
Mortality risk
Mortality risk for people of age
years, who have H7_CONVERGINSUFF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.065% | 0.274% |
| 5 | 0.501% | 1.774% |
| 10 | 1.179% | 4.347% |
| 15 | 2.336% | 8.311% |
| 20 | 4.254% | 13.689% |
Relationships between endpoints
↥Index endpoint: H7_CONVERGINSUFF – Convergence insufficiency and excess
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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