Risteys · H7_CONVERGINSUFF

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H51.1 Cause of death: ICD-10 — H51.1 2 out of 7 registries used, show all original rules.	530
4. Check minimum number of events None	530
5. Include endpoints None	530
6. Filter based on genotype QC (FinnGen only)	530

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3911	2548	1357
Only index persons	3670	2423	1247
Unadjusted period prevalence (%)
Whole population	0.06	0.07	0.04
Only index persons	0.07	0.09	0.05
Median age at first event (years)
Whole population	19.34	21.03	16.06
Only index persons	20.89	22.48	17.81

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	530	410	120
Unadjusted period prevalence (%)	0.12	0.14	0.05
Median age at first event (years)	30.70	28.61	37.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
449: Matched controls
4488

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H51.1

ICD-10 Finland

Convergence insufficiency and excess

+∞

323.0

449

H53.3

ICD-10 Finland

Other disorders of binocular vision

308.2

99.0

H50.52

ICD-10 Finland

Exophoria

+∞

78.5

H53.2

ICD-10 Finland

Diplopia

36.6

43.1

H50.31

ICD-10 Finland

Intermittent exotropia

+∞

38.1

H50.1

ICD-10 Finland

Divergent concomitant strabismus

+∞

28.4

R51.80

ICD-10 Finland

Headache

3.6

24.9

135

482

XCW99

NOMESCO Finland

Other investigative procedure of eye

5.2

23.1

169

WX704

NOMESCO Finland

Intubation

5.3

21.2

146

SPAT1301

SPAT

No procedures

2.7

19.9

177

863

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

3.6

19.0

312

WX725

NOMESCO Finland

Noninvasive ventilation

7.0

18.7

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.4

18.1

347

CEC00

NOMESCO Finland

Recession of extraocular muscle

+∞

17.8

AA1AD

NOMESCO Finland

CT of head and brain

3.0

17.4

112

441

N03AX12

ATC

gabapentin; oral

3.3

17.3

349

WX720

NOMESCO Finland

Own respiration

7.2

17.3

SPAT1028

SPAT

Ultrasound examination of paranasal sinuses

4.5

17.0

157

N02CC01

ATC

sumatriptan; nasal, systemic, rectal

2.8

15.9

123

538

N03AG01

ATC

valproic acid; systemic, rectal

4.4

15.6

145

CEC10

NOMESCO Finland

Recession and resection of extraocular muscle

+∞

14.7

H52.5

ICD-10 Finland

Disorders of accommodation

+∞

14.7

WX702

NOMESCO Finland

Supraglottic ventilation device

4.9

14.4

107

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

4.2

14.2

148

TPH04

NOMESCO Finland

Cathetrisation of vein

2.7

14.2

107

459

Z01.8

ICD-10 Finland

Other specified special examinations

2.6

13.7

118

544

SPAT1324

SPAT

Screening procedure

2.4

13.5

137

691

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

3.6

13.5

194

SPAT1263

SPAT

Sampling

2.1

13.3

222

1410

H53.1

ICD-10 Finland

Subjective visual disturbances

4.5

12.9

111

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

4.1

12.8

136

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

3.1

12.5

271

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

5.8

12.4

A02BC03

ATC

lansoprazole; oral

2.3

12.1

132

687

H52.1

ICD-10 Finland

Myopia

11.0

11.9

R03AC02

ATC

salbutamol; inhalant

2.0

11.5

262

1845

SPAT1310

SPAT

Counselling related to known health issue

2.1

11.2

166

984

K07.60

ICD-10 Finland

Snapping jaw

3.7

10.6

133

H50.2

ICD-10 Finland

Vertical strabismus

+∞

10.5

37301

ICD-8 Finland

Strabismus, Concomitans divergens

+∞

10.5

H52.0

ICD-10 Finland

Hypermetropia

16.5

10.4

N01

ICPC

Headache

2.5

10.3

381

SPAT1097

SPAT

Recording of ECG

2.9

10.2

237

SPAT1260

SPAT

Consultation of another employee

2.4

10.1

412

UKC02

NOMESCO Finland

Cystoscopy

3.0

10.0

226

SHB00

NOMESCO Finland

Prepation and fitting of bite rail to mouth

2.5

9.9

353

N06AX21

ATC

duloxetine; oral

2.8

9.9

264

N06AX11

ATC

mirtazapine; oral

2.0

9.6

148

878

H50.51

ICD-10 Finland

Esophoria

+∞

9.4

N06AA09

ATC

amitriptyline; systemic

3.2

9.0

164

WX400

NOMESCO Finland

Inhalation anesthesy

4.2

9.0

R03BA05

ATC

fluticasone; inhalant

2.2

8.9

104

550

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.9

8.8

154

951

SAA03

NOMESCO Finland

Extended examination of mouth

1.8

8.7

205

1405

R20.2

ICD-10 Finland

Paraesthesia of skin

3.2

8.5

153

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.8

8.5

183

1217

R44

ICPC

Respiratory, Preventive immunization/medic

13.1

8.4

H50.9

ICD-10 Finland

Strabismus, unspecified

+∞

8.4

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

2.9

8.3

188

SPAT1050

SPAT

Extensive neurological examination

7.3

8.3

M25.5

ICD-10 Finland

Pain in joint

1.9

8.3

137

826

HAMTE

NOMESCO Finland

14.8

8.2

XA800

NOMESCO Finland

Neuropsychological investigation

3.9

8.1

A02BA02

ATC

ranitidine; systemic

2.4

8.1

333

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

5.5

8.1

SXA05

NOMESCO Finland

10.3

8.1

G43.1

ICD-10 Finland

Migraine with aura [classical migraine]

2.6

8.0

253

NA7CG

NOMESCO Finland

Spine and spinal cord extensive MRI examination with high intensity magnet

11.1

7.8

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

2.9

7.8

168

TAB00

NOMESCO Finland

Lumbar puncture

3.5

7.8

105

F43.1

ICD-10 Finland

Post-traumatic stress disorder

4.1

7.8

XKC03

NOMESCO Finland

Water cystometry

5.6

7.6

AEA50

NOMESCO Finland

Adjustment of implanted neurostimulator

25.5

7.6

G40.20

ICD-10 Finland

Complex partial seizures with only alteration of consciousness

10.3

7.6

A02BC05

ATC

esomeprazole; systemic

1.8

7.3

165

1101

CEC30

NOMESCO Finland

Resection of extraocular muscle

+∞

7.3

M54.4

ICD-10 Finland

Lumbago with sciatica

2.2

7.3

399

KMAK

NOMESCO Finland

1.7

7.2

264

2035

-1

NOMESCO Finland

1.7

7.2

184

1276

A45

ICPC

General and Unspecified, Observ/health educat/advice/diet

5.5

7.2

A04

ICPC

Weakness/tiredness general

2.2

7.1

341

XCK00

NOMESCO Finland

Perimetry

3.4

7.0

A02BC01

ATC

omeprazole; systemic

1.9

7.0

111

656

G45.9

ICD-10 Finland

Transient cerebral ischaemic attack, unspecified

3.8

6.9

N05BA01

ATC

diazepam; systemic, rectal

2.4

6.9

267

SHA03

NOMESCO Finland

Correction of physiology of bite - demanding therapy visit

4.1

6.9

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

3.5

6.9

R42

ICD-10 Finland

Dizziness and giddiness

2.1

6.8

432

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

2.3

6.8

319

A06AC01

ATC

ispaghula (psylla seeds); oral

2.0

6.7

488

FM1DE

NOMESCO Finland

Doppler ultrasound examination of heart

3.0

6.7

134

SHA02

NOMESCO Finland

Correction of physiology of bite - basic therapy visit

2.6

6.7

204

N02AC04

ATC

dextropropoxyphene; oral

5.6

6.7

182

Kela drug reimbursment

Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide

6.0

6.7

R06.0

ICD-10 Finland

Dyspnoea

2.0

6.6

517

N03AF02

ATC

oxcarbazepine; oral

4.5

6.4

R09

ICPC

Sinus symptom/complaint

2.3

6.4

268

F45.8

ICD-10 Finland

Other somatoform disorders

2.4

6.4

244

R03DC03

ATC

montelukast; oral

2.0

6.4

469

CS444

NOMESCO Finland

Visual field testing with Octopus automated perimetry

5.3

6.4

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

3.5

6.4

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

2.6

6.4

196

M03BA52

ATC

carisoprodol, combinations excl. psycholeptics; oral

4.7

6.4

A01

ICPC

Pain general/multiple sites

2.8

6.4

151

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

2.8

6.3

142

XLD10

NOMESCO Finland

Gynaecological examination

11.2

6.3

H04.10

ICD-10 Finland

Dry eye syndrome

2.6

6.3

186

M03BX01

ATC

baclofen; systemic

7.2

6.3

H50.0

ICD-10 Finland

Convergent concomitant strabismus

+∞

6.3

NGA30

NOMESCO Finland

Exploration of knee joint, arthroscopic

3.7

6.2

H53.4

ICD-10 Finland

Visual field defects

7.8

6.2

F16

ICPC

Eyelid symptom/complaint

3.3

6.2

J45.9

ICD-10 Finland

Asthma, unspecified

2.0

6.1

443

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

2.8

6.1

149

N05AH04

ATC

quetiapine; oral

2.0

6.1

498

C07AA05

ATC

propranolol; systemic

1.9

6.1

103

618

N03AX14

ATC

levetiracetam; systemic

5.0

6.1

C07AB07

ATC

bisoprolol; oral

1.7

6.0

135

890

R01AD01

ATC

beclometasone; nasal

2.0

6.0

389

SPAT1044

SPAT

Tympanometry

4.4

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CONVERGINSUFF and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_CONVERGINSUFF	0.934 [0.75, 1.17]	0.547
Birth year	0.992 [0.98, 1.0]	0.087

During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 2408 females with H7_CONVERGINSUFF died.

Males

Parameter	HR [95% CI]	p-value
H7_CONVERGINSUFF	1.371 [1.07, 1.76]	0.012
Birth year	0.989 [0.98, 1.0]	0.015

During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 1274 males with H7_CONVERGINSUFF died.

Mortality risk

Mortality risk for people of age

years, who have H7_CONVERGINSUFF.

N-year risk	Females	Males
1	0.065%	0.274%
5	0.501%	1.774%
10	1.179%	4.347%
15	2.336%	8.311%
20	4.254%	13.689%

Relationships between endpoints

↥

Index endpoint: H7_CONVERGINSUFF – Convergence insufficiency and excess

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	H7_CONVERGINSUFF
CONTROL_EXCLUDE	H7_OCUMUSCLE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H511
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H511
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Convergence insufficiency and excess

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints