Other and unspecified disorders of sclera

H7_SCLERANAS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H15.8, H15.9 Hospital discharge: ICD-9 — 3791A Cause of death: ICD-10 — H15.8, H15.9 Cause of death: ICD-9 — 3791A 2 out of 7 registries used, show all original rules.	39
4. Check minimum number of events None	39
5. Include endpoints None	39
6. Filter based on genotype QC (FinnGen only)	39

Control definitions (FinnGen only)

Control exclude: H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4

NAME	H7_SCLERANAS
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H15[8-9]
HD_ICD_9	3791A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H15[8-9]
COD_ICD_9	3791A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other and unspecified disorders of sclera based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	362	196	165
Only index persons	313	174	139
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	51.04	55.01	46.16
Only index persons	50.67	55.27	44.91

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	39	27	12
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	59.24	60.42	56.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3008898) HLA-B27 [Presence]

8.59

3.17

1.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

225

3.34

2.50

5.3

4.2

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

2.69

2.24

2.5

2.4

105.8

262.7

u/l

0.78

(3009445) Proteinase 3 Ab [Units/volume] in Serum

5.55

2.14

1.0

1.2

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

3.10

2.11

2.4

3.6

32.1

30.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

2.73

1.84

1.2

10.9

55.2

iu/ml

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

111

2.39

1.84

2.2

1.9

104.6

94.4

pmol/l

—

(40768797) Stomach Pathology biopsy report

2.78

1.77

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.41

1.62

4.2

3.0

—

(40758558) Short blood count panel - Blood

2.31

1.60

7.2

7.4

—

(3022145) Colonoscopy Study observation

2.89

1.43

1.5

1.1

—

(42870588) Differential panel, method unspecified - Blood

106

2.07

1.32

8.0

6.8

—

(3013707) Erythrocyte sedimentation rate by Westergren method

232

1.98

1.00

6.4

4.3

10.0

11.8

mm/h

0.58

204

(3027801) Oxygen [Partial pressure] in Arterial blood

2.26

0.94

2.5

13.1

15.1

12.1

kpa

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

2.26

0.94

2.5

13.1

5.0

4.9

kpa

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

1.96

0.83

1.2

5.9

242.0

213.2

u/l

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

2.24

0.77

2.8

6.5

110.4

117.7

g/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.71

0.77

1.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

303

1.95

0.66

13.7

12.0

84.4

83.6

ml/min/173m2

0.08

244

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.78

0.60

1.3

2.2

—

(3044889) 12 lead EKG panel

228

1.60

0.59

4.6

4.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.73

0.59

1.2

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.73

0.59

1.2

—

(3002256) Pathology report gross observation

1.59

0.54

1.3

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.52

0.49

1.6

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

116

1.48

0.46

2.7

3.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.70

0.45

1.4

2.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.52

0.44

1.5

2.2

—

(3015736) pH of Urine

117

1.46

0.44

3.7

3.2

—

(3044640) Blood type and Crossmatch panel - Blood

1.47

0.43

1.6

2.4

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.42

0.0

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.49

0.41

1.6

1.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.41

0.0

1.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.47

0.37

1.6

1.4

—

(1761868) Lipid panel - Serum or Plasma

116

0.71

0.34

1.9

2.9

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

171

1.35

0.33

4.0

6.1

6.2

6.3

mmol/l

0.07

162

(3026782) Osmolality of Urine

1.36

0.33

2.3

2.7

528.0

479.1

mosm/kgh2o

—

(3018095) Leukocytes [#/volume] in Urine

114

1.36

0.31

4.3

3.2

7.6

66.8

e6/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.39

0.30

1.5

3.4

—

(4035726)

1.40

0.25

1.4

1.5

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

216

1.29

0.24

3.1

2.9

35.1

49.9

u/l

0.99

201

(3000494) Fungus identified in Specimen by Culture

1.32

0.24

1.6

1.4

—

(40768804) Tissue Pathology biopsy report

152

0.78

0.22

3.4

1.7

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.22

0.0

2.3

—

46.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.29

0.21

1.7

1.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.21

0.0

1.2

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

100

1.29

0.21

1.5

1.7

1.5

1.4

mmol/l

0.08

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

160

1.23

0.18

2.9

3.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.22

0.18

2.5

3.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

313

1.35

0.17

4.5

5.7

5.9

mmol/l

0.66

290

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.73

0.17

1.8

1.5

—

(3042936) Bacteria identified in Isolate by Culture

1.19

0.10

2.4

2.1

—

(3000850) Epithelial cells [#/volume] in Urine

1.14

0.09

2.4

4.8

7.0

e6/l

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

321

1.18

0.08

5.1

4.6

4.7

mmol/l

0.32

300

(3009542) Hematocrit [Volume Fraction] of Blood

308

1.22

0.08

18.7

15.3

41.6

40.0

1.25

227

(3003694) ABO and Rh group [Type] in Blood

100

0.87

0.07

1.7

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

210

1.11

0.05

3.3

3.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

112

1.10

0.03

2.8

2.7

—

(36304419) Bacteria [Presence] in Urine

1.10

0.02

3.3

2.8

—

(3026008) Bacteria identified in Urine by Culture

1.06

0.00

2.4

2.7

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.2

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.6

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.3

—

(3020891) Body temperature

0.00

0.0

5.0

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.0

1.8

—

69.8

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.0

2.4

—

23.5

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.2

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

1.7

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.8

—

(3010375) cycloSPORINE [Mass/volume] in Blood

0.00

0.0

33.8

—

139.2

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.2

—

2.3

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

2.6

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

4.6

—

8.7

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

2.1

—

0.4

—

(1616796) Gas panel - Central venous blood

0.00

0.0

5.6

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.2

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.7

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.2

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.1

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.4

—

(3028626) Oxygen [Partial pressure] in Capillary blood

0.00

0.0

6.8

—

8.7

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.1

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

4.7

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.6

—

(3023368) Bacteria identified in Blood by Culture

1.00

0.00

2.3

3.3

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

4.6

—

5.1

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

308

1.03

0.00

4.5

4.0

1.3

mmol/l

0.02

282

(4034850)

0.00

0.0

8.6

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.2

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.1

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3013512) EKG study

1.00

0.00

2.0

3.7

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

3.6

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.2

—

20.8

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

100

1.00

0.00

1.2

2.2

53.8

55.6

u/l

—

(3009508) Creatinine [Moles/volume] in Urine

0.91

0.00

4.1

3.0

6.8

7.8

mmol/l

—

(4146454)

0.00

0.0

1.8

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.2

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

1.4

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

3.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.4

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_SCLERANAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_SCLERANAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_SCLERANAS – Other and unspecified disorders of sclera

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other and unspecified disorders of sclera

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints