Staphylococcal scalded skin syndrome

L12_STAPHSCALDSKIN

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L00 Cause of death: ICD-10 — L00 2 out of 7 registries used, show all original rules.	40
4. Check minimum number of events None	40
5. Include endpoints None	40
6. Filter based on genotype QC (FinnGen only)	40

Control definitions (FinnGen only)

Control exclude: L12_INFECT_SKIN

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L00-L08
Name in latin: Syndroma exfoliativum staphylococcicum (cutis)

NAME	L12_STAPHSCALDSKIN
CONTROL_EXCLUDE	L12_INFECT_SKIN
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L00
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L00
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Staphylococcal scalded skin syndrome based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1126	519	604
Only index persons	707	321	386
Unadjusted period prevalence (%)
Whole population	0.02	0.01	0.02
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	0.27	0.06	0.06
Only index persons	0.05	0.05	0.05

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	40	25	15
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	12.89	17.75	4.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

3.38

2.74

3.5

3.1

3.0

4.0

e6/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.44

2.24

2.3

1.3

—

(36304419) Bacteria [Presence] in Urine

2.69

2.15

7.7

2.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

4.50

2.12

1.5

1.9

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

4.50

2.12

1.5

1.9

—

(3042936) Bacteria identified in Isolate by Culture

3.11

2.02

2.0

1.6

—

(3018095) Leukocytes [#/volume] in Urine

103

2.36

1.80

7.9

3.8

57.1

19.6

e6/l

0.35

(3023368) Bacteria identified in Blood by Culture

2.66

1.76

6.9

3.4

—

(3030467) Casts [#/volume] in Urine by Automated count

2.41

1.70

8.3

2.5

0.1

e6/l

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.92

1.67

1.4

4.6

156.2

155.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

2.33

1.64

1.6

1.5

95.9

105.7

pmol/l

—

(3002582) Erythrocytes [#/volume] in Urine

2.26

1.54

7.9

2.9

7.1

19.7

e6/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

3.02

1.32

1.4

—

(3022145) Colonoscopy Study observation

2.64

1.29

1.3

1.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.53

1.23

2.0

1.8

—

(3000991) Gas panel - Venous blood

2.52

1.17

12.4

15.1

—

(3002256) Pathology report gross observation

2.43

1.15

1.0

1.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

2.23

1.13

2.2

6.9

869.8

775.2

ng/l

—

(3012544) pH of Venous blood

2.35

1.12

9.9

7.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.06

1.11

3.3

4.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

103

1.92

1.09

7.2

3.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.08

0.99

1.9

2.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.34

0.96

2.0

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.44

0.94

11.6

3.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

127

0.54

0.82

8.4

3.9

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.82

0.0

2.6

—

(3000850) Epithelial cells [#/volume] in Urine

1.78

0.79

9.9

1.8

8.2

7.0

e6/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.34

0.79

1.4

2.4

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

331

0.55

0.78

10.1

8.1

24.1

23.5

u/l

0.09

325

(3026008) Bacteria identified in Urine by Culture

1.73

0.78

5.9

3.2

—

(3022313) Gas panel - Capillary blood

2.14

0.75

14.0

11.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.68

0.71

3.0

2.5

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.71

0.69

2.1

1.6

1.8

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.89

0.68

1.8

1.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.89

0.68

36.8

12.9

24.0

24.8

mmol/l

—

(3002032) Base excess in Venous blood by calculation

1.84

0.61

41.7

7.3

0.5

0.7

mmol/l

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.84

0.61

11.2

7.2

5.7

5.6

kpa

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.52

0.49

1.9

2.0

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.52

0.49

1.6

1.3

18.5

18.7

nmol/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.50

0.46

2.9

1.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.47

0.45

1.5

1.9

0.9

1.1

mmol/l

—

(40768804) Tissue Pathology biopsy report

1.48

0.45

1.8

1.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.64

0.44

1.8

4.5

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.59

0.43

13.2

7.5

5.3

5.4

kpa

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.46

0.42

1.5

1.9

1.7

g/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.42

0.0

5.8

—

1.2

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.41

0.0

1.6

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.41

0.0

1.7

—

(1761868) Lipid panel - Serum or Plasma

0.62

0.38

1.8

2.6

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.50

0.38

8.5

2.5

12.9

14.0

umol/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

241

0.73

0.36

4.1

3.3

1.4

1.2

mmol/l

0.61

222

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

250

1.40

0.35

13.9

7.7

79.6

93.4

ml/min/173m2

1.13

184

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

294

1.44

0.35

3.3

3.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.29

0.29

1.1

1.9

—

(3013512) EKG study

0.65

0.29

1.8

3.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

319

1.44

0.27

24.4

10.1

23.6

20.6

mg/l

0.25

227

(3001122) Ferritin [Mass/volume] in Serum or Plasma

156

1.28

0.25

4.2

2.6

89.9

58.7

ug/l

0.94

145

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.21

0.0

2.3

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3019060) Gas panel - Arterial blood

0.00

0.21

0.0

4.7

—

(3020891) Body temperature

0.00

0.21

0.0

5.9

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.21

0.0

1.6

—

(36660697) Celiac disease serology panel - Serum

1.23

0.21

1.3

1.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.20

0.0

1.7

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.20

0.0

6.3

—

0.9

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.28

0.20

2.6

2.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

130

0.79

0.19

2.4

1.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.18

0.19

3.6

2.4

—

(40761511) CBC panel - Blood by Automated count

332

0.82

0.18

17.8

9.6

—

(40758558) Short blood count panel - Blood

1.25

0.17

7.7

5.8

—

(42870588) Differential panel, method unspecified - Blood

122

1.23

0.17

8.5

6.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

0.76

0.16

7.9

4.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

246

0.85

0.13

4.2

3.8

4.5

mmol/l

0.02

230

(3001604) Monocytes [#/volume] in Blood

185

1.16

0.11

6.6

6.0

0.6

0.5

e9/l

0.16

167

(3006315) Basophils [#/volume] in Blood

185

1.16

0.11

6.6

6.0

0.0

e9/l

0.09

168

(3015736) pH of Urine

126

1.17

0.11

3.8

3.6

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

243

0.87

0.09

4.0

3.7

1.5

mmol/l

0.11

225

(3019832) Treponema pallidum Ab [Presence] in Serum

1.09

0.08

1.6

2.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

311

1.14

0.07

16.6

11.3

40.2

39.6

0.31

243

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

250

0.90

0.05

4.5

4.0

2.6

mmol/l

0.00

232

(3013115) Eosinophils [#/volume] in Blood

192

1.08

0.03

7.5

6.7

0.2

e9/l

0.14

176

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

198

0.92

0.03

2.8

3.1

35.3

40.5

u/l

0.30

190

(3013826) Glucose [Moles/volume] in Serum or Plasma

154

1.06

0.01

6.5

6.2

6.9

6.3

mmol/l

0.37

141

(3019198) Lymphocytes [#/volume] in Blood

194

1.06

0.01

6.6

5.9

2.3

2.1

e9/l

0.25

176

(3003694) ABO and Rh group [Type] in Blood

105

0.94

0.00

1.4

1.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

132

0.98

0.00

3.8

—

(3037467) Urinalysis macro (dipstick) panel - Urine

202

0.98

0.00

9.3

3.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.02

0.00

2.8

1.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.00

0.00

3.1

3.0

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

1.4

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.6

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.3

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(4211845)

0.00

0.0

1.4

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3027135) IgG subclass 1 [Mass/volume] in Serum

0.00

0.0

1.2

—

7.2

—

(3041672) Baker's yeast Ab [Presence] in Serum

0.00

0.0

1.4

—

(3023183) Ammonium ion [Moles/volume] in Plasma

0.00

0.0

1.0

—

33.2

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

0.0

1.3

—

(4034850)

0.00

0.0

7.2

—

(3024139) IgG subclass 3 [Mass/volume] in Serum

0.00

0.0

1.2

—

0.5

—

(3020393) Adenovirus Ag [Presence] in Stool

0.00

0.0

1.6

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(4062490)

0.00

0.0

1.2

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

3.4

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

3.2

—

(3028192) IgG subclass 2 [Mass/volume] in Serum

0.00

0.0

1.2

—

2.2

—

(3019150) Specific gravity of Urine by Refractometry

0.89

0.00

2.7

4.1

—

1.0

—

(3044889) 12 lead EKG panel

180

1.00

0.00

3.8

2.9

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

0.0

3.0

—

3.4

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

2.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

4.0

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.0

2.5

—

252.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(4268621)

0.00

0.0

1.8

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.2

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.0

2.7

—

37.1

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

4.9

—

(3006245) CD3-CD19+ cells/100 cells in Blood

0.00

0.0

1.4

—

25.7

—

(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood

0.00

0.0

1.4

—

17.4

—

(3044640) Blood type and Crossmatch panel - Blood

1.03

0.00

3.2

2.3

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

0.94

0.00

2.8

2.0

42.3

60.4

u/l

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

1.4

—

(1175426) CD3 cells/100 lymphocytes in Blood

0.00

0.0

1.3

—

54.8

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.0

2.7

—

1.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

0.96

0.00

2.0

3.9

30.0

33.7

u/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.01

0.00

3.7

3.1

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

0.90

0.00

2.4

3.0

1.8

0.9

mg/l

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.1

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.3

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

3.5

—

2.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_STAPHSCALDSKIN and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_STAPHSCALDSKIN.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_STAPHSCALDSKIN – Staphylococcal scalded skin syndrome

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Staphylococcal scalded skin syndrome

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints