Other drug-induced osteomalacia in adults

OTHER_DRUGADVERS_OSTEOMA_ADULTS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M83.5# 1 out of 7 registries used, show all original rules.	33
4. Check minimum number of events None	33
5. Include endpoints None	33
6. Filter based on genotype QC (FinnGen only)	33

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	OTHER_DRUGADVERS_OSTEOMA_ADULTS
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M835
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other drug-induced osteomalacia in adults based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	234	93	141
Only index persons	230	90	140
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.01
Median age at first event (years)
Whole population	-	40.21	35.77
Only index persons	37.62	40.20	35.97

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	33	14	19
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	37.49	38.53	36.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3026008) Bacteria identified in Urine by Culture

4.34

3.74

1.8

2.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

3.55

2.45

1.4

2.5

—

(3032080) INR in Blood by Coagulation assay

2.94

2.30

3.8

5.5

1.0

1.2

inr

—

(3037467) Urinalysis macro (dipstick) panel - Urine

174

3.32

2.28

4.4

3.7

—

(3023368) Bacteria identified in Blood by Culture

2.94

1.96

2.5

4.5

—

(3015736) pH of Urine

2.59

1.85

1.9

2.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.97

1.73

1.3

2.3

—

(3013707) Erythrocyte sedimentation rate by Westergren method

193

2.63

1.60

2.8

3.9

4.9

8.2

mm/h

3.57

185

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

3.73

1.58

1.0

—

(3020630) Protein [Mass/volume] in Serum or Plasma

3.73

1.58

1.0

3.1

67.2

66.1

g/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.69

1.39

2.0

1.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.34

1.31

1.5

2.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

2.91

1.26

1.2

1.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

229

2.46

1.15

4.5

4.2

1.6

1.7

mu/l

0.40

216

(3000492) Spirometry study

2.42

1.14

1.3

1.6

—

(3018010) Neutrophils/100 leukocytes in Blood

125

1.97

1.03

4.1

6.8

52.2

56.1

1.04

118

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

107

1.96

1.02

2.6

4.2

—

(3002030) Lymphocytes/100 leukocytes in Blood

126

1.94

1.00

4.1

7.2

33.2

29.2

1.40

120

(36660697) Celiac disease serology panel - Serum

2.49

0.99

1.0

1.2

—

(42870588) Differential panel, method unspecified - Blood

1.90

0.89

3.6

7.6

—

(3006504) Eosinophils/100 leukocytes in Blood

122

1.81

0.83

4.2

7.2

3.9

3.0

0.40

116

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

187

1.76

0.68

4.2

3.6

14.8

pmol/l

0.02

177

(3044889) 12 lead EKG panel

187

1.76

0.68

3.3

3.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.85

0.66

1.0

1.8

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

100

1.69

0.66

2.1

2.7

1.2

1.5

ug/l

0.38

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.73

0.63

4.6

2.3

—

(3022096) Basophils/100 leukocytes in Blood

120

1.65

0.63

4.4

7.0

0.8

0.7

0.14

112

(1002224) Polysomnography panel

0.00

0.62

0.0

1.2

—

(36304419) Bacteria [Presence] in Urine

1.62

0.60

4.7

2.2

—

(3019069) Monocytes/100 leukocytes in Blood

122

1.60

0.57

4.5

7.7

8.5

8.6

0.07

116

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

104

1.60

0.55

9.9

7.9

1.2

mmol/l

0.12

(3024561) Albumin [Mass/volume] in Serum or Plasma

1.56

0.49

5.2

6.1

37.6

37.1

g/l

0.21

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

217

1.63

0.48

4.0

3.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.54

0.47

4.2

2.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.53

0.47

2.0

2.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.50

0.46

2.6

2.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

270

0.70

0.44

3.7

3.6

1.5

1.4

mmol/l

0.14

255

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.42

0.0

1.8

—

3.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

130

1.45

0.39

4.9

6.7

10.1

10.3

umol/l

0.07

125

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.48

0.37

1.2

1.9

—

(3003694) ABO and Rh group [Type] in Blood

0.66

0.30

1.6

1.4

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

1.35

0.26

6.6

5.5

1.2

mmol/l

0.07

(40768797) Stomach Pathology biopsy report

1.37

0.24

1.2

1.3

—

(1761868) Lipid panel - Serum or Plasma

131

0.76

0.22

3.1

2.5

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

199

1.32

0.22

7.3

8.0

67.1

76.4

u/l

0.92

187

(4034850)

0.00

0.22

0.0

6.0

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.22

0.0

1.5

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.22

0.0

2.1

—

48.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.22

0.0

1.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.24

0.21

2.7

2.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.20

0.0

1.1

—

(3008898) HLA-B27 [Presence]

0.00

0.20

0.0

1.0

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

265

1.37

0.19

12.0

8.9

89.7

90.3

ml/min/173m2

0.06

214

(40760892) CBC W Ordered Manual Differential panel - Blood

1.23

0.18

2.1

4.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.19

0.18

5.3

2.2

—

(3009508) Creatinine [Moles/volume] in Urine

1.15

0.17

3.6

2.8

7.2

9.3

mmol/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.08

0.10

2.2

2.3

421.0

370.1

ng/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.19

0.10

1.5

1.8

—

(40768804) Tissue Pathology biopsy report

101

0.99

0.00

1.7

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

2.4

—

0.9

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.2

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.0

—

24.2

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

0.00

0.0

6.8

—

138.6

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.3

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

3.3

—

59.4

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.4

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3010421) pH of Blood

0.00

0.0

3.2

—

7.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.1

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

1.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

2.2

—

1.8

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

3.2

—

5.0

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

3.0

—

5.3

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

2.0

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.8

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.0

1.5

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.00

0.0

2.2

—

0.4

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

3.2

—

11.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3044640) Blood type and Crossmatch panel - Blood

0.98

0.00

2.1

2.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.4

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.4

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

88.1

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.4

—

(1616796) Gas panel - Central venous blood

0.00

0.0

1.4

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.9

—

(3026493) Urate [Moles/volume] in Serum or Plasma

1.02

0.00

4.8

2.5

336.9

339.9

umol/l

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.9

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.9

—

(40758558) Short blood count panel - Blood

1.04

0.00

4.3

7.4

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.9

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.9

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.9

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

6.8

—

1.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

2.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.9

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

274

1.14

0.00

3.8

4.0

1.4

mmol/l

0.16

260

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.86

0.00

1.2

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint OTHER_DRUGADVERS_OSTEOMA_ADULTS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have OTHER_DRUGADVERS_OSTEOMA_ADULTS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: OTHER_DRUGADVERS_OSTEOMA_ADULTS – Other drug-induced osteomalacia in adults

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other drug-induced osteomalacia in adults

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints