Osteomalacia

M13_OSTEOMALACIA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M83
  • Hospital discharge: ICD-9 2682A
  • Hospital discharge: ICD-8 2652
  • Cause of death: ICD-10 M83
  • Cause of death: ICD-9 2682A
  • Cause of death: ICD-8 2652

2 out of 7 registries used, show all original rules.

319

4. Check minimum number of events

None

319

5. Include endpoints

None

319

6. Filter based on genotype QC (FinnGen only)

311

Control definitions (FinnGen only)

Control exclude
M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M80-M85
Name in latin
Osteomalacia adultorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2358 1342 1003
Only index persons 2066 1151 915
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.03
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 45.50 47.04 43.34
Only index persons 43.40 44.63 41.87

-FinnGen-

Key figures

All Female Male
Number of individuals 311 205 106
Unadjusted period prevalence (%) 0.06 0.07 0.05
Median age at first event (years) 45.24 45.63 44.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
319
Matched controls
3190
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M83.2
ICD-10 Finland
Adult osteomalacia due to malabsorption
+∞
164.2
143
*
M83.9
ICD-10 Finland
Adult osteomalacia, unspecified
+∞
59.2
55
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
7.1
54.6
103
200
M83.5
ICD-10 Finland
Other drug-induced osteomalacia in adults
+∞
35.0
33
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
4.9
30.5
81
207
S83.5
ICD-10 Finland
Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
7.7
25.6
38
55
M83.8
ICD-10 Finland
Other adult osteomalacia
+∞
25.3
24
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
6.0
24.8
48
92
NGE35
NOMESCO Finland
Plastic repair of ligament of knee not using prosthetic material, anterior cruciate, arthroscopic
9.1
21.3
27
32
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.4
21.2
104
401
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
5.8
20.4
40
77
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
7.2
20.0
31
47
S83.2
ICD-10 Finland
Tear of meniscus, current
4.7
19.1
48
115
M83.4
ICD-10 Finland
Aluminium bone disease
+∞
17.9
17
*
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
3.7
17.5
63
197
M83.3
ICD-10 Finland
Adult osteomalacia due to malnutrition
+∞
16.8
16
*
M83.0
ICD-10 Finland
Puerperal osteomalacia
+∞
16.8
16
*
M83.1
ICD-10 Finland
Senile osteomalacia
+∞
13.6
13
*
N02AX02
ATC
tramadol; systemic, rectal
2.4
12.7
164
987
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.5
12.3
112
577
X58
ICD-10 Finland
Exposure to other specified factors
2.9
11.9
67
272
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
4.1
11.5
33
87
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.2
10.5
44
150
M25.5
ICD-10 Finland
Pain in joint
2.2
10.4
129
748
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.9
10.2
52
199
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
7.8
9.9
22
30
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.1
9.8
168
1099
ZXA05
NOMESCO Finland
Left side
2.3
9.5
89
457
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
9.5
134
812
ZXD20
NOMESCO Finland
Day surgery
2.7
8.9
55
232
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.9
8.9
44
165
N03AX16
ATC
[U] pregabalin
2.3
8.8
86
449
M01AH05
ATC
etoricoxib; oral
2.1
8.4
220
1645
N02AA05
ATC
oxycodone; systemic
2.4
8.1
60
277
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
7.9
52
227
ZXA00
NOMESCO Finland
Right side
2.1
7.7
91
508
L15
ICPC
Knee symptom/complaint
2.1
7.6
85
466
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
7.5
124
782
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.1
7.4
92
524
26520
ICD-8 Finland
Vitamin D deficiency, Osteomalacia
+∞
7.3
7
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.7
7.3
17
38
R10.0
ICD-10 Finland
Acute abdomen
4.7
7.3
17
38
J01DB01
ATC
cefalexin; oral
2.4
7.3
273
2270
M23.8
ICD-10 Finland
Other internal derangements of knee
3.9
7.2
21
56
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
4.5
7.0
17
39
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.0
7.0
31
109
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
7.0
128
830
M81.9
ICD-10 Finland
Osteoporosis, unspecified
7.4
6.8
15
21
ZXD05
NOMESCO Finland
Urgent procedure
1.9
6.8
110
685
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
3.6
6.7
22
64
X59
ICD-10 Finland
Exposure to unspecified factor
2.1
6.6
68
358
B01AB05
ATC
enoxaparin; parenteral
1.9
6.5
103
634
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
4.2
6.4
17
42
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
2.6
6.3
39
164
M01AH01
ATC
celecoxib; oral
2.1
6.3
65
343
M93.1
ICD-10 Finland
Kienböck disease of adults
+∞
6.3
6
*
2682A
ICD-9 Finland
Vitamin D deficiency, Osteomalacia, unspecified[OSTEOMALACIA]
+∞
6.3
6
*
M01AE02
ATC
naproxen; oral, rectal
1.8
6.3
194
1466
M79.6
ICD-10 Finland
Pain in limb
1.8
6.2
141
970
A02BC02
ATC
pantoprazole; systemic
1.9
6.2
216
1691
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
6.0
124
826
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
2.4
6.0
43
194

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
165
1053
2.17
10.48
13.1
11.7
1.16
1.20
inr
0.29
54
333
203
1442
2.12
9.33
5.5
4.7
6.56
6.60
mmol/l
0.10
192
1338
179
1216
2.08
9.25
5.8
6.1
—
—
—
0
0
184
1328
1.91
7.32
5.8
6.1
0.18
0.19
e9/l
0.15
165
1184
183
1319
1.91
7.31
5.8
5.7
1.93
2.03
e9/l
0.36
166
1186
179
1282
1.90
7.28
5.8
5.7
0.04
0.04
e9/l
0.06
161
1124
178
1281
1.88
7.04
5.8
5.7
0.52
0.56
e9/l
1.71
160
1123
55
268
2.27
6.48
1.8
1.5
—
—
—
0
0
109
700
1.85
5.96
3.6
2.7
—
—
—
0
0
168
1243
1.74
5.58
5.9
5.6
30.32
28.95
%
0.94
163
1180
166
1228
1.73
5.49
5.7
5.5
55.71
56.67
%
0.50
161
1167
238
1957
1.85
5.38
4.9
3.9
11.00
10.75
mm/h
0.12
228
1804
162
1198
1.72
5.30
5.8
5.6
2.77
2.85
%
0.17
157
1130
161
1193
1.71
5.19
2.9
2.5
—
—
—
0
0
162
1207
1.70
5.09
6.0
5.9
8.51
8.31
%
0.40
157
1143
100
652
1.78
5.08
3.2
2.5
331.25
8063.14
umol/l
3.33
84
578
155
1150
1.68
4.88
5.8
5.7
0.75
0.70
%
0.68
150
1079
105
707
1.72
4.71
5.8
3.8
7.37
7.40
ph
1.76
17
135
219
1806
1.68
4.37
4.8
4.0
—
—
—
0
0
43
229
2.01
4.02
5.4
9.5
1.52
1.09
mmol/l
0.42
36
191
25
106
2.47
4.02
1.6
1.9
—
—
—
0
0
186
1491
1.59
3.99
9.2
9.1
3.75
4.03
e9/l
1.27
165
1313
25
107
2.45
3.94
1.6
1.9
—
—
—
0
0
25
107
2.45
3.94
1.6
1.9
—
—
—
0
0
29
133
2.30
3.93
3.3
7.8
—
—
—
0
0
87
585
1.67
3.83
5.5
3.9
—
—
—
0
0
108
770
1.61
3.76
3.0
2.5
52.47
57.37
u/l
1.01
102
718
166
1313
1.55
3.65
5.0
3.3
0.00
0.00
estimate
0.50
38
258
293
2676
2.16
3.63
18.3
12.0
22.17
20.91
mg/l
0.29
242
2060
166
1315
1.55
3.61
6.3
4.7
0.00
0.00
estimate
-0.00
37
242
110
796
1.58
3.57
2.8
2.2
—
—
—
0
0
167
1329
1.54
3.53
5.0
3.4
0.00
0.00
estimate
-0.00
39
232
24
107
2.34
3.48
1.7
1.9
—
—
—
0
0
103
738
1.58
3.47
3.3
2.9
71.38
40.86
e6/l
0.25
77
553
23
101
2.38
3.45
1.5
1.9
—
—
—
0
0
74
494
1.65
3.31
1.4
1.3
23.47
34.64
iu/ml
0.65
29
155
71
473
1.64
3.19
1.9
1.7
447.66
444.01
pmol/l
0.04
58
399
134
1035
1.51
3.16
3.0
2.2
74.98
76.24
nmol/l
0.23
126
935
74
501
1.62
3.12
2.8
2.4
6.91
5.21
e6/l
0.63
67
447
14
51
2.83
3.02
3.4
1.8
4.42
5.26
mmol/24h
0.49
14
42
229
1986
1.54
3.02
9.3
7.3
74.89
77.35
u/l
0.49
221
1867
20
88
2.36
3.00
1.5
1.5
—
—
—
0
0
72
489
1.61
2.99
1.4
1.2
21.99
6.99
u/ml
0.49
28
197
117
888
1.50
2.96
3.9
3.4
108.00
75.54
e6/l
0.32
82
605
26
130
2.09
2.90
5.7
10.4
25.40
25.08
mmol/l
0.22
26
123
212
1823
1.49
2.79
4.2
3.5
—
—
—
0
0
95
699
1.51
2.76
6.1
3.4
0.00
0.00
estimate
0.50
36
239
28
147
1.99
2.75
5.4
2.6
—
—
—
0
0
29
156
1.94
2.67
2.3
2.7
69.38
69.56
e9/l
0.01
23
118
136
1083
1.45
2.63
4.8
3.2
5.92
5.81
ph
—
6
102
16
68
2.42
2.60
2.6
2.2
—
—
—
0
0
18
85
2.18
2.33
1.4
1.4
314.30
285.29
ug/g
—
10
49
63
439
1.54
2.33
4.8
3.5
160.74
114.80
ng/l
0.20
45
326
9
28
3.28
2.32
2.7
2.1
13.11
13.35
%
—
9
28
19
92
2.13
2.32
7.1
4.5
—
—
—
0
0
82
605
1.48
2.32
5.7
3.2
—
—
—
0
0
10
34
3.00
2.30
1.5
1.3
—
—
—
0
0
144
1181
1.40
2.28
9.3
6.4
1.22
1.22
mmol/l
0.03
132
1012
115
909
1.41
2.25
4.5
3.3
23.45
35.93
ng/l
0.93
73
584
97
746
1.43
2.20
3.1
3.1
8.20
8.02
mmol/l
0.14
91
629
32
191
1.75
2.16
6.3
10.6
127.87
121.33
g/l
0.71
32
186
88
667
1.44
2.15
3.0
2.7
—
—
—
0
0
157
1319
1.37
2.10
6.8
6.4
10.42
10.75
umol/l
0.27
152
1253
141
1171
1.37
2.00
10.4
8.3
0.00
0.00
e9/l
0.65
118
968
55
385
1.52
1.99
2.3
1.6
1457.32
1208.83
nmol/l
0.45
46
291
88
676
1.42
1.99
3.1
2.8
0.36
0.50
e6/l
0.41
66
498
29
173
1.74
1.97
7.2
8.0
—
—
—
0
0
255
2340
1.45
1.89
22.1
15.7
332.62
332.69
g/l
0.04
255
2334
287
2699
1.63
1.88
20.6
13.5
3.96
3.96
mmol/l
0.10
282
2620
48
331
1.53
1.87
2.5
2.0
—
—
—
0
0
33
208
1.65
1.86
5.3
3.3
—
—
—
0
0
6
17
3.58
1.84
1.3
1.2
—
—
—
0
0
139
1163
1.35
1.84
3.1
2.7
110.01
116.16
ug/l
0.12
132
1081
228
2056
1.38
1.84
4.6
3.9
14.84
14.64
pmol/l
0.55
215
1881
75
568
1.42
1.83
6.6
3.7
1.01
1.02
kg/l
—
8
78
54
384
1.49
1.82
1.4
1.3
288.57
539.31
titre
1.55
14
87
114
932
1.35
1.74
2.1
1.9
91.59
97.98
pmol/l
0.88
62
470
7
24
2.96
1.73
2.1
2.5
—
—
—
0
0
50
354
1.49
1.73
1.3
1.2
—
—
—
0
0
17
91
1.92
1.64
1.8
2.2
8351.26
3552.76
u/l
—
8
37
102
829
1.34
1.60
4.0
3.1
2.35
2.35
mmol/l
0.03
97
740
10
44
2.31
1.57
5.6
2.4
—
—
—
0
0
75
584
1.37
1.55
1.9
1.7
0.75
1.12
mg/l
1.21
51
453
5
15
3.37
1.53
4.0
4.3
60.80
84.13
nmol/l
—
5
15
92
744
1.33
1.49
3.7
3.0
—
—
—
0
0
295
2819
1.62
1.47
16.4
11.2
—
—
—
0
0
127
1078
1.30
1.44
2.0
2.0
—
—
—
0
0
43
307
1.46
1.44
3.1
2.2
24.11
24.23
%
0.02
36
269
27
174
1.60
1.42
2.6
2.5
—
—
—
0
0
20
119
1.73
1.41
7.2
6.9
25.24
24.99
mmol/l
0.11
20
119
5
17
2.97
1.36
1.4
2.5
21.90
18.88
mu/l
—
5
17
11
54
2.07
1.34
1.5
1.7
—
—
—
0
0
9
43
2.12
1.31
2.3
1.9
—
—
—
0
0
9
43
2.12
1.31
4.0
1.6
—
—
—
0
0
309
2999
1.97
1.31
26.6
18.0
40.13
40.61
%
0.83
296
2862
60
465
1.36
1.28
3.3
2.7
544.08
545.80
mosm/kgh2o
0.02
51
395
9
44
2.08
1.28
1.3
1.2
—
—
—
0
0
87
714
1.30
1.25
3.6
3.8
10.44
8.05
mg/mmol
0.16
61
448
22
140
1.61
1.24
1.5
1.3
29.60
24.18
iu/l
0.35
22
124
32
225
1.47
1.18
1.4
1.3
—
—
—
0
0
19
118
1.65
1.17
1.2
1.1
—
—
—
0
0
82
674
1.29
1.17
3.7
3.2
744.84
258.12
mg/l
0.31
60
426
283
2703
1.42
1.16
4.7
4.7
2.75
2.87
mmol/l
1.48
273
2538
11
58
1.93
1.13
1.7
1.7
189.09
243.02
pmol/l
0.79
11
53
8
40
2.03
1.13
1.9
3.4
5.36
4.95
e9/l
—
8
40
279
2662
1.38
1.12
4.3
4.3
4.67
4.79
mmol/l
1.13
270
2508
56
439
1.33
1.12
3.8
2.6
2.45
2.45
mmol/l
0.03
49
388
75
614
1.29
1.10
1.3
1.2
0.50
1.21
u/ml
2.69
20
176
270
2571
1.33
1.03
4.4
4.2
5.95
5.86
mmol/l
0.45
258
2395
9
47
1.94
1.03
7.8
2.9
5.26
4.99
kpa
—
9
47
9
47
1.94
1.03
7.8
2.8
8.59
8.74
kpa
—
9
47
9
48
1.90
1.01
1.1
1.2
—
—
—
0
0
41
312
1.36
1.00
1.6
1.4
—
—
—
0
0
9
49
1.86
0.99
12.7
5.8
—
—
—
0
0
5
23
2.19
0.98
1.4
1.1
—
—
—
0
0
277
2652
1.34
0.98
4.2
4.2
1.44
1.48
mmol/l
1.07
268
2490
39
296
1.36
0.97
1.2
1.3
—
—
—
0
0
76
634
1.26
0.96
3.7
4.3
1.59
2.46
ug/l
0.96
70
579
31
228
1.40
0.93
3.7
3.1
—
—
—
0
0
11
63
1.77
0.91
2.6
12.9
1.20
1.19
mmol/l
0.01
11
54
6
29
2.09
0.89
1.5
1.1
—
—
—
0
0
8
42
1.93
0.89
2.0
4.0
63.63
58.24
%
—
8
42
47
373
1.30
0.88
2.8
2.6
1.46
2.61
e6/l
1.07
21
198
6
30
2.02
0.87
1.2
1.2
—
—
—
0
0
68
567
1.25
0.87
1.5
1.4
2.04
2.44
g/l
1.21
41
361
28
205
1.40
0.87
4.1
3.2
2.45
2.24
mmol/l
0.14
23
169
268
2567
1.28
0.84
3.9
3.8
1.37
1.29
mmol/l
0.88
260
2398
258
2464
1.25
0.80
5.4
4.6
1.82
2.35
mu/l
0.56
245
2279
8
48
1.68
0.79
2.0
1.4
—
—
—
0
0
0
26
0.00
0.79
0.0
1.8
—
607.35
—
0
26
75
640
1.22
0.78
6.5
6.9
—
—
—
0
0
246
2345
1.21
0.74
18.5
14.5
14.77
14.61
%
0.17
246
2318
9
56
1.62
0.73
1.8
1.7
—
—
—
0
0
5
25
2.02
0.73
1.4
1.2
—
—
—
0
0
9
146
0.61
0.71
1.0
1.1
—
—
—
0
0
9
58
1.57
0.70
7.9
2.8
7.40
7.43
ph
—
9
48
7
41
1.72
0.70
1.3
1.3
—
—
—
0
0
12
78
1.56
0.66
3.2
10.1
1.96
1.47
%
0.64
12
72
28
217
1.32
0.64
5.6
4.4
—
—
—
0
0
13
87
1.52
0.64
1.4
1.7
—
—
—
0
0
5
29
1.74
0.64
2.0
2.3
—
—
—
0
0
200
1889
1.16
0.60
3.4
3.1
47.72
43.53
u/l
0.33
194
1786
0
21
0.00
0.60
0.0
9.1
—
0.60
—
0
21
0
21
0.00
0.60
0.0
1.1
—
3.46
—
0
6
16
114
1.42
0.60
5.4
2.2
0.54
0.67
%
0.91
16
114
0
22
0.00
0.59
0.0
2.1
—
6.14
—
0
17
0
22
0.00
0.59
0.0
2.4
—
—
—
0
0
26
203
1.31
0.58
1.5
1.5
—
—
—
0
0
16
216
0.73
0.56
1.4
1.4
—
—
—
0
0
6
37
1.63
0.56
1.3
1.1
82.98
52.94
mu/l
—
6
32
12
82
1.48
0.55
19.9
9.9
—
—
—
0
0
12
82
1.48
0.55
1.6
1.8
3.13
4.87
ug/l
0.16
12
75
14
99
1.43
0.55
8.6
15.2
—
—
—
0
0
25
198
1.28
0.51
4.2
4.8
0.55
1.01
%
0.96
11
77
23
181
1.29
0.49
4.4
5.1
0.00
0.08
%
—
10
60
50
431
1.19
0.49
1.7
1.6
—
—
—
0
0
7
46
1.53
0.48
5.1
2.4
—
—
—
0
0
27
218
1.26
0.48
1.1
1.2
—
—
—
0
0
79
710
1.15
0.47
3.3
3.5
—
—
—
0
0
21
165
1.29
0.46
1.5
1.2
80.01
308.51
u/ml
0.95
21
153
5
31
1.62
0.43
2.6
1.2
—
—
—
0
0
5
32
1.57
0.42
1.2
1.6
—
—
—
0
0
8
58
1.39
0.42
1.1
1.1
—
—
—
0
0
8
58
1.39
0.42
1.1
1.1
—
—
—
0
0
5
33
1.52
0.41
4.0
3.4
13.42
3.72
nmol/l
—
5
33
0
15
0.00
0.41
0.0
2.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
0.21
—
0
16
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.6
—
49.10
—
0
10
0
19
0.00
0.39
0.0
1.1
—
5.56
—
0
5
11
80
1.39
0.39
1.2
1.2
—
—
—
0
0
253
2460
1.14
0.39
5.6
5.2
39.64
39.26
mmol/mol
0.27
243
2317
14
107
1.32
0.38
1.4
1.6
—
—
—
0
0
12
90
1.35
0.36
1.7
1.2
—
—
—
0
0
6
41
1.47
0.36
1.2
1.1
—
—
—
0
0
6
42
1.44
0.35
1.3
3.1
—
—
—
0
0
21
172
1.24
0.35
4.5
5.1
0.14
0.06
%
—
7
51
19
156
1.23
0.31
1.2
1.2
—
—
—
0
0
36
316
1.16
0.31
1.7
1.6
—
—
—
0
0
37
327
1.15
0.29
1.2
1.2
—
—
—
0
0
35
309
1.15
0.28
1.5
1.4
—
—
—
0
0
31
272
1.15
0.27
1.3
1.4
—
—
—
0
0
38
339
1.14
0.27
2.4
2.2
153.96
102.71
ug/g
0.43
27
262
11
86
1.29
0.26
2.1
2.6
—
—
—
0
0
10
77
1.31
0.26
1.8
2.5
11.69
11.38
mg/l
—
10
71
22
188
1.18
0.26
1.3
1.4
—
—
—
0
0
15
123
1.23
0.26
1.1
1.1
—
—
—
0
0
21
180
1.18
0.24
3.2
4.8
0.90
0.66
%
—
10
60
5
38
1.32
0.23
1.4
1.5
56.58
19.31
u/l
—
5
33
5
39
1.29
0.23
3.8
18.3
10.20
10.68
mmol/l
—
5
34
5
39
1.29
0.23
3.8
18.3
103.60
105.21
mmol/l
—
5
34
7
91
0.76
0.23
1.7
1.3
—
—
—
0
0
7
93
0.75
0.22
1.1
1.2
—
—
—
0
0
20
172
1.17
0.22
1.3
1.2
—
—
—
0
0
5
40
1.25
0.22
1.2
1.1
0.07
1.50
u/ml
—
5
21
0
10
0.00
0.21
0.0
3.7
—
35800.00
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
10
80
1.26
0.20
2.8
9.9
0.69
0.87
%
—
10
75
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
31
281
1.11
0.18
1.8
1.8
—
—
—
0
0
7
61
1.15
0.17
1.7
2.2
—
—
—
0
0
7
62
1.13
0.17
1.1
1.3
—
—
—
0
0
8
70
1.15
0.16
1.1
1.6
—
—
—
0
0
8
73
1.10
0.16
2.8
2.5
1.74
1.42
mg/l
—
8
67
9
81
1.11
0.15
1.3
1.1
—
—
—
0
0
26
237
1.11
0.14
3.7
4.4
77.40
25.93
ug/l
0.30
21
190
68
712
0.94
0.13
1.6
1.6
1.43
1.41
mmol/l
0.08
58
598
37
346
1.08
0.12
1.2
1.4
—
—
—
0
0
12
105
1.15
0.11
3.0
3.4
—
—
—
0
0
19
207
0.91
0.10
1.1
1.2
396.03
118.71
iu/ml
—
6
84
78
757
1.04
0.08
1.4
1.5
—
—
—
0
0
36
378
0.95
0.08
2.6
2.9
0.80
0.72
ug/l
0.19
18
231
7
68
1.03
0.08
1.6
2.8
—
—
—
0
0
8
76
1.05
0.07
1.1
1.1
—
—
—
0
0
33
314
1.06
0.07
1.8
3.0
13.84
8.52
umol/l
0.28
27
273
12
109
1.10
0.06
2.7
2.3
—
—
—
0
0
15
140
1.07
0.04
2.6
3.4
—
7.42
—
0
17
13
123
1.06
0.01
3.5
3.3
—
—
—
0
0
17
177
0.96
0.01
1.5
1.7
—
—
—
0
0
105
1056
0.99
0.00
2.6
2.8
—
—
—
0
0
53
533
0.99
0.00
2.0
1.9
—
—
—
0
0
32
316
1.01
0.00
1.6
1.7
—
—
—
0
0
5
57
0.88
-0.00
4.4
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
66
0.91
-0.00
1.2
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
66.57
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
36.4
—
110.50
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
66
0.91
-0.00
1.2
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
2.14
—
0
8
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
54
0.92
-0.00
1.0
2.6
17.40
27.62
u/ml
—
5
54
0
6
0.00
-0.00
0.0
1.3
—
8.17
—
0
6
0
7
0.00
-0.00
0.0
1.7
—
135.34
—
0
7
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
-0.00
4.3
4.3
—
—
—
0
0
7
76
0.92
-0.00
1.3
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
3.92
—
0
6

Mortality – FinRegistry

Association

Association between endpoint M13_OSTEOMALACIA and mortality.

Females

Parameter HR [95% CI] p-value
M13_OSTEOMALACIA 1.361 [1.13, 1.63] 0.001
Birth year 0.999 [0.99, 1.01] 0.78

During the follow-up period (1.1.1998 — 31.12.2019), 159 out of 1044 females with M13_OSTEOMALACIA died.

Males

Parameter HR [95% CI] p-value
M13_OSTEOMALACIA 1.341 [1.1, 1.63] 0.003
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 827 males with M13_OSTEOMALACIA died.

Mortality risk

Mortality risk for people of age

years, who have M13_OSTEOMALACIA.

N-year risk Females Males
1 0.08% 0.194%
5 0.877% 1.441%
10 2.346% 3.536%
15 4.516% 6.561%
20 7.848% 11.19%

Relationships between endpoints

Index endpoint: M13_OSTEOMALACIA – Osteomalacia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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