No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
317 |
4. Check minimum number of eventsNone |
317 |
5. Include endpointsNone |
317 |
6. Filter based on genotype QC (FinnGen only) |
317 |
Control definitions (FinnGen only)
- Control exclude
- M13_OSTEOCHONDRO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M80-M85
- Name in latin
- Osteomalacia adultorum
Similar endpoints
↥List of similar endpoints to
Osteomalacia
based on the number of shared cases.
Similar with more cases:
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2358 | 1342 | 1003 |
| Only index persons | 2066 | 1151 | 915 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 45.50 | 47.04 | 43.34 |
| Only index persons | 43.40 | 44.63 | 41.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 317 | 208 | 109 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | 45.39 | 45.56 | 45.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 283
- Matched controls
- 2828
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M83.2
ICD-10 Finland
Adult osteomalacia due to malabsorption
+∞
144.5
126
*
M83.9
ICD-10 Finland
Adult osteomalacia, unspecified
+∞
53.9
50
*
M83.5
ICD-10 Finland
Other drug-induced osteomalacia in adults
+∞
30.8
29
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
6.6
30.2
87
178
M83.8
ICD-10 Finland
Other adult osteomalacia
+∞
21.1
20
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
5.1
19.4
67
163
M83.4
ICD-10 Finland
Aluminium bone disease
+∞
17.9
17
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.5
15.9
86
312
M83.0
ICD-10 Finland
Puerperal osteomalacia
+∞
15.8
15
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
10.0
14.6
29
32
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
6.0
14.5
41
78
M83.3
ICD-10 Finland
Adult osteomalacia due to malnutrition
+∞
13.6
13
*
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
5.9
13.1
37
70
S83.5
ICD-10 Finland
Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
6.8
12.7
32
52
M83.1
ICD-10 Finland
Senile osteomalacia
+∞
12.6
12
*
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
3.7
12.5
58
183
S83.2
ICD-10 Finland
Tear of meniscus, current
4.3
10.3
39
102
NGE35
NOMESCO Finland
Plastic repair of ligament of knee not using prosthetic material, anterior cruciate, arthroscopic
8.4
10.3
22
28
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.3
10.2
155
979
N02AX02
ATC
tramadol; systemic, rectal
2.3
9.7
136
822
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
8.9
92
474
ZXA00
NOMESCO Finland
Right side
2.4
8.7
85
427
M25.5
ICD-10 Finland
Pain in joint
2.3
8.3
97
530
N02BE01
ATC
paracetamol; systemic, rectal
2.6
7.8
247
2054
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
25.8
7.6
10
*
NGF20
NOMESCO Finland
Operation for osteochondritis of knee, open
82.2
7.5
8
*
M81.9
ICD-10 Finland
Osteoporosis, unspecified
11.3
7.4
13
12
26520
ICD-8 Finland
Vitamin D deficiency, Osteomalacia
+∞
7.3
7
*
X58
ICD-10 Finland
Exposure to other specified factors
2.7
7.3
51
211
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.0
7.2
42
157
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
6.6
7.1
17
27
M01AH05
ATC
etoricoxib; oral
2.0
7.0
181
1336
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
4.1
7.0
26
68
S18
ICPC
Laceration/cut
2.0
7.0
119
753
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
7.5
6.8
15
21
A12AA04
ATC
calcium carbonate; oral
17.2
6.8
10
6
M79.6
ICD-10 Finland
Pain in limb
2.0
6.7
106
646
ZXA05
NOMESCO Finland
Left side
2.2
6.6
80
437
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
4.5
6.4
21
49
N03AX16
ATC
pregabalin; oral
2.1
6.0
76
422
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
202
1445
2.10
9.00
5.5
4.7
6.6
6.6
mmol/l
0.14
192
1342
37
159
2.50
5.75
1.6
1.5
—
—
—
0
0
161
1187
1.72
5.36
4.9
4.0
—
—
—
0
0
236
1948
1.83
5.17
4.9
3.9
11.0
10.7
mm/h
0.12
226
1794
8
7
11.68
4.81
1.6
1.7
48.4
85.2
ug/l
—
8
7
99
654
1.75
4.77
3.2
2.5
333.4
8103.1
umol/l
3.33
82
575
43
231
2.00
3.93
5.4
9.4
1.5
1.1
mmol/l
0.46
35
189
185
1489
1.58
3.86
9.2
9.2
3.8
4.0
e9/l
1.25
164
1312
165
1308
1.55
3.58
5.1
3.4
0.0
0.0
estimate
0.00
35
245
291
2663
2.13
3.49
18.4
12.1
22.3
21.0
mg/l
0.30
240
2053
165
1314
1.53
3.47
6.3
4.7
0.0
0.0
estimate
0.00
36
244
107
775
1.57
3.44
3.1
2.5
52.4
55.7
u/l
0.77
101
721
166
1327
1.53
3.41
5.1
3.4
0.0
0.0
estimate
0.00
38
235
71
475
1.64
3.14
1.9
1.7
447.7
443.9
pmol/l
0.04
58
402
73
492
1.63
3.14
1.4
1.3
24.2
34.0
iu/ml
0.53
28
151
85
596
1.58
3.10
2.7
2.1
—
—
—
0
0
134
1040
1.50
3.07
3.0
2.2
75.0
76.4
nmol/l
0.25
126
940
228
1984
1.53
2.91
9.3
7.4
74.8
77.6
u/l
0.56
220
1864
71
485
1.60
2.88
1.4
1.2
22.0
7.0
u/ml
0.49
28
195
12
42
2.93
2.78
1.5
1.1
—
—
—
0
0
14
54
2.67
2.74
1.2
1.3
—
—
—
0
0
113
871
1.46
2.59
4.0
3.0
—
—
—
0
0
94
704
1.48
2.48
6.2
3.5
0.0
0.0
estimate
0.50
35
242
63
436
1.56
2.40
4.8
3.6
160.7
114.5
ng/l
0.20
45
327
14
58
2.48
2.40
1.3
1.2
—
—
—
0
0
5
8
6.33
2.38
1.4
1.0
—
—
—
0
0
129
1036
1.41
2.32
5.5
3.4
—
—
—
0
0
144
1186
1.39
2.21
9.3
6.4
1.2
1.2
mmol/l
0.06
132
1008
115
913
1.41
2.18
4.5
3.3
23.6
33.7
ng/l
0.72
72
587
42
270
1.64
2.17
29.1
17.4
1.2
1.2
inr
0.00
11
44
32
193
1.73
2.09
6.3
10.5
127.9
121.4
g/l
0.70
32
186
55
384
1.52
2.02
2.3
1.6
1457.3
1227.8
nmol/l
0.40
46
290
88
676
1.42
1.99
3.1
2.8
0.4
0.5
e6/l
0.41
65
493
13
58
2.29
1.93
1.5
1.4
—
—
—
0
0
156
1322
1.35
1.93
6.9
6.4
10.4
10.7
umol/l
0.24
151
1255
138
1155
1.34
1.83
3.1
2.7
110.4
117.1
ug/l
0.13
131
1074
8
29
2.80
1.80
2.9
2.1
13.1
13.3
%
—
8
29
17
88
1.98
1.78
1.8
2.2
8351.3
3153.5
u/l
—
8
35
285
2687
1.60
1.76
20.8
13.6
4.0
4.0
mmol/l
0.08
280
2610
226
2046
1.36
1.72
4.7
3.9
14.8
14.6
pmol/l
0.50
213
1872
114
934
1.34
1.72
2.1
1.9
91.6
97.7
pmol/l
0.83
62
473
37
247
1.56
1.67
2.8
3.0
—
—
—
0
0
113
932
1.33
1.61
2.6
3.1
29.9
33.6
u/l
1.01
108
896
6
20
3.04
1.59
1.3
1.2
—
—
—
0
0
6
20
3.04
1.59
1.3
1.2
—
—
—
0
0
8
33
2.46
1.55
1.8
1.5
—
—
—
0
0
8
33
2.46
1.55
1.8
1.5
—
—
—
0
0
8
33
2.46
1.55
1.8
1.5
—
—
—
0
0
8
33
2.46
1.55
1.8
1.5
—
—
—
0
0
5
15
3.37
1.53
4.0
4.3
60.8
84.1
nmol/l
—
5
15
49
355
1.45
1.52
1.8
1.8
—
—
—
0
0
75
586
1.37
1.52
1.9
1.7
0.7
1.1
mg/l
1.21
51
453
43
305
1.47
1.48
3.1
2.2
24.1
24.2
%
0.01
36
267
20
119
1.73
1.41
7.1
6.9
25.2
25.0
mmol/l
0.11
20
119
9
40
2.29
1.41
2.8
1.3
—
—
—
0
0
269
2533
1.41
1.39
15.8
11.1
85.4
84.3
ml/min/173m2
0.34
228
2079
101
840
1.30
1.33
4.0
3.1
2.4
2.4
mmol/l
0.08
95
741
8
34
2.39
1.30
1.8
1.5
—
—
—
0
0
15
85
1.80
1.25
8.1
2.3
6.9
7.4
g/l
—
10
69
15
85
1.80
1.25
8.1
2.3
3.6
3.7
g/l
—
10
65
15
85
1.80
1.25
8.1
2.3
—
—
—
0
0
9
45
2.03
1.24
1.1
1.1
—
—
—
0
0
31
214
1.50
1.24
2.8
3.0
73.1
65.9
ml/min/173m2
0.30
15
91
22
141
1.60
1.21
1.5
1.3
29.6
23.9
iu/l
0.37
22
124
11
57
1.96
1.18
1.7
1.6
189.1
244.6
pmol/l
0.81
11
52
282
2693
1.43
1.18
4.7
4.7
2.8
2.9
mmol/l
1.31
272
2524
278
2651
1.40
1.15
4.3
4.3
4.7
4.8
mmol/l
1.02
269
2494
40
297
1.40
1.11
12.1
6.2
—
—
—
0
0
15
89
1.72
1.09
2.1
1.9
—
—
—
0
0
7
33
2.15
1.06
1.9
1.5
—
—
—
0
0
56
446
1.31
1.01
3.6
2.6
2.4
2.4
mmol/l
0.10
49
394
11
61
1.83
0.99
1.2
1.2
—
—
—
0
0
276
2642
1.35
0.99
4.1
4.3
1.4
1.5
mmol/l
1.05
267
2477
18
116
1.58
0.99
1.6
1.4
—
—
—
0
0
76
634
1.26
0.96
3.7
4.3
1.6
2.5
ug/l
0.98
70
579
15
93
1.64
0.95
1.6
1.8
—
256.0
—
0
5
16
101
1.62
0.95
1.5
1.5
—
—
—
0
0
268
2560
1.30
0.93
4.4
4.3
6.0
5.9
mmol/l
0.41
256
2386
51
406
1.31
0.93
2.5
2.4
0.5
1.1
e6/l
1.51
24
229
21
143
1.50
0.92
1.0
1.0
—
—
—
0
0
74
619
1.26
0.92
1.3
1.2
0.5
1.2
u/ml
2.60
19
179
28
205
1.40
0.87
4.1
3.2
2.6
2.2
mmol/l
0.24
22
163
47
374
1.30
0.86
2.8
2.6
1.5
2.6
e6/l
1.07
21
198
267
2558
1.28
0.84
3.9
3.9
1.4
1.3
mmol/l
0.85
259
2390
13
82
1.61
0.79
1.8
1.8
—
—
—
0
0
14
91
1.56
0.76
1.1
1.2
—
—
—
0
0
15
100
1.52
0.74
2.0
2.0
—
—
—
0
0
256
2451
1.23
0.74
5.4
4.6
1.8
2.4
mu/l
0.57
243
2266
259
2484
1.23
0.72
15.7
12.8
39.7
40.5
%
0.88
192
1931
45
367
1.26
0.70
1.8
1.9
1.5
1.4
%
0.51
37
326
5
28
1.80
0.66
1.6
1.3
—
—
—
0
0
71
616
1.20
0.63
3.2
3.1
994.8
971.9
ng/l
0.03
62
514
236
2261
1.17
0.57
19.0
14.9
13.7
13.6
%
1.18
236
2229
60
518
1.20
0.57
4.0
4.0
22.5
21.7
%
0.11
27
228
6
37
1.63
0.56
1.0
1.5
—
—
—
0
0
21
160
1.33
0.55
1.5
1.2
80.0
310.9
u/ml
0.92
21
148
12
83
1.46
0.52
1.6
1.8
3.1
4.8
ug/l
0.16
12
76
18
135
1.35
0.52
1.6
1.3
—
—
—
0
0
31
253
1.25
0.50
1.6
1.7
—
—
—
0
0
198
1884
1.14
0.49
3.4
3.1
47.7
43.6
u/l
0.33
192
1781
31
254
1.24
0.49
1.7
1.7
—
—
—
0
0
7
47
1.50
0.48
1.4
1.9
—
—
—
0
0
5
82
0.60
0.46
1.2
1.5
—
0.0
—
0
16
7
51
1.38
0.44
1.0
1.4
—
—
—
0
0
7
51
1.38
0.44
4.6
1.5
—
—
—
0
0
5
31
1.62
0.43
1.2
1.2
—
—
—
0
0
8
56
1.44
0.43
1.5
1.8
—
—
—
0
0
5
32
1.57
0.42
1.2
1.3
—
—
—
0
0
5
33
1.52
0.41
4.0
3.4
13.4
3.7
nmol/l
—
5
33
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
192
1836
1.12
0.40
3.1
3.3
—
—
—
0
0
13
97
1.35
0.40
2.2
2.2
—
—
—
0
0
24
290
0.81
0.39
3.8
4.3
32.4
32.7
%
0.03
18
196
0
19
0.00
0.39
0.0
1.2
—
79.0
—
0
6
252
2452
1.14
0.37
5.6
5.3
39.6
39.3
mmol/mol
0.22
242
2310
6
44
1.37
0.34
1.0
1.4
—
—
—
0
0
17
136
1.26
0.34
1.2
1.5
—
—
—
0
0
7
57
1.23
0.29
1.6
1.5
—
—
—
0
0
9
73
1.24
0.25
2.6
1.8
—
—
—
0
0
9
74
1.22
0.25
1.2
1.3
—
—
—
0
0
5
39
1.29
0.23
1.0
1.5
—
—
—
0
0
7
91
0.76
0.23
1.0
1.2
—
—
—
0
0
7
91
0.76
0.23
1.0
1.2
—
—
—
0
0
5
40
1.25
0.22
1.4
1.6
56.6
18.4
u/l
—
5
35
40
364
1.11
0.21
2.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.8
—
674.2
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
6
48
1.25
0.20
1.2
1.5
—
—
—
0
0
13
154
0.84
0.19
1.4
1.9
—
—
—
0
0
27
297
0.90
0.16
2.0
1.7
—
—
—
0
0
47
498
0.93
0.13
1.6
1.4
—
—
—
0
0
26
240
1.09
0.11
3.7
4.4
77.4
25.7
ug/l
0.30
21
192
68
706
0.95
0.10
1.6
1.6
1.4
1.4
mmol/l
0.07
58
595
5
44
1.14
0.10
1.4
1.2
—
—
—
0
0
5
44
1.14
0.10
1.4
1.2
—
—
—
0
0
5
47
1.06
0.09
1.4
1.2
—
—
—
0
0
14
155
0.90
0.09
1.1
1.4
—
—
—
0
0
7
64
1.10
0.08
1.4
1.5
—
—
—
0
0
36
378
0.95
0.08
2.6
2.8
0.8
0.7
ug/l
0.16
18
233
7
67
1.05
0.08
1.6
1.5
—
—
—
0
0
6
70
0.85
0.07
2.8
2.3
—
—
—
0
0
8
78
1.03
0.07
1.0
1.1
—
—
—
0
0
33
314
1.06
0.07
1.8
3.0
13.8
8.5
umol/l
0.28
27
273
9
84
1.07
0.07
1.2
1.6
—
—
—
0
0
13
118
1.11
0.07
1.9
1.7
—
—
—
0
0
19
202
0.94
0.05
1.1
1.2
396.0
121.5
iu/ml
—
6
80
15
140
1.07
0.04
2.7
3.4
5.8
5.1
kpa
—
10
127
12
129
0.93
0.03
2.1
1.9
7.1
2.4
mg/l
—
6
97
10
93
1.08
0.02
1.3
1.5
—
—
—
0
0
32
328
0.97
0.02
2.0
2.0
—
—
—
0
0
54
537
1.01
0.00
1.9
1.5
—
—
—
0
0
20
195
1.03
0.00
1.8
2.0
—
—
—
0
0
7
77
0.91
0.00
1.3
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
5
54
0.92
0.00
1.0
2.6
17.4
27.5
u/ml
—
5
54
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
18
180
1.00
0.00
1.4
1.3
—
35.2
—
0
12
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
7
77
0.91
0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
7
77
0.91
0.00
1.3
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
25.1
—
0
6
8
83
0.96
0.00
1.0
1.1
—
2.4
—
0
12
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_OSTEOMALACIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_OSTEOMALACIA | 1.361 [1.13, 1.63] | 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.78 |
During the follow-up period (1.1.1998 — 31.12.2019), 159 out of 1044 females with M13_OSTEOMALACIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_OSTEOMALACIA | 1.341 [1.1, 1.63] | 0.003 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 827 males with M13_OSTEOMALACIA died.
Mortality risk
Mortality risk for people of age
years, who have M13_OSTEOMALACIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.08% | 0.194% |
| 5 | 0.877% | 1.441% |
| 10 | 2.346% | 3.536% |
| 15 | 4.516% | 6.561% |
| 20 | 7.848% | 11.19% |
Relationships between endpoints
↥Index endpoint: M13_OSTEOMALACIA – Osteomalacia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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