Merkel cell carcinoma of skin

C3_MERKEL_CELL_SKIN

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Cancer registry: Topography ICD-O-3 — C44 Cancer registry: Morphology ICD-O-3 — 8247 Cancer registry: Behaviour codes — 3 1 out of 7 registries used, show all original rules.	40
4. Check minimum number of events None	40
5. Include endpoints None	40
6. Filter based on genotype QC (FinnGen only)	40

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze: DF9

NAME	C3_MERKEL_CELL_SKIN
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C44
CANC_TOPO_EXCL
CANC_MORPH	8247
CANC_MORPH_EXCL
CANC_BEHAV	3

Similar endpoints

↥

List of similar endpoints to Merkel cell carcinoma of skin based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Merkel cell carcinoma of skin, excluding all cancers (controls excluding all cancers)

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	40	22	18
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	74.46	73.90	75.14

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(4035726)

7.18

7.98

1.8

1.2

—

(40768804) Tissue Pathology biopsy report

126

4.04

4.34

5.1

2.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.67

3.80

1.9

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

147

3.57

3.54

3.9

3.7

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

3.71

3.29

3.8

3.6

311.5

228.1

u/l

0.57

(3044640) Blood type and Crossmatch panel - Blood

113

3.10

3.04

2.5

2.0

—

(3002256) Pathology report gross observation

3.61

2.84

1.8

1.3

—

(4034850)

5.53

2.13

9.4

28.6

—

(40768443) Skin Pathology biopsy report

3.81

2.07

1.1

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.84

1.85

1.3

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.70

1.69

1.3

2.0

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

179

2.29

1.65

6.7

9.7

3.2

4.7

e9/l

5.87

155

(3025941) Bacteria identified in Stool by Culture

3.17

1.57

1.0

1.4

—

(3021589) Normoblasts [#/volume] in Blood

135

2.17

1.55

8.2

10.5

0.0

e9/l

0.50

115

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.88

1.42

2.3

2.5

125.8

119.5

g/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.40

1.42

2.0

1.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

181

2.02

1.26

6.9

5.9

1.2

mmol/l

0.58

154

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.00

1.23

0.0

1.8

—

33.0

—

(40758558) Short blood count panel - Blood

2.03

1.17

6.1

6.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.28

1.09

1.3

1.7

—

(3042936) Bacteria identified in Isolate by Culture

2.03

1.05

1.8

1.9

—

(36304419) Bacteria [Presence] in Urine

106

1.85

0.99

2.4

3.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.01

0.94

3.3

5.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.02

0.93

4.4

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.96

0.83

3.7

2.8

5.0

13.1

umol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.85

0.82

1.4

2.2

—

(3003694) ABO and Rh group [Type] in Blood

1.82

0.78

1.1

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

300

1.89

0.75

22.3

20.6

26.8

27.0

mg/l

0.01

255

(3018095) Leukocytes [#/volume] in Urine

142

1.64

0.74

3.3

4.1

218.1

106.3

e6/l

0.34

106

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

142

1.64

0.74

3.1

3.5

—

(3044889) 12 lead EKG panel

225

1.62

0.64

5.3

4.3

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.62

0.0

6.2

—

35.1

—

(3000991) Gas panel - Venous blood

1.90

0.62

7.3

8.1

—

(40761511) CBC panel - Blood by Automated count

304

1.79

0.62

23.9

19.1

—

(3029937) Albumin [Presence] in Urine by Test strip

104

1.53

0.52

5.5

4.5

0.0

estimate

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

1.55

0.52

3.8

2.0

3.8

3.3

mg/l

0.24

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

134

1.47

0.48

2.1

2.4

—

(40761536) Microorganisms panel - Urine sediment

1.70

0.45

4.8

4.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.70

0.45

1.6

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

175

1.42

0.43

5.6

4.5

0.0

estimate

—

(40761535) Cells panel - Urine sediment

1.59

0.43

4.6

3.7

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.42

0.0

1.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

0.42

0.0

7.7

—

(3000494) Fungus identified in Specimen by Culture

1.54

0.38

1.5

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

312

1.60

0.38

30.8

23.5

86.6

84.0

umol/l

0.15

312

(3012544) pH of Venous blood

1.50

0.38

4.5

3.2

—

(3002032) Base excess in Venous blood by calculation

1.50

0.38

4.5

3.2

0.9

1.9

mmol/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

149

1.38

0.37

2.7

2.1

96.2

89.1

pmol/l

0.25

(3009542) Hematocrit [Volume Fraction] of Blood

239

1.40

0.36

18.9

20.6

35.6

39.1

0.82

144

(40768797) Stomach Pathology biopsy report

1.42

0.33

1.1

1.3

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.34

0.29

2.1

1.9

2.2

2.3

g/l

—

(3015736) pH of Urine

154

1.31

0.28

5.6

4.1

—

(3009261) Glucose [Presence] in Urine by Test strip

175

1.29

0.26

4.9

4.5

0.0

estimate

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.40

0.25

5.4

8.1

120.0

121.6

g/l

—

(3031040) Bacteria [#/volume] in Urine by Automated count

236

1.29

0.24

6.0

—

3634.5

—

(3013512) EKG study

108

1.30

0.24

5.2

—

(3019060) Gas panel - Arterial blood

1.32

0.24

2.6

3.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.21

0.0

1.1

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

2.5

—

(3047181) Lactate [Moles/volume] in Blood

0.00

0.21

0.0

4.5

—

1.0

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.21

0.0

3.0

—

14.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

2.3

—

108.2

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

2.3

—

4.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.31

0.21

5.3

3.8

—

(42870588) Differential panel, method unspecified - Blood

101

1.27

0.19

3.8

5.4

—

(3023368) Bacteria identified in Blood by Culture

130

1.25

0.19

3.1

4.6

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

1.20

0.18

2.4

1.9

23.0

21.4

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.18

0.18

2.3

1.9

13.3

13.1

umol/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

175

1.16

0.11

7.3

6.1

0.0

estimate

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

136

1.16

0.10

7.3

5.0

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

0.83

0.09

1.0

2.5

0.8

mmol/l

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

1.05

0.08

6.4

3.6

133.3

35.5

ng/l

—

(3019150) Specific gravity of Urine by Refractometry

0.82

0.08

9.6

5.4

—

1.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

100

0.87

0.07

4.9

4.5

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

0.88

0.07

2.1

1.9

728.6

441.5

pmol/l

—

(3026008) Bacteria identified in Urine by Culture

139

0.90

0.04

3.8

4.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

234

1.06

0.01

4.7

4.8

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

103

0.96

0.00

3.6

3.5

39.8

33.7

u/l

—

(3016038) Potassium [Moles/volume] in Urine

0.00

0.0

1.0

—

27.2

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.8

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

2.4

—

10.2

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

8.4

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

6.2

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(1616796) Gas panel - Central venous blood

0.00

0.0

2.7

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.6

—

131.7

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

4.0

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

1.2

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

4.2

—

97.8

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

412.6

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.6

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

3.4

—

88.8

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.0

2.4

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

4.2

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.0

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.0

1.6

—

5.6

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.3

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.9

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.4

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.0

1.6

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(3039000) Anion gap in Blood

0.00

0.0

5.0

—

10.7

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.0

1.4

—

55.9

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

5.4

—

(1761868) Lipid panel - Serum or Plasma

0.93

0.00

3.8

3.9

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

4.3

—

7.0

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

3.6

—

70.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.3

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

4.3

—

(3018572) Chloride [Moles/volume] in Blood

0.00

0.0

5.0

—

106.1

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

6.7

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.0

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

3.1

—

1.6

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

2.9

—

6.0

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

4.2

—

5.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.0

1.5

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

47.9

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: C3_MERKEL_CELL_SKIN – Merkel cell carcinoma of skin

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Merkel cell carcinoma of skin

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Merkel cell carcinoma of skin (C3_MERKEL_CELL_SKIN)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints