Carcinoma in situ of lip, excluding all cancers

CD2_INSITU_LIP_EXALLC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data
1. Apply sex-specific rule None	-
2. Check conditions not C3_LIP	-
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D00.00& Cause of death: ICD-10 — D00.00& Cancer registry: Topography ICD-O-3 — C00 Cancer registry: Morphology ICD-O-3 — ANY Cancer registry: Behaviour codes — 2 3 out of 7 registries used, show all original rules.	-
4. Check minimum number of events None	-
5. Include endpoints None	-
6. Filter based on genotype QC (FinnGen only) None	-

Control definitions (FinnGen only)

Control exclude: C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF9
Parent code in ICD-10: D00
Name in latin: Carcinoma in situ glandulae thyreoideae

NAME	CD2_INSITU_LIP_EXALLC
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS	!C3_LIP
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D0000
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D0000
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C00
CANC_TOPO_EXCL
CANC_MORPH	ANY
CANC_MORPH_EXCL
CANC_BEHAV	2

Similar endpoints

↥

List of similar endpoints to Carcinoma in situ of lip, excluding all cancers based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Carcinoma in situ of lip

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	-	-	-
Only index persons	-	-	-
Unadjusted period prevalence (%)
Whole population	-	-	-
Only index persons	-	-	-
Median age at first event (years)
Whole population	-	-	-
Only index persons	-	-	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	33	10	23
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	67.61	58.16	71.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768804) Tissue Pathology biopsy report

5.15

5.02

2.8

1.5

—

(3002256) Pathology report gross observation

6.66

3.43

1.9

1.1

—

(3027801) Oxygen [Partial pressure] in Arterial blood

4.45

2.56

3.8

11.6

9.8

kpa

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

4.45

2.56

3.8

4.8

4.7

kpa

—

(3016502) Oxygen saturation in Arterial blood

4.24

2.46

4.0

3.7

92.0

92.1

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

7.11

2.46

4.4

4.9

—

(3000494) Fungus identified in Specimen by Culture

4.15

2.19

1.4

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

5.66

2.15

2.2

2.1

15.6

3.1

ug/l

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

3.94

2.10

4.0

3.9

114.3

127.2

g/l

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.13

1.69

3.6

1.7

—

(3000991) Gas panel - Venous blood

3.73

1.58

4.0

4.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.89

1.55

2.9

1.8

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.27

1.41

2.8

4.4

0.8

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

3.27

1.41

2.6

4.5

0.9

1.4

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.27

1.41

2.8

4.8

94.3

93.1

—

(3026008) Bacteria identified in Urine by Culture

2.33

1.40

4.4

2.6

—

(3023368) Bacteria identified in Blood by Culture

2.29

1.35

9.2

4.1

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

2.70

1.31

5.0

2.2

45.7

5.4

umol/l

—

(3044640) Blood type and Crossmatch panel - Blood

2.25

1.20

3.7

1.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.62

1.13

1.4

1.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

2.03

1.09

6.6

3.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.49

1.07

1.6

1.3

—

(3042936) Bacteria identified in Isolate by Culture

2.19

1.04

4.3

1.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.92

0.88

3.0

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.95

0.77

3.6

1.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.77

0.75

5.8

2.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.08

0.74

1.8

2.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.85

0.66

7.8

10.6

—

(36304419) Bacteria [Presence] in Urine

1.73

0.63

4.7

2.4

—

(3003694) ABO and Rh group [Type] in Blood

1.72

0.62

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

103

1.62

0.58

3.4

2.8

—

(3013512) EKG study

0.54

3.4

4.5

—

(40761511) CBC panel - Blood by Automated count

248

1.85

0.54

23.9

13.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

116

1.54

0.49

3.1

4.2

39.0

51.9

ng/l

—

(3002385) Erythrocyte distribution width [Ratio]

186

1.55

0.47

37.8

17.3

14.0

13.9

0.07

180

(3019150) Specific gravity of Urine by Refractometry

1.53

0.47

5.1

4.1

—

1.0

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

1.52

0.44

2.0

2.4

77.7

77.4

nmol/l

0.01

(3000850) Epithelial cells [#/volume] in Urine

1.44

0.44

5.6

1.9

2.4

4.8

e6/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.42

0.0

1.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.42

0.0

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

199

1.51

0.41

35.8

15.3

34.6

38.7

0.52

116

(42870588) Differential panel, method unspecified - Blood

1.53

0.40

6.1

4.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

245

1.56

0.39

35.0

16.9

106.8

86.6

umol/l

0.81

245

(3041096) Erythrocytes [Presence] in Urine by Automated

0.63

0.30

4.4

3.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

144

0.74

0.27

4.1

2.8

100.1

41.2

u/l

0.85

132

(21494755) Public health laboratory ask at order entry panel

0.00

0.22

0.0

1.3

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.22

0.0

1.5

—

(3000492) Spirometry study

0.00

0.21

0.0

1.8

—

(3026493) Urate [Moles/volume] in Serum or Plasma

1.21

0.19

3.4

2.0

326.3

12197.7

umol/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

161

1.26

0.18

6.2

4.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

103

0.83

0.16

5.6

3.6

—

(3044889) 12 lead EKG panel

154

1.21

0.14

5.7

4.1

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.11

0.09

5.3

4.0

—

(3026782) Osmolality of Urine

1.06

0.09

6.0

2.1

501.7

558.8

mosm/kgh2o

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

0.82

0.09

1.2

1.4

2.0

1.3

mmol/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

116

1.05

0.00

2.0

2.2

116.3

89.5

pmol/l

—

(3015736) pH of Urine

1.06

0.00

5.0

3.6

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.0

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.2

—

(40758558) Short blood count panel - Blood

1.00

0.00

6.2

5.1

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

2.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.1

—

(4094501)

0.00

0.0

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.1

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.0

1.0

—

(3010421) pH of Blood

0.00

0.0

3.9

—

7.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

1.9

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

4.0

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

22.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.5

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

3.6

—

8.7

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

3.6

—

4.8

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

0.86

0.00

1.2

1.4

1.2

mg/l

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

0.0

3.6

—

364.6

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.0

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

1.0

—

0.8

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.4

—

32.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

2.0

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

0.00

0.0

2.6

—

2.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

3.0

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_INSITU_LIP_EXALLC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_LIP_EXALLC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_LIP_EXALLC – Carcinoma in situ of lip, excluding all cancers

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Carcinoma in situ of lip, excluding all cancers

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints