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Carcinoma in situ of lip, excluding all cancers

CD2_INSITU_LIP_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

  • not C3_LIP
-

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D00.00&
  • Cause of death: ICD-10 D00.00&
  • Cancer registry: Topography ICD-O-3 C00
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 2

3 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D00
Name in latin
Carcinoma in situ glandulae thyreoideae

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population - - -
Only index persons - - -
Unadjusted period prevalence (%)
Whole population - - -
Only index persons - - -
Median age at first event (years)
Whole population - - -
Only index persons - - -

-FinnGen-

Key figures

All Female Male
Number of individuals 33 10 23
Unadjusted period prevalence (%) 0.01 0.00 0.01
Median age at first event (years) 67.61 58.16 71.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
51
5.15
5.02
2.8
1.5
—
—
—
0
0
8
15
6.66
3.43
1.9
1.1
—
—
—
0
0
8
22
4.45
2.56
3.8
3.8
11.6
9.8
kpa
—
8
22
8
22
4.45
2.56
3.8
3.8
4.8
4.7
kpa
—
8
22
8
23
4.24
2.46
4.0
3.7
92.0
92.1
%
—
8
23
7
20
4.15
2.19
1.4
1.4
—
—
—
0
0
5
10
5.66
2.15
2.2
2.1
15.6
3.1
ug/l
—
5
10
7
21
3.94
2.10
4.0
3.9
114.3
127.2
g/l
—
7
21
5
15
3.73
1.58
4.0
4.5
—
—
—
0
0
5
17
3.27
1.41
2.8
4.4
0.8
0.8
%
—
5
17
5
17
3.27
1.41
2.6
4.5
0.9
1.4
%
—
5
17
5
17
3.27
1.41
2.8
4.8
94.3
93.1
%
—
5
17
13
72
2.33
1.40
4.4
2.6
—
—
—
0
0
13
73
2.29
1.35
9.2
4.1
—
—
—
0
0
6
25
2.70
1.31
5.0
2.2
45.7
5.4
umol/l
—
6
19
11
60
2.25
1.20
3.7
1.9
—
—
—
0
0
5
21
2.62
1.13
1.4
1.7
—
—
—
0
0
5
22
2.49
1.07
1.6
1.3
—
—
—
0
0
7
36
2.19
1.04
4.3
1.8
—
—
—
0
0
5
26
2.08
0.74
1.8
2.2
—
—
—
0
0
11
74
1.73
0.63
4.7
2.4
—
—
—
0
0
9
59
1.72
0.62
1.4
1.4
—
—
—
0
0
5
82
0.54
0.54
3.4
4.5
—
—
—
0
0
28
248
1.85
0.54
23.9
13.3
—
—
—
0
0
15
116
1.54
0.49
3.1
4.2
39.0
51.9
ng/l
—
10
91
22
186
1.55
0.47
37.8
17.3
14.0
13.9
%
0.07
22
180
8
57
1.53
0.47
5.1
4.1
—
1.0
—
0
8
8
60
1.44
0.44
5.6
1.9
2.4
4.8
e6/l
—
8
52
0
15
0.00
0.42
0.0
1.6
—
—
—
0
0
0
17
0.00
0.42
0.0
1.3
—
—
—
0
0
23
199
1.51
0.41
35.8
15.3
34.6
38.7
%
0.52
11
116
10
73
1.53
0.40
6.1
4.7
—
—
—
0
0
27
245
1.56
0.39
35.0
16.9
106.8
86.6
umol/l
0.81
27
245
5
73
0.63
0.30
4.4
3.1
—
—
—
0
0
0
11
0.00
0.22
0.0
1.3
—
—
—
0
0
0
11
0.00
0.22
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
7
60
1.21
0.19
3.4
2.0
326.3
12197.7
umol/l
—
7
52
18
161
1.26
0.18
6.2
4.2
—
—
—
0
0
17
154
1.21
0.14
5.7
4.1
—
—
—
0
0
6
55
1.11
0.09
5.3
4.0
—
—
—
0
0
6
57
1.06
0.09
6.0
2.1
501.7
558.8
mosm/kgh2o
—
6
44
5
59
0.82
0.09
1.2
1.4
2.0
1.3
mmol/l
—
5
50
12
116
1.05
0.00
2.0
2.2
116.3
89.5
pmol/l
—
6
65
10
96
1.06
0.00
5.0
3.6
—
—
—
0
0
5
50
1.00
0.00
6.2
5.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.9
—
7.5
—
0
8
0
6
0.00
0.00
0.0
1.3
—
22.4
—
0
6
0
8
0.00
0.00
0.0
3.6
—
8.7
—
0
8
0
8
0.00
0.00
0.0
3.6
—
4.8
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.86
0.00
1.2
1.4
1.4
1.2
mg/l
—
5
45
0
5
0.00
0.00
0.0
3.6
—
364.6
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.8
—
0
5
0
5
0.00
0.00
0.0
1.4
—
32.0
—
0
5
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
2.1
—
0
7
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_INSITU_LIP_EXALLC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_LIP_EXALLC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: CD2_INSITU_LIP_EXALLC – Carcinoma in situ of lip, excluding all cancers

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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